{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:47:33Z","timestamp":1784238453495,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shantou Science and Technology Plan Medical and Health Category Project: Study on the Effect and Safety of Low Molecular Weight Heparin Application in the Treatment of Early onset Preeclampsia","award":["200617165260841"],"award-info":[{"award-number":["200617165260841"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-03548-6","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:15:58Z","timestamp":1764051358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA"],"prefix":"10.1186","volume":"30","author":[{"given":"Xuan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"4","key":"3548_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.18388\/pb.2018_146","volume":"64","author":"A Filipek","year":"2018","unstructured":"Filipek A, Jurewicz E. Preeclampsia - a disease of pregnant women. Postepy Biochem. 2018;64(4):229\u201332. https:\/\/doi.org\/10.18388\/pb.2018_146.","journal-title":"Postepy Biochem"},{"issue":"1","key":"3548_CR2","doi-asserted-by":"publisher","first-page":"4231","DOI":"10.1002\/cphy.c210051","volume":"13","author":"V Dines","year":"2023","unstructured":"Dines V, Suvakov S, Kattah A, Vermunt J, Narang K, Jayachandran M, et al. Preeclampsia and the kidney: pathophysiology and clinical implications. Compr Physiol. 2023;13(1):4231\u201367. https:\/\/doi.org\/10.1002\/cphy.c210051.","journal-title":"Compr Physiol"},{"issue":"1","key":"3548_CR3","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s12884-022-04827-4","volume":"22","author":"S Nachshon","year":"2022","unstructured":"Nachshon S, Hadar E, Bardin R, Barbash-Hazan S, Borovich A, Braun M, et al. The association between chronic liver diseases and preeclampsia. BMC Pregnancy Childbirth. 2022;22(1):500. https:\/\/doi.org\/10.1186\/s12884-022-04827-4.","journal-title":"BMC Pregnancy Childbirth"},{"key":"3548_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6","author":"E Dimitriadis","year":"2023","unstructured":"Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco R, et al. Pre-eclampsia. Nat Rev Dis Primers. 2023. https:\/\/doi.org\/10.1038\/s41572-023-00417-6.","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"3548_CR5","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8401","volume":"4","author":"Y Yang","year":"2021","unstructured":"Yang Y, Le Ray I, Zhu J, Zhang J, Hua J, Reilly M. Preeclampsia prevalence, risk factors, and pregnancy outcomes in sweden and China. JAMA Netw Open. 2021;4(5):e218401. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.8401.","journal-title":"JAMA Netw Open"},{"issue":"1","key":"3548_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bpa.2022.02.003","volume":"36","author":"E Overton","year":"2022","unstructured":"Overton E, Tobes D, Lee A. Preeclampsia diagnosis and management. Best Pract Res Clin Anaesthesiol. 2022;36(1):107\u201321. https:\/\/doi.org\/10.1016\/j.bpa.2022.02.003.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"6","key":"3548_CR7","doi-asserted-by":"publisher","first-page":"F1315","DOI":"10.1152\/ajprenal.00071.2020","volume":"318","author":"HR Turbeville","year":"2020","unstructured":"Turbeville HR, Sasser JM. Preeclampsia beyond pregnancy: long-term consequences for mother and child. Am J Physiol Renal Physiol. 2020;318(6):F1315\u201326. https:\/\/doi.org\/10.1152\/ajprenal.00071.2020.","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"3548_CR8","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/JU.0000000000002788","volume":"208","author":"ME Westerman","year":"2022","unstructured":"Westerman ME, Bree KK, Msaouel P, Kukreja JB, Mantaring C, Rukundo I, et al. Apixaban vs enoxaparin for post-surgical extended-duration venous thromboembolic event prophylaxis: a prospective quality improvement study. J Urol. 2022;208(4):886\u201395. https:\/\/doi.org\/10.1097\/JU.0000000000002788.","journal-title":"J Urol"},{"issue":"1","key":"3548_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12325-019-01124-z","volume":"37","author":"B Jacobson","year":"2020","unstructured":"Jacobson B, Rambiritch V, Paek D, Sayre T, Naidoo P, Shan J, et al. Safety and efficacy of enoxaparin in pregnancy: a systematic review and meta-analysis. Adv Ther. 2020;37(1):27\u201340. https:\/\/doi.org\/10.1007\/s12325-019-01124-z.","journal-title":"Adv Ther"},{"issue":"3","key":"3548_CR10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ajog.2017.01.014","volume":"216","author":"KM Groom","year":"2017","unstructured":"Groom KM, Mccowan LM, Mackay LK, Lee AC, Said JM, Kane SC, et al. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial. Am J Obstet Gynecol. 2017;216(3):291\u20136. https:\/\/doi.org\/10.1016\/j.ajog.2017.01.014.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"3548_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.amjsurg.2021.07.030","volume":"223","author":"A Taylor","year":"2022","unstructured":"Taylor A, Martinez-Quinones P, Huang E, Robinson T, White CQ. Effective use of weight-based enoxaparin for deep vein thrombosis chemoprophylaxis in patients with traumatic brain injury. Am J Surg. 2022;223(1):146\u201350. https:\/\/doi.org\/10.1016\/j.amjsurg.2021.07.030.","journal-title":"Am J Surg"},{"issue":"1","key":"3548_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00011-025-02067-8","volume":"74","author":"S Gupta","year":"2025","unstructured":"Gupta S, Kumar P, Sarangi PP. Fibulin-7 and its bioactive fragments: emerging immunomodulatory roles in disease. Inflamm Res. 2025;74(1):101. https:\/\/doi.org\/10.1007\/s00011-025-02067-8.","journal-title":"Inflamm Res"},{"issue":"1","key":"3548_CR13","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1186\/s13018-025-06177-1","volume":"20","author":"W Fan","year":"2025","unstructured":"Fan W, Jia B, Chen J, Ma R, Li S, Guo J, et al. Role of lncrna nonmmut104330.1-mir-709-ddx58 axis in mediating immunomodulatory effects of enoxaparin sodium bone cement on macrophage polarization and inflammatory response. J Orthop Surg Res. 2025;20(1):756. https:\/\/doi.org\/10.1186\/s13018-025-06177-1.","journal-title":"J Orthop Surg Res"},{"issue":"2S","key":"3548_CR14","doi-asserted-by":"publisher","first-page":"S1145","DOI":"10.1016\/j.ajog.2021.08.027","volume":"226","author":"K Mclaughlin","year":"2022","unstructured":"Mclaughlin K, Hobson SR, Chandran AR, Agrawal S, Windrim RC, Parks WT, et al. Circulating maternal placental growth factor responses to low-molecular-weight heparin in pregnant patients at risk of placental dysfunction. Am J Obstet Gynecol. 2022;226(2S):S1145\u201356. https:\/\/doi.org\/10.1016\/j.ajog.2021.08.027.","journal-title":"Am J Obstet Gynecol"},{"key":"3548_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020102","author":"KE Bohnsack","year":"2019","unstructured":"Bohnsack KE, Hobartner C, Bohnsack MT. Eukaryotic 5-methylcytosine (m(5)c) rna methyltransferases: mechanisms, cellular functions, and links to disease. Genes. 2019. https:\/\/doi.org\/10.3390\/genes10020102.","journal-title":"Genes"},{"issue":"1","key":"3548_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12915-020-00769-5","volume":"18","author":"U Schumann","year":"2020","unstructured":"Schumann U, Zhang HN, Sibbritt T, Pan A, Horvath A, Gross S, et al. Multiple links between 5-methylcytosine content of mrna and translation. BMC Biol. 2020;18(1):40. https:\/\/doi.org\/10.1186\/s12915-020-00769-5.","journal-title":"BMC Biol"},{"issue":"2","key":"3548_CR17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201248R","volume":"37","author":"X Wei","year":"2023","unstructured":"Wei X, Zhou S, Liao L, Liu M, Gao Y, Yin Y, et al. Comprehensive analysis of transcriptomic profiling of 5-methylcytosin modification in placentas from preeclampsia and normotensive pregnancies. FASEB J. 2023;37(2):e22751. https:\/\/doi.org\/10.1096\/fj.202201248R.","journal-title":"FASEB J"},{"key":"3548_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.semcdb.2015.08.014","volume":"44","author":"VR Paixao-Cortes","year":"2015","unstructured":"Paixao-Cortes VR, Salzano FM, Bortolini MC. Origins and evolvability of the pax family. Semin Cell Dev Biol. 2015;44:64\u201374. https:\/\/doi.org\/10.1016\/j.semcdb.2015.08.014.","journal-title":"Semin Cell Dev Biol"},{"key":"3548_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.semcdb.2015.09.016","volume":"44","author":"R Sharma","year":"2015","unstructured":"Sharma R, Sanchez-Ferras O, Bouchard M. Pax genes in renal development, disease and regeneration. Semin Cell Dev Biol. 2015;44:97\u2013106. https:\/\/doi.org\/10.1016\/j.semcdb.2015.09.016.","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"3548_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/1120672118810998","volume":"30","author":"DD Chen","year":"2020","unstructured":"Chen DD, Yang T, Zhu SQ. Recurrent pax 6 mutation in a Chinese family with congenital aniridia, progressive cataracts and mental retardation. Eur J Ophthalmol. 2020;30(1):181\u20138. https:\/\/doi.org\/10.1177\/1120672118810998.","journal-title":"Eur J Ophthalmol"},{"key":"3548_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101402","volume":"29","author":"H Zhang","year":"2020","unstructured":"Zhang H, He Y, Wang J, Chen M, Xu J, Jiang M, et al. Mir-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. Redox Biol. 2020;29:101402. https:\/\/doi.org\/10.1016\/j.redox.2019.101402.","journal-title":"Redox Biol"},{"key":"3548_CR22","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.biopha.2018.01.089","volume":"99","author":"N Wang","year":"2018","unstructured":"Wang N, Feng Y, Xu J, Zou J, Chen M, He Y, et al. Mir-362-3p regulates cell proliferation, migration and invasion of trophoblastic cells under hypoxia through targeting pax3. Biomed Pharmacother. 2018;99:462\u20138. https:\/\/doi.org\/10.1016\/j.biopha.2018.01.089.","journal-title":"Biomed Pharmacother"},{"issue":"17","key":"3548_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000033649","volume":"102","author":"Z Liu","year":"2023","unstructured":"Liu Z, Liu H, Wang C, Pei J, Chu N, Peng T, et al. Identification of lncrna-mirna-mrna cerna network in hypoxia-induced htr-8\/svneo cells for preeclampsia. Medicine. 2023;102(17):e33649. https:\/\/doi.org\/10.1097\/MD.0000000000033649.","journal-title":"Medicine"},{"key":"3548_CR24","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20182022","author":"Y Feng","year":"2019","unstructured":"Feng Y, Wang J, He Y, Zhang H, Jiang M, Cao D, et al. Hoxd8\/diaph2-as1 epigenetically regulates pax3 and impairs htr-8\/svneo cell function under hypoxia. 2019. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20182022."},{"key":"3548_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132036","author":"C Tersigni","year":"2022","unstructured":"Tersigni C, Maulucci G, Castellani R, Bianchetti G, Onori M, Franco R, et al. Enoxaparin increases d6 receptor expression and restores cytoskeleton organization in trophoblast cells from preeclampsia. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11132036.","journal-title":"Cells"},{"issue":"9","key":"3548_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18361","volume":"28","author":"X Lu","year":"2024","unstructured":"Lu X, Zhang W, Zhang J, Ren D, Zhao P, Ying Y. Epas1, a hypoxia- and ferroptosis-related gene, promotes malignant behaviour of cervical cancer by cerna and super-enhancer. J Cell Mol Med. 2024;28(9):e18361. https:\/\/doi.org\/10.1111\/jcmm.18361.","journal-title":"J Cell Mol Med"},{"issue":"1","key":"3548_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13046-019-1156-5","volume":"38","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Lu S, Li T, Yu L, Zhang Y, Zeng H, et al. Ace2 inhibits breast cancer angiogenesis via suppressing the vegfa\/vegfr2\/erk pathway. J Exp Clin Cancer Res. 2019;38(1):173. https:\/\/doi.org\/10.1186\/s13046-019-1156-5.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"3548_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s41419-023-05646-x","volume":"14","author":"M Yang","year":"2023","unstructured":"Yang M, Wei R, Zhang S, Hu S, Liang X, Yang Z, et al. Nsun2 promotes osteosarcoma progression by enhancing the stability of fabp5 mrna via m(5)c methylation. Cell Death Dis. 2023;14(2):125. https:\/\/doi.org\/10.1038\/s41419-023-05646-x.","journal-title":"Cell Death Dis"},{"issue":"2","key":"3548_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112802","volume":"408","author":"X Quan","year":"2021","unstructured":"Quan X, Ye J, Yang X, Xie Y. Hoxa9-induced chemerin signals through cmklr1\/ampk\/txnip\/nlrp3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia. Exp Cell Res. 2021;408(2):112802. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112802.","journal-title":"Exp Cell Res"},{"issue":"2","key":"3548_CR30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.tjog.2020.01.002","volume":"59","author":"FA Rahnemaei","year":"2020","unstructured":"Rahnemaei FA, Fashami MA, Abdi F, Abbasi M. Factors effective in the prevention of preeclampsia:a systematic review. Taiwan J Obstet Gynecol. 2020;59(2):173\u201382. https:\/\/doi.org\/10.1016\/j.tjog.2020.01.002.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"2S","key":"3548_CR31","doi-asserted-by":"publisher","first-page":"S1126","DOI":"10.1016\/j.ajog.2020.11.006","volume":"226","author":"M Cruz-Lemini","year":"2022","unstructured":"Cruz-Lemini M, Vazquez JC, Ullmo J, Llurba E. Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis. Am J Obstet Gynecol. 2022;226(2S):S1126\u201344. https:\/\/doi.org\/10.1016\/j.ajog.2020.11.006.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"3548_CR32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1161\/01.HYP.0000149950.05182.a3","volume":"45","author":"G Mello","year":"2005","unstructured":"Mello G, Parretti E, Fatini C, Riviello C, Gensini F, Marchionni M, et al. Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme dd women. Hypertension. 2005;45(1):86\u201391. https:\/\/doi.org\/10.1161\/01.HYP.0000149950.05182.a3.","journal-title":"Hypertension"},{"issue":"5","key":"3548_CR33","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1160\/TH16-02-0169","volume":"116","author":"SA Mastrolia","year":"2016","unstructured":"Mastrolia SA, Novack L, Thachil J, Rabinovich A, Pikovsky O, Klaitman V, et al. Lmwh in the prevention of preeclampsia and fetal growth restriction in women without thrombophilia. A systematic review and meta-analysis. Thromb Haemost. 2016;116(5):868\u201378. https:\/\/doi.org\/10.1160\/TH16-02-0169.","journal-title":"Thromb Haemost"},{"issue":"3","key":"3548_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.thromres.2006.10.011","volume":"120","author":"RC Carroll","year":"2007","unstructured":"Carroll RC, Craft RM, Whitaker GL, Snider CC, Kirby RK, Elder RF, et al. Thrombelastography monitoring of resistance to enoxaparin anticoagulation in thrombophilic pregnancy patients. Thromb Res. 2007;120(3):367\u201370. https:\/\/doi.org\/10.1016\/j.thromres.2006.10.011.","journal-title":"Thromb Res"},{"issue":"11","key":"3548_CR35","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1002\/jcb.30479","volume":"124","author":"J Tong","year":"2023","unstructured":"Tong J, Li H, Zhang C. Altered 5-methylcytosine modification of mrna is involved in the pathogenesis of pre-eclampsia. J Cell Biochem. 2023;124(11):1720\u201333. https:\/\/doi.org\/10.1002\/jcb.30479.","journal-title":"J Cell Biochem"},{"issue":"4","key":"3548_CR36","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1093\/biolre\/ioae096","volume":"111","author":"T Zhang","year":"2024","unstructured":"Zhang T, Li H, Jiang E, Liu L, Zhang C. The downregulation of nsun5 may contribute to preeclampsiadagger. Biol Reprod. 2024;111(4):856\u201365. https:\/\/doi.org\/10.1093\/biolre\/ioae096.","journal-title":"Biol Reprod"},{"issue":"2","key":"3548_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.108899","volume":"27","author":"H Zhang","year":"2024","unstructured":"Zhang H, Li H, Yao J, Zhao M, Zhang C. The mutation of nsun5 r295c promotes preeclampsia by impairing decidualization through downregulating il-11ralpha. Iscience. 2024;27(2):108899. https:\/\/doi.org\/10.1016\/j.isci.2024.108899.","journal-title":"Iscience"},{"key":"3548_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.70054","author":"L Belfiore","year":"2025","unstructured":"Belfiore L, Balakrishnan A, Touahri Y, Zinyk D, Noman H, Okawa S, et al. Combinatorial expression of glial transcription factors induces schwann cell-specific gene expression in mouse embryonic fibroblasts. Dev Dyn. 2025. https:\/\/doi.org\/10.1002\/dvdy.70054.","journal-title":"Dev Dyn"},{"key":"3548_CR39","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.16.654522","author":"RA Hoffman","year":"2025","unstructured":"Hoffman RA, Wang M, Sunkel BD, Nguyen TH, Lopez-Nava J, Chatterjee B, et al. Fusion transcription factor dosage controls cell state in rhabdomyosarcoma. Biorxiv. 2025. https:\/\/doi.org\/10.1101\/2025.05.16.654522.","journal-title":"Biorxiv"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03548-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-03548-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03548-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T13:01:39Z","timestamp":1767099699000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40001-025-03548-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3548"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-03548-6","relation":{"references":[{"id-type":"doi","id":"10.1042\/BSR20182022","asserted-by":"subject"}]},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"4 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Second Afffliated Hospital of Shantou University Medical College (Approval Number: 2020\u201353). Written informed consent was obtained from all patients. This study was performed in line with the principles of the Declaration of Helsinki. The animal experiments was approved by the Ethics Committee of MDKN Biotechnology Co., Lt. (Approval Number: MDKN-2024\u2013047). All animal experiments comply with the ARRIVE guidelines. All experiments were performed in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1283"}}