{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T04:07:08Z","timestamp":1794370028719,"version":"4.9.0"},"reference-count":273,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91949204"],"award-info":[{"award-number":["91949204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830037"],"award-info":[{"award-number":["81830037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971145"],"award-info":[{"award-number":["81971145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271477"],"award-info":[{"award-number":["82271477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Neurodegener"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as a key contributor to the pathogenesis of various neurodegenerative diseases (NDs) including Alzheimer\u2019s disease, Parkinson\u2019s disease, amyotrophic lateral sclerosis, and Huntington\u2019s disease through delivery of bioactive cargos within the central nervous system (CNS). Importantly, CNS cell-derived EVs can be purified via immunoprecipitation, and EV cargos with altered levels have been identified as potential biomarkers for the diagnosis and prognosis of NDs. Given the essential impact of EVs on the pathogenesis of NDs, pathological EVs have been considered as therapeutic targets and EVs with therapeutic effects have been utilized as potential therapeutic agents or drug delivery platforms for the treatment of NDs. In this review, we focus on recent research progress on the pathological roles of EVs released from CNS cells in the pathogenesis of NDs, summarize findings that identify CNS-derived EV cargos as potential biomarkers to diagnose NDs, and comprehensively discuss promising potential of EVs as therapeutic targets, agents, and drug delivery systems in treating NDs, together with current concerns and challenges for basic research and clinical applications of EVs regarding NDs.<\/jats:p>","DOI":"10.1186\/s40035-022-00330-0","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T10:02:46Z","timestamp":1670839366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases"],"prefix":"10.1186","volume":"11","author":[{"given":"Xiaohuan","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-6319","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin C.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"330_CR1","doi-asserted-by":"crossref","unstructured":"Dugger BN, Dickson DW. Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2017;9(7).","DOI":"10.1101\/cshperspect.a028035"},{"key":"330_CR2","doi-asserted-by":"publisher","first-page":"101694","DOI":"10.1016\/j.pneurobio.2019.101694","volume":"183","author":"X Xia","year":"2019","unstructured":"Xia X, Wang Y, Huang Y, Zhang H, Lu H, Zheng JC. Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents. Prog Neurobiol. 2019;183:101694.","journal-title":"Prog Neurobiol"},{"issue":"47","key":"330_CR3","doi-asserted-by":"publisher","first-page":"9269","DOI":"10.1523\/JNEUROSCI.0147-18.2019","volume":"39","author":"AF Hill","year":"2019","unstructured":"Hill AF. Extracellular vesicles and neurodegenerative diseases. J Neurosci. 2019;39(47):9269\u201373.","journal-title":"J Neurosci"},{"key":"330_CR4","doi-asserted-by":"publisher","first-page":"101558","DOI":"10.1016\/j.arr.2021.101558","volume":"74","author":"X Xia","year":"2022","unstructured":"Xia X, Wang Y, Qin Y, Zhao S, Zheng JC. Exosome: a novel neurotransmission modulator or non-canonical neurotransmitter? Ageing Res Rev. 2022;74:101558.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"330_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","volume":"21","author":"M Mathieu","year":"2019","unstructured":"Mathieu M, Martin-Jaular L, Lavieu G, Thery C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9\u201317.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"330_CR6","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/0006-291X(83)91776-X","volume":"113","author":"C Harding","year":"1983","unstructured":"Harding C, Stahl P. Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing. Biochem Biophys Res Commun. 1983;113(2):650\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"330_CR7","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","volume":"33","author":"BT Pan","year":"1983","unstructured":"Pan BT, Johnstone RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell. 1983;33(3):967\u201378.","journal-title":"Cell"},{"issue":"4","key":"330_CR8","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/imm.13329","volume":"163","author":"X Xia","year":"2021","unstructured":"Xia X, Yuan P, Liu Y, Wang Y, Cao W, Zheng JC. Emerging roles of extracellular vesicles in COVID-19, a double-edged sword? Immunology. 2021;163(4):416\u201330.","journal-title":"Immunology"},{"key":"330_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neubiorev.2021.02.027","volume":"125","author":"S Zhao","year":"2021","unstructured":"Zhao S, Sheng S, Wang Y, Ding L, Xu X, Xia X, et al. Astrocyte-derived extracellular vesicles: a double-edged sword in central nervous system disorders. Neurosci Biobehav Rev. 2021;125:148\u201359.","journal-title":"Neurosci Biobehav Rev"},{"key":"330_CR10","doi-asserted-by":"publisher","first-page":"793388","DOI":"10.3389\/fcell.2022.793388","volume":"10","author":"L Ding","year":"2022","unstructured":"Ding L, Yang X, Xia X, Li Y, Wang Y, Li C, et al. Exosomes mediate APP dysregulation via APP-miR-185-5p axis. Front Cell Dev Biol. 2022;10:793388.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"330_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.fmre.2021.02.005","volume":"1","author":"X Xia","year":"2021","unstructured":"Xia X, Wang Y, Zheng JC. Emerging roles of extracellular vesicles in mediating RNA virus infection. Fundamental Res. 2021;1(2):7.","journal-title":"Fundamental Res"},{"key":"330_CR12","doi-asserted-by":"crossref","unstructured":"D\u2019Acunzo P, Perez-Gonzalez R, Kim Y, Hargash T, Miller C, Alldred MJ, et al Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. Sci Adv. 2021;7(7).","DOI":"10.1126\/sciadv.abe5085"},{"issue":"1","key":"330_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","volume":"113","author":"JC Akers","year":"2013","unstructured":"Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013;113(1):1\u201311.","journal-title":"J Neurooncol"},{"issue":"1","key":"330_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.celrep.2018.03.037","volume":"23","author":"MC Morton","year":"2018","unstructured":"Morton MC, Neckles VN, Seluzicki CM, Holmberg JC, Feliciano DM. Neonatal subventricular zone neural stem cells release extracellular vesicles that act as a microglial morphogen. Cell Rep. 2018;23(1):78\u201389.","journal-title":"Cell Rep"},{"key":"330_CR15","doi-asserted-by":"crossref","unstructured":"Sharma P, Mesci P, Carromeu C, McClatchy DR, Schiapparelli L, Yates JR 3. Exosomes regulate neurogenesis and circuit assembly. Proc Natl Acad Sci U S A. 2019;116(32):16086\u201394. rd, et al.","DOI":"10.1073\/pnas.1902513116"},{"key":"330_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2017.02.002","volume":"306","author":"I Selmaj","year":"2017","unstructured":"Selmaj I, Mycko MP, Raine CS, Selmaj KW. The role of exosomes in CNS inflammation and their involvement in multiple sclerosis. J Neuroimmunol. 2017;306:1\u201310.","journal-title":"J Neuroimmunol"},{"issue":"6","key":"330_CR17","doi-asserted-by":"publisher","first-page":"e936","DOI":"10.1002\/ctm2.936","volume":"12","author":"G Gao","year":"2022","unstructured":"Gao G, Li C, Zhu J, Sheng S, Liang Z, Fu S, et al. Induced neural stem\/progenitor cell-derived extracellular vesicles promote recovery post-stroke. Clin Transl Med. 2022;12(6):e936.","journal-title":"Clin Transl Med"},{"issue":"8","key":"330_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nrm2216","volume":"8","author":"S Mayor","year":"2007","unstructured":"Mayor S, Pagano RE. Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol. 2007;8(8):603\u201312.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"17","key":"330_CR19","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1038\/emboj.2011.286","volume":"30","author":"J Huotari","year":"2011","unstructured":"Huotari J, Helenius A. Endosome maturation. EMBO J. 2011;30(17):3481\u2013500.","journal-title":"EMBO J"},{"issue":"11","key":"330_CR20","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1091\/mbc.e12-07-0544","volume":"24","author":"H Zhu","year":"2013","unstructured":"Zhu H, Guariglia S, Yu RY, Li W, Brancho D, Peinado H, et al. Mutation of SIMPLE in Charcot-Marie-Tooth 1\u00a0C alters production of exosomes. Mol Biol Cell. 2013;24(11):1619\u201337. S1611-1613.","journal-title":"Mol Biol Cell"},{"issue":"3","key":"330_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2010.04.013","volume":"141","author":"M Cabrera","year":"2010","unstructured":"Cabrera M, Ungermann C. Guiding endosomal maturation. Cell. 2010;141(3):404\u20136.","journal-title":"Cell"},{"issue":"Pt 24","key":"330_CR22","first-page":"5553","volume":"126","author":"M Colombo","year":"2013","unstructured":"Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P, et al. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci. 2013;126(Pt 24):5553\u201365.","journal-title":"J Cell Sci"},{"issue":"14","key":"330_CR23","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1242\/dev.126516","volume":"143","author":"IJ McGough","year":"2016","unstructured":"McGough IJ, Vincent JP. Exosomes in developmental signalling. Development. 2016;143(14):2482\u201393.","journal-title":"Development"},{"issue":"1","key":"330_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/jb\/mvj128","volume":"140","author":"G van Niel","year":"2006","unstructured":"van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: a common pathway for a specialized function. J Biochem. 2006;140(1):13\u201321.","journal-title":"J Biochem"},{"issue":"7235","key":"330_CR25","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nature07836","volume":"458","author":"T Wollert","year":"2009","unstructured":"Wollert T, Wunder C, Lippincott-Schwartz J, Hurley JH. Membrane scission by the ESCRT-III complex. Nature. 2009;458(7235):172\u20137.","journal-title":"Nature"},{"issue":"4","key":"330_CR26","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.ceb.2011.04.008","volume":"23","author":"M Babst","year":"2011","unstructured":"Babst M. MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr Opin Cell Biol. 2011;23(4):452\u20137.","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"330_CR27","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.devcel.2011.08.019","volume":"21","author":"G van Niel","year":"2011","unstructured":"van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell. 2011;21(4):708\u201321.","journal-title":"Dev Cell"},{"issue":"10","key":"330_CR28","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","volume":"73","author":"S Mathivanan","year":"2010","unstructured":"Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteom. 2010;73(10):1907\u201320.","journal-title":"J Proteom"},{"issue":"9","key":"330_CR29","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrm2755","volume":"10","author":"BD Grant","year":"2009","unstructured":"Grant BD, Donaldson JG. Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol. 2009;10(9):597\u2013608.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"330_CR30","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tcb.2015.01.004","volume":"25","author":"E Cocucci","year":"2015","unstructured":"Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 2015;25(6):364\u201372.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"330_CR31","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1515\/BC.2001.059","volume":"382","author":"T Kobayashi","year":"2001","unstructured":"Kobayashi T, Startchev K, Whitney AJ, Gruenber J. Localization of lysobisphosphatidic acid-rich membrane domains in late endosomes. Biol Chem. 2001;382(3):483\u20135.","journal-title":"Biol Chem"},{"issue":"3","key":"330_CR32","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1074\/mcp.M112.021303","volume":"12","author":"BJ Tauro","year":"2013","unstructured":"Tauro BJ, Greening DW, Mathias RA, Mathivanan S, Ji H, Simpson RJ. Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol Cell Proteomics. 2013;12(3):587\u201398.","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"330_CR33","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1039\/C7NR08360B","volume":"10","author":"MI Ramirez","year":"2018","unstructured":"Ramirez MI, Amorim MG, Gadelha C, Milic I, Welsh JA, Freitas VM, et al. Technical challenges of working with extracellular vesicles. Nanoscale. 2018;10(3):881\u2013906.","journal-title":"Nanoscale"},{"issue":"14","key":"330_CR34","doi-asserted-by":"publisher","first-page":"e12144","DOI":"10.1002\/jev2.12144","volume":"10","author":"Y Couch","year":"2021","unstructured":"Couch Y, Buzas EI, Di Vizio D, Gho YS, Harrison P, Hill AF, et al. A brief history of nearly EV-erything - the rise and rise of extracellular vesicles. J Extracell Vesicles. 2021;10(14):e12144.","journal-title":"J Extracell Vesicles"},{"key":"330_CR35","doi-asserted-by":"publisher","first-page":"32945","DOI":"10.3402\/jev.v5.32945","volume":"5","author":"C Gardiner","year":"2016","unstructured":"Gardiner C, Di Vizio D, Sahoo S, Thery C, Witwer KW, Wauben M, et al. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. J Extracell Vesicles. 2016;5:32945.","journal-title":"J Extracell Vesicles"},{"key":"330_CR36","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cca.2021.03.026","volume":"518","author":"J Wang","year":"2021","unstructured":"Wang J, Huang X, Xie J, Han Y, Huang Y, Zhang H. Exosomal analysis: advances in biosensor technology. Clin Chim Acta. 2021;518:142\u201350.","journal-title":"Clin Chim Acta"},{"key":"330_CR37","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.2147\/IJN.S264498","volume":"15","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome. A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine. 2020;15:6917\u201334.","journal-title":"Int J Nanomedicine"},{"key":"330_CR38","doi-asserted-by":"crossref","unstructured":"Luo T, Chen SY, Qiu ZX, Miao YR, Ding Y, Pan XY, et al Transcriptomic features in a single extracellular vesicle via single-cell RNA sequencing. Small Methods. 2022:e2200881.","DOI":"10.1002\/smtd.202200881"},{"issue":"8","key":"330_CR39","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.molmed.2022.05.003","volume":"28","author":"S Ferguson","year":"2022","unstructured":"Ferguson S, Yang KS, Weissleder R. Single extracellular vesicle analysis for early cancer detection. Trends Mol Med. 2022;28(8):681\u201392.","journal-title":"Trends Mol Med"},{"key":"330_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3410\/B3-15","volume":"3","author":"C Thery","year":"2011","unstructured":"Thery C. Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep. 2011;3:15.","journal-title":"F1000 Biol Rep"},{"issue":"4","key":"330_CR41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373\u201383.","journal-title":"J Cell Biol"},{"key":"330_CR42","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.nbd.2018.12.003","volume":"124","author":"Y Ma","year":"2019","unstructured":"Ma Y, Wang K, Pan J, Fan Z, Tian C, Deng X, et al. Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal-regulated kinase pathways. Neurobiol Dis. 2019;124:322\u201334.","journal-title":"Neurobiol Dis"},{"issue":"6","key":"330_CR43","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1074\/mcp.M900381-MCP200","volume":"9","author":"JE Park","year":"2010","unstructured":"Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, et al. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics. 2010;9(6):1085\u201399.","journal-title":"Mol Cell Proteomics"},{"key":"330_CR44","doi-asserted-by":"crossref","unstructured":"Crescitelli R, Lasser C, Szabo TG, Kittel A, Eldh M, Dianzani I, et al Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles. 2013;2.","DOI":"10.3402\/jev.v2i0.20677"},{"issue":"1","key":"330_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00702-009-0288-8","volume":"117","author":"M Guescini","year":"2010","unstructured":"Guescini M, Genedani S, Stocchi V, Agnati LF. Astrocytes and glioblastoma cells release exosomes carrying mtDNA. J Neural Transm (Vienna). 2010;117(1):1\u20134.","journal-title":"J Neural Transm (Vienna)"},{"issue":"6","key":"330_CR46","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654\u20139.","journal-title":"Nat Cell Biol"},{"key":"330_CR47","doi-asserted-by":"crossref","unstructured":"Matarredona ER, Pastor AM. Extracellular vesicle-mediated communication between the glioblastoma and its microenvironment. Cells. 2019;9(1).","DOI":"10.3390\/cells9010096"},{"issue":"5","key":"330_CR48","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.celrep.2016.03.085","volume":"15","author":"AJ McKenzie","year":"2016","unstructured":"McKenzie AJ, Hoshino D, Hong NH, Cha DJ, Franklin JL, Coffey RJ, et al. KRAS-MEK signaling controls Ago2 sorting into exosomes. Cell Rep. 2016;15(5):978\u201387.","journal-title":"Cell Rep"},{"key":"330_CR49","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.plipres.2017.03.001","volume":"66","author":"T Skotland","year":"2017","unstructured":"Skotland T, Sandvig K, Llorente A. Lipids in exosomes: current knowledge and the way forward. Prog Lipid Res. 2017;66:30\u201341.","journal-title":"Prog Lipid Res"},{"issue":"7","key":"330_CR50","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.bbalip.2013.04.011","volume":"1831","author":"A Llorente","year":"2013","unstructured":"Llorente A, Skotland T, Sylvanne T, Kauhanen D, Rog T, Orlowski A, et al. Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta. 2013;1831(7):1302\u20139.","journal-title":"Biochim Biophys Acta"},{"key":"330_CR51","doi-asserted-by":"crossref","unstructured":"Ratajczak MZ, Ratajczak J. Extracellular microvesicles\/exosomes: discovery, disbelief, acceptance, and the future? Leukemia. 2020;34(12):3126\u20133135.","DOI":"10.1038\/s41375-020-01041-z"},{"issue":"1","key":"330_CR52","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1038\/s41467-021-24384-2","volume":"12","author":"M Mathieu","year":"2021","unstructured":"Mathieu M, Nevo N, Jouve M, Valenzuela JI, Maurin M, Verweij FJ, et al. Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9. Nat Commun. 2021;12(1):4389.","journal-title":"Nat Commun"},{"issue":"7","key":"330_CR53","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/ncb2502","volume":"14","author":"MF Baietti","year":"2012","unstructured":"Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A, et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat Cell Biol. 2012;14(7):677\u201385.","journal-title":"Nat Cell Biol"},{"issue":"14","key":"330_CR54","doi-asserted-by":"publisher","first-page":"10093","DOI":"10.1074\/jbc.C112.444562","volume":"288","author":"CA Thompson","year":"2013","unstructured":"Thompson CA, Purushothaman A, Ramani VC, Vlodavsky I, Sanderson RD. Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem. 2013;288(14):10093\u20139.","journal-title":"J Biol Chem"},{"issue":"1","key":"330_CR55","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.devcel.2011.05.015","volume":"21","author":"WM Henne","year":"2011","unstructured":"Henne WM, Buchkovich NJ, Emr SD. The ESCRT pathway. Dev Cell. 2011;21(1):77\u201391.","journal-title":"Dev Cell"},{"key":"330_CR56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.semcancer.2014.04.009","volume":"28","author":"C Villarroya-Beltri","year":"2014","unstructured":"Villarroya-Beltri C, Baixauli F, Gutierrez-Vazquez C, Sanchez-Madrid F, Mittelbrunn M. Sorting it out: regulation of exosome loading. Semin Cancer Biol. 2014;28:3\u201313.","journal-title":"Semin Cancer Biol"},{"issue":"5","key":"330_CR57","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1111\/febs.12110","volume":"280","author":"D Mazurov","year":"2013","unstructured":"Mazurov D, Barbashova L, Filatov A. Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes. FEBS J. 2013;280(5):1200\u201313.","journal-title":"FEBS J"},{"issue":"47","key":"330_CR58","doi-asserted-by":"publisher","first-page":"32621","DOI":"10.1074\/jbc.M804120200","volume":"283","author":"U Putz","year":"2008","unstructured":"Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, et al. Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem. 2008;283(47):32621\u20137.","journal-title":"J Biol Chem"},{"issue":"13","key":"330_CR59","doi-asserted-by":"publisher","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","volume":"102","author":"A de Gassart","year":"2003","unstructured":"de Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M. Lipid raft-associated protein sorting in exosomes. Blood. 2003;102(13):4336\u201344.","journal-title":"Blood"},{"issue":"11","key":"330_CR60","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1038\/emboj.2011.123","volume":"30","author":"FJ Verweij","year":"2011","unstructured":"Verweij FJ, van Eijndhoven MA, Hopmans ES, Vendrig T, Wurdinger T, Cahir-McFarland E, et al. LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-kappaB activation. EMBO J. 2011;30(11):2115\u201329.","journal-title":"EMBO J"},{"issue":"5","key":"330_CR61","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.celrep.2014.07.035","volume":"8","author":"ML Squadrito","year":"2014","unstructured":"Squadrito ML, Baer C, Burdet F, Maderna C, Gilfillan GD, Lyle R, et al. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 2014;8(5):1432\u201346.","journal-title":"Cell Rep"},{"key":"330_CR62","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1038\/ncomms3980","volume":"4","author":"C Villarroya-Beltri","year":"2013","unstructured":"Villarroya-Beltri C, Gutierrez-Vazquez C, Sanchez-Cabo F, Perez-Hernandez D, Vazquez J, Martin-Cofreces N, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4:2980.","journal-title":"Nat Commun"},{"issue":"3","key":"330_CR63","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.celrep.2016.09.031","volume":"17","author":"L Santangelo","year":"2016","unstructured":"Santangelo L, Giurato G, Cicchini C, Montaldo C, Mancone C, Tarallo R, et al. The RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting. Cell Rep. 2016;17(3):799\u2013808.","journal-title":"Cell Rep"},{"key":"330_CR64","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","volume":"78","author":"GJ Doherty","year":"2009","unstructured":"Doherty GJ, McMahon HT. Mechanisms of endocytosis. Annu Rev Biochem. 2009;78:857\u2013902.","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"330_CR65","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1158\/1541-7786.MCR-18-0891","volume":"17","author":"A Gonda","year":"2019","unstructured":"Gonda A, Kabagwira J, Senthil GN, Wall NR. Internalization of \u2018sis. Mol Cancer Res. 2019;17(2):337\u201347.","journal-title":"Mol Cancer Res"},{"issue":"32","key":"330_CR66","doi-asserted-by":"publisher","first-page":"22258","DOI":"10.1074\/jbc.M114.588046","volume":"289","author":"T Tian","year":"2014","unstructured":"Tian T, Zhu YL, Zhou YY, Liang GF, Wang YY, Hu FH, et al. Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery. J Biol Chem. 2014;289(32):22258\u201367.","journal-title":"J Biol Chem"},{"issue":"1","key":"330_CR67","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12885-017-3958-1","volume":"18","author":"S Horibe","year":"2018","unstructured":"Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y. Mechanism of recipient cell-dependent differences in exosome uptake. BMC Cancer. 2018;18(1):47.","journal-title":"BMC Cancer"},{"issue":"5","key":"330_CR68","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1600-0854.2010.01041.x","volume":"11","author":"D Feng","year":"2010","unstructured":"Feng D, Zhao WL, Ye YY, Bai XC, Liu RQ, Chang LF, et al. Cellular internalization of exosomes occurs through phagocytosis. Traffic. 2010;11(5):675\u201387.","journal-title":"Traffic"},{"issue":"6","key":"330_CR69","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/glia.22963","volume":"64","author":"K Guitart","year":"2016","unstructured":"Guitart K, Loers G, Buck F, Bork U, Schachner M, Kleene R. Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein. Glia. 2016;64(6):896\u2013910.","journal-title":"Glia"},{"issue":"1","key":"330_CR70","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","volume":"19","author":"S Gurung","year":"2021","unstructured":"Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19(1):47.","journal-title":"Cell Commun Signal"},{"issue":"49","key":"330_CR71","doi-asserted-by":"publisher","first-page":"34211","DOI":"10.1074\/jbc.M109.041152","volume":"284","author":"I Parolini","year":"2009","unstructured":"Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, De Milito A, et al. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem. 2009;284(49):34211\u201322.","journal-title":"J Biol Chem"},{"issue":"5","key":"330_CR72","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1182\/blood-2004-03-1095","volume":"106","author":"I Del Conde","year":"2005","unstructured":"Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106(5):1604\u201311.","journal-title":"Blood"},{"issue":"20","key":"330_CR73","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.15252\/embj.201696003","volume":"36","author":"M Tkach","year":"2017","unstructured":"Tkach M, Kowal J, Zucchetti AE, Enserink L, Jouve M, Lankar D, et al. Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes. EMBO J. 2017;36(20):3012\u201328.","journal-title":"EMBO J"},{"issue":"1\u20132","key":"330_CR74","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cellimm.2014.03.016","volume":"289","author":"A Sobo-Vujanovic","year":"2014","unstructured":"Sobo-Vujanovic A, Munich S, Vujanovic NL. Dendritic-cell exosomes cross-present toll-like receptor-ligands and activate bystander dendritic cells. Cell Immunol. 2014;289(1\u20132):119\u201327.","journal-title":"Cell Immunol"},{"key":"330_CR75","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","volume":"167","author":"JA Soria Lopez","year":"2019","unstructured":"Soria Lopez JA, Gonzalez HM, Leger GC. Alzheimer\u2019s disease. Handb Clin Neurol. 2019;167:231\u201355.","journal-title":"Handb Clin Neurol"},{"issue":"3","key":"330_CR76","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","volume":"17","author":"F Leng","year":"2021","unstructured":"Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol. 2021;17(3):157\u201372.","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"330_CR77","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877\u20132013.","journal-title":"Physiol Rev"},{"issue":"3","key":"330_CR78","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield DA, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 2019;20(3):148\u201360.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"330_CR79","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13195-020-00623-4","volume":"12","author":"X Gallart-Palau","year":"2020","unstructured":"Gallart-Palau X, Guo X, Serra A, Sze SK. Alzheimer\u2019s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. Alzheimers Res Ther. 2020;12(1):54.","journal-title":"Alzheimers Res Ther"},{"issue":"11","key":"330_CR80","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nn.4132","volume":"18","author":"H Asai","year":"2015","unstructured":"Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18(11):1584\u201393.","journal-title":"Nat Neurosci"},{"issue":"7","key":"330_CR81","doi-asserted-by":"publisher","first-page":"e12089","DOI":"10.1002\/jev2.12089","volume":"10","author":"H Su","year":"2021","unstructured":"Su H, Rustam YH, Masters CL, Makalic E, McLean CA, Hill AF, et al. Characterization of brain-derived extracellular vesicle lipids in Alzheimer\u2019s disease. J Extracell Vesicles. 2021;10(7):e12089.","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"330_CR82","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1038\/s41467-019-11534-w","volume":"10","author":"Y Men","year":"2019","unstructured":"Men Y, Yelick J, Jin S, Tian Y, Chiang MSR, Higashimori H, et al. Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS. Nat Commun. 2019;10(1):4136.","journal-title":"Nat Commun"},{"issue":"1","key":"330_CR83","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1212\/WNL.0000000000001702","volume":"85","author":"EJ Goetzl","year":"2015","unstructured":"Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, et al. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology. 2015;85(1):40\u20137.","journal-title":"Neurology"},{"issue":"5","key":"330_CR84","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/acn3.309","volume":"3","author":"EL Abner","year":"2016","unstructured":"Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ. Plasma neuronal exosomal levels of Alzheimer\u2019s disease biomarkers in normal aging. Ann Clin Transl Neurol. 2016;3(5):399\u2013403.","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"330_CR85","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41592-021-01174-8","volume":"18","author":"M Norman","year":"2021","unstructured":"Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJK, Lee JH, et al. L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma. Nat Methods. 2021;18(6):631\u20134.","journal-title":"Nat Methods"},{"key":"330_CR86","doi-asserted-by":"crossref","unstructured":"Gomes DE, Witwer KW. L1CAM-associated extracellular vesicles: a systematic review of nomenclature, sources, separation, and characterization. J Extracell Biol. 2022;1(3).","DOI":"10.1002\/jex2.35"},{"key":"330_CR87","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biochi.2018.05.015","volume":"155","author":"A Fernandes","year":"2018","unstructured":"Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D. Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling. Biochimie. 2018;155:67\u201382.","journal-title":"Biochimie"},{"issue":"1","key":"330_CR88","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00401-018-1868-1","volume":"136","author":"M Sardar Sinha","year":"2018","unstructured":"Sardar Sinha M, Ansell-Schultz A, Civitelli L, Hildesjo C, Larsson M, Lannfelt L, et al. Alzheimer\u2019s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. Acta Neuropathol. 2018;136(1):41\u201356.","journal-title":"Acta Neuropathol"},{"issue":"14","key":"330_CR89","doi-asserted-by":"publisher","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","volume":"287","author":"K Yuyama","year":"2012","unstructured":"Yuyama K, Sun H, Mitsutake S, Igarashi Y. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia. J Biol Chem. 2012;287(14):10977\u201389.","journal-title":"J Biol Chem"},{"key":"330_CR90","doi-asserted-by":"crossref","unstructured":"Nogueras-Ortiz CJ, Mahairaki V, Delgado-Peraza F, Das D, Avgerinos K, Eren E, et al Astrocyte- and neuron-derived extracellular vesicles from Alzheimer\u2019s disease patients effect complement-mediated neurotoxicity. Cells. 2020;9(7).","DOI":"10.3390\/cells9071618"},{"issue":"9","key":"330_CR91","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV. Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol. 2020;41(9):758\u201370.","journal-title":"Trends Immunol"},{"key":"330_CR92","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jconrel.2020.04.017","volume":"323","author":"R Upadhya","year":"2020","unstructured":"Upadhya R, Zingg W, Shetty S, Shetty AK. Astrocyte-derived extracellular vesicles: neuroreparative properties and role in the pathogenesis of neurodegenerative disorders. J Control Release. 2020;323:225\u201339.","journal-title":"J Control Release"},{"issue":"1","key":"330_CR93","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13024-016-0098-z","volume":"11","author":"S Sollvander","year":"2016","unstructured":"Sollvander S, Nikitidou E, Brolin R, Soderberg L, Sehlin D, Lannfelt L, et al. Accumulation of amyloid-beta by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons. Mol Neurodegener. 2016;11(1):38.","journal-title":"Mol Neurodegener"},{"issue":"4","key":"330_CR94","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.3233\/JAD-160292","volume":"53","author":"M Abdullah","year":"2016","unstructured":"Abdullah M, Takase H, Nunome M, Enomoto H, Ito J, Gong JS, et al. Amyloid-beta reduces exosome release from astrocytes by enhancing JNK phosphorylation. J Alzheimers Dis. 2016;53(4):1433\u201341.","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"330_CR95","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.neurobiolaging.2014.02.012","volume":"35","author":"MB Dinkins","year":"2014","unstructured":"Dinkins MB, Dasgupta S, Wang G, Zhu G, Bieberich E. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer\u2019s disease. Neurobiol Aging. 2014;35(8):1792\u2013800.","journal-title":"Neurobiol Aging"},{"issue":"25","key":"330_CR96","doi-asserted-by":"publisher","first-page":"21384","DOI":"10.1074\/jbc.M112.340513","volume":"287","author":"G Wang","year":"2012","unstructured":"Wang G, Dinkins M, He Q, Zhu G, Poirier C, Campbell A, et al. Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD). J Biol Chem. 2012;287(25):21384\u201395.","journal-title":"J Biol Chem"},{"key":"330_CR97","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3389\/fnins.2017.00217","volume":"11","author":"A Chiarini","year":"2017","unstructured":"Chiarini A, Armato U, Gardenal E, Gui L, Dal Pra I. Amyloid beta-exposed human astrocytes overproduce phospho-tau and overrelease it within exosomes, effects suppressed by calcilytic NPS 2143-further implications for Alzheimer\u2019s therapy. Front Neurosci. 2017;11:217.","journal-title":"Front Neurosci"},{"issue":"1","key":"330_CR98","doi-asserted-by":"publisher","first-page":"1378056","DOI":"10.1080\/20013078.2017.1378056","volume":"6","author":"K Menck","year":"2017","unstructured":"Menck K, Sonmezer C, Worst TS, Schulz M, Dihazi GH, Streit F, et al. Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane. J Extracell Vesicles. 2017;6(1):1378056.","journal-title":"J Extracell Vesicles"},{"issue":"11","key":"330_CR99","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1096\/fj.201600756R","volume":"30","author":"EJ Goetzl","year":"2016","unstructured":"Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, et al. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer\u2019s disease. FASEB J. 2016;30(11):3853\u20139.","journal-title":"FASEB J"},{"issue":"3","key":"330_CR100","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/ana.25172","volume":"83","author":"EJ Goetzl","year":"2018","unstructured":"Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. High complement levels in astrocyte-derived exosomes of Alzheimer disease. Ann Neurol. 2018;83(3):544\u201352.","journal-title":"Ann Neurol"},{"key":"330_CR101","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.dadm.2018.11.002","volume":"11","author":"CN Winston","year":"2019","unstructured":"Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer\u2019s disease dementia. Alzheimers Dement (Amst). 2019;11:61\u20136.","journal-title":"Alzheimers Dement (Amst)"},{"issue":"1","key":"330_CR102","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","volume":"11","author":"X Hu","year":"2015","unstructured":"Hu X, Leak RK, Shi Y, Suenaga J, Gao Y, Zheng P, et al. Microglial and macrophage polarization-new prospects for brain repair. Nat Rev Neurol. 2015;11(1):56\u201364.","journal-title":"Nat Rev Neurol"},{"key":"330_CR103","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","volume":"35","author":"M Colonna","year":"2017","unstructured":"Colonna M, Butovsky O. Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol. 2017;35:441\u201368.","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"330_CR104","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.molmed.2019.08.013","volume":"25","author":"EC Wright-Jin","year":"2019","unstructured":"Wright-Jin EC, Gutmann DH. Microglia as dynamic cellular mediators of brain function. Trends Mol Med. 2019;25(11):967\u201379.","journal-title":"Trends Mol Med"},{"issue":"4","key":"330_CR105","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nri.2017.125","volume":"18","author":"Q Li","year":"2018","unstructured":"Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18(4):225\u201342.","journal-title":"Nat Rev Immunol"},{"issue":"17","key":"330_CR106","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/j.devcel.2022.07.015","volume":"57","author":"DA Menassa","year":"2022","unstructured":"Menassa DA, Muntslag TAO, Martin-Estebane M, Barry-Carroll L, Chapman MA, Adorjan I, et al. The spatiotemporal dynamics of microglia across the human lifespan. Dev Cell. 2022;57(17):2127\u201339 e2126.","journal-title":"Dev Cell"},{"issue":"1","key":"330_CR107","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12974-022-02613-9","volume":"19","author":"Y Li","year":"2022","unstructured":"Li Y, Xia X, Wang Y, Zheng JC. Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer\u2019s disease. J Neuroinflammation. 2022;19(1):248.","journal-title":"J Neuroinflammation"},{"issue":"5","key":"330_CR108","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","volume":"173","author":"A Deczkowska","year":"2018","unstructured":"Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I. Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell. 2018;173(5):1073\u201381.","journal-title":"Cell"},{"issue":"10","key":"330_CR109","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","volume":"21","author":"S Hickman","year":"2018","unstructured":"Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci. 2018;21(10):1359\u201369.","journal-title":"Nat Neurosci"},{"key":"330_CR110","doi-asserted-by":"publisher","first-page":"630808","DOI":"10.3389\/fnmol.2021.630808","volume":"14","author":"M Guo","year":"2021","unstructured":"Guo M, Hao Y, Feng Y, Li H, Mao Y, Dong Q, et al. Microglial exosomes in neurodegenerative disease. Front Mol Neurosci. 2021;14:630808.","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"330_CR111","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1021\/acschemneuro.8b00029","volume":"9","author":"LK Gouwens","year":"2018","unstructured":"Gouwens LK, Ismail MS, Rogers VA, Zeller NT, Garrad EC, Amtashar FS, et al. Abeta42 protofibrils interact with and are trafficked through microglial-derived microvesicles. ACS Chem Neurosci. 2018;9(6):1416\u201325.","journal-title":"ACS Chem Neurosci"},{"key":"330_CR112","doi-asserted-by":"publisher","first-page":"766082","DOI":"10.3389\/fphar.2021.766082","volume":"12","author":"W Cohn","year":"2021","unstructured":"Cohn W, Melnik M, Huang C, Teter B, Chandra S, Zhu C, et al. Multi-omics analysis of microglial extracellular vesicles from human Alzheimer\u2019s disease brain tissue reveals disease-associated signatures. Front Pharmacol. 2021;12:766082.","journal-title":"Front Pharmacol"},{"issue":"5","key":"330_CR113","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","volume":"12","author":"SELA Mager","year":"2013","unstructured":"Mager SELA, Breakefield I, Wood XO. MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12(5):347\u201357.","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"330_CR114","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/1873-3468.14336","volume":"596","author":"S Huang","year":"2022","unstructured":"Huang S, Liao X, Wu J, Zhang X, Li Y, Xiang D, et al. The microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-beta by microglia. FEBS Lett. 2022;596(8):1059\u201371.","journal-title":"FEBS Lett"},{"issue":"1","key":"330_CR115","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s13760-016-0679-1","volume":"117","author":"DA Chistiakov","year":"2017","unstructured":"Chistiakov DA, Chistiakov AA. Alpha-synuclein-carrying extracellular vesicles in Parkinson\u2019s disease: deadly transmitters. Acta Neurol Belg. 2017;117(1):43\u201351.","journal-title":"Acta Neurol Belg"},{"issue":"20","key":"330_CR116","doi-asserted-by":"publisher","first-page":"6838","DOI":"10.1523\/JNEUROSCI.5699-09.2010","volume":"30","author":"E Emmanouilidou","year":"2010","unstructured":"Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, et al. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci. 2010;30(20):6838\u201351.","journal-title":"J Neurosci"},{"issue":"3","key":"330_CR117","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","volume":"42","author":"L Alvarez-Erviti","year":"2011","unstructured":"Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, et al. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis. 2011;42(3):360\u20137.","journal-title":"Neurobiol Dis"},{"issue":"6","key":"330_CR118","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/ene.14208","volume":"27","author":"M Niu","year":"2020","unstructured":"Niu M, Li Y, Li G, Zhou L, Luo N, Yao M, et al. A longitudinal study on alpha-synuclein in plasma neuronal exosomes as a biomarker for Parkinson\u2019s disease development and progression. Eur J Neurol. 2020;27(6):967\u201374.","journal-title":"Eur J Neurol"},{"issue":"7","key":"330_CR119","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1136\/jnnp-2019-322588","volume":"91","author":"C Jiang","year":"2020","unstructured":"Jiang C, Hopfner F, Katsikoudi A, Hein R, Catli C, Evetts S, et al. Serum neuronal exosomes predict and differentiate Parkinson\u2019s disease from atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2020;91(7):720\u20139.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"330_CR120","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1750-1326-7-42","volume":"7","author":"KM Danzer","year":"2012","unstructured":"Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, et al. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol neurodegeneration. 2012;7:42.","journal-title":"Mol neurodegeneration"},{"issue":"15","key":"330_CR121","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.2217\/epi-2019-0222","volume":"11","author":"T Zhou","year":"2019","unstructured":"Zhou T, Lin D, Chen Y, Peng S, Jing X, Lei M, et al. Alpha-synuclein accumulation in SH-SY5Y cell impairs autophagy in microglia by exosomes overloading miR-19a-3p. Epigenomics. 2019;11(15):1661\u201377.","journal-title":"Epigenomics"},{"issue":"5","key":"330_CR122","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00401-015-1408-1","volume":"129","author":"M Kunadt","year":"2015","unstructured":"Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, et al. Extracellular vesicle sorting of alpha-synuclein is regulated by sumoylation. Acta Neuropathol. 2015;129(5):695\u2013713.","journal-title":"Acta Neuropathol"},{"key":"330_CR123","doi-asserted-by":"publisher","first-page":"572058","DOI":"10.3389\/fgene.2020.572058","volume":"11","author":"R Kumar","year":"2020","unstructured":"Kumar R, Donakonda S, Muller SA, Botzel K, Hoglinger GU, Koeglsperger T. FGF2 affects Parkinson\u2019s Disease-Associated Molecular Networks through Exosomal Rab8b\/Rab31. Front Genet. 2020;11:572058.","journal-title":"Front Genet"},{"key":"330_CR124","doi-asserted-by":"crossref","unstructured":"Anastasi F, Masciandaro SM, Carratore RD, Dell\u2019Anno MT, Signore G, Falleni A, et al Proteomics profiling of neuron-derived small extracellular vesicles from human plasma: enabling single-subject analysis. International journal of molecular sciences. 2021;22(6).","DOI":"10.3390\/ijms22062951"},{"issue":"2","key":"330_CR125","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12015-020-10050-5","volume":"18","author":"X Xia","year":"2022","unstructured":"Xia X, Wang Y, Zheng JC. The microRNA-17 ~ 92 family as a key regulator of neurogenesis and potential regenerative therapeutics of neurological disorders. Stem Cell Rev Rep. 2022;18(2):401\u201311.","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"330_CR126","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s13287-019-1387-6","volume":"10","author":"X Xia","year":"2019","unstructured":"Xia X, Lu H, Li C, Huang Y, Wang Y, Yang X, et al. miR-106b regulates the proliferation and differentiation of neural stem\/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis. Stem Cell Res Ther. 2019;10(1):282.","journal-title":"Stem Cell Res Ther"},{"key":"330_CR127","doi-asserted-by":"publisher","first-page":"136414","DOI":"10.1016\/j.neulet.2021.136414","volume":"771","author":"Y Li","year":"2022","unstructured":"Li Y, Li Z, Gu J, Xu X, Chen H, Gui Y. Exosomes isolated during dopaminergic neuron differentiation suppressed neuronal inflammation in a rodent model of Parkinson\u2019s disease. Neurosci Lett. 2022;771:136414.","journal-title":"Neurosci Lett"},{"key":"330_CR128","doi-asserted-by":"crossref","unstructured":"Valdinocci D, Radford RA, Siow SM, Chung RS, Pountney DL. Potential modes of intercellular alpha-synuclein transmission. Int J Mol Sci. 2017;18(2).","DOI":"10.3390\/ijms18020469"},{"issue":"5","key":"330_CR129","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s11064-020-02977-5","volume":"45","author":"M Norshalena Shakespear","year":"2020","unstructured":"Norshalena Shakespear M, Ogura, Yamaki J, Homma Y. Astrocyte-derived exosomal microRNA miR-200a-3p prevents MPP(+)-induced apoptotic cell death through down-regulation of MKK4. Neurochem Res. 2020;45(5):1020\u201333.","journal-title":"Neurochem Res"},{"issue":"5","key":"330_CR130","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1093\/brain\/awaa090","volume":"143","author":"M Guo","year":"2020","unstructured":"Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, et al. Microglial exosomes facilitate alpha-synuclein transmission in Parkinson\u2019s disease. Brain. 2020;143(5):1476\u201397.","journal-title":"Brain"},{"key":"330_CR131","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neulet.2013.06.009","volume":"548","author":"C Chang","year":"2013","unstructured":"Chang C, Lang H, Geng N, Wang J, Li N, Wang X. Exosomes of BV-2 cells induced by alpha-synuclein: important mediator of neurodegeneration in PD. Neurosci Lett. 2013;548:190\u20135.","journal-title":"Neurosci Lett"},{"issue":"2","key":"330_CR132","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bbrc.2019.02.076","volume":"511","author":"R Tsutsumi","year":"2019","unstructured":"Tsutsumi R, Hori Y, Seki T, Kurauchi Y, Sato M, Oshima M, et al. Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures. Biochem Biophys Res Commun. 2019;511(2):427\u201333.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"330_CR133","doi-asserted-by":"publisher","first-page":"e1001604","DOI":"10.1371\/journal.pbio.1001604","volume":"11","author":"C Fruhbeis","year":"2013","unstructured":"Fruhbeis C, Frohlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11(7):e1001604.","journal-title":"PLoS Biol"},{"issue":"12","key":"330_CR134","doi-asserted-by":"publisher","first-page":"e3000621","DOI":"10.1371\/journal.pbio.3000621","volume":"18","author":"C Fruhbeis","year":"2020","unstructured":"Fruhbeis C, Kuo-Elsner WP, Muller C, Barth K, Peris L, Tenzer S, et al. Oligodendrocytes support axonal transport and maintenance via exosome secretion. PLoS Biol. 2020;18(12):e3000621.","journal-title":"PLoS Biol"},{"key":"330_CR135","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.parkreldis.2018.11.021","volume":"61","author":"T Ohmichi","year":"2019","unstructured":"Ohmichi T, Mitsuhashi M, Tatebe H, Kasai T, Ali El-Agnaf OM, Tokuda T. Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson\u2019s and related diseases. Parkinsonism Relat Disord. 2019;61:82\u20137.","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"330_CR136","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00401-021-02324-0","volume":"142","author":"S Dutta","year":"2021","unstructured":"Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, et al. Alpha-synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson\u2019s disease from multiple system atrophy. Acta Neuropathol. 2021;142(3):495\u2013511.","journal-title":"Acta Neuropathol"},{"issue":"10","key":"330_CR137","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1074\/jbc.RA118.004825","volume":"294","author":"JM Silverman","year":"2019","unstructured":"Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, et al. CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)(G93A) ALS mice originate from astrocytes and neurons and carry misfolded SOD1. J Biol Chem. 2019;294(10):3744\u201359.","journal-title":"J Biol Chem"},{"key":"330_CR138","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3389\/fnins.2017.00273","volume":"11","author":"S Pinto","year":"2017","unstructured":"Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in miR-124 and drive alterations in microglia phenotype. Front Neurosci. 2017;11:273.","journal-title":"Front Neurosci"},{"issue":"3","key":"330_CR139","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.celrep.2016.09.032","volume":"17","author":"T Westergard","year":"2016","unstructured":"Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, et al. Cell-to-cell transmission of dipeptide repeat proteins linked to C9orf72-ALS\/FTD. Cell Rep. 2016;17(3):645\u201352.","journal-title":"Cell Rep"},{"issue":"15","key":"330_CR140","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1007\/s00018-021-03872-0","volume":"78","author":"JR Kok","year":"2021","unstructured":"Kok JR, Palminha NM, Dos Santos Souza C, El-Khamisy SF, Ferraiuolo L. DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity. Cell Mol Life Sci. 2021;78(15):5707\u201329.","journal-title":"Cell Mol Life Sci"},{"key":"330_CR141","doi-asserted-by":"publisher","first-page":"134176","DOI":"10.1016\/j.neulet.2019.03.048","volume":"708","author":"M Katsu","year":"2019","unstructured":"Katsu M, Hama Y, Utsumi J, Takashina K, Yasumatsu H, Mori F, et al. MicroRNA expression profiles of neuron-derived extracellular vesicles in plasma from patients with amyotrophic lateral sclerosis. Neurosci Lett. 2019;708:134176.","journal-title":"Neurosci Lett"},{"key":"330_CR142","doi-asserted-by":"publisher","first-page":"660429","DOI":"10.3389\/fnmol.2021.660429","volume":"14","author":"Y Qi","year":"2021","unstructured":"Qi Y, Ma N, Chen X, Wang Y, Zhang W, Wan J. CircRtn4 acts as the sponge of mir-24-3p to promote neurite growth by regulating CHD5. Front Mol Neurosci. 2021;14:660429.","journal-title":"Front Mol Neurosci"},{"issue":"8","key":"330_CR143","doi-asserted-by":"publisher","first-page":"e0006521","DOI":"10.1128\/MCB.00065-21","volume":"41","author":"G Di","year":"2021","unstructured":"Di G, Yang X, Cheng F, Liu H, Xu M. CEBPA-AS1 knockdown alleviates oxygen-glucose deprivation\/reperfusion-induced neuron cell damage by the microRNA 24-3p\/BOK axis. Mol Cell Biol. 2021;41(8):e0006521.","journal-title":"Mol Cell Biol"},{"key":"330_CR144","doi-asserted-by":"publisher","first-page":"136635","DOI":"10.1016\/j.neulet.2022.136635","volume":"779","author":"H Luo","year":"2022","unstructured":"Luo H, Ye G, Liu Y, Huang D, Luo Q, Chen W, et al. Mir-150-3p enhances neuroprotective effects of neural stem cell exosomes after hypoxic-ischemic brain injury by targeting CASP2. Neurosci Lett. 2022;779:136635.","journal-title":"Neurosci Lett"},{"key":"330_CR145","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12014-020-09294-7","volume":"17","author":"AG Thompson","year":"2020","unstructured":"Thompson AG, Gray E, Mager I, Thezenas ML, Charles PD, Talbot K, et al. CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis. Clin Proteom. 2020;17:31.","journal-title":"Clin Proteom"},{"issue":"22","key":"330_CR146","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","volume":"288","author":"M Basso","year":"2013","unstructured":"Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, et al. Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis. J Biol Chem. 2013;288(22):15699\u2013711.","journal-title":"J Biol Chem"},{"key":"330_CR147","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ebiom.2018.11.067","volume":"40","author":"A Varcianna","year":"2019","unstructured":"Varcianna A, Myszczynska MA, Castelli LM, O\u2019Neill B, Kim Y, Talbot J, et al. Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine. 2019;40:626\u201335.","journal-title":"EBioMedicine"},{"key":"330_CR148","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3389\/fnins.2019.00574","volume":"13","author":"Y Chen","year":"2019","unstructured":"Chen Y, Xia K, Chen L, Fan D. Increased interleukin-6 levels in the astrocyte-derived exosomes of sporadic amyotrophic lateral sclerosis patients. Front Neurosci. 2019;13:574.","journal-title":"Front Neurosci"},{"issue":"5778","key":"330_CR149","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"S Boillee","year":"2006","unstructured":"Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006;312(5778):1389\u201392.","journal-title":"Science"},{"issue":"12","key":"330_CR150","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1016\/j.bbadis.2018.10.013","volume":"1864","author":"F Massenzio","year":"2018","unstructured":"Massenzio F, Pena-Altamira E, Petralla S, Virgili M, Zuccheri G, Miti A, et al. Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose. Biochim Biophys Acta Mol Basis Dis. 2018;1864(12):3771\u201385.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"330_CR151","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fncel.2019.00109","volume":"13","author":"AR Vaz","year":"2019","unstructured":"Vaz AR, Pinto S, Ezequiel C, Cunha C, Carvalho LA, Moreira R, et al. Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, inflammatory and immunomodulatory conditions. Front Cell Neurosci. 2019;13:109.","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"330_CR152","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12974-019-1673-3","volume":"17","author":"S Zhang","year":"2020","unstructured":"Zhang S, Hu L, Jiang J, Li H, Wu Q, Ooi K, et al. HMGB1\/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia. J Neuroinflammation. 2020;17(1):15.","journal-title":"J Neuroinflammation"},{"issue":"7","key":"330_CR153","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1002\/glia.23988","volume":"69","author":"MS Aloi","year":"2021","unstructured":"Aloi MS, Prater KE, Sopher B, Davidson S, Jayadev S, Garden GA. The pro-inflammatory microRNA miR-155 influences fibrillar beta-Amyloid1 -42 catabolism by microglia. Glia. 2021;69(7):1736\u201348.","journal-title":"Glia"},{"issue":"1","key":"330_CR154","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-021-02165-4","volume":"18","author":"B Yang","year":"2021","unstructured":"Yang B, Yang R, Xu B, Fu J, Qu X, Li L, et al. miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses. J Neuroinflammation. 2021;18(1):114.","journal-title":"J Neuroinflammation"},{"issue":"4","key":"330_CR155","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/jnc.14853","volume":"151","author":"EE Wanker","year":"2019","unstructured":"Wanker EE, Ast A, Schindler F, Trepte P, Schnoegl S. The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington\u2019s disease. J Neurochem. 2019;151(4):507\u201319.","journal-title":"J Neurochem"},{"key":"330_CR156","doi-asserted-by":"crossref","unstructured":"Ananbeh H, Novak J, Juhas S, Juhasova J, Klempir J, Doleckova K, et al Huntingtin co-isolates with small extracellular vesicles from blood plasma of TgHD and KI-HD pig models of Huntington\u2019s disease and human blood plasma. International journal of molecular sciences. 2022;23(10).","DOI":"10.3390\/ijms23105598"},{"issue":"3","key":"330_CR157","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s10571-016-0350-7","volume":"36","author":"X Zhang","year":"2016","unstructured":"Zhang X, Abels ER, Redzic JS, Margulis J, Finkbeiner S, Breakefield XO. Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington\u2019s disease: background and evaluation in cell culture. Cell Mol Neurobiol. 2016;36(3):459\u201370.","journal-title":"Cell Mol Neurobiol"},{"key":"330_CR158","doi-asserted-by":"crossref","unstructured":"Morais R, Sogorb-Gonzalez M, Bar C, Timmer NC, Van der Bent ML, Wartel M, et al Functional intercellular transmission of miHTT via extracellular vesicles: an in Vitro Proof-of-mechanism study. Cells. 2022;11(17).","DOI":"10.3390\/cells11172748"},{"issue":"3","key":"330_CR159","doi-asserted-by":"publisher","first-page":"608","DOI":"10.4103\/1673-5374.320999","volume":"17","author":"HM Xie","year":"2022","unstructured":"Xie HM, Su X, Zhang FY, Dai CL, Wu RH, Li Y, et al. Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms. Neural Regen Res. 2022;17(3):608\u201317.","journal-title":"Neural Regen Res"},{"issue":"39","key":"330_CR160","doi-asserted-by":"publisher","first-page":"9550","DOI":"10.1523\/JNEUROSCI.1418-17.2017","volume":"37","author":"Y Hong","year":"2017","unstructured":"Hong Y, Zhao T, Li XJ, Li S. Mutant huntingtin inhibits \u03b1B-Crystallin expression and impairs exosome secretion from astrocytes. J Neurosci. 2017;37(39):9550\u201363.","journal-title":"J Neurosci"},{"issue":"17","key":"330_CR161","doi-asserted-by":"publisher","first-page":"e2105316","DOI":"10.1002\/advs.202105316","volume":"9","author":"YL Jiang","year":"2022","unstructured":"Jiang YL, Wang ZX, Liu XX, Wan MD, Liu YW, Jiao B, et al. The protective effects of osteocyte-derived extracellular vesicles against Alzheimer\u2019s disease diminished with aging. Adv Sci (Weinh). 2022;9(17):e2105316.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"330_CR162","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s12967-021-02861-y","volume":"19","author":"L Zhao","year":"2021","unstructured":"Zhao L, Ye Y, Gu L, Jian Z, Stary CM, Xiong X. Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis. J Transl Med. 2021;19(1):202.","journal-title":"J Transl Med"},{"key":"330_CR163","doi-asserted-by":"publisher","first-page":"783049","DOI":"10.3389\/fcimb.2021.783049","volume":"11","author":"S Xi","year":"2021","unstructured":"Xi S, Wang Y, Wu C, Peng W, Zhu Y, Hu W. Intestinal epithelial cell exosome launches IL-1beta-mediated neuron injury in sepsis-associated encephalopathy. Front Cell Infect Microbiol. 2021;11:783049.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"330_CR164","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12974-021-02364-z","volume":"18","author":"L Chavez","year":"2021","unstructured":"Chavez L, Meguro J, Chen S, de Paiva VN, Zambrano R, Eterno JM, et al. Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury. J Neuroinflammation. 2021;18(1):310.","journal-title":"J Neuroinflammation"},{"key":"330_CR165","doi-asserted-by":"crossref","unstructured":"Gao G, Li C, Zhu J, Wang Y, Huang Y, Zhao S, et al Glutaminase 1 regulates neuroinflammation after cerebral ischemia through enhancing microglial activation and pro-inflammatory exosome release. Frontiers Immunol. 2020;11.","DOI":"10.3389\/fimmu.2020.00161"},{"issue":"1","key":"330_CR166","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13195-020-00670-x","volume":"12","author":"M Guo","year":"2020","unstructured":"Guo M, Yin Z, Chen F, Lei P. Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer\u2019s disease. Alzheimers Res Ther. 2020;12(1):109.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"330_CR167","doi-asserted-by":"publisher","first-page":"10772","DOI":"10.1038\/s41598-020-67460-1","volume":"10","author":"M Nakano","year":"2020","unstructured":"Nakano M, Kubota K, Kobayashi E, Chikenji TS, Saito Y, Konari N, et al. Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer\u2019s disease model by increasing the expression of microRNA-146a in hippocampus. Sci Rep. 2020;10(1):10772.","journal-title":"Sci Rep"},{"key":"330_CR168","doi-asserted-by":"crossref","unstructured":"Casella G, Rasouli J, Boehm A, Zhang W, Xiao D, Ishikawa LLW, et al Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice. Sci Transl Med. 2020;12(568).","DOI":"10.1126\/scitranslmed.aba0599"},{"issue":"1","key":"330_CR169","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12951-020-00665-8","volume":"18","author":"D Jiang","year":"2020","unstructured":"Jiang D, Gong F, Ge X, Lv C, Huang C, Feng S, et al. Neuron-derived exosomes-transmitted mir-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes. J Nanobiotechnol. 2020;18(1):105.","journal-title":"J Nanobiotechnol"},{"issue":"8","key":"330_CR170","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S1474-4422(17)30159-X","volume":"16","author":"GB Frisoni","year":"2017","unstructured":"Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, et al. Strategic roadmap for an early diagnosis of Alzheimer\u2019s disease based on biomarkers. Lancet Neurol. 2017;16(8):661\u201376.","journal-title":"Lancet Neurol"},{"issue":"10","key":"330_CR171","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/mp.2014.127","volume":"20","author":"L Cheng","year":"2015","unstructured":"Cheng L, Doecke JD, Sharples RA, Villemagne VL, Fowler CJ, Rembach A, et al. Prognostic serum miRNA biomarkers associated with Alzheimer\u2019s disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry. 2015;20(10):1188\u201396.","journal-title":"Mol Psychiatry"},{"issue":"5","key":"330_CR172","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1007\/s12035-022-02762-1","volume":"59","author":"T Soares Martins","year":"2022","unstructured":"Soares Martins T, Marcalo R, da Cruz ESCB, Trindade D, Catita J, Amado F, et al. Novel exosome biomarker candidates for Alzheimer\u2019s disease unravelled through mass spectrometry analysis. Mol Neurobiol. 2022;59(5):2838\u201354.","journal-title":"Mol Neurobiol"},{"key":"330_CR173","doi-asserted-by":"crossref","unstructured":"Wang Y, Yuan P, Ding L, Zhu J, Qi X, Zhang Y, et al Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer\u2019s disease. Frontiers in cellular neuroscience. 2022;16.","DOI":"10.3389\/fncel.2022.955511"},{"issue":"10","key":"330_CR174","doi-asserted-by":"publisher","first-page":"e0139233","DOI":"10.1371\/journal.pone.0139233","volume":"10","author":"G Lugli","year":"2015","unstructured":"Lugli G, Cohen AM, Bennett DA, Shah RC, Fields CJ, Hernandez AG, et al. Plasma exosomal miRNAs in persons with and without Alzheimer Disease: altered expression and prospects for biomarkers. PLoS ONE. 2015;10(10):e0139233.","journal-title":"PLoS ONE"},{"issue":"2","key":"330_CR175","first-page":"87","volume":"31","author":"TT Yang","year":"2018","unstructured":"Yang TT, Liu CG, Gao SC, Zhang Y, Wang PC. The serum exosome derived microRNA-135a, -193b, and \u2013 384 were potential Alzheimer\u2019s disease biomarkers. Biomed Environ Sci. 2018;31(2):87\u201396.","journal-title":"Biomed Environ Sci"},{"issue":"1","key":"330_CR176","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biopsych.2021.12.015","volume":"92","author":"L Jia","year":"2022","unstructured":"Jia L, Zhu M, Yang J, Pang Y, Wang Q, Li T, et al. Exosomal microRNA-based predictive model for preclinical Alzheimer\u2019s disease: a multicenter study. Biol Psychiatry. 2022;92(1):44\u201353.","journal-title":"Biol Psychiatry"},{"issue":"3","key":"330_CR177","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s12031-019-01364-2","volume":"69","author":"SN Fotuhi","year":"2019","unstructured":"Fotuhi SN, Khalaj-Kondori M, Hoseinpour Feizi MA, Talebi M. Long non-coding RNA BACE1-AS may serve as an Alzheimer\u2019s disease blood-based biomarker. J Mol Neurosci. 2019;69(3):351\u20139.","journal-title":"J Mol Neurosci"},{"issue":"7","key":"330_CR178","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1111\/cns.13846","volume":"28","author":"Y Li","year":"2022","unstructured":"Li Y, Meng S, Di W, Xia M, Dong L, Zhao Y, et al. Amyloid-beta protein and MicroRNA-384 in NCAM-Labeled exosomes from peripheral blood are potential diagnostic markers for Alzheimer\u2019s disease. CNS Neurosci Ther. 2022;28(7):1093\u2013107.","journal-title":"CNS Neurosci Ther"},{"key":"330_CR179","doi-asserted-by":"publisher","first-page":"105800","DOI":"10.1016\/j.nbd.2022.105800","volume":"171","author":"Y Li","year":"2022","unstructured":"Li Y, Xia M, Meng S, Wu D, Ling S, Chen X, et al. MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline. Neurobiol Dis. 2022;171:105800.","journal-title":"Neurobiol Dis"},{"key":"330_CR180","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.3389\/fnins.2019.01208","volume":"13","author":"DJ Cha","year":"2019","unstructured":"Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, et al. miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer\u2019s patients. Front Neurosci. 2019;13:1208.","journal-title":"Front Neurosci"},{"issue":"6","key":"330_CR181","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","volume":"11","author":"MS Fiandaca","year":"2015","unstructured":"Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, et al. Identification of preclinical Alzheimer\u2019s disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study. Alzheimers Dement. 2015;11(6):600\u20137 e601.","journal-title":"Alzheimers Dement"},{"issue":"6","key":"330_CR182","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.2337\/db21-0969","volume":"71","author":"H Chi","year":"2022","unstructured":"Chi H, Yao R, Sun C, Leng B, Shen T, Wang T, et al. Blood neuroexosomal mitochondrial proteins predict Alzheimer disease in diabetes. Diabetes. 2022;71(6):1313\u201323.","journal-title":"Diabetes"},{"issue":"5","key":"330_CR183","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s00401-014-1314-y","volume":"128","author":"M Shi","year":"2014","unstructured":"Shi M, Liu C, Cook TJ, Bullock KM, Zhao Y, Ginghina C, et al. Plasma exosomal alpha-synuclein is likely CNS-derived and increased in Parkinson\u2019s disease. Acta Neuropathol. 2014;128(5):639\u201350.","journal-title":"Acta Neuropathol"},{"key":"330_CR184","doi-asserted-by":"publisher","first-page":"134866","DOI":"10.1016\/j.neulet.2020.134866","volume":"723","author":"B Leng","year":"2020","unstructured":"Leng B, Sun H, Zhao J, Liu Y, Shen T, Liu W, et al. Plasma exosomal prion protein levels are correlated with cognitive decline in PD patients. Neurosci Lett. 2020;723:134866.","journal-title":"Neurosci Lett"},{"issue":"35","key":"330_CR185","doi-asserted-by":"publisher","first-page":"37043","DOI":"10.18632\/oncotarget.6158","volume":"6","author":"Y Gui","year":"2015","unstructured":"Gui Y, Liu H, Zhang L, Lv W, Hu X. Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget. 2015;6(35):37043\u201353.","journal-title":"Oncotarget"},{"key":"330_CR186","doi-asserted-by":"crossref","unstructured":"Zhou Q, He L, Hu J, Gao Y, Shen D, Ni Y, et al Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target. Front Med. 2022.","DOI":"10.1007\/s11684-021-0905-y"},{"key":"330_CR187","doi-asserted-by":"publisher","first-page":"117070","DOI":"10.1016\/j.jns.2020.117070","volume":"418","author":"PC Chen","year":"2020","unstructured":"Chen PC, Wu D, Hu CJ, Chen HY, Hsieh YC, Huang CC. Exosomal TAR DNA-binding protein-43 and neurofilaments in plasma of amyotrophic lateral sclerosis patients: a longitudinal follow-up study. J Neurol Sci. 2020;418:117070.","journal-title":"J Neurol Sci"},{"issue":"4","key":"330_CR188","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00401-017-1803-x","volume":"135","author":"I Prada","year":"2018","unstructured":"Prada I, Gabrielli M, Turola E, Iorio A, D\u2019Arrigo G, Parolisi R, et al. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Acta Neuropathol. 2018;135(4):529\u201350.","journal-title":"Acta Neuropathol"},{"key":"330_CR189","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3389\/fnins.2017.00731","volume":"11","author":"R Waller","year":"2017","unstructured":"Waller R, Wyles M, Heath PR, Kazoka M, Wollff H, Shaw PJ, et al. Small RNA sequencing of sporadic amyotrophic lateral sclerosis cerebrospinal fluid reveals differentially expressed miRNAs related to neural and glial activity. Front Neurosci. 2017;11:731.","journal-title":"Front Neurosci"},{"key":"330_CR190","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.brainres.2018.12.016","volume":"1708","author":"D Saucier","year":"2019","unstructured":"Saucier D, Wajnberg G, Roy J, Beauregard AP, Chacko S, Crapoulet N, et al. Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients. Brain Res. 2019;1708:100\u20138.","journal-title":"Brain Res"},{"issue":"6","key":"330_CR191","doi-asserted-by":"publisher","first-page":"200116","DOI":"10.1098\/rsob.200116","volume":"10","author":"SA Banack","year":"2020","unstructured":"Banack SA, Dunlop RA, Cox PA. An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis\/motor neuron disease. Open Biol. 2020;10(6):200116.","journal-title":"Open Biol"},{"key":"330_CR192","doi-asserted-by":"crossref","unstructured":"Ananbeh H, Vodicka P, Kupcova Skalnikova H. Emerging roles of exosomes in Huntington\u2019s disease. Int J Mol Sci. 2021;22(8).","DOI":"10.3390\/ijms22084085"},{"issue":"3","key":"330_CR193","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1136\/jnnp-2018-318854","volume":"90","author":"HL Denis","year":"2019","unstructured":"Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, et al. Platelet abnormalities in Huntington\u2019s disease. J Neurol Neurosurg Psychiatry. 2019;90(3):272\u201383.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"330_CR194","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1007\/s00415-018-9022-5","volume":"265","author":"HL Denis","year":"2018","unstructured":"Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Weiss A, Chouinard S, et al. Platelet-derived extracellular vesicles in Huntington\u2019s disease. J Neurol. 2018;265(11):2704\u201312.","journal-title":"J Neurol"},{"issue":"2","key":"330_CR195","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3233\/JAD-161179","volume":"57","author":"J Riancho","year":"2017","unstructured":"Riancho J, Vazquez-Higuera JL, Pozueta A, Lage C, Kazimierczak M, Bravo M, et al. MicroRNA profile in patients with Alzheimer\u2019s disease: analysis of mir-9-5p and miR-598 in raw and exosome enriched cerebrospinal fluid samples. J Alzheimers Dis. 2017;57(2):483\u201391.","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"330_CR196","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.bbadis.2016.06.001","volume":"1862","author":"S Kumar","year":"2016","unstructured":"Kumar S, Reddy PH. Are circulating microRNAs peripheral biomarkers for Alzheimer\u2019s disease? Biochim Biophys Acta. 2016;1862(9):1617\u201327.","journal-title":"Biochim Biophys Acta"},{"key":"330_CR197","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","volume":"88","author":"DM Pegtel","year":"2019","unstructured":"Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487\u2013514.","journal-title":"Annu Rev Biochem"},{"issue":"9","key":"330_CR198","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","volume":"33","author":"R Isaac","year":"2021","unstructured":"Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021;33(9):1744\u201362.","journal-title":"Cell Metab"},{"key":"330_CR199","doi-asserted-by":"crossref","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478).","DOI":"10.1126\/science.aau6977"},{"issue":"1","key":"330_CR200","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s40478-019-0821-4","volume":"7","author":"RZ Fan","year":"2019","unstructured":"Fan RZ, Guo M, Luo S, Cui M, Tieu K. Exosome release and neuropathology induced by alpha-synuclein: new insights into protective mechanisms of Drp1 inhibition. Acta Neuropathol Commun. 2019;7(1):184.","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"330_CR201","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/jnc.15288","volume":"157","author":"JR Pinnell","year":"2021","unstructured":"Pinnell JR, Cui M, Tieu K. Exosomes in Parkinson disease. J Neurochem. 2021;157(3):413\u201328.","journal-title":"J Neurochem"},{"issue":"11","key":"330_CR202","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.1021\/acs.jmedchem.0c00278","volume":"63","author":"M Sala","year":"2020","unstructured":"Sala M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, et al. Novel human neutral sphingomyelinase 2 inhibitors as potential therapeutics for Alzheimer\u2019s disease. J Med Chem. 2020;63(11):6028\u201356.","journal-title":"J Med Chem"},{"issue":"5867","key":"330_CR203","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","volume":"319","author":"K Trajkovic","year":"2008","unstructured":"Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008;319(5867):1244\u20137.","journal-title":"Science"},{"issue":"36","key":"330_CR204","doi-asserted-by":"publisher","first-page":"7789","DOI":"10.1523\/JNEUROSCI.1146-04.2004","volume":"24","author":"J Rohrbough","year":"2004","unstructured":"Rohrbough J, Rushton E, Palanker L, Woodruff E, Matthies HJ, Acharya U, et al. Ceramidase regulates synaptic vesicle exocytosis and trafficking. J Neurosci. 2004;24(36):7789\u2013803.","journal-title":"J Neurosci"},{"issue":"11","key":"330_CR205","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1016\/j.cellsig.2015.07.022","volume":"27","author":"AB Abdel Shakor","year":"2015","unstructured":"Abdel Shakor AB, Atia M, Alshehri AS, Sobota A, Kwiatkowska K. Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione. Cell Signal. 2015;27(11):2220\u201330.","journal-title":"Cell Signal"},{"issue":"6","key":"330_CR206","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.cmet.2020.10.001","volume":"32","author":"V Heras","year":"2020","unstructured":"Heras V, Castellano JM, Fernandois D, Velasco I, Rodriguez-Vazquez E, Roa J, et al. Central ceramide signaling mediates obesity-induced precocious puberty. Cell Metab. 2020;32(6):951\u201366 e958.","journal-title":"Cell Metab"},{"key":"330_CR207","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cellimm.2017.06.006","volume":"326","author":"X Chen","year":"2018","unstructured":"Chen X, Wang S, Cao W. Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases. Cell Immunol. 2018;326:8\u201314.","journal-title":"Cell Immunol"},{"key":"330_CR208","doi-asserted-by":"crossref","unstructured":"Chen YA, Lu CH, Ke CC, Chiu SJ, Jeng FS, Chang CW, et al Mesenchymal stem cell-derived exosomes ameliorate Alzheimer\u2019s disease pathology and improve cognitive deficits. Biomedicines. 2021;9(6).","DOI":"10.3390\/biomedicines9060594"},{"key":"330_CR209","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/7651_2014_98","volume":"1212","author":"T Katsuda","year":"2015","unstructured":"Katsuda T, Oki K, Ochiya T. Potential application of extracellular vesicles of human adipose tissue-derived mesenchymal stem cells in Alzheimer\u2019s disease therapeutics. Methods Mol Biol. 2015;1212:171\u201381.","journal-title":"Methods Mol Biol"},{"key":"330_CR210","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/srep01197","volume":"3","author":"T Katsuda","year":"2013","unstructured":"Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, et al. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep. 2013;3:1197.","journal-title":"Sci Rep"},{"issue":"10","key":"330_CR211","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jcyt.2021.04.002","volume":"23","author":"CR Marques","year":"2021","unstructured":"Marques CR, Pereira-Sousa J, Teixeira FG, Sousa RA, Teixeira-Castro A, Salgado AJ. Mesenchymal stem cell secretome protects against alpha-synuclein-induced neurodegeneration in a Caenorhabditis elegans model of Parkinson\u2019s disease. Cytotherapy. 2021;23(10):894\u2013901.","journal-title":"Cytotherapy"},{"issue":"1","key":"330_CR212","doi-asserted-by":"publisher","first-page":"112635","DOI":"10.1016\/j.yexcr.2021.112635","volume":"405","author":"X Kang","year":"2021","unstructured":"Kang X, Jiang L, Chen X, Wang X, Gu S, Wang J, et al. Exosomes derived from hypoxic bone marrow mesenchymal stem cells rescue OGD-induced injury in neural cells by suppressing NLRP3 inflammasome-mediated pyroptosis. Exp Cell Res. 2021;405(1):112635.","journal-title":"Exp Cell Res"},{"issue":"4","key":"330_CR213","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41419-020-2490-4","volume":"11","author":"H Wei","year":"2020","unstructured":"Wei H, Xu Y, Chen Q, Chen H, Zhu X, Li Y. Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis. Cell Death Dis. 2020;11(4):290.","journal-title":"Cell Death Dis"},{"key":"330_CR214","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.brainres.2018.03.034","volume":"1691","author":"M Lee","year":"2018","unstructured":"Lee M, Ban JJ, Yang S, Im W, Kim M. The exosome of adipose-derived stem cells reduces beta-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer\u2019s disease. Brain Res. 2018;1691:87\u201393.","journal-title":"Brain Res"},{"issue":"4","key":"330_CR215","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41419-020-2473-5","volume":"11","author":"HX Chen","year":"2020","unstructured":"Chen HX, Liang FC, Gu P, Xu BL, Xu HJ, Wang WT, et al. Exosomes derived from mesenchymal stem cells repair a Parkinson\u2019s disease model by inducing autophagy. Cell Death Dis. 2020;11(4):288.","journal-title":"Cell Death Dis"},{"key":"330_CR216","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fbioe.2019.00294","volume":"7","author":"B Mendes-Pinheiro","year":"2019","unstructured":"Mendes-Pinheiro B, Anjo SI, Manadas B, Da Silva JD, Marote A, Behie LA, et al. Bone marrow mesenchymal stem cells\u2019 secretome exerts neuroprotective effects in a Parkinson\u2019s disease rat model. Front Bioeng Biotechnol. 2019;7:294.","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"330_CR217","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.14336\/AD.2020.1221","volume":"12","author":"C Xue","year":"2021","unstructured":"Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, et al. MSC-derived exosomes can enhance the angiogenesis of human brain MECs and show therapeutic potential in a mouse model of Parkinson\u2019s disease. Aging Dis. 2021;12(5):1211\u201322.","journal-title":"Aging Dis"},{"key":"330_CR218","doi-asserted-by":"crossref","unstructured":"Teixeira FG, Vilaca-Faria H, Domingues AV, Campos J, Salgado AJ. Preclinical comparison of stem cells secretome and levodopa application in a 6-hydroxydopamine rat model of Parkinson\u2019s disease. Cells. 2020;9(2).","DOI":"10.3390\/cells9020315"},{"key":"330_CR219","doi-asserted-by":"crossref","unstructured":"Bonafede R, Brandi J, Manfredi M, Scambi I, Schiaffino L, Merigo F, et al The anti-apoptotic effect of ASC-exosomes in an in vitro ALS model and their proteomic analysis. Cells. 2019;8(9).","DOI":"10.3390\/cells8091087"},{"key":"330_CR220","doi-asserted-by":"crossref","unstructured":"Bonafede R, Turano E, Scambi I, Busato A, Bontempi P, Virla F, et al ASC-exosomes ameliorate the disease progression in SOD1(G93A) murine model underlining their potential therapeutic use in human ALS. Int J Mol Sci. 2020;21(10).","DOI":"10.3390\/ijms21103651"},{"issue":"3","key":"330_CR221","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3233\/JAD-170848","volume":"61","author":"SS Wang","year":"2018","unstructured":"Wang SS, Jia J, Wang Z. Mesenchymal stem cell-derived extracellular vesicles suppresses iNOS expression and ameliorates neural impairment in Alzheimer\u2019s disease mice. J Alzheimers Dis. 2018;61(3):1005\u201313.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"330_CR222","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41420-021-00471-7","volume":"7","author":"M Garcia-Contreras","year":"2021","unstructured":"Garcia-Contreras M, Thakor AS. Human adipose tissue-derived mesenchymal stem cells and their extracellular vesicles modulate lipopolysaccharide activated human microglia. Cell Death Discov. 2021;7(1):98.","journal-title":"Cell Death Discov"},{"key":"330_CR223","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ejpb.2017.09.014","volume":"121","author":"A Chierchia","year":"2017","unstructured":"Chierchia A, Chirico N, Boeri L, Raimondi I, Riva GA, Raimondi MT, et al. Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson\u2019s disease related toxin 6-hydroxydopamine. Eur J Pharm Biopharm. 2017;121:113\u201320.","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"330_CR224","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.yexcr.2015.12.009","volume":"340","author":"R Bonafede","year":"2016","unstructured":"Bonafede R, Scambi I, Peroni D, Potrich V, Boschi F, Benati D, et al. Exosome derived from murine adipose-derived stromal cells: neuroprotective effect on in vitro model of amyotrophic lateral sclerosis. Exp Cell Res. 2016;340(1):150\u20138.","journal-title":"Exp Cell Res"},{"issue":"4","key":"330_CR225","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","volume":"17","author":"AM Bond","year":"2015","unstructured":"Bond AM, Ming GL, Song H. Adult mammalian neural stem cells and neurogenesis: five decades later. Cell Stem Cell. 2015;17(4):385\u201395.","journal-title":"Cell Stem Cell"},{"key":"330_CR226","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ebiom.2018.11.026","volume":"38","author":"A Vogel","year":"2018","unstructured":"Vogel A, Upadhya R, Shetty AK. Neural stem cell derived extracellular vesicles: attributes and prospects for treating neurodegenerative disorders. EBioMedicine. 2018;38:273\u201382.","journal-title":"EBioMedicine"},{"issue":"5","key":"330_CR227","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s12975-017-0599-2","volume":"9","author":"RL Webb","year":"2018","unstructured":"Webb RL, Kaiser EE, Scoville SL, Thompson TA, Fatima S, Pandya C, et al. Human neural stem cell extracellular vesicles improve tissue and functional recovery in the murine thromboembolic stroke model. Transl Stroke Res. 2018;9(5):530\u20139.","journal-title":"Transl Stroke Res"},{"issue":"1","key":"330_CR228","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13195-021-00791-x","volume":"13","author":"LA Apodaca","year":"2021","unstructured":"Apodaca LA, Baddour AAD, Garcia C Jr, Alikhani L, Giedzinski E, Ru N, et al. Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer\u2019s disease. Alzheimers Res Ther. 2021;13(1):57.","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"330_CR229","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/jnc.15001","volume":"154","author":"B Li","year":"2020","unstructured":"Li B, Liu J, Gu G, Han X, Zhang Q, Zhang W. Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer\u2019s disease. J Neurochem. 2020;154(5):502\u201318.","journal-title":"J Neurochem"},{"issue":"1","key":"330_CR230","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12951-022-01356-2","volume":"20","author":"EJ Lee","year":"2022","unstructured":"Lee EJ, Choi Y, Lee HJ, Hwang DW, Lee DS. Human neural stem cell-derived extracellular vesicles protect against Parkinson\u2019s disease pathologies. J Nanobiotechnol. 2022;20(1):198.","journal-title":"J Nanobiotechnol"},{"key":"330_CR231","doi-asserted-by":"crossref","unstructured":"Liu Y, Huber CC, Wang H. Disrupted blood-brain barrier in 5xFAD mouse model of Alzheimer\u2019s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomes. Biochemical and biophysical research communications; 2020.","DOI":"10.1016\/j.bbrc.2020.02.074"},{"issue":"1","key":"330_CR232","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/1535370219895491","volume":"245","author":"D Zhong","year":"2020","unstructured":"Zhong D, Cao Y, Li CJ, Li M, Rong ZJ, Jiang L, et al. Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis. Exp Biol Med (Maywood). 2020;245(1):54\u201365.","journal-title":"Exp Biol Med (Maywood)"},{"key":"330_CR233","doi-asserted-by":"crossref","unstructured":"Henningson CT Jr, Stanislaus MA, Gewirtz AM. 28. Embryonic and adult stem cell therapy. J Allergy Clin Immunol. 2003;111(2 Suppl):S745-753.","DOI":"10.1067\/mai.2003.133"},{"key":"330_CR234","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40035-018-0132-x","volume":"7","author":"K Ma","year":"2018","unstructured":"Ma K, Deng X, Xia X, Fan Z, Qi X, Wang Y, et al. Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons. Transl Neurodegener. 2018;7:29.","journal-title":"Transl Neurodegener"},{"key":"330_CR235","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40035-020-0184-6","volume":"9","author":"X Xia","year":"2020","unstructured":"Xia X, Li C, Wang Y, Deng X, Ma Y, Ding L, et al. Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts. Transl Neurodegener. 2020;9:6.","journal-title":"Transl Neurodegener"},{"issue":"1","key":"330_CR236","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12964-019-0418-3","volume":"17","author":"Y Ma","year":"2019","unstructured":"Ma Y, Li C, Huang Y, Wang Y, Xia X, Zheng JC. Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a. Cell Commun Signal. 2019;17(1):96.","journal-title":"Cell Commun Signal"},{"key":"330_CR237","doi-asserted-by":"crossref","unstructured":"Ma Y, Xu X, Li C, Wang Y, Zhu J, Xia X, et al Induced neural progenitor cell-derived extracellular vesicles promote neural progenitor cell survival via extracellular signal-regulated kinase pathway. CNS Neurosci Ther. 2021.","DOI":"10.1111\/cns.13744"},{"issue":"7","key":"330_CR238","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.jcyt.2014.07.013","volume":"17","author":"A Jarmalaviciute","year":"2015","unstructured":"Jarmalaviciute A, Tunaitis V, Pivoraite U, Venalis A, Pivoriunas A. Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis. Cytotherapy. 2015;17(7):932\u20139.","journal-title":"Cytotherapy"},{"issue":"35","key":"330_CR239","doi-asserted-by":"publisher","first-page":"24488","DOI":"10.1074\/jbc.M114.577213","volume":"289","author":"K Yuyama","year":"2014","unstructured":"Yuyama K, Sun H, Sakai S, Mitsutake S, Okada M, Tahara H, et al. Decreased amyloid-beta pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice. J Biol Chem. 2014;289(35):24488\u201398.","journal-title":"J Biol Chem"},{"issue":"Pt B","key":"330_CR240","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.phrs.2016.02.002","volume":"113","author":"A Jarmalaviciute","year":"2016","unstructured":"Jarmalaviciute A, Pivoriunas A. Exosomes as a potential novel therapeutic tools against neurodegenerative diseases. Pharmacol Res. 2016;113(Pt B):816\u201322.","journal-title":"Pharmacol Res"},{"key":"330_CR241","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-0-12-396962-0.00011-2","volume":"503","author":"WM Pardridge","year":"2012","unstructured":"Pardridge WM, Boado RJ. Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier. Methods Enzymol. 2012;503:269\u201392.","journal-title":"Methods Enzymol"},{"issue":"4","key":"330_CR242","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","volume":"6","author":"D Ha","year":"2016","unstructured":"Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B. 2016;6(4):287\u201396.","journal-title":"Acta Pharm Sin B"},{"key":"330_CR243","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3389\/fphys.2012.00228","volume":"3","author":"CP Lai","year":"2012","unstructured":"Lai CP, Breakefield XO. Role of exosomes\/microvesicles in the nervous system and use in emerging therapies. Front Physiol. 2012;3:228.","journal-title":"Front Physiol"},{"issue":"10","key":"330_CR244","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1038\/mt.2011.164","volume":"19","author":"X Zhuang","year":"2011","unstructured":"Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011;19(10):1769\u201379.","journal-title":"Mol Ther"},{"issue":"4","key":"330_CR245","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nbt.1807","volume":"29","author":"L Alvarez-Erviti","year":"2011","unstructured":"Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341\u20135.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"330_CR246","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41467-018-03733-8","volume":"9","author":"R Kojima","year":"2018","unstructured":"Kojima R, Bojar D, Rizzi G, Hamri GC, El-Baba MD, Saxena P, et al. Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson\u2019s disease treatment. Nat Commun. 2018;9(1):1305.","journal-title":"Nat Commun"},{"issue":"12","key":"330_CR247","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/mds.25978","volume":"29","author":"JM Cooper","year":"2014","unstructured":"Cooper JM, Wiklander PB, Nordin JZ, Al-Shawi R, Wood MJ, Vithlani M, et al. Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice. Mov Disord. 2014;29(12):1476\u201385.","journal-title":"Mov Disord"},{"issue":"10","key":"330_CR248","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1038\/mt.2016.126","volume":"24","author":"MC Didiot","year":"2016","unstructured":"Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, et al. Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing. Mol Ther. 2016;24(10):1836\u201347.","journal-title":"Mol Ther"},{"issue":"12","key":"330_CR249","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/j.ymthe.2019.08.010","volume":"27","author":"M Izco","year":"2019","unstructured":"Izco M, Blesa J, Schleef M, Schmeer M, Porcari R, Al-Shawi R, et al. Systemic exosomal delivery of shRNA minicircles prevents parkinsonian pathology. Mol Ther. 2019;27(12):2111\u201322.","journal-title":"Mol Ther"},{"issue":"21","key":"330_CR250","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.2217\/nnm-2017-0210","volume":"12","author":"R Maheshwari","year":"2017","unstructured":"Maheshwari R, Tekade M, Gondaliya P, Kalia K, D\u2019Emanuele A, Tekade RK. Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers. Nanomed (Lond). 2017;12(21):2653\u201375.","journal-title":"Nanomed (Lond)"},{"key":"330_CR251","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3389\/fnins.2020.00564","volume":"14","author":"Y Jahangard","year":"2020","unstructured":"Jahangard Y, Monfared H, Moradi A, Zare M, Mirnajafi-Zadeh J, Mowla SJ. Therapeutic effects of transplanted exosomes containing miR-29b to a rat model of Alzheimer\u2019s disease. Front Neurosci. 2020;14:564.","journal-title":"Front Neurosci"},{"issue":"15","key":"330_CR252","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1111\/jcmm.16787","volume":"25","author":"L Zhai","year":"2021","unstructured":"Zhai L, Shen H, Sheng Y, Guan Q. ADMSC Exo-MicroRNA-22 improve neurological function and neuroinflammation in mice with Alzheimer\u2019s disease. J Cell Mol Med. 2021;25(15):7513\u201323.","journal-title":"J Cell Mol Med"},{"key":"330_CR253","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.omtn.2021.01.022","volume":"23","author":"Q Li","year":"2021","unstructured":"Li Q, Wang Z, Xing H, Wang Y, Guo Y. Exosomes derived from mir-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson\u2019s disease. Mol Ther Nucleic Acids. 2021;23:1334\u201344.","journal-title":"Mol Ther Nucleic Acids"},{"key":"330_CR254","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","volume":"207","author":"MJ Haney","year":"2015","unstructured":"Haney MJ, Klyachko NL, Zhao Y, Gupta R, Plotnikova EG, He Z, et al. Exosomes as drug delivery vehicles for Parkinson\u2019s disease therapy. J Control Release. 2015;207:18\u201330.","journal-title":"J Control Release"},{"key":"330_CR255","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jconrel.2018.08.035","volume":"287","author":"M Qu","year":"2018","unstructured":"Qu M, Lin Q, Huang L, Fu Y, Wang L, He S, et al. Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson\u2019s disease. J Control Release. 2018;287:156\u201366.","journal-title":"J Control Release"},{"issue":"3","key":"330_CR256","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1039\/D1BM01142A","volume":"10","author":"XY Wu","year":"2022","unstructured":"Wu XY, Liao BY, Xiao D, Wu WC, Xiao Y, Alexander T, et al. Encapsulation of bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects in the cuprizone-induced demyelinating animal model of multiple sclerosis. Biomater Sci. 2022;10(3):714\u201327.","journal-title":"Biomater Sci"},{"key":"330_CR257","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbrc.2022.01.051","volume":"594","author":"Y Xiao","year":"2022","unstructured":"Xiao Y, Zhang Y, Gao YH, Zhao ZH, He J, Gao R, et al. A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases. Biochem Biophys Res Commun. 2022;594:31\u20137.","journal-title":"Biochem Biophys Res Commun"},{"key":"330_CR258","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.intimp.2018.12.001","volume":"67","author":"Z Li","year":"2019","unstructured":"Li Z, Liu F, He X, Yang X, Shan F, Feng J. Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia. Int Immunopharmacol. 2019;67:268\u201380.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"330_CR259","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s13287-019-1445-0","volume":"10","author":"E Mianehsaz","year":"2019","unstructured":"Mianehsaz E, Mirzaei HR, Mahjoubin-Tehran M, Rezaee A, Sahebnasagh R, Pourhanifeh MH, et al. Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis? Stem Cell Res Ther. 2019;10(1):340.","journal-title":"Stem Cell Res Ther"},{"key":"330_CR260","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","volume":"219","author":"EV Batrakova","year":"2015","unstructured":"Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396\u2013405.","journal-title":"J Control Release"},{"issue":"5","key":"330_CR261","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","volume":"20","author":"GC Terstappen","year":"2021","unstructured":"Terstappen GC, Meyer AH, Bell RD, Zhang W. Strategies for delivering therapeutics across the blood-brain barrier. Nat Rev Drug Discov. 2021;20(5):362\u201383.","journal-title":"Nat Rev Drug Discov"},{"key":"330_CR262","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","volume":"150","author":"T Tian","year":"2018","unstructured":"Tian T, Zhang HX, He CP, Fan S, Zhu YL, Qi C, et al. Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy. Biomaterials. 2018;150:137\u201349.","journal-title":"Biomaterials"},{"key":"330_CR263","doi-asserted-by":"crossref","unstructured":"Lorca C, Laparra M, Cespedes MV, Casani L, Florit S, Jove M, et al Industrial By-products as a novel circular source of biocompatible extracellular vesicles. Adv Funct Mater. 2022;32(29).","DOI":"10.1002\/adfm.202202700"},{"key":"330_CR264","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mattod.2020.02.001","volume":"37","author":"S Ding","year":"2020","unstructured":"Ding S, Khan AI, Cai X, Song Y, Lyu Z, Du D, et al. Overcoming blood-brain barrier transport: advances in nanoparticle-based drug delivery strategies. Mater Today (Kidlington). 2020;37:112\u201325.","journal-title":"Mater Today (Kidlington)"},{"issue":"9","key":"330_CR265","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nrmicro2395","volume":"8","author":"S Salinas","year":"2010","unstructured":"Salinas S, Schiavo G, Kremer EJ. A hitchhiker\u2019s guide to the nervous system: the complex journey of viruses and toxins. Nat Rev Microbiol. 2010;8(9):645\u201355.","journal-title":"Nat Rev Microbiol"},{"issue":"7149","key":"330_CR266","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nature05901","volume":"448","author":"P Kumar","year":"2007","unstructured":"Kumar P, Wu H, McBride JL, Jung KE, Kim MH, Davidson BL, et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature. 2007;448(7149):39\u201343.","journal-title":"Nature"},{"key":"330_CR267","doi-asserted-by":"publisher","first-page":"212770","DOI":"10.1016\/j.bioadv.2022.212770","volume":"136","author":"Y Hao","year":"2022","unstructured":"Hao Y, Su C, Liu X, Sui H, Shi Y, Zhao L. Bioengineered microglia-targeted exosomes facilitate Abeta clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer\u2019s disease. Biomater Adv. 2022;136:212770.","journal-title":"Biomater Adv"},{"key":"330_CR268","doi-asserted-by":"crossref","unstructured":"Saint-Pol J, Gosselet F, Duban-Deweer S, Pottiez G, Karamanos Y. Targeting and crossing the blood-brain barrier with Extracellular vesicles. Cells. 2020;9(4).","DOI":"10.3390\/cells9040851"},{"issue":"4","key":"330_CR269","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s12195-016-0458-3","volume":"9","author":"CC Chen","year":"2016","unstructured":"Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, et al. Elucidation of exosome migration across the blood-brain barrier model in vitro. Cell Mol Bioeng. 2016;9(4):509\u201329.","journal-title":"Cell Mol Bioeng"},{"key":"330_CR270","doi-asserted-by":"crossref","unstructured":"Fu SY, Wang Y, Xia XH, Zheng JLC. Exosome engineering: current progress in cargo loading and targeted delivery. Nanoimpact. 2020;20.","DOI":"10.1016\/j.impact.2020.100261"},{"issue":"1","key":"330_CR271","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1021\/acs.molpharmaceut.8b00901","volume":"16","author":"CK Das","year":"2019","unstructured":"Das CK, Jena BC, Banerjee I, Das S, Parekh A, Bhutia SK, Mandal M. Exosome as a novel shuttle for delivery of therapeutics across biological barriers. Mol Pharm. 2019;16(1):24\u201340.","journal-title":"Mol Pharm."},{"key":"330_CR272","doi-asserted-by":"publisher","first-page":"e545","DOI":"10.1038\/cddis.2013.73","volume":"4","author":"L Alvarez-Erviti","year":"2013","unstructured":"Alvarez-Erviti L, Seow Y, Schapira AH, Rodriguez-Oroz MC, Obeso JA, Cooper JM. Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson\u2019s disease. Cell Death Dis. 2013;4:e545.","journal-title":"Cell Death Dis"},{"issue":"39","key":"330_CR273","doi-asserted-by":"publisher","first-page":"9550","DOI":"10.1523\/JNEUROSCI.1418-17.2017","volume":"37","author":"Y Hong","year":"2017","unstructured":"Hong Y, Zhao T, Li XJ, Li S. Mutant huntingtin inhibits alphab-crystallin expression and impairs exosome secretion from astrocytes. J Neurosci. 2017;37(39):9550\u201363.","journal-title":"J Neurosci"}],"container-title":["Translational Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40035-022-00330-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40035-022-00330-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40035-022-00330-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T20:45:00Z","timestamp":1701549900000},"score":1,"resource":{"primary":{"URL":"https:\/\/translationalneurodegeneration.biomedcentral.com\/articles\/10.1186\/s40035-022-00330-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":273,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["330"],"URL":"https:\/\/doi.org\/10.1186\/s40035-022-00330-0","relation":{},"ISSN":["2047-9158"],"issn-type":[{"value":"2047-9158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"26 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors approved the final manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and Consent to participate"}},{"value":"The authors approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests regarding the publication of this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"53"}}