{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:00:17Z","timestamp":1793941217461,"version":"4.8.0"},"reference-count":194,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92249305"],"award-info":[{"award-number":["92249305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Funding for Chongqing Postdoctoral Research Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Neurodegener"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aetiologies and origins of neurodegenerative diseases, such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington\u2019s disease (HD), are complex and multifaceted. A growing body of evidence suggests that the gut microbiome plays crucial roles in the development and progression of neurodegenerative diseases. Clinicians have come to realize that therapeutics targeting the gut microbiome have the potential to halt the progression of neurodegenerative diseases. This narrative review examines the alterations in the gut microbiome in AD, PD, ALS and HD, highlighting the close relationship between the gut microbiome and the brain in neurodegenerative diseases. Processes that mediate the gut microbiome\u2013brain communication in neurodegenerative diseases, including the immunological, vagus nerve and circulatory pathways, are evaluated. Furthermore, we summarize potential therapeutics for neurodegenerative diseases that modify the gut microbiome and its metabolites, including diets, probiotics and prebiotics, microbial metabolites, antibacterials and faecal microbiome transplantation. Finally, current challenges and future directions are discussed.<\/jats:p>","DOI":"10.1186\/s40035-024-00404-1","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T06:02:33Z","timestamp":1709013753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside"],"prefix":"10.1186","volume":"13","author":[{"given":"Yuan-Yuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-6112","authenticated-orcid":false,"given":"Yan-Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"3","key":"404_CR1","first-page":"145","volume":"2","author":"VK Ramanan","year":"2013","unstructured":"Ramanan VK, Saykin AJ. Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer\u2019s disease, Parkinson\u2019s disease, and related disorders. Am J Neurodegener Dis. 2013;2(3):145\u201375.","journal-title":"Am J Neurodegener Dis"},{"key":"404_CR2","doi-asserted-by":"publisher","first-page":"163173","DOI":"10.1016\/j.scitotenv.2023.163173","volume":"878","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Yang Z, Yu L, Xu L, Wu Y, Zhang X, et al. Residential greenness, air pollution and incident neurodegenerative disease: a cohort study in China. Sci Total Environ. 2023;878:163173.","journal-title":"Sci Total Environ"},{"issue":"11","key":"404_CR3","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","volume":"13","author":"J Wang","year":"2017","unstructured":"Wang J, Gu BJ, Masters CL, Wang Y-J. A systemic view of Alzheimer disease\u2014insights from amyloid-\u03b2 metabolism beyond the brain. Nat Rev Neurol. 2017;13(11):612\u201323.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"404_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41531-022-00307-w","volume":"8","author":"SL Farrow","year":"2022","unstructured":"Farrow SL, Cooper AA, O\u2019Sullivan JM. Redefining the hypotheses driving Parkinson\u2019s diseases research. NPJ Parkinsons Dis. 2022;8(1):45.","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"404_CR5","doi-asserted-by":"publisher","first-page":"e2308706120","DOI":"10.1073\/pnas.2308706120","volume":"121","author":"NL Ritz","year":"2023","unstructured":"Ritz NL, Brocka M, Butler MI, Cowan CSM, Barrera-Bugue\u00f1o C, Turkington CJR, et al. Social anxiety disorder-associated gut microbiota increases social fear. Proc Natl Acad Sci USA. 2023;121(1):e2308706120.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"404_CR6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.biopsych.2023.10.018","volume":"95","author":"FC Ross","year":"2024","unstructured":"Ross FC, Mayer DE, Gupta A, Gill CIR, Del Rio D, Cryan JF, et al. Existing and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disorders. Biol Psychiatry. 2024;95(4):348\u201360.","journal-title":"Biol Psychiatry"},{"issue":"2","key":"404_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cell.2015.03.033","volume":"161","author":"V Ridaura","year":"2015","unstructured":"Ridaura V, Belkaid Y. Gut microbiota: the link to your second brain. Cell. 2015;161(2):193\u20134.","journal-title":"Cell"},{"issue":"1","key":"404_CR8","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s41467-023-37055-1","volume":"14","author":"K Brown","year":"2023","unstructured":"Brown K, Thomson CA, Wacker S, Drikic M, Groves R, Fan V, et al. Microbiota alters the metabolome in an age- and sex- dependent manner in mice. Nat Commun. 2023;14(1):1348.","journal-title":"Nat Commun"},{"issue":"1","key":"404_CR9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s40168-022-01364-2","volume":"10","author":"P Bianchimano","year":"2022","unstructured":"Bianchimano P, Britton GJ, Wallach DS, Smith EM, Cox LM, Liu S, et al. Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis. Microbiome. 2022;10(1):174.","journal-title":"Microbiome"},{"key":"404_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","volume":"38","author":"S Shandilya","year":"2022","unstructured":"Shandilya S, Kumar S, Kumar Jha N, Kumar Kesari K, Ruokolainen J. Interplay of gut microbiota and oxidative stress: perspective on neurodegeneration and neuroprotection. J Adv Res. 2022;38:223\u201344.","journal-title":"J Adv Res"},{"issue":"10","key":"404_CR11","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1038\/s41380-023-02216-7","volume":"28","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Shen Y, Liufu N, Liu L, Li W, Shi Z, et al. Transmission of Alzheimer\u2019s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients. Mol Psychiatry. 2023;28(10):4421\u201337.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"404_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40035-023-00392-8","volume":"12","author":"X Zhang","year":"2023","unstructured":"Zhang X, Tang B, Guo J. Parkinson\u2019s disease and gut microbiota: from clinical to mechanistic and therapeutic studies. Transl Neurodegener. 2023;12(1):59.","journal-title":"Transl Neurodegener"},{"issue":"2","key":"404_CR13","doi-asserted-by":"publisher","first-page":"2271613","DOI":"10.1080\/19490976.2023.2271613","volume":"15","author":"T Zhang","year":"2023","unstructured":"Zhang T, Gao G, Kwok L-Y, Sun Z. Gut microbiome-targeted therapies for Alzheimer\u2019s disease. Gut Microbes. 2023;15(2):2271613.","journal-title":"Gut Microbes"},{"key":"404_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuroscience.2023.02.014","volume":"518","author":"N Molinero","year":"2023","unstructured":"Molinero N, Ant\u00f3n-Fern\u00e1ndez A, Hern\u00e1ndez F, \u00c1vila J, Bartolom\u00e9 B, Moreno-Arribas MV. Gut microbiota, an additional hallmark of human aging and neurodegeneration. Neuroscience. 2023;518:141\u201361.","journal-title":"Neuroscience"},{"key":"404_CR15","doi-asserted-by":"publisher","first-page":"103908","DOI":"10.1016\/j.ebiom.2022.103908","volume":"77","author":"L Liu","year":"2022","unstructured":"Liu L, Huh JR, Shah K. Microbiota and the gut-brain-axis: implications for new therapeutic design in the CNS. eBioMedicine. 2022;77:103908.","journal-title":"eBioMedicine"},{"key":"404_CR16","doi-asserted-by":"publisher","first-page":"1007166","DOI":"10.3389\/fncel.2022.1007166","volume":"16","author":"HM Hashim","year":"2022","unstructured":"Hashim HM, Makpol S. A review of the preclinical and clinical studies on the role of the gut microbiome in aging and neurodegenerative diseases and its modulation. Front Cell Neurosci. 2022;16:1007166.","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"404_CR17","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1111\/j.1532-5415.2011.03667.x","volume":"59","author":"JH Wu","year":"2011","unstructured":"Wu JH, Guo Z, Kumar S, Lapuerta P. Incidence of serious upper and lower gastrointestinal events in older adults with and without Alzheimer\u2019s disease. J Am Geriatr Soc. 2011;59(11):2053\u201361.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"404_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","volume":"8","author":"T Warnecke","year":"2022","unstructured":"Warnecke T, Sch\u00e4fer KH, Claus I, Del Tredici K, Jost WH. Gastrointestinal involvement in Parkinson\u2019s disease: pathophysiology, diagnosis, and management. NPJ Parkinsons Dis. 2022;8(1):31.","journal-title":"NPJ Parkinsons Dis"},{"issue":"1\u20132","key":"404_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000517613","volume":"21","author":"C Parra-Cantu","year":"2021","unstructured":"Parra-Cantu C, Zaldivar-Ruenes A, Martinez-Vazquez M, Martinez HR. Prevalence of gastrointestinal symptoms, severity of dysphagia, and their correlation with severity of amyotrophic lateral sclerosis in a Mexican cohort. Neurodegener Dis. 2021;21(1\u20132):42\u20137.","journal-title":"Neurodegener Dis"},{"issue":"5","key":"404_CR20","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.3390\/ijms24054477","volume":"24","author":"D Wronka","year":"2023","unstructured":"Wronka D, Karlik A, Misiorek JO, Przybyl L. What the gut tells the brain\u2014Is there a link between microbiota and Huntington\u2019s disease? Int J Mol Sci. 2023;24(5):4477.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"404_CR21","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.chom.2020.06.008","volume":"28","author":"P Fang","year":"2020","unstructured":"Fang P, Kazmi SA, Jameson KG, Hsiao EY. The microbiome as a modifier of neurodegenerative disease risk. Cell Host Microbe. 2020;28(2):201\u201322.","journal-title":"Cell Host Microbe"},{"issue":"2","key":"404_CR22","doi-asserted-by":"publisher","first-page":"fcaa110","DOI":"10.1093\/braincomms\/fcaa110","volume":"2","author":"CI Wasser","year":"2020","unstructured":"Wasser CI, Mercieca E-C, Kong G, Hannan AJ, McKeown SJ, Glikmann-Johnston Y, et al. Gut dysbiosis in Huntington\u2019s disease: associations among gut microbiota, cognitive performance and clinical outcomes. Brain Commun. 2020;2(2):fcaa110.","journal-title":"Brain Commun"},{"issue":"1","key":"404_CR23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.18632\/aging.203826","volume":"14","author":"C-C Hung","year":"2022","unstructured":"Hung C-C, Chang C-C, Huang C-W, Nouchi R, Cheng C-H. Gut microbiota in patients with Alzheimer\u2019s disease spectrum: a systematic review and meta-analysis. Aging. 2022;14(1):477\u201396.","journal-title":"Aging"},{"issue":"1","key":"404_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13195-022-00977-x","volume":"14","author":"C Sheng","year":"2022","unstructured":"Sheng C, Yang K, He B, Du W, Cai Y, Han Y. Combination of gut microbiota and plasma amyloid-\u03b2 as a potential index for identifying preclinical Alzheimer\u2019s disease: a cross-sectional analysis from the SILCODE study. Alzheimers Res Ther. 2022;14(1):35.","journal-title":"Alzheimers Res Ther"},{"issue":"700","key":"404_CR25","doi-asserted-by":"publisher","first-page":"eabo2984","DOI":"10.1126\/scitranslmed.abo2984","volume":"15","author":"AL Ferreiro","year":"2023","unstructured":"Ferreiro AL, Choi J, Ryou J, Newcomer EP, Thompson R, Bollinger RM, et al. Gut microbiome composition may be an indicator of preclinical Alzheimer\u2019s disease. Sci Transl Med. 2023;15(700):eabo2984.","journal-title":"Sci Transl Med"},{"issue":"1","key":"404_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12974-022-02599-4","volume":"19","author":"X Qian","year":"2022","unstructured":"Qian X, Liu X, Chen G, Chen S, Tang H. injection of amyloid-\u03b2 to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer\u2019s disease. J Neuroinflamm. 2022;19(1):236.","journal-title":"J Neuroinflamm"},{"key":"404_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.bbi.2021.09.002","volume":"98","author":"N Kim","year":"2021","unstructured":"Kim N, Jeon SH, Ju IG, Gee MS, Do J, Oh MS, et al. Transplantation of gut microbiota derived from Alzheimer\u2019s disease mouse model impairs memory function and neurogenesis in C57BL\/6 mice. Brain Behav Immun. 2021;98:357\u201365.","journal-title":"Brain Behav Immun"},{"issue":"11","key":"404_CR28","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1136\/gutjnl-2021-326269","volume":"71","author":"C Chen","year":"2022","unstructured":"Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, et al. Gut microbiota regulate Alzheimer\u2019s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022;71(11):2233\u201352.","journal-title":"Gut"},{"issue":"1","key":"404_CR29","doi-asserted-by":"publisher","first-page":"e20200895","DOI":"10.1084\/jem.20200895","volume":"219","author":"HB Dodiya","year":"2022","unstructured":"Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, et al. Gut microbiota-driven brain A\u03b2 amyloidosis in mice requires microglia. J Exp Med. 2022;219(1):e20200895.","journal-title":"J Exp Med"},{"issue":"1","key":"404_CR30","doi-asserted-by":"publisher","first-page":"41802","DOI":"10.1038\/srep41802","volume":"7","author":"T Harach","year":"2017","unstructured":"Harach T, Marungruang N, Duthilleul N, Cheatham V, Mc Coy KD, Frisoni G, et al. Reduction of abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep. 2017;7(1):41802.","journal-title":"Sci Rep"},{"issue":"6628","key":"404_CR31","doi-asserted-by":"publisher","first-page":"eadd1236","DOI":"10.1126\/science.add1236","volume":"379","author":"D-o Seo","year":"2023","unstructured":"Seo D-o, O\u2019Donnell D, Jain N, Ulrich JD, Herz J, Li Y, et al. APOE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science. 2023;379(6628):eadd1236.","journal-title":"Science"},{"issue":"8","key":"404_CR32","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41582-022-00681-2","volume":"18","author":"AH Tan","year":"2022","unstructured":"Tan AH, Lim SY, Lang AE. The microbiome\u2013gut\u2013brain axis in Parkinson disease\u2014from basic research to the clinic. Nat Rev Neurol. 2022;18(8):476\u201395.","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"404_CR33","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1093\/brain\/awab156","volume":"144","author":"Q Wang","year":"2021","unstructured":"Wang Q, Luo Y, Ray Chaudhuri K, Reynolds R, Tan E-K, Pettersson S. The role of gut dysbiosis in Parkinson\u2019s disease: mechanistic insights and therapeutic options. Brain. 2021;144(9):2571\u201393.","journal-title":"Brain"},{"issue":"1","key":"404_CR34","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1038\/s41467-023-38248-4","volume":"14","author":"B Huang","year":"2023","unstructured":"Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, et al. Gut microbiome dysbiosis across early Parkinson\u2019s disease, REM sleep behavior disorder and their first-degree relatives. Nat Commun. 2023;14(1):2501.","journal-title":"Nat Commun"},{"issue":"6","key":"404_CR35","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","volume":"167","author":"TR Sampson","year":"2016","unstructured":"Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease. Cell. 2016;167(6):1469\u20131480e1412.","journal-title":"Cell"},{"key":"404_CR36","doi-asserted-by":"publisher","first-page":"839526","DOI":"10.3389\/fcimb.2022.839526","volume":"12","author":"S Martin","year":"2022","unstructured":"Martin S, Battistini C, Sun J. A gut feeling in amyotrophic lateral sclerosis: Microbiome of mice and men. Front Cell Infect Microbiol. 2022;12:839526.","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"404_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.7555\/JBR.36.20220198","volume":"37","author":"Z Gong","year":"2023","unstructured":"Gong Z, Ba L, Tang J, Yang Y, Li Z, Liu M, et al. Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: a multi-omics study. J Biomed Res. 2023;37(2):125\u201337.","journal-title":"J Biomed Res"},{"issue":"1","key":"404_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40168-022-01232-z","volume":"10","author":"LM Cox","year":"2022","unstructured":"Cox LM, Calcagno N, Gauthier C, Madore C, Butovsky O, Weiner HL. The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis. Microbiome. 2022;10(1):47.","journal-title":"Microbiome"},{"key":"404_CR39","doi-asserted-by":"publisher","first-page":"603594","DOI":"10.3389\/fimmu.2020.603594","volume":"11","author":"G Du","year":"2021","unstructured":"Du G, Dong W, Yang Q, Yu X, Ma J, Gu W, et al. Altered gut microbiota related to inflammatory responses in patients with Huntington\u2019s disease. Front Immunol. 2021;11:603594.","journal-title":"Front Immunol"},{"issue":"4","key":"404_CR40","doi-asserted-by":"publisher","first-page":"fcac205","DOI":"10.1093\/braincomms\/fcac205","volume":"4","author":"C Gubert","year":"2022","unstructured":"Gubert C, Choo JM, Love CJ, Kodikara S, Masson BA, Liew JJM, et al. Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington\u2019s disease mice. Brain Commun. 2022;4(4):fcac205.","journal-title":"Brain Commun"},{"key":"404_CR41","doi-asserted-by":"publisher","first-page":"127647","DOI":"10.1016\/j.ijbiomac.2023.127647","volume":"253","author":"L Liang","year":"2023","unstructured":"Liang L, Yue Y, Zhong L, Liang Y, Shi R, Luo R, et al. Anti-aging activities of Rehmannia Glutinosa Libosch. Crude polysaccharide in Caenorhabditis elegans based on gut microbiota and metabonomic analysis. Int J Biol Macromol. 2023;253:127647 (Pt 8).","journal-title":"Int J Biol Macromol"},{"issue":"14","key":"404_CR42","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1182\/blood.2022017514","volume":"141","author":"X Zeng","year":"2023","unstructured":"Zeng X, Li X, Li X, Wei C, Shi C, Hu K, et al. Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation. Blood. 2023;141(14):1691\u2013707.","journal-title":"Blood"},{"key":"404_CR43","doi-asserted-by":"publisher","first-page":"736204","DOI":"10.3389\/fcimb.2021.736204","volume":"11","author":"X Gai","year":"2021","unstructured":"Gai X, Wang H, Li Y, Zhao H, He C, Wang Z, et al. Fecal microbiota transplantation protects the intestinal mucosal barrier by reconstructing the gut microbiota in a murine model of sepsis. Front Cell Infect Microbiol. 2021;11:736204.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"404_CR44","doi-asserted-by":"publisher","first-page":"113591","DOI":"10.1016\/j.celrep.2023.113591","volume":"43","author":"C-J Yang","year":"2024","unstructured":"Yang C-J, Chang H-C, Sung P-C, Ge M-C, Tang H-Y, Cheng M-L, et al. Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury. Cell Rep. 2024;43(1):113591.","journal-title":"Cell Rep"},{"key":"404_CR45","doi-asserted-by":"crossref","unstructured":"Loffredo L, Ettorre E, Zicari AM, Inghilleri M, Nocella C, Perri L et al. Oxidative stress and gut-derived lipopolysaccharides in neurodegenerative disease: Role of NOX2. Oxid Med Cell Longev. 2020; 2020:1\u20137.","DOI":"10.1155\/2020\/8630275"},{"issue":"1","key":"404_CR46","doi-asserted-by":"publisher","first-page":"2206504","DOI":"10.1080\/19490976.2023.2206504","volume":"15","author":"TK Das","year":"2023","unstructured":"Das TK, Ganesh BP. Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer\u2019s disease progression. Gut Microbes. 2023;15(1):2206504.","journal-title":"Gut Microbes"},{"issue":"1","key":"404_CR47","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","volume":"19","author":"A DeMaio","year":"2022","unstructured":"DeMaio A, Mehrotra S, Sambamurti K, Husain S. The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases. J Neuroinflamm. 2022;19(1):251.","journal-title":"J Neuroinflamm"},{"issue":"4","key":"404_CR48","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00401-021-02268-5","volume":"141","author":"AS Harms","year":"2021","unstructured":"Harms AS, Ferreira SA, Romero-Ramos M. Periphery and brain, innate and adaptive immunity in Parkinson\u2019s disease. Acta Neuropathol. 2021;141(4):527\u201345.","journal-title":"Acta Neuropathol"},{"key":"404_CR49","doi-asserted-by":"publisher","first-page":"890958","DOI":"10.3389\/fnagi.2022.890958","volume":"14","author":"W Yu","year":"2022","unstructured":"Yu W, He J, Cai X, Yu Z, Zou Z, Fan D. Neuroimmune crosstalk between the peripheral and the central immune system in amyotrophic lateral sclerosis. Front Aging Neurosci. 2022;14:890958.","journal-title":"Front Aging Neurosci"},{"issue":"24","key":"404_CR50","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.3390\/cells12242824","volume":"12","author":"A Malvaso","year":"2023","unstructured":"Malvaso A, Gatti A, Negro G, Calatozzolo C, Medici V, Poloni TE. Microglial senescence and activation in healthy aging and Alzheimer\u2019s disease: systematic review and neuropathological scoring. Cells. 2023;12(24):2824.","journal-title":"Cells"},{"issue":"6","key":"404_CR51","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.4103\/1673-5374.385845","volume":"19","author":"T Han","year":"2024","unstructured":"Han T, Xu Y, Sun L, Hashimoto M, Wei J. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural Regen Res. 2024;19(6):1241\u20138.","journal-title":"Neural Regen Res"},{"issue":"3","key":"404_CR52","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","volume":"15","author":"A Khosravi","year":"2014","unstructured":"Khosravi A, Y\u00e1\u00f1ez A, Price Jeremy G, Chow A, Merad M, Goodridge Helen S, et al. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014;15(3):374\u201381.","journal-title":"Cell Host Microbe"},{"issue":"7","key":"404_CR53","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"D Erny","year":"2015","unstructured":"Erny D, Hrab\u011b de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18(7):965\u201377.","journal-title":"Nat Neurosci"},{"issue":"3","key":"404_CR54","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.cell.2017.11.042","volume":"172","author":"MS Thion","year":"2018","unstructured":"Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, et al. Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell. 2018;172(3):500\u2013516e516.","journal-title":"Cell"},{"issue":"3","key":"404_CR55","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41593-022-01027-3","volume":"25","author":"O Mossad","year":"2022","unstructured":"Mossad O, Batut B, Yilmaz B, Dokalis N, Mez\u00f6 C, Nent E, et al. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine. Nat Neurosci. 2022;25(3):295\u2013305.","journal-title":"Nat Neurosci"},{"issue":"4","key":"404_CR56","doi-asserted-by":"publisher","first-page":"102356","DOI":"10.1016\/j.isci.2021.102356","volume":"24","author":"P Kolypetri","year":"2021","unstructured":"Kolypetri P, Liu S, Cox LM, Fujiwara M, Raheja R, Ghitza D, et al. Regulation of splenic monocyte homeostasis and function by gut microbial products. iScience. 2021;24(4):102356.","journal-title":"iScience"},{"issue":"20","key":"404_CR57","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1182\/blood-2015-10-675173","volume":"127","author":"CB Hergott","year":"2016","unstructured":"Hergott CB, Roche AM, Tamashiro E, Clarke TB, Bailey AG, Laughlin A, et al. Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis. Blood. 2016;127(20):2460\u201371.","journal-title":"Blood"},{"issue":"10","key":"404_CR58","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.tim.2023.05.006","volume":"31","author":"P Kolypetri","year":"2023","unstructured":"Kolypetri P, Weiner HL. Monocyte regulation by gut microbial signals. Trends Microbiol. 2023;31(10):1044\u201357.","journal-title":"Trends Microbiol"},{"issue":"2","key":"404_CR59","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/gutjnl-2018-317431","volume":"69","author":"M-S Kim","year":"2020","unstructured":"Kim M-S, Kim Y, Choi H, Kim W, Park S, Lee D, et al. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer\u2019s disease animal model. Gut. 2020;69(2):283\u201394.","journal-title":"Gut"},{"issue":"1","key":"404_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12974-023-02723-y","volume":"20","author":"Y Xu","year":"2023","unstructured":"Xu Y, Li Y, Wang C, Han T, Liu H, Sun L, et al. The reciprocal interactions between microglia and T cells in Parkinson\u2019s disease: a double-edged sword. J Neuroinflamm. 2023;20(1):33.","journal-title":"J Neuroinflamm"},{"key":"404_CR61","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3389\/fnins.2020.00575","volume":"14","author":"Z Liu","year":"2020","unstructured":"Liu Z, Cheng X, Zhong S, Zhang X, Liu C, Liu F, et al. Peripheral and central nervous system immune response crosstalk in amyotrophic lateral sclerosis. Front Neurosci. 2020;14:575.","journal-title":"Front Neurosci"},{"issue":"12","key":"404_CR62","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.1002\/alz.13136","volume":"19","author":"C Gericke","year":"2023","unstructured":"Gericke C, Kirabali T, Flury R, Mallone A, Rickenbach C, Kulic L, et al. Early \u03b2-amyloid accumulation in the brain is associated with peripheral T cell alterations. Alzheimers Dement. 2023;19(12):5642\u201362.","journal-title":"Alzheimers Dement"},{"issue":"7953","key":"404_CR63","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","volume":"615","author":"X Chen","year":"2023","unstructured":"Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature. 2023;615(7953):668\u201377.","journal-title":"Nature"},{"issue":"3","key":"404_CR64","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.cell.2020.06.026","volume":"182","author":"E Pasciuto","year":"2020","unstructured":"Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, et al. Microglia require CD4 T cells to complete the fetal-to-adult transition. Cell. 2020;182(3):625\u2013640e624.","journal-title":"Cell"},{"issue":"1","key":"404_CR65","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s40168-023-01685-w","volume":"11","author":"X-B Bai","year":"2023","unstructured":"Bai X-B, Xu S, Zhou L-J, Meng X-Q, Li Y-L, Chen Y-L, et al. Oral pathogens exacerbate Parkinson\u2019s disease by promoting Th1 cell infiltration in mice. Microbiome. 2023;11(1):254.","journal-title":"Microbiome"},{"issue":"15","key":"404_CR66","doi-asserted-by":"publisher","first-page":"e147700","DOI":"10.1172\/jci.insight.147700","volume":"7","author":"D Rei","year":"2022","unstructured":"Rei D, Saha S, Haddad M, Rubio AH, Perlaza BL, Berard M, et al. Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner. JCI Insight. 2022;7(15):e147700.","journal-title":"JCI Insight"},{"key":"404_CR67","doi-asserted-by":"publisher","first-page":"866434","DOI":"10.3389\/fnhum.2022.866434","volume":"16","author":"M Vargas-Caballero","year":"2022","unstructured":"Vargas-Caballero M, Warming H, Walker R, Holmes C, Cruickshank G, Patel B. Vagus nerve stimulation as a potential therapy in early Alzheimer\u2019s disease: a review. Front Hum Neurosci. 2022;16:866434.","journal-title":"Front Hum Neurosci"},{"issue":"6","key":"404_CR68","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.brs.2022.11.006","volume":"15","author":"F Torrecillos","year":"2022","unstructured":"Torrecillos F, Tan H, Brown P, Capone F, Ricciuti R, Di Lazzaro V, et al. Non-invasive vagus nerve stimulation modulates subthalamic beta activity in Parkinson\u2019s disease. Brain Stimulat. 2022;15(6):1513\u20136.","journal-title":"Brain Stimulat"},{"issue":"3","key":"404_CR69","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neurom.2022.03.011","volume":"26","author":"Y Yu","year":"2023","unstructured":"Yu Y, Jiang X, Fang X, Wang Y, Liu P, Ling J, et al. Transauricular vagal nerve stimulation at 40 Hz inhibits hippocampal P2X7R\/NLRP3\/Caspase-1 signaling and improves spatial learning and memory in 6-month-old APP\/PS1 mice. Neuromodulation. 2023;26(3):589\u2013600.","journal-title":"Neuromodulation"},{"issue":"1","key":"404_CR70","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12974-021-02356-z","volume":"18","author":"Y Wu","year":"2021","unstructured":"Wu Y, Zhang Y, Xie B, Abdelgawad A, Chen X, Han M, et al. Rhanp attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota\u2013brain axis. J Neuroinflammation. 2021;18(1):300.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"404_CR71","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13024-022-00548-6","volume":"17","author":"E Connell","year":"2022","unstructured":"Connell E, Le Gall G, Pontifex MG, Sami S, Cryan JF, Clarke G, et al. Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia. Mol Neurodegener. 2022;17(1):43.","journal-title":"Mol Neurodegener"},{"issue":"6239","key":"404_CR72","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/341226a0","volume":"341","author":"CL Joachim","year":"1989","unstructured":"Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer\u2019s disease. Nature. 1989;341(6239):226\u201330.","journal-title":"Nature"},{"issue":"1","key":"404_CR73","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41422-019-0241-9","volume":"30","author":"EH Ahn","year":"2019","unstructured":"Ahn EH, Kang SS, Liu X, Chen G, Zhang Z, Chandrasekharan B, et al. Initiation of Parkinson\u2019s disease from gut to brain by \u03b4-secretase. Cell Res. 2019;30(1):70\u201387.","journal-title":"Cell Res"},{"issue":"3","key":"404_CR74","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s12264-022-00957-z","volume":"39","author":"R Wang","year":"2022","unstructured":"Wang R, Ren H, Kaznacheyeva E, Lu X, Wang G. Association of glial activation and \u03b1-synuclein pathology in Parkinson\u2019s disease. Neurosci Bull. 2022;39(3):479\u201390.","journal-title":"Neurosci Bull"},{"issue":"12","key":"404_CR75","doi-asserted-by":"publisher","first-page":"e1006654","DOI":"10.1371\/journal.ppat.1006654","volume":"13","author":"JB Bliska","year":"2017","unstructured":"Bliska JB, Friedland RP, Chapman MR. The role of microbial amyloid in neurodegeneration. PLoS Pathog. 2017;13(12):e1006654.","journal-title":"PLoS Pathog"},{"issue":"19","key":"404_CR76","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1113\/JP279919","volume":"598","author":"Y Sun","year":"2020","unstructured":"Sun Y, Sommerville NR, Liu JYH, Ngan MP, Poon D, Ponomarev ED, et al. Intra-gastrointestinal amyloid\u2010\u03b21\u201342 oligomers perturb enteric function and induce Alzheimer\u2019s disease pathology. J Physiol. 2020;598(19):4209\u201323.","journal-title":"J Physiol"},{"issue":"23","key":"404_CR77","doi-asserted-by":"publisher","first-page":"e172192","DOI":"10.1172\/jci.insight.172192","volume":"8","author":"R Chandra","year":"2023","unstructured":"Chandra R, Sokratian A, Chavez KR, King S, Swain SM, Snyder JC, et al. Gut mucosal cells transfer \u03b1-synuclein to the vagus nerve. JCI Insight. 2023;8(23):e172192.","journal-title":"JCI Insight"},{"key":"404_CR78","doi-asserted-by":"publisher","first-page":"1241418","DOI":"10.3389\/fnins.2023.1241418","volume":"17","author":"B Sun","year":"2023","unstructured":"Sun B, Sawant H, Borthakur A, Bihl JC. Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders. Front Neurosci. 2023;17:1241418.","journal-title":"Front Neurosci"},{"issue":"1","key":"404_CR79","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s40168-020-00881-2","volume":"8","author":"K-E Lee","year":"2020","unstructured":"Lee K-E, Kim J-K, Han S-K, Lee DY, Lee H-J, Yim S-V, et al. The extracellular vesicle of gut microbial paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment. Microbiome. 2020;8(1):107.","journal-title":"Microbiome"},{"issue":"4","key":"404_CR80","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/ana.24448","volume":"78","author":"E Svensson","year":"2015","unstructured":"Svensson E, Horv\u00e1th-Puh\u00f3 E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, et al. Vagotomy and subsequent risk of Parkinson\u2019s disease. Ann Neurol. 2015;78(4):522\u20139.","journal-title":"Ann Neurol"},{"issue":"21","key":"404_CR81","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1212\/WNL.0000000000003961","volume":"88","author":"B Liu","year":"2017","unstructured":"Liu B, Fang F, Pedersen NL, Tillander A, Ludvigsson JF, Ekbom A, et al. Vagotomy and Parkinson disease. Neurology. 2017;88(21):1996\u20132002.","journal-title":"Neurology"},{"issue":"4","key":"404_CR82","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/femsre\/fuv013","volume":"39","author":"M Potgieter","year":"2015","unstructured":"Potgieter M, Bester J, Kell DB, Pretorius E, Danchin PA. The dormant blood microbiome in chronic, inflammatory diseases. FEMS Microbiol Rev. 2015;39(4):567\u201391.","journal-title":"FEMS Microbiol Rev"},{"issue":"10","key":"404_CR83","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.jalz.2019.07.002","volume":"15","author":"B Li","year":"2019","unstructured":"Li B, He Y, Ma J, Huang P, Du J, Cao L, et al. Mild cognitive impairment has similar alterations as Alzheimer\u2019s disease in gut microbiota. Alzheimers Dement. 2019;15(10):1357\u201366.","journal-title":"Alzheimers Dement"},{"issue":"12","key":"404_CR84","doi-asserted-by":"publisher","first-page":"e28032","DOI":"10.1371\/journal.pone.0028032","volume":"6","author":"C Oreja-Guevara","year":"2011","unstructured":"Oreja-Guevara C, Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, et al. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson\u2019s disease. PLoS ONE. 2011;6(12):e28032.","journal-title":"PLoS ONE"},{"issue":"2","key":"404_CR85","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3233\/JAD-200306","volume":"78","author":"M Marizzoni","year":"2020","unstructured":"Marizzoni M, Cattaneo A, Mirabelli P, Festari C, Lopizzo N, Nicolosi V, et al. Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer\u2019s disease. J Alzheimers Dis. 2020;78(2):683\u201397.","journal-title":"J Alzheimers Dis"},{"issue":"20","key":"404_CR86","doi-asserted-by":"publisher","first-page":"12671","DOI":"10.3390\/ijms232012671","volume":"23","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Jaber VR, Pogue AI, Sharfman NM, Taylor C, Lukiw WJ. Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer\u2019s disease (AD). Int J Mol Sci. 2022;23(20):12671.","journal-title":"Int J Mol Sci"},{"key":"404_CR87","doi-asserted-by":"publisher","first-page":"1123228","DOI":"10.3389\/fcimb.2023.1123228","volume":"13","author":"Y Mon\u00e9","year":"2023","unstructured":"Mon\u00e9 Y, Earl JP, Kr\u00f3l JE, Ahmed A, Sen B, Ehrlich GD, et al. Evidence supportive of a bacterial component in the etiology for Alzheimer\u2019s disease and for a temporal-spatial development of a pathogenic microbiome in the brain. Front Cell Infect Microbiol. 2023;13:1123228.","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"404_CR88","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","volume":"33","author":"D Erny","year":"2021","unstructured":"Erny D, Dokalis N, Mez\u00f6 C, Castoldi A, Mossad O, Staszewski O, et al. Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metab. 2021;33(11):2260\u20132276e2267.","journal-title":"Cell Metab"},{"issue":"9","key":"404_CR89","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.1007\/s12035-023-03392-x","volume":"60","author":"C-M Qiao","year":"2023","unstructured":"Qiao C-M, Quan W, Zhou Y, Niu G-Y, Hong H, Wu J, et al. Orally induced high serum level of trimethylamine N-oxide worsened glial reaction and neuroinflammation on MPTP-induced acute Parkinson\u2019s disease model mice. Mol Neurobiol. 2023;60(9):5137\u201354.","journal-title":"Mol Neurobiol"},{"issue":"9","key":"404_CR90","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2174\/1389203724666230717125406","volume":"24","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Jian W. Signal pathways and intestinal flora through trimethylamine N-oxide in Alzheimer\u2019s disease. Curr Protein Pept Sci. 2023;24(9):721\u201336.","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"404_CR91","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1212\/WNL.0000000000201336","volume":"100","author":"I Glans","year":"2023","unstructured":"Glans I, Sonestedt E, N\u00e4gga K, Gustavsson A-M, Gonz\u00e1lez-Padilla E, Borne Y, et al. Association between dietary habits in midlife with dementia incidence over a 20-year period. Neurology. 2023;100(1):e28\u2013e37.","journal-title":"Neurology"},{"issue":"15","key":"404_CR92","doi-asserted-by":"publisher","first-page":"e2095","DOI":"10.1212\/WNL.0000000000010523","volume":"95","author":"S Molsberry","year":"2020","unstructured":"Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology. 2020;95(15):e2095\u2013108.","journal-title":"Neurology"},{"issue":"8","key":"404_CR93","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1017\/S1368980013002115","volume":"17","author":"N Shivappa","year":"2013","unstructured":"Shivappa N, Steck SE, Hurley TG, Hussey JR, H\u00e9bert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2013;17(8):1689\u201396.","journal-title":"Public Health Nutr"},{"key":"404_CR94","doi-asserted-by":"publisher","first-page":"108994","DOI":"10.1016\/j.jnutbio.2022.108994","volume":"105","author":"V Balomenos","year":"2022","unstructured":"Balomenos V, Bounou L, Charisis S, Stamelou M, Ntanasi E, Georgiadi K, et al. Dietary inflammatory index score and prodromal Parkinson\u2019s disease incidence: the HELIAD study. J Nutr Biochem. 2022;105:108994.","journal-title":"J Nutr Biochem"},{"issue":"24","key":"404_CR95","doi-asserted-by":"publisher","first-page":"e2381","DOI":"10.1212\/WNL.0000000000012973","volume":"97","author":"S Charisis","year":"2021","unstructured":"Charisis S, Ntanasi E, Yannakoulia M, Anastasiou CA, Kosmidis MH, Dardiotis E, et al. Diet inflammatory index and dementia incidence. Neurology. 2021;97(24):e2381\u201391.","journal-title":"Neurology"},{"issue":"9","key":"404_CR96","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1017\/S0007114520001853","volume":"124","author":"J Zheng","year":"2020","unstructured":"Zheng J, Hoffman KL, Chen J-S, Shivappa N, Sood A, Browman GJ, et al. Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study. Br J Nutr. 2020;124(9):931\u201342.","journal-title":"Br J Nutr"},{"issue":"4","key":"404_CR97","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/mds.28464","volume":"36","author":"A Metcalfe-Roach","year":"2021","unstructured":"Metcalfe-Roach A, Yu AC, Golz E, Cirstea M, Sundvick K, Kliger D, et al. Mind and Mediterranean diets associated with later onset of Parkinson\u2019s disease. Mov Disord. 2021;36(4):977\u201384.","journal-title":"Mov Disord"},{"issue":"7","key":"404_CR98","doi-asserted-by":"publisher","first-page":"e2221982","DOI":"10.1001\/jamanetworkopen.2022.21982","volume":"5","author":"B Moustafa","year":"2022","unstructured":"Moustafa B, Trifan G, Isasi CR, Lipton RB, Sotres-Alvarez D, Cai J, et al. Association of Mediterranean diet with cognitive decline among diverse hispanic or latino adults from the Hispanic Community Health Study\/Study of Latinos. JAMA Netw Open. 2022;5(7):e2221982.","journal-title":"JAMA Netw Open"},{"issue":"2","key":"404_CR99","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3233\/JAD-180184","volume":"65","author":"JE de la Rubia Ort\u00ed","year":"2018","unstructured":"de la Rubia Ort\u00ed JE, Garc\u00eda-Pardo MP, Drehmer E, Sancho Cantus D, Juli\u00e1n Rochina M, Aguilar MA, et al. Improvement of main cognitive functions in patients with Alzheimer\u2019s disease after treatment with coconut oil enriched Mediterranean diet: a pilot study. J Alzheimers Dis. 2018;65(2):577\u201387.","journal-title":"J Alzheimers Dis"},{"key":"404_CR100","doi-asserted-by":"publisher","first-page":"102366","DOI":"10.1016\/j.ctim.2020.102366","volume":"50","author":"Z Paknahad","year":"2020","unstructured":"Paknahad Z, Sheklabadi E, Derakhshan Y, Bagherniya M, Chitsaz A. The effect of the Mediterranean diet on cognitive function in patients with Parkinson\u2019s disease: a randomized clinical controlled trial. Complement Ther Med. 2020;50:102366.","journal-title":"Complement Ther Med"},{"issue":"3","key":"404_CR101","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/alz.12421","volume":"18","author":"S Hoscheidt","year":"2021","unstructured":"Hoscheidt S, Sanderlin AH, Baker LD, Jung Y, Lockhart S, Kellar D, et al. Mediterranean and western diet effects on Alzheimer\u2019s disease biomarkers, cerebral perfusion, and cognition in mid-life: a randomized trial. Alzheimers Dement. 2021;18(3):457\u201368.","journal-title":"Alzheimers Dement"},{"key":"404_CR102","doi-asserted-by":"publisher","first-page":"120166","DOI":"10.1016\/j.jns.2022.120166","volume":"434","author":"RJ Solch","year":"2022","unstructured":"Solch RJ, Aigbogun JO, Voyiadjis AG, Talkington GM, Darensbourg RM, O\u2019Connell S, et al. Mediterranean diet adherence, gut microbiota, and Alzheimer\u2019s or Parkinson\u2019s disease risk: a systematic review. J Neurol Sci. 2022;434:120166.","journal-title":"J Neurol Sci"},{"issue":"1","key":"404_CR103","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13195-021-00783-x","volume":"13","author":"MCL Phillips","year":"2021","unstructured":"Phillips MCL, Deprez LM, Mortimer GMN, Murtagh DKJ, McCoy S, Mylchreest R, et al. Randomized crossover trial of a modified ketogenic diet in Alzheimer\u2019s disease. Alzheimers Res Ther. 2021;13(1):51.","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"404_CR104","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/mds.27390","volume":"33","author":"MCL Phillips","year":"2018","unstructured":"Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDP. Low-fat versus ketogenic diet in Parkinson\u2019s disease: a pilot randomized controlled trial. Mov Disord. 2018;33(8):1306\u201314.","journal-title":"Mov Disord"},{"issue":"7","key":"404_CR105","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.cell.2018.04.027","volume":"173","author":"CA Olson","year":"2018","unstructured":"Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell. 2018;173(7):1728\u20131741e1713.","journal-title":"Cell"},{"issue":"6","key":"404_CR106","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1093\/ajcn\/nqz148","volume":"110","author":"MPT Ylilauri","year":"2019","unstructured":"Ylilauri MPT, Voutilainen S, L\u00f6nnroos E, Virtanen HEK, Tuomainen T-P, Salonen JT, et al. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease risk factor study. Am J Clin Nutr. 2019;110(6):1416\u201323.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"404_CR107","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/ajcn\/nqac193","volume":"116","author":"J Yuan","year":"2022","unstructured":"Yuan J, Liu X, Liu C, Ang AFA, Massaro J, Devine SA, et al. Is dietary choline intake related to dementia and Alzheimer\u2019s disease risks? Results from the Framingham Heart Study. Am J Clin Nutr. 2022;116(5):1201\u20137.","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"404_CR108","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3233\/JAD-220685","volume":"89","author":"X Gong","year":"2022","unstructured":"Gong X, Shi L, Wu Y, Luo Y, Kwok T. B vitamin supplementation slows cognitive decline in mild cognitive impairment patients with frontal lobe atrophy. J Alzheimers Dis. 2022;89(4):1453\u201361.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"404_CR109","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jama.2013.282834","volume":"311","author":"MW Dysken","year":"2014","unstructured":"Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease. JAMA. 2014;311(1):33\u201344.","journal-title":"JAMA"},{"issue":"2","key":"404_CR110","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1212\/01.wnl.0000225050.57553.6d","volume":"67","author":"LML de Lau","year":"2006","unstructured":"de Lau LML, Koudstaal PJ, Witteman JCM, Hofman A, Breteler MMB. Dietary folate, vitamin B 12, and vitamin B 6 and the risk of Parkinson disease. Neurology. 2006;67(2):315\u20138.","journal-title":"Neurology"},{"issue":"7","key":"404_CR111","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.3390\/nu15071684","volume":"15","author":"A Thiel","year":"2023","unstructured":"Thiel A, Hermanns C, Lauer AA, Reichrath J, Erhardt T, Hartmann T, et al. Vitamin D and its analogues: from differences in molecular mechanisms to potential benefits of adapted use in the treatment of Alzheimer\u2019s disease. Nutrients. 2023;15(7):1684.","journal-title":"Nutrients"},{"issue":"8","key":"404_CR112","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.chom.2022.07.010","volume":"30","author":"A Brauer-Nikonow","year":"2022","unstructured":"Brauer-Nikonow A, Zimmermann M. How the gut microbiota helps keep us vitaminized. Cell Host Microbe. 2022;30(8):1063\u20136.","journal-title":"Cell Host Microbe"},{"issue":"2","key":"404_CR113","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.copbio.2012.08.005","volume":"24","author":"JG LeBlanc","year":"2013","unstructured":"LeBlanc JG, Milani C, de Giori GS, Sesma F, van Sinderen D, Ventura M. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol. 2013;24(2):160\u20138.","journal-title":"Curr Opin Biotechnol"},{"issue":"1","key":"404_CR114","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s40168-022-01298-9","volume":"10","author":"Q Jiang","year":"2022","unstructured":"Jiang Q, Lin L, Xie F, Jin W, Zhu W, Wang M, et al. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microbiome. 2022;10(1):109.","journal-title":"Microbiome"},{"issue":"8","key":"404_CR115","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1080\/09637486.2020.1748580","volume":"71","author":"S Jiang","year":"2020","unstructured":"Jiang S, Zhu Q, Mai M, Yang W, Du G. Vitamin B and vitamin D as modulators of gut microbiota in overweight individuals. Int J Food Sci Nutr. 2020;71(8):1001\u20139.","journal-title":"Int J Food Sci Nutr"},{"issue":"1","key":"404_CR116","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1038\/s41467-020-19793-8","volume":"11","author":"RL Thomas","year":"2020","unstructured":"Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, et al. Vitamin D metabolites and the gut microbiome in older men. Nat Commun. 2020;11(1):5997.","journal-title":"Nat Commun"},{"key":"404_CR117","doi-asserted-by":"publisher","first-page":"753351","DOI":"10.3389\/fnagi.2021.753351","volume":"13","author":"B-W Chen","year":"2021","unstructured":"Chen B-W, Zhang K-W, Chen S-J, Yang C, Li P-G. Vitamin A deficiency exacerbates gut microbiota dysbiosis and cognitive deficits in amyloid precursor protein\/presenilin 1 transgenic mice. Front Aging Neurosci. 2021;13:753351.","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"404_CR118","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3390\/nu14061159","volume":"14","author":"C-S Chu","year":"2022","unstructured":"Chu C-S, Hung C-F, Ponnusamy VK, Chen K-C, Chen N-C. Higher serum dha and slower cognitive decline in patients with Alzheimer\u2019s disease: two-year follow-up. Nutrients. 2022;14(6):1159.","journal-title":"Nutrients"},{"issue":"17","key":"404_CR119","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.3390\/ijms20174256","volume":"20","author":"R Avallone","year":"2019","unstructured":"Avallone R, Vitale G, Bertolotti M. Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials. Int J Mol Sci. 2019;20(17):4256.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"404_CR120","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1016\/j.pnpbp.2008.05.015","volume":"32","author":"C-C Chiu","year":"2008","unstructured":"Chiu C-C, Su K-P, Cheng T-C, Liu H-C, Chang C-J, Dewey ME, et al. The effects of omega-3 fatty acids monotherapy in Alzheimer\u2019s disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1538\u201344.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2\u20133","key":"404_CR121","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jad.2008.03.008","volume":"111","author":"TM da Silva","year":"2008","unstructured":"da Silva TM, Munhoz RP, Alvarez C, Naliwaiko K, Kiss \u00c1, Andreatini R, et al. Depression in Parkinson\u2019s disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord. 2008;111(2\u20133):351\u20139.","journal-title":"J Affect Disord"},{"issue":"2","key":"404_CR122","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3233\/JAD-160439","volume":"55","author":"Y-P Zhang","year":"2016","unstructured":"Zhang Y-P, Miao R, Li Q, Wu T, Ma F. Effects of DHA supplementation on hippocampal volume and cognitive function in older adults with mild cognitive impairment: a 12-month randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2016;55(2):497\u2013507.","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"404_CR123","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3233\/JAD-180176","volume":"63","author":"Z-Q Zhuang","year":"2018","unstructured":"Zhuang Z-Q, Shen L-L, Li W-W, Fu X, Zeng F, Gui L, et al. Gut microbiota is altered in patients with Alzheimer\u2019s disease. J Alzheimers Dis. 2018;63(4):1337\u201346.","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"404_CR124","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.3390\/ijms18122645","volume":"18","author":"L Costantini","year":"2017","unstructured":"Costantini L, Molinari R, Farinon B, Merendino N. Impact of omega-3 fatty acids on the gut microbiota. Int J Mol Sci. 2017;18(12):2645.","journal-title":"Int J Mol Sci"},{"key":"404_CR125","doi-asserted-by":"publisher","first-page":"101347","DOI":"10.1016\/j.arr.2021.101347","volume":"69","author":"S-Y Zheng","year":"2021","unstructured":"Zheng S-Y, Li H-X, Xu R-C, Miao W-T, Dai M-Y, Ding S-T, et al. Potential roles of gut microbiota and microbial metabolites in Parkinson\u2019s disease. Ageing Res Rev. 2021;69:101347.","journal-title":"Ageing Res Rev"},{"issue":"6","key":"404_CR126","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","volume":"38","author":"OR Tamtaji","year":"2019","unstructured":"Tamtaji OR, Heidari-soureshjani R, Mirhosseini N, Kouchaki E, Bahmani F, Aghadavod E, et al. Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer\u2019s disease: a randomized, double-blind, controlled trial. Clin Nutr. 2019;38(6):2569\u201375.","journal-title":"Clin Nutr"},{"issue":"17","key":"404_CR127","doi-asserted-by":"publisher","first-page":"7014","DOI":"10.18632\/aging.204266","volume":"14","author":"C-T Hong","year":"2022","unstructured":"Hong C-T, Chen J-H, Huang T-W. Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials. Aging. 2022;14(17):7014\u201325.","journal-title":"Aging"},{"issue":"3","key":"404_CR128","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.clnu.2018.05.018","volume":"38","author":"OR Tamtaji","year":"2019","unstructured":"Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R, Kouchaki E, Bahmani F, Borzabadi S, et al. Clinical and metabolic response to probiotic administration in people with Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019;38(3):1031\u20135.","journal-title":"Clin Nutr"},{"issue":"2","key":"404_CR129","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/nutrit\/nuaa037","volume":"79","author":"JF Kr\u00fcger","year":"2021","unstructured":"Kr\u00fcger JF, Hillesheim E, Pereira ACSN, Camargo CQ, Rabito EI. Probiotics for dementia: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2021;79(2):160\u201370.","journal-title":"Nutr Rev"},{"issue":"6","key":"404_CR130","doi-asserted-by":"publisher","first-page":"e0328622","DOI":"10.1128\/spectrum.03286-22","volume":"10","author":"K Wang","year":"2022","unstructured":"Wang K, Wang K, Wang J, Yu F, Ye C, Fu Y. Protective effect of Clostridium butyricum on Escherichia coli-induced endometritis in mice via ameliorating endometrial barrier and inhibiting inflammatory response. Microbiol Spectr. 2022;10(6):e0328622.","journal-title":"Microbiol Spectr"},{"issue":"2","key":"404_CR131","doi-asserted-by":"publisher","first-page":"e1900636","DOI":"10.1002\/mnfr.201900636","volume":"64","author":"J Sun","year":"2019","unstructured":"Sun J, Xu J, Yang B, Chen K, Kong Y, Fang N, et al. Effect of Clostridium butyricum against microglia-mediated neuroinflammation in Alzheimer\u2019s disease via regulating gut microbiota and metabolites butyrate. Mol Nutr Food Res. 2019;64(2):e1900636.","journal-title":"Mol Nutr Food Res"},{"key":"404_CR132","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","volume":"91","author":"J Sun","year":"2021","unstructured":"Sun J, Li H, Jin Y, Yu J, Mao S, Su K-P, et al. Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson\u2019s disease via gut microbiota-GLP-1 pathway. Brain Behav Immun. 2021;91:703\u201315.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"404_CR133","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s40168-021-01189-5","volume":"9","author":"J Shin","year":"2021","unstructured":"Shin J, Noh J-R, Choe D, Lee N, Song Y, Cho S, et al. Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing. Microbiome. 2021;9(1):240.","journal-title":"Microbiome"},{"issue":"1","key":"404_CR134","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41387-020-0115-8","volume":"10","author":"Z Ou","year":"2020","unstructured":"Ou Z, Deng L, Lu Z, Wu F, Liu W, Huang D, et al. Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer\u2019s disease. Nutr Diabetes. 2020;10(1):12.","journal-title":"Nutr Diabetes"},{"key":"404_CR135","doi-asserted-by":"publisher","first-page":"111959","DOI":"10.1016\/j.exger.2022.111959","volume":"170","author":"X He","year":"2022","unstructured":"He X, Yan C, Zhao S, Zhao Y, Huang R, Li Y. The preventive effects of probiotic Akkermansia muciniphila on D-galactose\/AlCl3 mediated Alzheimer\u2019s disease-like rats. Exp Gerontol. 2022;170:111959.","journal-title":"Exp Gerontol"},{"issue":"7770","key":"404_CR136","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41586-019-1443-5","volume":"572","author":"E Blacher","year":"2019","unstructured":"Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 2019;572(7770):474\u201380.","journal-title":"Nature"},{"issue":"1","key":"404_CR137","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41531-022-00328-5","volume":"8","author":"H Nishiwaki","year":"2022","unstructured":"Nishiwaki H, Ito M, Hamaguchi T, Maeda T, Kashihara K, Tsuboi Y, et al. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson\u2019s disease. NPJ Parkinson\u2019s Disease. 2022;8(1):65.","journal-title":"NPJ Parkinson\u2019s Disease"},{"issue":"3","key":"404_CR138","doi-asserted-by":"publisher","first-page":"103908","DOI":"10.1016\/j.isci.2022.103908","volume":"25","author":"DP Amorim Neto","year":"2022","unstructured":"Amorim Neto DP, Bosque BP, Pereira de Godoy JV, Rodrigues PV, Meneses DD, Tostes K, et al. Akkermansia muciniphila induces mitochondrial calcium overload and \u03b1 -synuclein aggregation in an enteroendocrine cell line. iScience. 2022;25(3):103908.","journal-title":"iScience"},{"issue":"4","key":"404_CR139","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s10571-022-01268-7","volume":"43","author":"D Cuervo-Zanatta","year":"2022","unstructured":"Cuervo-Zanatta D, Syeda T, S\u00e1nchez-Valle V, Irene-Fierro M, Torres-Aguilar P, Torres-Ramos MA, et al. Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer\u2019s mouse model. Cell Mol Neurobiol. 2022;43(4):1595\u2013618.","journal-title":"Cell Mol Neurobiol"},{"key":"404_CR140","doi-asserted-by":"publisher","first-page":"e81453","DOI":"10.7554\/eLife.81453","volume":"11","author":"R Abdel-Haq","year":"2022","unstructured":"Abdel-Haq R, Schlachetzki JCM, Boktor JC, Cantu-Jungles TM, Thron T, Zhang M, et al. A prebiotic diet modulates microglial states and motor deficits in \u03b1-synuclein overexpressing mice. eLife. 2022;11:e81453.","journal-title":"eLife"},{"key":"404_CR141","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.bbi.2023.12.023","volume":"116","author":"C Gubert","year":"2024","unstructured":"Gubert C, Kong G, Costello C, Adams CD, Masson BA, Qin W, et al. Dietary fibre confers therapeutic effects in a preclinical model of Huntington\u2019s disease. Brain Behav Immun. 2024;116:404\u201318.","journal-title":"Brain Behav Immun"},{"issue":"12","key":"404_CR142","doi-asserted-by":"publisher","first-page":"984","DOI":"10.2174\/1567205019666211222115142","volume":"18","author":"Y Gu","year":"2021","unstructured":"Gu Y, Nishikawa M, Brickman AM, Manly JJ, Schupf N, Mayeux RP. Association of dietary prebiotic consumption with reduced risk of Alzheimer\u2019s disease in a multiethnic population. Curr Alzheimer Res. 2021;18(12):984\u201392.","journal-title":"Curr Alzheimer Res"},{"issue":"5","key":"404_CR143","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00002826-199210000-00004","volume":"15","author":"R Astarloa","year":"1992","unstructured":"Astarloa R, Mena MA, S\u00e1nchez V, de la Vega L, de Y\u00e9benes JG. Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease. Clin Neuropharmacol. 1992;15(5):375\u201380.","journal-title":"Clin Neuropharmacol"},{"key":"404_CR144","doi-asserted-by":"publisher","first-page":"109452","DOI":"10.1016\/j.cbi.2021.109452","volume":"341","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Li K, Li X, Xu L, Yang Z. Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5xFAD mice. Chem Biol Interact. 2021;341:109452.","journal-title":"Chem Biol Interact"},{"issue":"1","key":"404_CR145","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00213-021-06025-0","volume":"239","author":"C Wang","year":"2021","unstructured":"Wang C, Zheng D, Weng F, Jin Y, He L. Sodium butyrate ameliorates the cognitive impairment of Alzheimer\u2019s disease by regulating the metabolism of astrocytes. Psychopharmacology. 2021;239(1):215\u201327.","journal-title":"Psychopharmacology"},{"issue":"27","key":"404_CR146","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1021\/acs.jafc.0c02807","volume":"68","author":"J Liu","year":"2020","unstructured":"Liu J, Li H, Gong T, Chen W, Mao S, Kong Y, et al. Anti-neuroinflammatory effect of short-chain fatty acid acetate against Alzheimer\u2019s disease via upregulating GPR41 and inhibiting ERK\/JNK\/NF-\u03baB. J Agric Food Chem. 2020;68(27):7152\u201361.","journal-title":"J Agric Food Chem"},{"key":"404_CR147","doi-asserted-by":"publisher","first-page":"136887","DOI":"10.1016\/j.neulet.2022.136887","volume":"791","author":"W Lang","year":"2022","unstructured":"Lang W, Li X, Wang Y, Duan Y, Wang Y, Wei P, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer\u2019s disease. Neurosci Lett. 2022;791:136887.","journal-title":"Neurosci Lett"},{"issue":"21","key":"404_CR148","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.3390\/nu14214688","volume":"14","author":"J Neuffer","year":"2022","unstructured":"Neuffer J, Gonz\u00e1lez-Dom\u00ednguez R, Lef\u00e8vre-Arbogast S, Low DY, Driollet B, Helmer C, et al. Exploration of the gut\u2013brain axis through metabolomics identifies serum propionic acid associated with higher cognitive decline in older persons. Nutrients. 2022;14(21):4688.","journal-title":"Nutrients"},{"issue":"9","key":"404_CR149","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1007\/s11064-020-03074-3","volume":"45","author":"C-M Qiao","year":"2020","unstructured":"Qiao C-M, Sun M-F, Jia X-B, Li Y, Zhang B-P, Zhao L-P, et al. Sodium butyrate exacerbates Parkinson\u2019s disease by aggravating neuroinflammation and colonic inflammation in MPTP-induced mice model. Neurochem Res. 2020;45(9):2128\u201342.","journal-title":"Neurochem Res"},{"issue":"2","key":"404_CR150","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.clinthera.2016.12.014","volume":"39","author":"Y-g Zhang","year":"2017","unstructured":"Zhang Y-g, Wu S, Yi J, Xia Y, Jin D, Zhou J, et al. Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis. Clin Ther. 2017;39(2):322\u201336.","journal-title":"Clin Ther"},{"issue":"1","key":"404_CR151","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","volume":"15","author":"S MahmoudianDehkordi","year":"2018","unstructured":"MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, et al. Altered bile acid profile associates with cognitive impairment in Alzheimer\u2019s disease\u2014an emerging role for gut microbiome. Alzheimers Dement. 2018;15(1):76\u201392.","journal-title":"Alzheimers Dement"},{"issue":"4","key":"404_CR152","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.3233\/JPD-223179","volume":"12","author":"S-J Chen","year":"2022","unstructured":"Chen S-J, Chen C-C, Liao H-Y, Wu Y-W, Liou J-M, Wu M-S, et al. Alteration of gut microbial metabolites in the systemic circulation of patients with Parkinson\u2019s disease. J Parkinsons Dis. 2022;12(4):1219\u201330.","journal-title":"J Parkinsons Dis"},{"issue":"2","key":"404_CR153","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/JAD-210608","volume":"84","author":"A Mulak","year":"2021","unstructured":"Mulak A. Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer\u2019s disease. J Alzheimers Dis. 2021;84(2):461\u201377.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"404_CR154","doi-asserted-by":"publisher","first-page":"15198","DOI":"10.1038\/s41598-020-72184-3","volume":"10","author":"L Chen","year":"2020","unstructured":"Chen L, Chen Y, Zhao M, Zheng L, Fan D. Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis. Sci Rep. 2020;10(1):15198.","journal-title":"Sci Rep"},{"issue":"5","key":"404_CR155","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3390\/brainsci13050790","volume":"13","author":"W Quan","year":"2023","unstructured":"Quan W, Qiao C-M, Niu G-Y, Wu J, Zhao L-P, Cui C, et al. Trimethylamine N-oxide exacerbates neuroinflammation and motor dysfunction in an acute MPTP mice model of Parkinson\u2019s disease. Brain Sci. 2023;13(5):790.","journal-title":"Brain Sci"},{"issue":"2","key":"404_CR156","first-page":"525","volume":"62","author":"L Zhang","year":"2023","unstructured":"Zhang L, Yu F, Xia J. Trimethylamine N-oxide: role in cell senescence and age-related diseases. Eur J Nutr. 2023;62(2):525\u201341.","journal-title":"Eur J Nutr"},{"issue":"19","key":"404_CR157","doi-asserted-by":"publisher","first-page":"8642","DOI":"10.18632\/aging.102352","volume":"11","author":"Q Gao","year":"2019","unstructured":"Gao Q, Wang Y, Wang X, Fu S, Zhang X, Wang R-T, et al. Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer\u2019s disease. Aging. 2019;11(19):8642\u201363.","journal-title":"Aging"},{"issue":"5","key":"404_CR158","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1021\/acs.jafc.0c05205","volume":"69","author":"J Li","year":"2020","unstructured":"Li J, Zhang L, Wu T, Li Y, Zhou X, Ruan Z. Indole-3-propionic acid improved the intestinal barrier by enhancing epithelial barrier and mucus barrier. J Agric Food Chem. 2020;69(5):1487\u201395.","journal-title":"J Agric Food Chem"},{"issue":"3","key":"404_CR159","doi-asserted-by":"publisher","first-page":"e0012522","DOI":"10.1128\/spectrum.00125-22","volume":"10","author":"H Fang","year":"2022","unstructured":"Fang H, Fang M, Wang Y, Zhang H, Li J, Chen J, et al. Indole-3-propionic acid as a potential therapeutic agent for sepsis-induced gut microbiota disturbance. Microbiol Spectr. 2022;10(3):e0012522.","journal-title":"Microbiol Spectr"},{"issue":"1\u20132","key":"404_CR160","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s12031-002-0036-0","volume":"19","author":"PE Bendheim","year":"2002","unstructured":"Bendheim PE, Poeggeler B, Neria E, Ziv V, Pappolla MA, Chain DG. Development of indole-3-propionic acid (oxigon\u2122) for Alzheimer\u2019s disease. J Mol Neurosci. 2002;19(1\u20132):213\u20137.","journal-title":"J Mol Neurosci"},{"issue":"19","key":"404_CR161","doi-asserted-by":"publisher","first-page":"11921","DOI":"10.3390\/ijms231911921","volume":"23","author":"A Sekikawa","year":"2022","unstructured":"Sekikawa A, Wharton W, Butts B, Veliky CV, Garfein J, Li J, et al. Potential protective mechanisms of S-equol, a metabolite of soy isoflavone by the gut microbiome, on cognitive decline and dementia. Int J Mol Sci. 2022;23(19):11921.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"404_CR162","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s11130-020-00840-0","volume":"75","author":"SL Johnson","year":"2020","unstructured":"Johnson SL, Park HY, Vattem DA, Grammas P, Ma H, Seeram NP. Equol, a blood\u2013brain barrier permeable gut microbial metabolite of dietary isoflavone daidzein, exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells and Caenorhabditis elegans. Plant Foods Hum Nutr. 2020;75(4):512\u20137.","journal-title":"Plant Foods Hum Nutr"},{"issue":"18","key":"404_CR163","doi-asserted-by":"publisher","first-page":"e2100380","DOI":"10.1002\/mnfr.202100380","volume":"65","author":"V Cecarini","year":"2021","unstructured":"Cecarini V, Cuccioloni M, Zheng Y, Bonfili L, Gong C, Angeletti M, et al. Flavan-3\u2010ol microbial metabolites modulate proteolysis in neuronal cells reducing amyloid\u2010beta (1\u201042) levels. Mol Nutr Food Res. 2021;65(18):e2100380.","journal-title":"Mol Nutr Food Res"},{"issue":"11","key":"404_CR164","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/S1473-3099(21)00144-4","volume":"21","author":"PN Sipil\u00e4","year":"2021","unstructured":"Sipil\u00e4 PN, Heikkil\u00e4 N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, et al. Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort. Lancet Infect Dis. 2021;21(11):1557\u201367.","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"404_CR165","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/antibiotics11060726","volume":"11","author":"F Bruno","year":"2022","unstructured":"Bruno F, Malvaso A, Canterini S, Bruni AC. Antimicrobial peptides (AMPs) in the pathogenesis of Alzheimer\u2019s disease: implications for diagnosis and treatment. Antibiot (Basel). 2022;11(6):726.","journal-title":"Antibiot (Basel)"},{"issue":"1","key":"404_CR166","doi-asserted-by":"publisher","first-page":"10411","DOI":"10.1038\/s41598-017-11047-w","volume":"7","author":"MR Minter","year":"2017","unstructured":"Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, et al. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE\/PS1\u2206E9 murine model of Alzheimer\u2019s disease. Sci Rep. 2017;7(1):10411.","journal-title":"Sci Rep"},{"key":"404_CR167","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainresbull.2021.08.004","volume":"176","author":"B Mosaferi","year":"2021","unstructured":"Mosaferi B, Jand Y, Salari A-A. Antibiotic-induced gut microbiota depletion from early adolescence exacerbates spatial but not recognition memory impairment in adult male C57BL\/6 mice with Alzheimer-like disease. Brain Res Bull. 2021;176:8\u201317.","journal-title":"Brain Res Bull"},{"issue":"2","key":"404_CR168","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3233\/JAD-181094","volume":"69","author":"PJD Goetghebeur","year":"2019","unstructured":"Goetghebeur PJD, Wesnes KA, Targum SD. D-cycloserine improves difficult discriminations in a pattern separation task in Alzheimer\u2019s disease patients with dementia. J Alzheimers Dis. 2019;69(2):377\u201383.","journal-title":"J Alzheimers Dis"},{"key":"404_CR169","doi-asserted-by":"publisher","first-page":"888333","DOI":"10.3389\/fphar.2022.888333","volume":"13","author":"M Kim","year":"2022","unstructured":"Kim M, Park SJ, Choi S, Chang J, Kim SM, Jeong S, et al. Association between antibiotics and dementia risk: a retrospective cohort study. Front Pharmacol. 2022;13:888333.","journal-title":"Front Pharmacol"},{"issue":"1","key":"404_CR170","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3233\/JAD-220018","volume":"87","author":"G Tern\u00e1k","year":"2022","unstructured":"Tern\u00e1k G, N\u00e9meth M, Rozanovic M, Bog\u00e1r L. Alzheimer\u2019s disease-related dysbiosis might be triggered by certain classes of antibiotics with time-lapse: new insights into the pathogenesis? J Alzheimers Dis. 2022;87(1):443\u201351.","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"404_CR171","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/gps.3846","volume":"28","author":"DW Molloy","year":"2012","unstructured":"Molloy DW, Standish TI, Zhou Q, Guyatt G. A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer\u2019s disease: the DARAD trial. Int J Geriatr Psychiatry. 2012;28(5):463\u201370.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1\u20132","key":"404_CR172","first-page":"72","volume":"18","author":"C Cui","year":"2022","unstructured":"Cui C, Hong H, Shi Y, Zhou Y, Qiao C-M, Zhao W-J, et al. Vancomycin pretreatment on MPTP-induced Parkinson\u2019s disease mice exerts neuroprotection by suppressing inflammation both in brain and gut. J Neuroimmune Pharmacol. 2022;18(1\u20132):72\u201389.","journal-title":"J Neuroimmune Pharmacol"},{"key":"404_CR173","doi-asserted-by":"crossref","unstructured":"Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M et al. Neuroprotective effect of ceftriaxone on MPTP-induced Parkinson\u2019s disease mouse model by regulating inflammation and intestinal microbiota. Oxid Med Cell Longev. 2021; 2021:1\u201315.","DOI":"10.1155\/2021\/9424582"},{"issue":"21","key":"404_CR174","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.3390\/cells11213468","volume":"11","author":"C-T Hong","year":"2022","unstructured":"Hong C-T, Chan L, Chen K-Y, Lee H-H, Huang L-K, Yang Y-CSH, et al. Rifaximin modifies gut microbiota and attenuates inflammation in Parkinson\u2019s disease: preclinical and clinical studies. Cells. 2022;11(21):3468.","journal-title":"Cells"},{"issue":"5","key":"404_CR175","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1212\/01.wnl.0000201252.57661.e1","volume":"66","author":"NN-P Investigators","year":"2006","unstructured":"Investigators NN-P. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006;66(5):664\u201371.","journal-title":"Neurology"},{"issue":"3","key":"404_CR176","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/mds.27924","volume":"35","author":"TH Mertsalmi","year":"2019","unstructured":"Mertsalmi TH, Pekkonen E, Scheperjans F. Antibiotic exposure and risk of Parkinson\u2019s disease in Finland: a nationwide case-control study. Mov Disord. 2019;35(3):431\u201342.","journal-title":"Mov Disord"},{"issue":"11","key":"404_CR177","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1111\/ene.13986","volume":"26","author":"J Sun","year":"2019","unstructured":"Sun J, Zhan Y, Mariosa D, Larsson H, Almqvist C, Ingre C, et al. Antibiotics use and risk of amyotrophic lateral sclerosis in Sweden. Eur J Neurol. 2019;26(11):1355\u201361.","journal-title":"Eur J Neurol"},{"issue":"4814","key":"404_CR178","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/S0140-6736(01)20383-3","volume":"186","author":"FW Twort","year":"1915","unstructured":"Twort FW. An investigation on the nature of ultra-microscopic viruses. Lancet. 1915;186(4814):1241\u20133.","journal-title":"Lancet"},{"issue":"2","key":"404_CR179","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41575-021-00536-z","volume":"19","author":"Y Duan","year":"2021","unstructured":"Duan Y, Young R, Schnabl B. Bacteriophages and their potential for treatment of gastrointestinal diseases. Nat Rev Gastroenterol Hepatol. 2021;19(2):135\u201344.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"404_CR180","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.chom.2022.05.005","volume":"30","author":"Y Teng","year":"2022","unstructured":"Teng Y, Mu J, Xu F, Zhang X, Sriwastva MK, Liu QM, et al. Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death. Cell Host Microbe. 2022;30(7):944\u2013960e948.","journal-title":"Cell Host Microbe"},{"key":"404_CR181","doi-asserted-by":"publisher","first-page":"1286429","DOI":"10.3389\/fmicb.2023.1286429","volume":"14","author":"X Zhang","year":"2023","unstructured":"Zhang X, Luo X, Tian L, Yue P, Li M, Liu K, et al. The gut microbiome dysbiosis and regulation by fecal microbiota transplantation: Umbrella review. Front Microbiol. 2023;14:1286429.","journal-title":"Front Microbiol"},{"issue":"1","key":"404_CR182","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41398-019-0525-3","volume":"9","author":"J Sun","year":"2019","unstructured":"Sun J, Xu J, Ling Y, Wang F, Gong T, Yang C, et al. Fecal microbiota transplantation alleviated Alzheimer\u2019s disease-like pathogenesis in APP\/PS1 transgenic mice. Transl Psychiatry. 2019;9(1):189.","journal-title":"Transl Psychiatry"},{"issue":"1","key":"404_CR183","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/cells12010119","volume":"12","author":"S Elangovan","year":"2022","unstructured":"Elangovan S, Borody TJ, Holsinger RMD. Fecal microbiota transplantation reduces pathology and improves cognition in a mouse model of Alzheimer\u2019s disease. Cells. 2022;12(1):119.","journal-title":"Cells"},{"issue":"1","key":"404_CR184","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","volume":"9","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Ning J, Bao X-q, Shang M, Ma J, Li G, et al. Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome. 2021;9(1):226.","journal-title":"Microbiome"},{"issue":"16","key":"404_CR185","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.18632\/aging.204230","volume":"14","author":"S-H Park","year":"2022","unstructured":"Park S-H, Lee J-H, Kim J-S, Kim TJ, Shin J, Im JH, et al. Fecal microbiota transplantation can improve cognition in patients with cognitive decline and Clostridioides difficile infection. Aging. 2022;14(16):6449\u201366.","journal-title":"Aging"},{"issue":"2","key":"404_CR186","doi-asserted-by":"publisher","first-page":"2284247","DOI":"10.1080\/19490976.2023.2284247","volume":"15","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Tan G, Zhu Q, Wang C, Ruan G, Ying S, et al. Efficacy of fecal microbiota transplantation in patients with Parkinson\u2019s disease: clinical trial results from a randomized, placebo-controlled design. Gut Microbes. 2023;15(2):2284247.","journal-title":"Gut Microbes"},{"issue":"35","key":"404_CR187","doi-asserted-by":"publisher","first-page":"e22035","DOI":"10.1097\/MD.0000000000022035","volume":"99","author":"L-J Xue","year":"2020","unstructured":"Xue L-J, Yang X-Z, Tong Q, Shen P, Ma S-J, Wu S-N, et al. Fecal microbiota transplantation therapy for Parkinson\u2019s disease. Medicine (Baltimore). 2020;99(35):e22035.","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"404_CR188","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41579-021-00667-9","volume":"20","author":"MT Sorbara","year":"2022","unstructured":"Sorbara MT, Pamer EG. Microbiome-based therapeutics. Nat Rev Microbiol. 2022;20(6):365\u201380.","journal-title":"Nat Rev Microbiol"},{"issue":"19","key":"404_CR189","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1016\/j.cell.2022.08.003","volume":"185","author":"AG Cheng","year":"2022","unstructured":"Cheng AG, Ho P-Y, Aranda-D\u00edaz A, Jain S, Yu FB, Meng X, et al. Design, construction, and in vivo augmentation of a complex gut microbiome. Cell. 2022;185(19):3617\u20133636e3619.","journal-title":"Cell"},{"issue":"26","key":"404_CR190","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1038\/s41388-020-1341-1","volume":"39","author":"W Fong","year":"2020","unstructured":"Fong W, Li Q, Yu J. Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer. Oncogene. 2020;39(26):4925\u201343.","journal-title":"Oncogene"},{"key":"404_CR191","doi-asserted-by":"publisher","first-page":"619051","DOI":"10.3389\/fnins.2021.619051","volume":"15","author":"M Hou","year":"2021","unstructured":"Hou M, Xu G, Ran M, Luo W, Wang H. APOE-\u03b54 carrier status and gut microbiota dysbiosis in patients with Alzheimer disease. Front Neurosci. 2021;15:619051.","journal-title":"Front Neurosci"},{"issue":"1","key":"404_CR192","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1038\/s41598-023-31730-5","volume":"13","author":"D Cammann","year":"2023","unstructured":"Cammann D, Lu Y, Cummings MJ, Zhang ML, Cue JM, Do J, et al. Genetic correlations between Alzheimer\u2019s disease and gut microbiome genera. Sci Rep. 2023;13(1):5258.","journal-title":"Sci Rep"},{"issue":"1","key":"404_CR193","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41522-021-00242-3","volume":"7","author":"Y Yan","year":"2021","unstructured":"Yan Y, Ren S, Duan Y, Lu C, Niu Y, Wang Z, et al. Gut microbiota and metabolites of \u03b1-synuclein transgenic monkey models with early stage of Parkinson\u2019s disease. NPJ Biofilms Microbiomes. 2021;7(1):69.","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"3","key":"404_CR194","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/gutjnl-2020-321747","volume":"70","author":"M Fassarella","year":"2021","unstructured":"Fassarella M, Blaak EE, Penders J, Nauta A, Smidt H, Zoetendal EG. Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health. Gut. 2021;70(3):595\u2013605.","journal-title":"Gut"}],"container-title":["Translational Neurodegeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40035-024-00404-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40035-024-00404-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40035-024-00404-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T11:10:20Z","timestamp":1709032220000},"score":1,"resource":{"primary":{"URL":"https:\/\/translationalneurodegeneration.biomedcentral.com\/articles\/10.1186\/s40035-024-00404-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":194,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["404"],"URL":"https:\/\/doi.org\/10.1186\/s40035-024-00404-1","relation":{},"ISSN":["2047-9158"],"issn-type":[{"value":"2047-9158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"15 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12"}}