{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:42:18Z","timestamp":1787020938560,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Anthropol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s40101-016-0089-3","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T22:33:21Z","timestamp":1457390001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neural substrates of sexual arousal in heterosexual males: event-related fMRI investigation"],"prefix":"10.1186","volume":"35","author":[{"given":"Ji-Woo","family":"Seok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hun","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaejoon","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"issue":"1","key":"89_CR1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10508-009-9556-9","volume":"39","author":"ML Chivers","year":"2010","unstructured":"Chivers ML, Seto MC, Lalumiere ML, Laan E, Grimbos T. Agreement of self-reported and genital measures of sexual arousal in men and women: a meta-analysis. Arch Sex Behav. 2010;39(1):5\u201356.","journal-title":"Arch Sex Behav"},{"key":"89_CR2","doi-asserted-by":"crossref","unstructured":"Gillath O, Canterberry M. Neural correlates of exposure to subliminal and supraliminal sexual cues. Soc Cogn Affect Neurosci. 2011; nsr065.","DOI":"10.1093\/scan\/nsr065"},{"key":"89_CR3","unstructured":"Rosen RC, Beck JG. Patterns of sexual arousal: Psychophysiological processes and clinical applications. Guilford Press; 1988."},{"issue":"2","key":"89_CR4","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1097\/01.ju.0000075362.08363.a4","volume":"170","author":"K-E Andersson","year":"2003","unstructured":"Andersson K-E. Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol. 2003;170(2):S6\u201314.","journal-title":"J Urol"},{"issue":"2","key":"89_CR5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1212\/WNL.44.2.243","volume":"44","author":"MJ Morrell","year":"1994","unstructured":"Morrell MJ, Sperling MR, Stecker M, Dichter MA. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology. 1994;44(2):243.","journal-title":"Neurology"},{"issue":"4","key":"89_CR6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000065541","volume":"39","author":"U Simonsen","year":"2002","unstructured":"Simonsen U, Garc\u00eda-Sacrist\u00e1n A, Prieto D. Penile arteries and erection. J Vasc Res. 2002;39(4):283\u2013303.","journal-title":"J Vasc Res"},{"issue":"5","key":"89_CR7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/brain\/awf108","volume":"125","author":"BA Arnow","year":"2002","unstructured":"Arnow BA, Desmond JE, Banner LL, Glover GH, Solomon A, Polan ML, et al. Brain activation and sexual arousal in healthy, heterosexual males. Brain. 2002;125(5):1014\u201323.","journal-title":"Brain"},{"key":"89_CR8","doi-asserted-by":"crossref","unstructured":"Beauregard M, Levesque J, & Bourgouin P. Neural correlates of conscious self-regulation of emotion. J Neurosci. 2001.","DOI":"10.1523\/JNEUROSCI.21-18-j0001.2001"},{"issue":"1","key":"89_CR9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00221-006-0429-3","volume":"174","author":"ER Gizewski","year":"2006","unstructured":"Gizewski ER, Krause E, Karama S, Baars A, Senf W, Forsting M. There are differences in cerebral activation between females in distinct menstrual phases during viewing of erotic stimuli: a fMRI study. Exp Brain Res. 2006;174(1):101\u20138.","journal-title":"Exp Brain Res"},{"issue":"4","key":"89_CR10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nn1208","volume":"7","author":"S Hamann","year":"2004","unstructured":"Hamann S, Herman RA, Nolan CL, Wallen K. Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci. 2004;7(4):411\u20136.","journal-title":"Nat Neurosci"},{"issue":"5","key":"89_CR11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/sj.ijir.3901449","volume":"18","author":"S Kim","year":"2006","unstructured":"Kim S, Sohn D, Cho Y, Yang W, Lee K, Juh R, et al. Brain activation by visual erotic stimuli in healthy middle aged males. Int J Impot Res. 2006;18(5):452\u20137.","journal-title":"Int J Impot Res"},{"issue":"2","key":"89_CR12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1053-8119(03)00408-7","volume":"20","author":"H Mouras","year":"2003","unstructured":"Mouras H, Stol\u00e9ru S, Bittoun J, Glutron D, P\u00e9l\u00e9grini-Issac M, Paradis A-L, et al. Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage. 2003;20(2):855\u201369.","journal-title":"Neuroimage"},{"issue":"1-2","key":"89_CR13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10334-007-0103-1","volume":"21","author":"M Walter","year":"2008","unstructured":"Walter M, Stadler J, Tempelmann C, Speck O, Northoff G. High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T. Magn Reson Mater Phys Biol Med. 2008;21(1-2):103\u201311.","journal-title":"Magn Reson Mater Phys Biol Med"},{"issue":"1","key":"89_CR14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/nimg.2001.0964","volume":"15","author":"RM Birn","year":"2002","unstructured":"Birn RM, Cox RW, Bandettini PA. Detection versus estimation in event-related fMRI: choosing the optimal stimulus timing. Neuroimage. 2002;15(1):252\u201364.","journal-title":"Neuroimage"},{"issue":"3","key":"89_CR15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/nimg.2001.0990","volume":"15","author":"G Aguirre","year":"2002","unstructured":"Aguirre G, Detre J, Zarahn E, Alsop D. Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage. 2002;15(3):488\u2013500.","journal-title":"Neuroimage"},{"issue":"4","key":"89_CR16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1097-0193(1998)6:4<270::AID-HBM6>3.0.CO;2-0","volume":"6","author":"G Bush","year":"1998","unstructured":"Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL. The counting Stroop: an interference task specialized for functional neuroimaging\u2014validation study with functional MRI. Hum Brain Mapp. 1998;6(4):270\u201382.","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"89_CR17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.125.1.155","volume":"125","author":"M D\u2019Esposito","year":"1999","unstructured":"D\u2019Esposito M, Zarahn E, Aguirre GK. Event-related functional MRI: implications for cognitive psychology. Psychol Bull. 1999;125(1):155.","journal-title":"Psychol Bull"},{"key":"89_CR18","doi-asserted-by":"crossref","unstructured":"Donaldson DI, Buckner RL. Effective paradigm design. Paper presented at the IN P. JEZZARD (ED.), FUNCTIONAL MRI; 2001.","DOI":"10.1093\/acprof:oso\/9780192630711.003.0009"},{"issue":"3","key":"89_CR19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hbm.10092","volume":"18","author":"MW Chee","year":"2003","unstructured":"Chee MW, Venkatraman V, Westphal C, Siong SC. Comparison of block and event-related fMRI designs in evaluating the word-frequency effect. Hum Brain Mapp. 2003;18(3):186\u201393.","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"89_CR20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-9081-4-30","volume":"4","author":"M B\u00fchler","year":"2008","unstructured":"B\u00fchler M, Vollst\u00e4dt-Klein S, Klemen J, Smolka MN. Does erotic stimulus presentation design affect brain activation patterns? Event-related vs. blocked fMRI designs. Behav Brain Funct. 2008;4(1):30.","journal-title":"Behav Brain Funct"},{"key":"89_CR21","unstructured":"Lang PJ, Bradley MM, Cuthbert BN. International affective picture system (IAPS): affective ratings of pictures and instruction manual. Tech Report. 2008; A-8."},{"issue":"6","key":"89_CR22","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.neubiorev.2012.03.006","volume":"36","author":"S Stol\u00e9ru","year":"2012","unstructured":"Stol\u00e9ru S, Fonteille V, Corn\u00e9lis C, Joyal C, Moulier V. Functional neuroimaging studies of sexual arousal and orgasm in healthy men and women: a review and meta-analysis. Neurosci Biobehav Rev. 2012;36(6):1481\u2013509.","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"89_CR23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/1097-0193(200011)11:3<162::AID-HBM30>3.0.CO;2-A","volume":"11","author":"J Redout\u00e9","year":"2000","unstructured":"Redout\u00e9 J, Stol\u00e9ru S, Gr\u00e9goire MC, Costes N, Cinotti L, Lavenne F, et al. Brain processing of visual sexual stimuli in human males. Hum Brain Mapp. 2000;11(3):162\u201377.","journal-title":"Hum Brain Mapp"},{"issue":"7","key":"89_CR24","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1176\/ajp.154.7.926","volume":"154","author":"RD Lane","year":"1997","unstructured":"Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry. 1997;154(7):926\u201333.","journal-title":"Am J Psychiatry"},{"issue":"11","key":"89_CR25","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0028-3932(97)00070-5","volume":"35","author":"RD Lane","year":"1997","unstructured":"Lane RD, Reiman EM, Bradley MM, Lang PJ, Ahern GL, Davidson RJ, et al. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia. 1997;35(11):1437\u201344.","journal-title":"Neuropsychologia"},{"issue":"8","key":"89_CR26","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1523\/JNEUROSCI.11-08-02383.1991","volume":"11","author":"M Corbetta","year":"1991","unstructured":"Corbetta M, Miezin FM, Dobmeyer S, Shulman GL, Petersen SE. Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography. J Neurosci. 1991;11(8):2383\u2013402.","journal-title":"J Neurosci"},{"issue":"1","key":"89_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1018733420467","volume":"28","author":"S Stoleru","year":"1999","unstructured":"Stoleru S, Gregoire M-C, Gerard D, Decety J, Lafarge E, Cinotti L, et al. Neuroanatomical correlates of visually evoked sexual arousal in human males. Arch Sex Behav. 1999;28(1):1\u201321.","journal-title":"Arch Sex Behav"},{"issue":"1","key":"89_CR28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2009.12.034","volume":"50","author":"JR Georgiadis","year":"2010","unstructured":"Georgiadis JR, Farrell MJ, Boessen R, Denton DA, Gavrilescu M, Kortekaas R, et al. Dynamic subcortical blood flow during male sexual activity with ecological validity: a perfusion fMRI study. Neuroimage. 2010;50(1):208\u201316.","journal-title":"Neuroimage"},{"issue":"25","key":"89_CR29","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1523\/JNEUROSCI.0712-05.2005","volume":"25","author":"CA Kell","year":"2005","unstructured":"Kell CA, von Kriegstein K, R\u00f6sler A, Kleinschmidt A, Laufs H. The sensory cortical representation of the human penis: revisiting somatotopy in the male homunculus. J Neurosci. 2005;25(25):5984\u20137.","journal-title":"J Neurosci"},{"issue":"6","key":"89_CR30","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0090-4295(01)00992-X","volume":"57","author":"K Park","year":"2001","unstructured":"Park K, Kang HK, Seo JJ, Kim HJ, Ryu SB, Jeong GW. Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response. Urology. 2001;57(6):1189\u201394.","journal-title":"Urology"},{"issue":"2","key":"89_CR31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.ijir.3900649","volume":"13","author":"K Park","year":"2001","unstructured":"Park K, Seo J, Kang H, Ryu S, Kim H, Jeong G. A new potential of blood oxygenation level dependent (BOLD) functional MRI for evaluating cerebral centers of penile erection. Int J Impot Res. 2001;13(2):73\u201381.","journal-title":"Int J Impot Res"},{"issue":"2","key":"89_CR32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neuroimage.2006.06.037","volume":"33","author":"V Moulier","year":"2006","unstructured":"Moulier V, Mouras H, P\u00e9l\u00e9grini-Issac M, Glutron D, Rouxel R, Grandjean B, et al. Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males. Neuroimage. 2006;33(2):689\u201399.","journal-title":"Neuroimage"},{"issue":"3","key":"89_CR33","first-page":"483","volume":"19","author":"V Meseguer","year":"2007","unstructured":"Meseguer V, Romero MJ, Barr\u00f3s-Loscertales A, Belloch V, Bosch-Morell F, Romero J. Mapping the apetitive and aversive systems with emotional pictures using a block-design fMRI procedure. Psicothema. 2007;19(3):483\u20138.","journal-title":"Psicothema"},{"issue":"1","key":"89_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.10014","volume":"16","author":"S Karama","year":"2002","unstructured":"Karama S, Lecours AR, Leroux JM, Bourgouin P, Beaudoin G, Joubert S, et al. Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp. 2002;16(1):1\u201313.","journal-title":"Hum Brain Mapp"},{"key":"89_CR35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnana.2010.00138","volume":"4","author":"CD Metzger","year":"2010","unstructured":"Metzger CD, Eckert U, Steiner J, Sartorius A, Buchmann JE, Stadler J, et al. High field FMRI reveals thalamocortical integration of segregated cognitive and emotional processing in mediodorsal and intralaminar thalamic nuclei. Front Neuroanat. 2010;4:138.","journal-title":"Front Neuroanat"},{"issue":"4","key":"89_CR36","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuroimage.2005.03.025","volume":"26","author":"A Ferretti","year":"2005","unstructured":"Ferretti A, Caulo M, Del Gratta C, Di Matteo R, Merla A, Montorsi F, et al. Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage. 2005;26(4):1086\u201396.","journal-title":"Neuroimage"},{"issue":"6","key":"89_CR37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/hbm.20435","volume":"29","author":"T Paul","year":"2008","unstructured":"Paul T, Schiffer B, Zwarg T, Kr\u00fcger TH, Karama S, Schedlowski M, et al. Brain response to visual sexual stimuli in heterosexual and homosexual males. Hum Brain Mapp. 2008;29(6):726\u201335.","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"89_CR38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.neuroimage.2006.08.002","volume":"33","author":"J Ponseti","year":"2006","unstructured":"Ponseti J, Bosinski HA, Wolff S, Peller M, Jansen O, Mehdorn HM, et al. A functional endophenotype for sexual orientation in humans. Neuroimage. 2006;33(3):825\u201333.","journal-title":"Neuroimage"},{"issue":"1","key":"89_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4927(99)00020-7","volume":"91","author":"SL Rauch","year":"1999","unstructured":"Rauch SL, Shin LM, Dougherty DD, Alpert NM, Orr SP, Lasko M, et al. Neural activation during sexual and competitive arousal in healthy men. Psychiatry Res Neuroimaging. 1999;91(1):1\u201310.","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"4","key":"89_CR40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1192\/bjp.164.4.459","volume":"164","author":"P McGuire","year":"1994","unstructured":"McGuire P, Bench C, Frith C, Marks I, Frackowiak R, Dolan R. Functional anatomy of obsessive-compulsive phenomena. Br J Psychiatry. 1994;164(4):459\u201368.","journal-title":"Br J Psychiatry"},{"issue":"1","key":"89_CR41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1196\/annals.1401.004","volume":"1121","author":"MR Roesch","year":"2007","unstructured":"Roesch MR, Olson CR. Neuronal activity related to anticipated reward in frontal cortex. Ann N Y Acad Sci. 2007;1121(1):431\u201346.","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"89_CR42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0925-4927(03)00068-4","volume":"124","author":"S Stol\u00e9ru","year":"2003","unstructured":"Stol\u00e9ru S, Redout\u00e9 J, Costes N, Lavenne F, Le Bars D, Dechaud H, et al. Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder. Psychiatry Res Neuroimaging. 2003;124(2):67\u201386.","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"3","key":"89_CR43","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuroimage.2008.05.051","volume":"42","author":"H Mouras","year":"2008","unstructured":"Mouras H, Stol\u00e9ru S, Moulier V, P\u00e9l\u00e9grini-Issac M, Rouxel R, Grandjean B, et al. Activation of mirror-neuron system by erotic video clips predicts degree of induced erection: an fMRI study. Neuroimage. 2008;42(3):1142\u201350.","journal-title":"Neuroimage"},{"issue":"2","key":"89_CR44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archneur.1968.00480020070007","volume":"19","author":"BW Robinson","year":"1968","unstructured":"Robinson BW, Mishkin M. Penile erection evoked from forebrain structures in Macaca mulatta. Arch Neurol. 1968;19(2):184\u201398.","journal-title":"Arch Neurol"},{"issue":"8","key":"89_CR45","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/cercor\/bhn214","volume":"19","author":"Y Worbe","year":"2009","unstructured":"Worbe Y, Baup N, Grabli D, Chaigneau M, Mounayar S, McCairn K, et al. Behavioral and movement disorders induced by local inhibitory dysfunction in primate striatum. Cereb Cortex. 2009;19(8):1844\u201356.","journal-title":"Cereb Cortex"},{"issue":"3","key":"89_CR46","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1152\/jn.00230.2007","volume":"98","author":"D Sabatinelli","year":"2007","unstructured":"Sabatinelli D, Bradley MM, Lang PJ, Costa VD, Versace F. Pleasure rather than salience activates human nucleus accumbens and medial prefrontal cortex. J Neurophysiol. 2007;98(3):1374\u20139.","journal-title":"J Neurophysiol"},{"issue":"39","key":"89_CR47","doi-asserted-by":"crossref","first-page":"13095","DOI":"10.1523\/JNEUROSCI.3501-10.2010","volume":"30","author":"G Sescousse","year":"2010","unstructured":"Sescousse G, Redout\u00e9 J, Dreher J-C. The architecture of reward value coding in the human orbitofrontal cortex. J Neurosci. 2010;30(39):13095\u2013104.","journal-title":"J Neurosci"}],"container-title":["Journal of Physiological Anthropology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40101-016-0089-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T05:20:51Z","timestamp":1567660851000},"score":1,"resource":{"primary":{"URL":"http:\/\/jphysiolanthropol.biomedcentral.com\/articles\/10.1186\/s40101-016-0089-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["89"],"URL":"https:\/\/doi.org\/10.1186\/s40101-016-0089-3","relation":{},"ISSN":["1880-6805"],"issn-type":[{"value":"1880-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]},"article-number":"8"}}