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High-sensitivity C-reactive protein (hs-CRP) is a biomarker of systemic inflammation, but its relationship with MetS and its components remains unclear. This study investigates the association between hs-CRP and MetS in a representative Korean population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Using data from the 2022 Korea National Health and Nutrition Examination Survey (KNHANES), we analyzed 4,823 adults. MetS was defined according to revised NCEP-ATP III criteria. Multivariate analyses were conducted, adjusting for confounders such as sex, age, income, education, smoking, alcohol consumption, physical activity, and waist circumference.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among the study population, 1,784 participants (37.0%) were diagnosed with MetS. hs-CRP levels were significantly higher in individuals with MetS (1.06\u00a0mg\/L vs. 0.79\u00a0mg\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and increased with the number of MetS components (p for trend\u2009&lt;\u20090.001). Significant associations were observed between hs-CRP and all MetS components. However, after adjusting for waist circumference, these associations lost statistical significance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study confirms a strong association between hs-CRP and MetS, primarily influenced by central obesity. The findings highlight abdominal obesity as a key contributor to systemic inflammation in MetS. Further longitudinal studies are needed to explore the causal relationship and underlying mechanisms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40101-025-00396-5","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:38:00Z","timestamp":1749119880000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Loss of significant association between high-sensitivity C-reactive protein (hs-CRP) and metabolic syndrome after adjustment for waist circumference found in 2022 Korea National Health and Nutrition Examination Survey data"],"prefix":"10.1186","volume":"44","author":[{"given":"Bo-Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Yeon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ah","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-3934","authenticated-orcid":false,"given":"Seong-Woo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"issue":"4","key":"396_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1161\/ATVBAHA.107.151092","volume":"28","author":"SM Grundy","year":"2008","unstructured":"Grundy SM. 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