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Therefore, this 28-day study compared the effects of\n                      <jats:italic>S. boulardii<\/jats:italic>\n                      mafic-1701 and aureomycin in diets for weaned piglets on growth performance, antioxidant parameters, inflammation and intestinal microbiota. One hundred and eight piglets, weaned at 28 d of age (8.5\u2009\u00b1\u20091.1\u2009kg), were randomly divided into the three dietary treatment groups with six pens and six piglets per pen (half male and half female). The dietary treatment groups were as follows: 1) basal diet (CON); 2) basal diet supplemented with 75\u2009mg\/kg aureomycin (ANT); 3) basal diet supplemented with 1\u2009\u00d7\u200910\n                      <jats:sup>8<\/jats:sup>\n                      \u2009CFU\/kg\u2009\n                      <jats:italic>S. boulardii<\/jats:italic>\n                      mafic-1701 (SB).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to CON group, SB group had higher feed efficiency (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) in the last 14\u2009d and lower diarrhea rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.05) over the entire 28\u2009d. Total superoxide dismutase in serum was markedly increased in SB group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Moreover, compared with CON group, SB group decreased the levels of pro-inflammatory cytokines interleukin-6 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.01) and Tumor necrosis factor-\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) in jejunum. Supplementation of\n                      <jats:italic>S. boulardii<\/jats:italic>\n                      mafic-1701 increased the abundance of\n                      <jats:italic>Ruminococcaceae_UCG_009<\/jats:italic>\n                      and\n                      <jats:italic>Turicibacter<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas the abundance of unclassified\n                      <jats:italic>_Clostridiaceae_4<\/jats:italic>\n                      was decreased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore,\n                      <jats:italic>S. boulardii<\/jats:italic>\n                      mafic-1701 administration increased cecal concentration of microbial metabolites, isobutyrate and valerate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The improvement in feed conversion ratio, reduction in diarrhea rate in weaned piglets provided diets supplemented with\n                      <jats:italic>S. boulardii<\/jats:italic>\n                      mafic-1701 may be associated with enhanced antioxidant activity, anti-inflammatory responses and improved intestinal microbial ecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40104-020-00516-4","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T19:05:16Z","timestamp":1607022316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Administration of Saccharomyces boulardii mafic-1701 improves feed conversion ratio, promotes antioxidant capacity, alleviates intestinal inflammation and modulates gut microbiota in weaned piglets"],"prefix":"10.1186","volume":"11","author":[{"given":"Wenxiu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengling","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-0928","authenticated-orcid":false,"given":"Yunhe","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"516_CR1","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.chom.2018.11.006","volume":"24","author":"J Hu","year":"2018","unstructured":"Hu J, Ma L, Nie Y, Chen J, Zheng W, Wang X, et al. 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