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However, the mechanism by which SDP from\n                      <jats:italic>Enteromorpha<\/jats:italic>\n                      mediates pig growth are not fully understood. This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Exp. 1, 240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200, 400 or 800\u2009mg\/kg SDP, respectively, in a 21-day trial. Pigs on the 400 or 800\u2009mg\/kg SDP-supplemented group had greater ADG and lower F\/G ratio than those on the control group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). In Exp. 2, 20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet (CON group) or a basal diet supplemented with 400\u2009mg\/kg SDP (the optimum does from Exp. 1), in a 21-day trial. Pigs fed the SDP diet had greater ADG, the concentrations of serum IL-6 and TNF-\u03b1 and the activities of glutathione peroxidase, superoxide dismutase and catalase (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05), and lower F\/G, diarrhea rate, as well as serum\n                      <jats:italic>D<\/jats:italic>\n                      -lactate concentrations and diamine oxidase activity (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). Moreover, dietary SDP supplementation enhanced secretory immunoglobulin A content, villus height and villous height: crypt depth ratio in small intestine, as well as the lactase and maltase activities in jejunum mucosa (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). SDP supplementation elevated the mRNA levels of inflammatory response-related genes (\n                      <jats:italic>IL-6<\/jats:italic>\n                      ,\n                      <jats:italic>TNF-\u03b1<\/jats:italic>\n                      ,\n                      <jats:italic>TLR4<\/jats:italic>\n                      ,\n                      <jats:italic>TLR6<\/jats:italic>\n                      and\n                      <jats:italic>MyD88<\/jats:italic>\n                      ), and the mRNA and protein levels of ZO-1, claudin-1 and occludin in jejunum mucosa (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). Importantly, SDP not only increased the\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      population but also reduced the\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      population in cecum (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). Furthermore, SDP increased acetic acid and butyric acid concentrations in cecum (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions, but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40104-021-00552-8","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T19:06:58Z","timestamp":1615316818000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations"],"prefix":"10.1186","volume":"12","author":[{"given":"Tiande","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2362-2323","authenticated-orcid":false,"given":"Jinming","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"552_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nri3608","volume":"14","author":"LW Peterson","year":"2014","unstructured":"Peterson LW, Artis D. 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