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This study determined effects of exogenous P4 on transport of select nutrients and pathways that enhance conceptus development. Pregnant ewes (<jats:italic>n<\/jats:italic>\u2009=\u200938) were treated with either 25\u2009mg P4 in 1\u2009mL corn oil (P4, <jats:italic>n<\/jats:italic>\u2009=\u200918) or 1\u2009mL corn oil alone (CO, <jats:italic>n<\/jats:italic>\u2009=\u200920) from day 1.5 through day 8 of pregnancy and hysterectomized on either day 9 or day 12 of pregnancy. Endometrial expression of genes encoding enzymes for synthesis of polyamines, transporters of glucose, arginine, and glycine, as well as progestamedins was determined by RT-qPCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>On day 12 of pregnancy, conceptuses from P4-treated ewes had elongated while those from CO-treated ewes were spherical. The mRNA expression of <jats:italic>AZIN2,<\/jats:italic> an arginine decarboxylase, was lower in endometria of P4-treated than CO-treated ewes on day 9 of pregnancy. Expression of <jats:italic>FGF10<\/jats:italic>, a progestamedin, was greater in endometria of CO and P4-treated ewes on day 12 of gestation in addition to P4-treated ewes necropsied on day 9 of gestation. Treatment with P4 down-regulated endometrial expression of amino acid transporter <jats:italic>SLC1A4<\/jats:italic> on day 12 of pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Results indicated that administration of exogenous P4 during the pre-implantation period advanced the expression of <jats:italic>FGF10<\/jats:italic>, which may accelerate proliferation of trophectoderm cells, but also was correlated with decreased expression of glycine and serine transporters and polyamine synthesis enzyme <jats:italic>AZIN2.<\/jats:italic> Further research with increased sample sizes may determine how differential expression affects endometrial functions and potentially embryonic loss.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40104-021-00554-6","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:05:21Z","timestamp":1614902721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins"],"prefix":"10.1186","volume":"12","author":[{"given":"Emily C.","family":"Hoskins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Stenhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn M.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin A.","family":"Dunlap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Satterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-5086","authenticated-orcid":false,"given":"Fuller W.","family":"Bazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"554_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1530\/rep.1.00398","volume":"128","author":"TE Spencer","year":"2004","unstructured":"Spencer TE, Johnson GA, Bazer FW, Burghardt RC. 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