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Inflammation and 25-hydroxycholecalciferol (25-OH-D<jats:sub>3<\/jats:sub>) have shown to play a negative and positive role, respectively, in the regulation of bone mass. Hence the potential of 25-OH-D<jats:sub>3<\/jats:sub> in alleviating heat induced bone alterations and its mechanisms was studied.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Heat stress (HS) directly induced a decrease in tibia material properties and bone mass, as demonstrated by lower mineral content, and HS caused a notable increase in intestinal permeability. Treatment with dietary 25-OH-D<jats:sub>3<\/jats:sub> reversed the HS-induced bone loss and barrier leak. Broilers suffering from HS exhibited dysbiosis and increased expression of inflammatory cytokines in the ileum and bone marrow, as well as increased osteoclast number and activity. The changes were prevented by dietary 25-OH-D<jats:sub>3<\/jats:sub> administration. Specifically, dietary 25-OH-D<jats:sub>3<\/jats:sub> addition decreased abundance of B- and T-cells in blood, and the expression of inflammatory cytokines, especially TNF-\u03b1, in both the ileum and bone marrow, but did not alter the diversity and population or composition of major bacterial phyla. With regard to bone remodeling, dietary 25-OH-D<jats:sub>3<\/jats:sub> supplementation was linked to a decrease in serum C-terminal cross-linked telopeptide of type I collagen reflecting bone resorption and a concomitant decrement in osteoclast-specific marker genes expression (e.g. cathepsin K), whereas it did not apparently change serum bone formation markers during HS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These data underscore the damage of HS to intestinal integrity and bone health, as well as that dietary 25-OH-D<jats:sub>3<\/jats:sub> supplementation was identified as a potential therapy for preventing these adverse effects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40104-021-00627-6","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T02:22:11Z","timestamp":1633832531000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation"],"prefix":"10.1186","volume":"12","author":[{"given":"Huaiyong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Majdeddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djoere","family":"Gaublomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Taminiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Boone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Elewaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Daube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Josipovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-0045","authenticated-orcid":false,"given":"Joris","family":"Michiels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"issue":"3","key":"627_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/ps\/81.3.293","volume":"81","author":"N Deeb","year":"2002","unstructured":"Deeb N, Cahaner A. 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