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The objective of this study was to investigate the effect of supplemental branched-chain amino acids (BCAA) and limiting amino acids (LAA) on Ca digestibility, absorption and reabsorption in pigs fed with VLP diets. Forty-eight piglets were assigned to six treatments: positive control (PC), negative control (NC), and NC containing LAA 25%, LAA 50%, LAA\u2009+\u2009BCAA 25% (LB25) and LAA\u2009+\u2009BCAA 50% (LB50) more than recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Relative to PC or NC, LB25 and LB50 had higher digestibility of Ca and plasma Ca and phosphorus (P), but lower plasma vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      . LB50 tended to increase vitamin D receptor transcript and protein in the gut, but decreased mRNA or protein abundance of parathyroid hormone 1 receptor (PTH1R), calbindin 1 (CALB1), cytochrome P450 family 27 subfamily B member 1 and occludin in small intestine. LB50 increased the transcript of cytochrome P450 family 24 subfamily A member 1 and\n                      <jats:italic>PTH1R<\/jats:italic>\n                      but decreased the transcript of transient receptor potential cation channel subfamily V member 5,\n                      <jats:italic>CALB1<\/jats:italic>\n                      and solute carrier family 17 member 4 in kidney.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, BCAA increased Ca digestibility through regulating the transcellular and paracellular\u00a0Ca absorption in the gut and reabsorption in kidney during protein restriction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40104-021-00669-w","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T19:02:44Z","timestamp":1644433364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary branched-chain amino acids modulate the dynamics of calcium absorption and reabsorption in protein-restricted pigs"],"prefix":"10.1186","volume":"13","author":[{"given":"Mohammad","family":"Habibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedrick N.","family":"Shili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parniyan","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-7682","authenticated-orcid":false,"given":"Adel","family":"Pezeshki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"issue":"2","key":"669_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5713\/ajas.1999.305","volume":"12","author":"NP Lenis","year":"1999","unstructured":"Lenis NP, Jongbloed AW. 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