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A total of 120 piglets (Duroc \u00d7 [Landrace \u00d7 Yorkshire]; weighted 7.66\u2009\u00b1\u20091.79\u2009kg, weaned at d 28) were randomly selected and allocated to 3 treatments with 4 replicates per group and 10 piglets per replicate according to the initial body weight and gender. The dietary treatments were as follows: 1) basal diet (Ctrl); 2) Ctrl + chlortetracycline (75\u2009mg\/kg) (AGP); 3) Ctrl+ MOA (1500\u2009mg\/kg). The experiment period was lasted for 21 d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the Ctrl group, dietary supplemented MOA alleviated (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the diarrhea rate from d 12 to 21, enhanced (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the concentration of serum interlukin-10 and glutathione peroxidase in piglets on d 11 after weaning and serum superoxide dismutase in 21-day\u00a0piglets. The MOA group also improved (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the apparent digestibility of dry matter (DM), organic matter (OM) and gross energy (GE), up-regulated (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the mRNA expression level of occludin, claudin-1 and mucin-2 in ileum and increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the contents of propionic and butyric acids in the cecum of piglets. The MOA group modulated the cecal and colonic microbial community structure and increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) the abundance of\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and Muribaculaceae in cecum and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      and\n                      <jats:italic>Weissella<\/jats:italic>\n                      in colon. Additionally, AGP group decreased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) apparent digestibility of DM, OM and GE as well as down-regulated (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) relative gene expression level of claudin-1 in duodenum and jejunum,\n                      <jats:italic>ZO-1<\/jats:italic>\n                      and mucin-1 in jejunum of piglets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, dietary supplemented MOA alleviated diarrhea and improved nutrient apparent digestibility in piglets via enhancing immuno-antioxidant properties, increasing digestive enzyme activity, up-regulating the expression of intestinal barrier-related genes, and modifying the microbial community structure of the cecum and colon. Therefore, dietary supplementation with MOA as an alternative to antibiotics was feasible to improve intestinal health of piglets in practical production.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40104-021-00670-3","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T19:02:56Z","timestamp":1644519776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Microencapsulated essential oils combined with organic acids improves immune antioxidant capacity and intestinal barrier function as well as modulates the hindgut microbial community in piglets"],"prefix":"10.1186","volume":"13","author":[{"given":"Jiayu","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenfei","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-3028","authenticated-orcid":false,"given":"Xiangshu","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"issue":"1","key":"670_CR1","doi-asserted-by":"publisher","first-page":"18068","DOI":"10.1038\/s41598-018-33649-8","volume":"8","author":"Y Li","year":"2018","unstructured":"Li Y, Guo Y, Wen Z, Jiang X, Ma X, Han X. 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