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To explore the importance of early nutrition regulation in animals, soy protein concentrate (SPC) was added to the early diet of broilers to investigate its effects on amino acid digestibility, intestinal development, especially intestinal microorganisms, and broiler metabolites. A total of 192 one-day-old Arbor Acres (AA) male broilers were randomly assigned to two experimental treatments with 8 replicates of 12 birds. The control group was fed a basal diet (control), and the treatment group was fed a basal diet supplemented with 12% SPC (SPC12) during the first 10 d (starter phase). From d 11 to 21 (grower phase) and d 22 to 42 (finisher phase), a basal diet was fed to both treatment groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>SPC reduced the pH value and acid-binding capacity of the starter diet (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10); SPC in the early diet enhanced the gizzard weight (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10 and d 42) and the ileum weight (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10) and decreased the weight and length of the jejunum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10) and the relative length of the duodenum and jejunum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10). At the same time, SPC enhanced villus height (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10) and muscle thickness in the jejunum and ileum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10) and increased the number of goblet cells in the duodenum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10). Meanwhile, SPC increased the Chao1 index and the ACE index (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10) and altered the composition of caecal microflora at d 10. SPC also increased the relative abundance of <jats:italic>Alistipes<\/jats:italic>, <jats:italic>Anaerotruncus<\/jats:italic>, <jats:italic>Erysipelatoclostridium<\/jats:italic>, <jats:italic>Intestinimonas<\/jats:italic> and <jats:italic>Flavonifractor<\/jats:italic> bacteria (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10). At the same time, the concentrations of caecal butyric acid and total short-chain fatty acids (SCFAs) were also increased in the SPC12 group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, d 10).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In summary, the results showed that supplementing the starter diet of broilers with SPC has a significant effect on the early development of the intestine and the microflora.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s40104-022-00749-5","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:02:28Z","timestamp":1662595348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Supplementing the early diet of broilers with soy protein concentrate can improve intestinal development and enhance short-chain fatty acid-producing microbes and short-chain fatty acids, especially butyric acid"],"prefix":"10.1186","volume":"13","author":[{"given":"Qianyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Hj\u00f8llund","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shourong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"issue":"Suppl 3","key":"749_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000490842","volume":"73","author":"MP Francino","year":"2018","unstructured":"Francino MP. 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