{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:09:19Z","timestamp":1784138959226,"version":"3.55.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The China Agriculture Research System","award":["CARS-35-PIG"],"award-info":[{"award-number":["CARS-35-PIG"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32272847"],"award-info":[{"award-number":["32272847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U22A20516"],"award-info":[{"award-number":["U22A20516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key Research and Development Program of China","award":["No. 2021YFF1000602"],"award-info":[{"award-number":["No. 2021YFF1000602"]}]},{"name":"the Key Research and Development Program of Shaanxi Province","award":["No. 2022ZDLNY01\u201304"],"award-info":[{"award-number":["No. 2022ZDLNY01\u201304"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Animal Sci Biotechnol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Increased backfat thickness of sows in early gestation is negative to reproductive performance. Endometrial receptivity is an important determinant of reproductive success, but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits. The present study seeks to answer these questions through in vitro and in vivo investigations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows. In cells treated with melatonin, the MT2\/PI3K\/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity. Furthermore, we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice. Notably, melatonin treatment caused a significant reduction in the deposition of endometrial collagen, an increase in the number of glands, and repair of the pinopode structure, ultimately improving endometrial receptivity, promoting embryo implantation, and increasing the number of litter size of mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Collectively, the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2\/PI3K\/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40104-024-01137-x","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:01:50Z","timestamp":1735948910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melatonin improves endometrial receptivity and embryo implantation via MT2\/PI3K\/LIF signaling pathway in sows"],"prefix":"10.1186","volume":"16","author":[{"given":"Xue","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"1137_CR1","doi-asserted-by":"publisher","first-page":"154193","DOI":"10.1016\/j.metabol","volume":"107","author":"G Mintziori","year":"2020","unstructured":"Mintziori G, Nigdelis MP, Mathew H, Mousiolis A, Goulis DG, Mantzoros CS. The effect of excess body fat on female and male reproduction. Metabolism. 2020;107:154193. https:\/\/doi.org\/10.1016\/j.metabol.","journal-title":"Metabolism."},{"issue":"3","key":"1137_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/humupd\/dmp058","volume":"16","author":"A Maheshwari","year":"2010","unstructured":"Maheshwari A. Overweight and obesity in infertility: cost and consequences. Hum Reprod Update. 2010;16(3):229\u201330. https:\/\/doi.org\/10.1093\/humupd\/dmp058.","journal-title":"Hum Reprod Update."},{"issue":"24","key":"1137_CR3","doi-asserted-by":"publisher","first-page":"e742","DOI":"10.1503\/cmaj.171233","volume":"190","author":"M Belan","year":"2018","unstructured":"Belan M, Harnois-Leblanc S, Laferr\u00e8re B, Baillargeon JP. Optimizing reproductive health in women with obesity and infertility. CMAJ. 2018;190(24):e742-5. https:\/\/doi.org\/10.1503\/cmaj.171233.","journal-title":"CMAJ."},{"issue":"3","key":"1137_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.tem.2010.12.002","volume":"22","author":"E Cardozo","year":"2011","unstructured":"Cardozo E, Pavone ME, Hirshfeld-Cytron JE. Metabolic syndrome and oocyte quality. Trends Endocrinol Metab. 2011;22(3):103\u20139. https:\/\/doi.org\/10.1016\/j.tem.2010.12.002.","journal-title":"Trends Endocrinol Metab."},{"issue":"2","key":"1137_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/humupd\/dmt033","volume":"20","author":"AN Comninos","year":"2014","unstructured":"Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update. 2014;20(2):153\u201374. https:\/\/doi.org\/10.1093\/humupd\/dmt033.","journal-title":"Hum Reprod Update."},{"issue":"6","key":"1137_CR6","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.fertnstert.2020.09.139","volume":"115","author":"M Cozzolino","year":"2021","unstructured":"Cozzolino M, Garc\u00eda-Velasco JA, Meseguer M, Pellicer A, Bellver J. Female obesity increases the risk of miscarriage of euploid embryos. Fertil Steril. 2021;115(6):1495\u2013502. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.09.139.","journal-title":"Fertil Steril."},{"issue":"5","key":"1137_CR7","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/humupd\/dml024","volume":"12","author":"GG Gosman","year":"2006","unstructured":"Gosman GG, Katcher HI, Legro RS. Obesity and the role of gut and adipose hormones in female reproduction. Hum Reprod Update. 2006;12(5):585\u2013601. https:\/\/doi.org\/10.1093\/humupd\/dml024.","journal-title":"Hum Reprod Update."},{"issue":"1","key":"1137_CR8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12958-018-0336-z","volume":"16","author":"E Silvestris","year":"2018","unstructured":"Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):22. https:\/\/doi.org\/10.1186\/s12958-018-0336-z.","journal-title":"Reprod Biol Endocrinol."},{"key":"1137_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev-cellbio-011723-021442","volume":"39","author":"CJ Ang","year":"2023","unstructured":"Ang CJ, Skokan TD, McKinley KL. Mechanisms of regeneration and fibrosis in the endometrium. Annu Rev Cell Dev Biol. 2023;39:197\u2013221. https:\/\/doi.org\/10.1146\/annurev-cellbio-011723-021442.","journal-title":"Annu Rev Cell Dev Biol."},{"issue":"5","key":"1137_CR10","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/humupd\/dml033","volume":"12","author":"T Strowitzki","year":"2006","unstructured":"Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update. 2006;12(5):617\u201330. https:\/\/doi.org\/10.1093\/humupd\/dml033.","journal-title":"Hum Reprod Update."},{"issue":"3","key":"1137_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nrg1808","volume":"7","author":"H Wang","year":"2006","unstructured":"Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet. 2006;7(3):185\u201399. https:\/\/doi.org\/10.1038\/nrg1808.","journal-title":"Nat Rev Genet."},{"key":"1137_CR12","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1007\/s43032-021-00631-1","volume":"28","author":"J Bellver","year":"2021","unstructured":"Bellver J, Mar\u00edn C, Lathi RB, Murugappan G, Labarta E, Vidal C, et al. Obesity affects endometrial receptivity by displacing the window of implantation. Reprod Sci. 2021;28:3171\u201380. https:\/\/doi.org\/10.1007\/s43032-021-00631-1.","journal-title":"Reprod Sci."},{"key":"1137_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4274\/tjod.98475","volume":"12","author":"\u0130 Demiral","year":"2015","unstructured":"Demiral \u0130, Do\u011fan M, Ba\u015ftu E, Buyru F. Genomic, proteomic and lipidomic evaluation of endometrial receptivity. Turk J Obstet Gynecol. 2015;12:237\u201343. https:\/\/doi.org\/10.4274\/tjod.98475.","journal-title":"Turk J Obstet Gynecol."},{"issue":"8","key":"1137_CR14","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1007\/s11427-023-2557-x","volume":"67","author":"X Zang","year":"2024","unstructured":"Zang X, Gu S, Wang W, Shi J, Gan J, Hu Q, et al. Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy. Sci China Life Sci. 2024;67(8):1676\u201396. https:\/\/doi.org\/10.1007\/s11427-023-2557-x.","journal-title":"Sci China Life Sci."},{"issue":"1","key":"1137_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12951-023-01834-1","volume":"21","author":"L Hong","year":"2023","unstructured":"Hong L, Zang X, Hu Q, He Y, Xu Z, Xie Y, et al. Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation. J Nanobiotechnology. 2023;21(1):79. https:\/\/doi.org\/10.1186\/s12951-023-01834-1.","journal-title":"J Nanobiotechnology."},{"issue":"1\u20132","key":"1137_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","volume":"87","author":"FW Bazer","year":"2014","unstructured":"Bazer FW, Johnson GA. Pig blastocyst-uterine interactions. Differentiation. 2014;87:52\u201365. https:\/\/doi.org\/10.1016\/j.diff.2013.11.005.","journal-title":"Differentiation."},{"issue":"3","key":"1137_CR17","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","volume":"101","author":"JM Franasiak","year":"2014","unstructured":"Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril. 2014;101(3):656\u201363. https:\/\/doi.org\/10.1016\/j.fertnstert.2013.11.004.","journal-title":"Fertil Steril."},{"issue":"2","key":"1137_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tem.2019.11.008","volume":"31","author":"X Ye","year":"2020","unstructured":"Ye X. Uterine luminal epithelium as the transient gateway for embryo implantation. Trends Endocrinol Metab. 2020;31(2):165\u201380. https:\/\/doi.org\/10.1016\/j.tem.2019.11.008.","journal-title":"Trends Endocrinol Metab."},{"issue":"6","key":"1137_CR19","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/humupd\/dmad019","volume":"29","author":"ADS Pathare","year":"2023","unstructured":"Pathare ADS, Loid M, Saare M, Gidl\u00f6f SB, Zamani EM, Acharya G, et al. Endometrial receptivity in women of advanced age: an underrated factor in infertility. Hum Reprod Update. 2023;29(6):773\u201393. https:\/\/doi.org\/10.1093\/humupd\/dmad019.","journal-title":"Hum Reprod Update."},{"issue":"1","key":"1137_CR20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41392-022-01149-x","volume":"7","author":"X Wen","year":"2022","unstructured":"Wen X, Zhang B, Wu B, Xiao H, Li Z, Li R, et al. Signaling pathways in obesity: mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2022;7(1):298. https:\/\/doi.org\/10.1038\/s41392-022-01149-x.","journal-title":"Signal Transduct Target Ther."},{"issue":"10","key":"1137_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11892-018-1049-6","volume":"18","author":"EM Desjardins","year":"2018","unstructured":"Desjardins EM, Steinberg GR. Emerging role of AMPK in brown and beige adipose tissue (BAT): implications for obesity, insulin resistance, and type 2 diabetes. Curr Diab Rep. 2018;18(10):80. https:\/\/doi.org\/10.1007\/s11892-018-1049-6.","journal-title":"Curr Diab Rep."},{"issue":"11","key":"1137_CR22","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.7150\/ijbs.27173","volume":"14","author":"X Huang","year":"2018","unstructured":"Huang X, Liu G, Guo J, Su Z. The PI3K\/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci. 2018;14(11):1483\u201396. https:\/\/doi.org\/10.7150\/ijbs.27173.","journal-title":"Int J Biol Sci."},{"issue":"9","key":"1137_CR23","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3390\/biom10091256","volume":"10","author":"T Kassouf","year":"2020","unstructured":"Kassouf T, Sumara G. Impact of conventional and atypical MAPKs on the development of metabolic diseases. Biomolecules. 2020;10(9):1256. https:\/\/doi.org\/10.3390\/biom10091256.","journal-title":"Biomolecules."},{"issue":"2","key":"1137_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00125-008-1215-5","volume":"52","author":"AK Lim","year":"2009","unstructured":"Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, et al. Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db\/db mice. Diabetologia. 2009;52(2):347\u201358. https:\/\/doi.org\/10.1007\/s00125-008-1215-5.","journal-title":"Diabetologia."},{"issue":"1","key":"1137_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cmet.2006.04.014","volume":"4","author":"C Buettner","year":"2006","unstructured":"Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG Jr, Rossetti L. Critical role of STAT3 in leptin\u2019s metabolic actions. Cell Metab. 2006;4(1):49\u201360. https:\/\/doi.org\/10.1016\/j.cmet.2006.04.014.","journal-title":"Cell Metab."},{"key":"1137_CR26","doi-asserted-by":"publisher","first-page":"709823","DOI":"10.3389\/fcell.2021.709823","volume":"9","author":"AF Abou","year":"2021","unstructured":"Abou AF, Lim GE. Metabolic contributions of Wnt signaling: more than controlling flight. Front Cell Dev Biol. 2021;9:709823. https:\/\/doi.org\/10.3389\/fcell.2021.709823.","journal-title":"Front Cell Dev Biol."},{"key":"1137_CR27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.metabol.2017.01.021","volume":"69","author":"A Do\u011fan","year":"2017","unstructured":"Do\u011fan A, Demirci S, Apdik H, Bayrak OF, Gulluoglu S, Tuysuz EC, et al. A new hope for obesity management: boron inhibits adipogenesis in progenitor cells through the Wnt\/\u03b2-catenin pathway. Metabolism. 2017;69:130\u201342. https:\/\/doi.org\/10.1016\/j.metabol.2017.01.021.","journal-title":"Metabolism."},{"issue":"1","key":"1137_CR28","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1038\/s41467-021-23571-5","volume":"12","author":"D Monsivais","year":"2021","unstructured":"Monsivais D, Nagashima T, Prunskaite-Hyyryl\u00e4inen R, Nozawa K, Shimada K, Tang S, et al. Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1\/SMAD5 axis. Nat Commun. 2021;12:3386. https:\/\/doi.org\/10.1038\/s41467-021-23571-5.","journal-title":"Nat Commun."},{"issue":"6","key":"1137_CR29","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1002\/jcp.26252","volume":"233","author":"L Zhang","year":"2018","unstructured":"Zhang L, Liu X, Liu J, Ma X, Zhou Z, Song Y, et al. miR-26a promoted endometrial epithelium cells (EECs) proliferation and induced stromal cells (ESCs) apoptosis via the PTEN-PI3K\/AKT pathway in dairy goats. J Cell Physiol. 2018;233(6):4688\u2013706. https:\/\/doi.org\/10.1002\/jcp.26252.","journal-title":"J Cell Physiol."},{"issue":"17","key":"1137_CR30","doi-asserted-by":"publisher","first-page":"5049","DOI":"10.7150\/thno.32097","volume":"9","author":"JJ Chen","year":"2019","unstructured":"Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, et al. MRP4 sustains Wnt\/\u03b2-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics. 2019;9(17):5049\u201364. https:\/\/doi.org\/10.7150\/thno.32097.","journal-title":"Theranostics."},{"issue":"11","key":"1137_CR31","doi-asserted-by":"publisher","first-page":"19629","DOI":"10.1002\/jcp.28562","volume":"234","author":"MBH Shariati","year":"2019","unstructured":"Shariati MBH, Niknafs B, Seghinsara AM, Shokrzadeh N, Alivand MR. Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1\/2-mTOR pathway. J Cell Physiol. 2019;234(11):19629\u201339. https:\/\/doi.org\/10.1002\/jcp.28562.","journal-title":"J Cell Physiol."},{"issue":"20","key":"1137_CR32","doi-asserted-by":"publisher","first-page":"12303","DOI":"10.3390\/ijms232012303","volume":"23","author":"SL Yu","year":"2022","unstructured":"Yu SL, Kang Y, Jeong DU, Lee DC, Jeon HJ, Kim TH, et al. The miR-182\u20135p\/NDRG1 axis controls endometrial receptivity through the NF-\u03baB\/ZEB1\/E-Cadherin pathway. Int J Mol Sci. 2022;23(20):12303. https:\/\/doi.org\/10.3390\/ijms232012303.","journal-title":"Int J Mol Sci."},{"issue":"6","key":"1137_CR33","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1093\/humupd\/dmac026","volume":"28","author":"T Yang","year":"2022","unstructured":"Yang T, Zhao J, Liu F, Li Y. Lipid metabolism and endometrial receptivity. Hum Reprod Update. 2022;28(6):858\u201389. https:\/\/doi.org\/10.1093\/humupd\/dmac026.","journal-title":"Hum Reprod Update."},{"issue":"4","key":"1137_CR34","doi-asserted-by":"publisher","first-page":"e2302887","DOI":"10.1002\/advs.202302887","volume":"11","author":"Y Lu","year":"2024","unstructured":"Lu Y, Shao Y, Cui W, Jia Z, Zhang Q, Zhao Q, et al. Excessive lipid peroxidation in uterine epithelium causes implantation failure and pregnancy loss. Adv Sci. 2024;11(4):e2302887. https:\/\/doi.org\/10.1002\/advs.202302887.","journal-title":"Adv Sci."},{"key":"1137_CR35","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/humupd\/dmv029","volume":"21","author":"S Palomba","year":"2015","unstructured":"Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 2015;21:575\u201392. https:\/\/doi.org\/10.1093\/humupd\/dmv029.","journal-title":"Hum Reprod Update."},{"issue":"8","key":"1137_CR36","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1007\/s11427-021-2035-2","volume":"65","author":"H Xu","year":"2022","unstructured":"Xu H, Li J, Jin L, Zhang D, Chen B, Liu X, et al. Intrauterine hyperglycemia impairs endometrial receptivity via up-regulating SGK1 in diabetes. Sci China Life Sci. 2022;65(8):1578\u201389. https:\/\/doi.org\/10.1007\/s11427-021-2035-2.","journal-title":"Sci China Life Sci."},{"issue":"5","key":"1137_CR37","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1093\/humrep\/dex052","volume":"32","author":"SJ Pugh","year":"2017","unstructured":"Pugh SJ, Schisterman EF, Browne RW, Lynch AM, Mumford SL, Perkins NJ, et al. Preconception maternal lipoprotein levels in relation to fecundability. Hum Reprod. 2017;32(5):1055\u201363. https:\/\/doi.org\/10.1093\/humrep\/dex052.","journal-title":"Hum Reprod."},{"key":"1137_CR38","doi-asserted-by":"publisher","unstructured":"Alebi\u0107 M\u0160. Endometrial receptivity and PCOS; endometrial gene expression specificities- literature review. Clin Exp Obstet Gynecol. 2022;49(2):48. https:\/\/doi.org\/10.31083\/j.ceog4902048.","DOI":"10.31083\/j.ceog4902048"},{"issue":"2","key":"1137_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41574-018-0130-1","volume":"15","author":"A Karamitri","year":"2019","unstructured":"Karamitri A, Jockers R. Melatonin in type 2 diabetes mellitus and obesity. Nat Rev Endocrinol. 2019;15(2):105\u201325. https:\/\/doi.org\/10.1038\/s41574-018-0130-1.","journal-title":"Nat Rev Endocrinol."},{"issue":"4","key":"1137_CR40","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jpi.12137","volume":"56","author":"J Cipolla-Neto","year":"2014","unstructured":"Cipolla-Neto J, Amaral FG, Afeche SC, Tan DX, Reiter RJ. Melatonin, energy metabolism, and obesity: a review. J Pineal Res. 2014;56(4):371\u201381. https:\/\/doi.org\/10.1111\/jpi.12137.","journal-title":"J Pineal Res."},{"issue":"3","key":"1137_CR41","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/jpi.12216","volume":"58","author":"C He","year":"2015","unstructured":"He C, Wang J, Li Y, Zhu K, Xu Z, Song Y, et al. Melatonin-related genes expressed in the mouse uterus during early gestation promote embryo implantation. J Pineal Res. 2015;58(3):300\u20139. https:\/\/doi.org\/10.1111\/jpi.12216.","journal-title":"J Pineal Res."},{"issue":"2","key":"1137_CR42","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/humupd\/dmt054","volume":"20","author":"RJ Reiter","year":"2014","unstructured":"Reiter RJ, Tan DX, Korkmaz A, Rosales-Corral SA. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum Reprod Update. 2014;20(2):293\u2013307. https:\/\/doi.org\/10.1093\/humupd\/dmt054.","journal-title":"Hum Reprod Update."},{"key":"1137_CR43","doi-asserted-by":"publisher","unstructured":"Li YZ, Wang LH, Johnston LJ. Sorting by parity to reduce aggression toward first-parity sows in groupgestation housing systems. J Anim Sci. 2012;90(12):4514-22. https:\/\/doi.org\/10.2527\/jas.2011-4869..","DOI":"10.2527\/jas.2011-4869"},{"issue":"6","key":"1137_CR44","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1073\/pnas.0630588100","volume":"100","author":"LL Listenberger","year":"2003","unstructured":"Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003;100(6):3077\u201382. https:\/\/doi.org\/10.1073\/pnas.0630588100.","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"1137_CR45","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/hep.21752","volume":"46","author":"S Joshi-Barve","year":"2007","unstructured":"Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology. 2007;46(3):823\u201330. https:\/\/doi.org\/10.1002\/hep.21752.","journal-title":"Hepatology."},{"key":"1137_CR46","doi-asserted-by":"publisher","unstructured":"Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, et,al. Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells. J Anim Sci Biotechnol. 2024;8;15:108. https:\/\/doi.org\/10.1186\/s40104-024-01064-x.","DOI":"10.1186\/s40104-024-01064-x"},{"key":"1137_CR47","doi-asserted-by":"publisher","unstructured":"Das N, Mandala A, Naaz S, Giri S, Jain M, Bandyopadhyay D, et al. Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. J Pineal Res. 2017;62(4). https:\/\/doi.org\/10.1111\/jpi.12404.","DOI":"10.1111\/jpi.12404"},{"issue":"2","key":"1137_CR48","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1600-079X.2012.00980.x","volume":"53","author":"JK Jeong","year":"2012","unstructured":"Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity. J Pineal Res. 2012;53(2):138\u201346. https:\/\/doi.org\/10.1111\/j.1600-079X.2012.00980.x.","journal-title":"J Pineal Res."},{"key":"1137_CR49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s40104-024-01029-0","volume":"15","author":"TT Zhao","year":"2024","unstructured":"Zhao TT, Tian TT, Yu H, Cao CC, Zhang ZY, He ZZ, et al. Identification of porcine fast\/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes. J Animal Sci Biotechnol. 2024;15:73. https:\/\/doi.org\/10.1186\/s40104-024-01029-0.","journal-title":"J Animal Sci Biotechnol"},{"key":"1137_CR50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40104-024-01043-2","volume":"15","author":"S Shi","year":"2024","unstructured":"Shi S, Yuan H, Zhang L, Gao L, Zhao LL, Zeng XF, et al. UCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1. J Animal Sci Biotechnol. 2024;15:85. https:\/\/doi.org\/10.1186\/s40104-024-01043-2.","journal-title":"J Animal Sci Biotechnol"},{"issue":"11","key":"1137_CR51","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/s41419-019-2071-6","volume":"10","author":"W Hu","year":"2019","unstructured":"Hu W, Liang YX, Luo JM, Gu XW, Chen ZC, Fu T, et al. Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines. Cell Death Dis. 2019;10(11):831. https:\/\/doi.org\/10.1038\/s41419-019-2071-6.","journal-title":"Cell Death Dis."},{"issue":"3","key":"1137_CR52","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008;22(3):659\u201361. https:\/\/doi.org\/10.1096\/fj.07-9574LSF.","journal-title":"FASEB J."},{"issue":"4","key":"1137_CR53","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1600-079X.2006.00377.x","volume":"41","author":"JH Weishaupt","year":"2006","unstructured":"Weishaupt JH, Bartels C, P\u00f6lking E, Dietrich J, Rohde G, Poeggeler B, et al. Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res. 2006;41(4):313\u201323. https:\/\/doi.org\/10.1111\/j.1600-079X.2006.00377.x.","journal-title":"J Pineal Res."},{"key":"1137_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09064702.2015.1045932","volume":"65","author":"JS Kim","year":"2015","unstructured":"Kim JS, Yang X, Pangeni D, Baidoo SK. Relationship between backfat thickness of sows during late gestation and reproductive efficiency at different parities. Acta Agriculturae Scandinavica Section A-Animal Science. 2015;65:1\u20138. https:\/\/doi.org\/10.1080\/09064702.2015.1045932.","journal-title":"Acta Agriculturae Scandinavica Section A-Animal Science"},{"issue":"2","key":"1137_CR55","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/humupd\/dmn052","volume":"15","author":"CE Quinn","year":"2009","unstructured":"Quinn CE, Casper RF. Pinopodes: a questionable role in endometrial receptivity. Hum Reprod Update. 2009;15(2):229\u201336. https:\/\/doi.org\/10.1093\/humupd\/dmn052.","journal-title":"Hum Reprod Update."},{"issue":"4","key":"1137_CR56","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/s0015-0282(00)00717-2","volume":"74","author":"OH Develioglu","year":"2000","unstructured":"Develioglu OH, Nikas G, Hsiu JG, Toner JP, Jones HW Jr. Detection of endometrial pinopodes by light microscopy. Fertil Steril. 2000;74(4):767\u201370. https:\/\/doi.org\/10.1016\/s0015-0282(00)00717-2.","journal-title":"Fertil Steril."},{"issue":"3","key":"1137_CR57","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/biom12030388","volume":"12","author":"W Lian","year":"2022","unstructured":"Lian W, Gao D, Huang C, Zhong Q, Hua R, Lei M. Heat stress impairs maternal endometrial integrity and results in embryo implantation failure by regulating transport-related gene expression in tongcheng pigs. Biomolecules. 2022;12(3):388. https:\/\/doi.org\/10.3390\/biom12030388.","journal-title":"Biomolecules."},{"issue":"16","key":"1137_CR58","doi-asserted-by":"publisher","first-page":"e2200703","DOI":"10.1002\/mnfr.202200703","volume":"67","author":"Q Ye","year":"2023","unstructured":"Ye Q, Li H, Xu B, He Z, Yan X. Butyrate improves porcine endometrial epithelial cell receptivity via enhancing acetylation of histone H3K9. Mol Nutr Food Res. 2023;67(16):e2200703. https:\/\/doi.org\/10.1002\/mnfr.202200703.","journal-title":"Mol Nutr Food Res."},{"issue":"6","key":"1137_CR59","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1093\/humrep\/dew048","volume":"31","author":"JS Rhee","year":"2016","unstructured":"Rhee JS, Saben JL, Mayer AL, Schulte MB, Asghar Z, Stephens C, et al. Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy. Hum Reprod. 2016;31(6):1315\u201326. https:\/\/doi.org\/10.1093\/humrep\/dew048.","journal-title":"Hum Reprod."},{"key":"1137_CR60","doi-asserted-by":"publisher","first-page":"874487","DOI":"10.3389\/fgene.2022.874487","volume":"13","author":"S Liu","year":"2022","unstructured":"Liu S, Hong L, Lian R, Xiao S, Li Y, Diao L, et al. Transcriptomic analysis reveals endometrial dynamics in normoweight and overweight\/obese polycystic ovary syndrome women. Front Genet. 2022;13:874487. https:\/\/doi.org\/10.3389\/fgene.2022.874487.","journal-title":"Front Genet."},{"issue":"3","key":"1137_CR61","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/jpi.12069","volume":"55","author":"F Wang","year":"2013","unstructured":"Wang F, Tian X, Zhang L, Tan D, Reiter RJ, Liu G. Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine. J Pineal Res. 2013;55(3):267\u201374. https:\/\/doi.org\/10.1111\/jpi.12069.","journal-title":"J Pineal Res."},{"issue":"1","key":"1137_CR62","doi-asserted-by":"publisher","first-page":"e12772","DOI":"10.1111\/jpi.12772","volume":"72","author":"E Cecon","year":"2022","unstructured":"Cecon E, Izabelle C, Poder SL, Real F, Zhu A, Tu L, et al. Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2. J Pineal Res. 2022;72(1):e12772. https:\/\/doi.org\/10.1111\/jpi.12772.","journal-title":"J Pineal Res."},{"issue":"3","key":"1137_CR63","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/jpi.12212","volume":"58","author":"A Naskar","year":"2015","unstructured":"Naskar A, Prabhakar V, Singh R, Dutta D, Mohanakumar KP. Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. J Pineal Res. 2015;58(3):262\u201374. https:\/\/doi.org\/10.1111\/jpi.12212.","journal-title":"J Pineal Res."},{"issue":"2","key":"1137_CR64","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/jpi.12056","volume":"55","author":"R Zanuto","year":"2013","unstructured":"Zanuto R, Siqueira-Filho MA, Caperuto LC, Bacurau RF, Hirata E, Peliciari-Garcia RA, et al. Melatonin improves insulin sensitivity independently of weight loss in old obese rats. J Pineal Res. 2013;55(2):156\u201365. https:\/\/doi.org\/10.1111\/jpi.12056.","journal-title":"J Pineal Res."},{"issue":"2","key":"1137_CR65","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1600-079X","volume":"39","author":"CN Borges-Silva","year":"2005","unstructured":"Borges-Silva CN, Fonseca-Alaniz MH, Alonso-Vale MI, Takada J, Andreotti S, Peres SB, et al. Reduced lipolysis and increased lipogenesis in adipose tissue from pinealectomized rats adapted to training. J Pineal Res. 2005;39(2):178\u201384. https:\/\/doi.org\/10.1111\/j.1600-079X.","journal-title":"J Pineal Res."},{"issue":"5 Suppl","key":"1137_CR66","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.fertnstert.2007.03.050","volume":"89","author":"EL Dair","year":"2008","unstructured":"Dair EL, Simoes RS, Sim\u00f5es MJ, Romeu LR, Oliveira-Filho RM, Haidar MA, et al. Effects of melatonin on the endometrial morphology and embryo implantation in rats. Fertil Steril. 2008;89(5 Suppl):1299\u2013305. https:\/\/doi.org\/10.1016\/j.fertnstert.2007.03.050.","journal-title":"Fertil Steril."},{"issue":"2","key":"1137_CR67","doi-asserted-by":"publisher","first-page":"e12670","DOI":"10.1111\/jpi.12670","volume":"69","author":"H Bae","year":"2020","unstructured":"Bae H, Yang C, Lee JY, Park S, Bazer FW, Song G, et al. Melatonin improves uterine-conceptus interaction via regulation of sirt1 during early pregnancy. J Pineal Res. 2020;69(2):e12670. https:\/\/doi.org\/10.1111\/jpi.12670.","journal-title":"J Pineal Res."},{"issue":"8","key":"1137_CR68","doi-asserted-by":"publisher","first-page":"7127","DOI":"10.3390\/ijms24087127","volume":"24","author":"X Ma","year":"2023","unstructured":"Ma X, Wang J, Wang L, Yan L, Liu Y, Ma W, et al. The uterine melatonergic systems of AANAT and melatonin membrane receptor 2 (MT2) are essential for endometrial receptivity and early implantation in mice. Int J Mol Sci. 2023;24(8):7127. https:\/\/doi.org\/10.3390\/ijms24087127.","journal-title":"Int J Mol Sci."},{"issue":"3","key":"1137_CR69","doi-asserted-by":"publisher","first-page":"e12952","DOI":"10.1111\/jpi.12952","volume":"76","author":"HH Okamoto","year":"2024","unstructured":"Okamoto HH, Cecon E, Nureki O, Rivara S, Jockers R. Melatonin receptor structure and signaling. J Pineal Res. 2024;76(3):e12952. https:\/\/doi.org\/10.1111\/jpi.12952.","journal-title":"J Pineal Res."},{"issue":"7","key":"1137_CR70","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1172\/JCI34882","volume":"118","author":"Y Kubota","year":"2008","unstructured":"Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008;118(7):2393\u2013403. https:\/\/doi.org\/10.1172\/JCI34882.","journal-title":"J Clin Invest."},{"issue":"49","key":"1137_CR71","doi-asserted-by":"publisher","first-page":"19357","DOI":"10.1073\/pnas.0710110104","volume":"104","author":"CA White","year":"2007","unstructured":"White CA, Zhang JG, Salamonsen LA, Baca M, Fairlie WD, Metcalf D, et al. Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy. Proc Natl Acad Sci U S A. 2007;104(49):19357\u201362. https:\/\/doi.org\/10.1073\/pnas.0710110104.","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"12","key":"1137_CR72","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1210\/endo.141.12.7855","volume":"141","author":"JR Chen","year":"2000","unstructured":"Chen JR, Cheng JG, Shatzer T, Sewell L, Hernandez L, Stewart CL. Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis. Endocrinology. 2000;141(12):4365\u201372. https:\/\/doi.org\/10.1210\/endo.141.12.7855.","journal-title":"Endocrinology."},{"issue":"15","key":"1137_CR73","doi-asserted-by":"publisher","first-page":"8680","DOI":"10.1073\/pnas.151180898","volume":"98","author":"JG Cheng","year":"2001","unstructured":"Cheng JG, Chen JR, Hernandez L, Alvord WG, Stewart CL. Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci U S A. 2001;98(15):8680\u20135. https:\/\/doi.org\/10.1073\/pnas.151180898.","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"1137_CR74","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/s1472-6483(10)60875-9","volume":"14","author":"M Metwally","year":"2007","unstructured":"Metwally M, Tuckerman EM, Laird SM, Ledger WL, Li TC. Impact of high body mass index on endometrial morphology and function in the peri-implantation period in women with recurrent miscarriage. Reprod Biomed Online. 2007;14(3):328\u201334. https:\/\/doi.org\/10.1016\/s1472-6483(10)60875-9.","journal-title":"Reprod Biomed Online."},{"key":"1137_CR75","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1477-7827-12-75","volume":"12","author":"M Metwally","year":"2014","unstructured":"Metwally M, Preece R, Thomas J, Ledger W, Li TC. A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect. Reprod Biol Endocrinol. 2014;12:75. https:\/\/doi.org\/10.1186\/1477-7827-12-75.","journal-title":"Reprod Biol Endocrinol."}],"container-title":["Journal of Animal Science and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40104-024-01137-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40104-024-01137-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40104-024-01137-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T01:02:00Z","timestamp":1735952520000},"score":1,"resource":{"primary":{"URL":"https:\/\/jasbsci.biomedcentral.com\/articles\/10.1186\/s40104-024-01137-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,4]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1137"],"URL":"https:\/\/doi.org\/10.1186\/s40104-024-01137-x","relation":{},"ISSN":["2049-1891"],"issn-type":[{"value":"2049-1891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,4]]},"assertion":[{"value":"27 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures involving animals were conducted in accordance with the guidelines established by the Northwest A&F University Animal Care Committee and received approval (Approval number: IACUC2023-1101 and IACUC2024-0702).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}