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Targeted next-generation sequencing of a 659-gene panel was performed for tissues from 53 patients with PTCLs. The correlation of mutation landscape with clinical outcomes was analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>TET2<\/jats:italic> was the most frequently mutated gene (64%), followed by <jats:italic>RHOA<\/jats:italic> (43%), <jats:italic>PCLO<\/jats:italic> (23%), <jats:italic>DNMT3A<\/jats:italic> (19%), <jats:italic>IDH2<\/jats:italic> (17%), <jats:italic>PIEZO1<\/jats:italic> (17%) and <jats:italic>TP53<\/jats:italic> (15%). When mutated genes were categorized into functional groups, the most common mutations were those involved in epigenetic\/chromatin modification (75%), T-cell activation (74%), and the DNA repair\/TP53 pathway (64%). <jats:italic>TET2\/TP53<\/jats:italic> mutations were significantly associated with positive B symptoms (<jats:italic>P<\/jats:italic>\u2009=\u20090.045), and elevated lactate dehydrogenase (LDH) level (<jats:italic>P<\/jats:italic>\u2009=\u20090.011). Moreover, <jats:italic>TET2\/TP53<\/jats:italic> mutation was a risk factor for PTCL patient survival (HR 3.574, 95% CI 1.069\u00a0\u2212\u200911.941,<jats:italic> P<\/jats:italic>\u2009=\u20090.039). The occurrence of JAK\/STAT pathway mutations in angioimmunoblastic T-cell lymphoma (AITL) patients conferred a worse progression-free survival (HR 2.366, 95% CI 0.9130\u20136.129, <jats:italic>P<\/jats:italic>\u2009=\u20090.0334).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Heterogeneous gene mutations occur in PTCL, some of which have a negative impact on the survival outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40164-021-00200-x","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T03:58:51Z","timestamp":1612756731000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas"],"prefix":"10.1186","volume":"10","author":[{"given":"Yingying","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokun","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-2547","authenticated-orcid":false,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"200_CR1","doi-asserted-by":"crossref","unstructured":"A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. 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