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However, the functions and mechanisms of pseudogenes in clear cell renal cell carcinoma (ccRCC) remain largely elusive.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We quantified <jats:italic>PEBP1P2<\/jats:italic> expression in ccRCC tissues and cells using fluorescence in situ hybridization and real-time PCR. Besides, we evaluated the role of <jats:italic>PEBP1P2<\/jats:italic> in ccRCC using a lung metastasis model and a transwell assay. Finally, we documented the interactions between <jats:italic>PEBP1P2<\/jats:italic>, PEBP1, and KLF13 by performing luciferase, RNA immunoprecipitation, RNA pulldown, and targeted RNA demethylation assays.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Low <jats:italic>PEBP1P2<\/jats:italic> expression correlates significantly with advanced stages and poor prognosis in ccRCC patients. Besides, <jats:italic>PEBP1P2<\/jats:italic> overexpression inhibits ccRCC metastasis formation in vivo and in vitro. Interestingly, <jats:italic>PEBP1P2<\/jats:italic> directly interacted with 5-methylcytosine (m<jats:sup>5<\/jats:sup>C)-containing PEBP1 mRNA and recruited the YBX1\/ELAVL1 complex, stabilizing PEBP1 mRNA. In addition, <jats:italic>PEBP1P2<\/jats:italic> increased KLF13 mRNA levels by acting as a sponge for miR-296, miR-616, and miR-3194.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>PEBP1P2<\/jats:italic> inhibits ccRCC metastasis formation and regulates both PEBP1 and KLF13. Therefore, molecular therapies targeting <jats:italic>PEBP1P2<\/jats:italic> might be an effective treatment strategy against ccRCC and other cancers with low <jats:italic>PEBP1P2<\/jats:italic> levels.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40164-022-00346-2","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T16:17:32Z","timestamp":1667924252000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA"],"prefix":"10.1186","volume":"11","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoli","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexing","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"issue":"11","key":"346_CR1","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1093\/annonc\/mdx492","volume":"28","author":"S Buti","year":"2017","unstructured":"Buti S, Puligandla M, Bersanelli M, DiPaola RS, Manola J, Taguchi S, et al. 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