{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:01:33Z","timestamp":1774987293761,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006367","name":"Association Instituts Carnot","doi-asserted-by":"publisher","award":["OPALE GRANT"],"award-info":[{"award-number":["OPALE GRANT"]}],"id":[{"id":"10.13039\/501100006367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Hematol Oncol"],"DOI":"10.1186\/s40164-026-00766-4","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:54:41Z","timestamp":1774950881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis"],"prefix":"10.1186","volume":"15","author":[{"given":"C\u00e9cile","family":"Favreau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxence","family":"Bourgoin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coline","family":"Savy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Botton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Granger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Birck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Zerhouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Kerreneur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Rivault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Vigroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Dussart-Gautheret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Arcangeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Poterszman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cluzeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Jacquel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Benhida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Auberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-6979","authenticated-orcid":false,"given":"Anthony R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-2222","authenticated-orcid":false,"given":"Guillaume","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"766_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.beha.2014.01.001","volume":"26","author":"R Itzykson","year":"2013","unstructured":"Itzykson R, Kosmider O, Fenaux P. Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes. Best Pract Res Clin Haematol. 2013;26:355\u201364. https:\/\/doi.org\/10.1016\/j.beha.2014.01.001.","journal-title":"Best Pract Res Clin Haematol"},{"key":"766_CR2","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(13)61901-7","volume":"383","author":"L Ad\u00e8s","year":"2014","unstructured":"Ad\u00e8s L, Itzykson R, Fenaux P. Myelodysplastic syndromes. Lancet. 2014;383:2239\u201352. https:\/\/doi.org\/10.1016\/S0140-6736(13)61901-7.","journal-title":"Lancet"},{"key":"766_CR3","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1016\/j.ejca.2012.05.024","volume":"48","author":"O Visser","year":"2012","unstructured":"Visser O, Trama A, Maynadi\u00e9 M, Stiller C, Marcos-Gragera R, De Angelis R, et al. Incidence, survival and prevalence of myeloid malignancies in Europe. Eur J Cancer. 2012;48:3257\u201366. https:\/\/doi.org\/10.1016\/j.ejca.2012.05.024.","journal-title":"Eur J Cancer"},{"key":"766_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13148-016-0237-y","volume":"8","author":"J Diesch","year":"2016","unstructured":"Diesch J, Zwick A, Garz A-K, Palau A, Buschbeck M, G\u00f6tze KS. A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clin Epigenetics. 2016;8:71. https:\/\/doi.org\/10.1186\/s13148-016-0237-y.","journal-title":"Clin Epigenetics"},{"key":"766_CR5","doi-asserted-by":"publisher","first-page":"e106700","DOI":"10.15252\/embj.2020106700","volume":"40","author":"M Kist","year":"2021","unstructured":"Kist M, Vucic D. Cell death pathways: intricate connections and disease implications. EMBO J. 2021;40:e106700. https:\/\/doi.org\/10.15252\/embj.2020106700.","journal-title":"EMBO J"},{"key":"766_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JF Kerr","year":"1972","unstructured":"Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239\u201357. https:\/\/doi.org\/10.1038\/bjc.1972.33.","journal-title":"Br J Cancer"},{"key":"766_CR7","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1096\/fasebj.7.5.8462789","volume":"7","author":"ZF Zakeri","year":"1993","unstructured":"Zakeri ZF, Quaglino D, Latham T, Lockshin RA. Delayed internucleosomal DNA fragmentation in programmed cell death. FASEB J. 1993;7:470\u20138. https:\/\/doi.org\/10.1096\/fasebj.7.5.8462789.","journal-title":"FASEB J"},{"key":"766_CR8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev-biochem-060815-014830","volume":"85","author":"K Newton","year":"2016","unstructured":"Newton K, Manning G. Necroptosis and Inflammation. Annu Rev Biochem. 2016;85:743\u201363. https:\/\/doi.org\/10.1146\/annurev-biochem-060815-014830.","journal-title":"Annu Rev Biochem"},{"key":"766_CR9","doi-asserted-by":"publisher","first-page":"9505","DOI":"10.1074\/jbc.M109488200","volume":"277","author":"X Sun","year":"2002","unstructured":"Sun X, Yin J, Starovasnik MA, Fairbrother WJ, Dixit VM. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem. 2002;277:9505\u201311. https:\/\/doi.org\/10.1074\/jbc.M109488200.","journal-title":"J Biol Chem"},{"key":"766_CR10","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1080\/15548627.2017.1343770","volume":"13","author":"A Kuma","year":"2017","unstructured":"Kuma A, Komatsu M, Mizushima N. Autophagy-monitoring and autophagy-deficient mice. Autophagy Taylor Francis. 2017;13:1619. https:\/\/doi.org\/10.1080\/15548627.2017.1343770.","journal-title":"Autophagy Taylor Francis"},{"key":"766_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/cdd.2017.186","volume":"25","author":"J Kale","year":"2018","unstructured":"Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: changing partners in the dance towards death. Cell Death Differ. 2018;25:65\u201380. https:\/\/doi.org\/10.1038\/cdd.2017.186.","journal-title":"Cell Death Differ"},{"key":"766_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/bjh.19105","volume":"204","author":"A Nanaa","year":"2024","unstructured":"Nanaa A, He R, Foran JM, Badar T, Gangat N, Pardanani A, et al. Venetoclax plus hypomethylating agents in DDX41-mutated acute myeloid leukaemia and myelodysplastic syndrome: Mayo Clinic series on 12 patients. Br J Haematol. 2024;204:171\u20136. https:\/\/doi.org\/10.1111\/bjh.19105.","journal-title":"Br J Haematol"},{"key":"766_CR13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171:273\u201385. https:\/\/doi.org\/10.1016\/j.cell.2017.09.021.","journal-title":"Cell"},{"key":"766_CR14","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1089\/ars.2011.4391","volume":"18","author":"J Lewerenz","year":"2013","unstructured":"Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, et al. The Cystine\/Glutamate Antiporter System xc\u2009\u2013\u2009in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities. Antioxid Redox Signal. 2013;18:522\u201355. https:\/\/doi.org\/10.1089\/ars.2011.4391.","journal-title":"Antioxid Redox Signal"},{"key":"766_CR15","doi-asserted-by":"publisher","first-page":"e1800311","DOI":"10.1002\/pmic.201800311","volume":"19","author":"GC Forcina","year":"2019","unstructured":"Forcina GC, Dixon SJ. GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis. Proteomics. 2019;19:e1800311. https:\/\/doi.org\/10.1002\/pmic.201800311.","journal-title":"Proteomics"},{"key":"766_CR16","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JPF Angeli","year":"2014","unstructured":"Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16:1180\u201391. https:\/\/doi.org\/10.1038\/ncb3064.","journal-title":"Nat Cell Biol"},{"key":"766_CR17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15:234\u201345. https:\/\/doi.org\/10.1016\/j.chembiol.2008.02.010.","journal-title":"Chem Biol"},{"key":"766_CR18","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell Elsevier. 2012;149:1060\u201372. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042.","journal-title":"Cell Elsevier"},{"key":"766_CR19","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s11658-024-00613-6","volume":"29","author":"P Auberger","year":"2024","unstructured":"Auberger P, Favreau C, Savy C, Jacquel A, Robert G. Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia. Cell Mol Biol Lett. 2024;29:98. https:\/\/doi.org\/10.1186\/s11658-024-00613-6.","journal-title":"Cell Mol Biol Lett"},{"key":"766_CR20","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1038\/s41388-021-01924-0","volume":"40","author":"S Karunanithi","year":"2021","unstructured":"Karunanithi S, Liu R, Hou Y, Gonzalez G, Oldford N, Roe AJ, et al. Thioredoxin Reductase is a major regulator of metabolism in leukemia cells. Oncogene. 2021;40:5236\u201346. https:\/\/doi.org\/10.1038\/s41388-021-01924-0.","journal-title":"Oncogene"},{"key":"766_CR21","doi-asserted-by":"publisher","first-page":"111004","DOI":"10.1016\/j.cbi.2024.111004","volume":"395","author":"M-S Hsieh","year":"2024","unstructured":"Hsieh M-S, Ling HH, Setiawan SA, Hardianti MS, Fong I-H, Yeh C-T, et al. Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. Chem Biol Interact. 2024;395:111004. https:\/\/doi.org\/10.1016\/j.cbi.2024.111004.","journal-title":"Chem Biol Interact"},{"key":"766_CR22","doi-asserted-by":"publisher","first-page":"21952","DOI":"10.1021\/acs.jmedchem.4c01902","volume":"67","author":"A Chatterjee","year":"2024","unstructured":"Chatterjee A, Mondal J, Paul S, Sharma H, Goswami RK, Sen P. Deciphering the Comprehensive Structure-Activity Relationship of Sunshinamide for Breast Cancer Therapy through Dual Modulation of Apoptotic and Ferroptotic Pathways via TrxR1 and Gpx4 Inhibition. J Med Chem. 2024;67:21952\u201374. https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01902.","journal-title":"J Med Chem"},{"key":"766_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-pharmtox-052220-102509","volume":"62","author":"R Gencheva","year":"2022","unstructured":"Gencheva R, Arn\u00e9r ESJ. Thioredoxin Reductase Inhibition for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2022;62:177\u201396. https:\/\/doi.org\/10.1146\/annurev-pharmtox-052220-102509.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"766_CR24","doi-asserted-by":"publisher","first-page":"7674565","DOI":"10.1155\/2021\/7674565","volume":"2021","author":"S Liu","year":"2021","unstructured":"Liu S, Wu W, Chen Q, Zheng Z, Jiang X, Xue Y, et al. TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro. Oxid Med Cell Longev. 2021;2021:7674565. https:\/\/doi.org\/10.1155\/2021\/7674565.","journal-title":"Oxid Med Cell Longev"},{"key":"766_CR25","doi-asserted-by":"publisher","first-page":"103134","DOI":"10.1016\/j.redox.2024.103134","volume":"72","author":"C Morgenstern","year":"2024","unstructured":"Morgenstern C, Lastres-Becker I, Demird\u00f6\u011fen BC, Costa VM, Daiber A, Foresti R, et al. Biomarkers of NRF2 signalling: Current status and future challenges. Redox Biol. 2024;72:103134. https:\/\/doi.org\/10.1016\/j.redox.2024.103134.","journal-title":"Redox Biol"},{"key":"766_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","volume":"34","author":"M de la Rojo","year":"2018","unstructured":"de la Rojo M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018;34:21\u201343. https:\/\/doi.org\/10.1016\/j.ccell.2018.03.022.","journal-title":"Cancer Cell"},{"key":"766_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40164-023-00411-4","volume":"12","author":"X Liu","year":"2023","unstructured":"Liu X, Zhong S, Qiu K, Chen X, Wu W, Zheng J, et al. Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis. Exp Hematol Oncol BioMed Cent. 2023;12:1\u201312. https:\/\/doi.org\/10.1186\/s40164-023-00411-4.","journal-title":"Exp Hematol Oncol BioMed Cent"},{"key":"766_CR28","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1158\/0008-5472.CAN-20-2114","volume":"81","author":"M Zerhouni","year":"2021","unstructured":"Zerhouni M, Martin AR, Furstoss N, Gutierrez VS, Jaune E, Tekaya N, et al. Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma. Cancer Res. 2021;81:3806\u201321. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-2114.","journal-title":"Cancer Res"},{"key":"766_CR29","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1158\/2159-8290.CD-22-0411","volume":"13","author":"M Sabatier","year":"2023","unstructured":"Sabatier M, Birsen R, Lauture L, Mouche S, Angelino P, Dehairs J, et al. C\/EBP\u03b1 Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia. Cancer Discov. 2023;13:1720\u201347. https:\/\/doi.org\/10.1158\/2159-8290.CD-22-0411.","journal-title":"Cancer Discov"},{"key":"766_CR30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cell.2020.01.025","volume":"180","author":"CG Parker","year":"2020","unstructured":"Parker CG, Pratt MR. Click Chemistry in Proteomic Investigations. Cell. 2020;180:605\u201332. https:\/\/doi.org\/10.1016\/j.cell.2020.01.025.","journal-title":"Cell"},{"key":"766_CR31","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","volume":"368","author":"Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia","year":"2013","unstructured":"Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia. New Engl J Med Mass Med Soc. 2013;368:2059\u201374. https:\/\/doi.org\/10.1056\/NEJMoa1301689.","journal-title":"New Engl J Med Mass Med Soc"},{"key":"766_CR32","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/s41419-021-04306-2","volume":"12","author":"Y Sun","year":"2021","unstructured":"Sun Y, Berleth N, Wu W, Schl\u00fctermann D, Deitersen J, Stuhldreier F, et al. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis. 2021;12:1028. https:\/\/doi.org\/10.1038\/s41419-021-04306-2.","journal-title":"Cell Death Dis"},{"key":"766_CR33","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.bbalip.2018.06.006","volume":"1863","author":"A Borchert","year":"2018","unstructured":"Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter H-G, et al. Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:1095\u2013107. https:\/\/doi.org\/10.1016\/j.bbalip.2018.06.006.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"766_CR34","doi-asserted-by":"publisher","first-page":"102703","DOI":"10.1016\/j.redox.2023.102703","volume":"62","author":"DM Cheff","year":"2023","unstructured":"Cheff DM, Huang C, Scholzen KC, Gencheva R, Ronzetti MH, Cheng Q, et al. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1. Redox Biol. 2023;62:102703. https:\/\/doi.org\/10.1016\/j.redox.2023.102703.","journal-title":"Redox Biol"},{"key":"766_CR35","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1089\/ars.2017.7342","volume":"29","author":"C Tonelli","year":"2018","unstructured":"Tonelli C, Chio IIC, Tuveson DA. Transcriptional Regulation by Nrf2. Antioxid Redox Signal. 2018;29:1727\u201345. https:\/\/doi.org\/10.1089\/ars.2017.7342.","journal-title":"Antioxid Redox Signal"},{"key":"766_CR36","doi-asserted-by":"publisher","first-page":"102719","DOI":"10.1016\/j.redox.2023.102719","volume":"63","author":"DM Cheff","year":"2023","unstructured":"Cheff DM, Cheng Q, Guo H, Travers J, Klumpp-Thomas C, Shen M, et al. Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4. Redox Biol. 2023;63:102719. https:\/\/doi.org\/10.1016\/j.redox.2023.102719.","journal-title":"Redox Biol"},{"key":"766_CR37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","volume":"21","author":"C Zhang","year":"2022","unstructured":"Zhang C, Liu X, Jin S, Chen Y, Guo R. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer. 2022;21:47. https:\/\/doi.org\/10.1186\/s12943-022-01530-y.","journal-title":"Mol Cancer"},{"key":"766_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s43018-023-00653-5","volume":"5","author":"C Bruedigam","year":"2024","unstructured":"Bruedigam C, Porter AH, Song A, Vroeg in de Wei G, Stoll T, Straube J, et al. Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia. Nat Cancer Nat Publishing Group. 2024;5:47\u201365. https:\/\/doi.org\/10.1038\/s43018-023-00653-5.","journal-title":"Nat Cancer Nat Publishing Group"},{"key":"766_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41420-024-01800-2","volume":"10","author":"X Yu","year":"2024","unstructured":"Yu X, Wang Y, Tan J, Li Y, Yang P, Liu X, et al. Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway. Cell Death Discov Nat Publishing Group. 2024;10:1\u201310. https:\/\/doi.org\/10.1038\/s41420-024-01800-2.","journal-title":"Cell Death Discov Nat Publishing Group"},{"key":"766_CR40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3324\/haematol.2020.259531","volume":"107","author":"R Birsen","year":"2022","unstructured":"Birsen R, Larrue C, Decroocq J, Johnson N, Guiraud N, Gotanegre M, et al. APR-246 induces early cell death by ferroptosis in acute myeloid leukemia. Haematologica. 2022;107:403\u201316. https:\/\/doi.org\/10.3324\/haematol.2020.259531.","journal-title":"Haematologica"},{"key":"766_CR41","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/s41375-022-01573-6","volume":"36","author":"B Pardieu","year":"2022","unstructured":"Pardieu B, Pasanisi J, Ling F, Dal Bello R, Penneroux J, Su A, et al. Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia. Leukemia. 2022;36:1585\u201395. https:\/\/doi.org\/10.1038\/s41375-022-01573-6.","journal-title":"Leukemia"},{"key":"766_CR42","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/S0140-6736(06)69780-8","volume":"368","author":"E Estey","year":"2006","unstructured":"Estey E, D\u00f6hner H. Acute myeloid leukaemia. Lancet. 2006;368:1894\u2013907. https:\/\/doi.org\/10.1016\/S0140-6736(06)69780-8.","journal-title":"Lancet"},{"key":"766_CR43","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1182\/blood-2011-01-326025","volume":"117","author":"PS Hole","year":"2011","unstructured":"Hole PS, Darley RL, Tonks A. Do reactive oxygen species play a role in myeloid leukemias? Blood. 2011;117:5816\u201326. https:\/\/doi.org\/10.1182\/blood-2011-01-326025.","journal-title":"Blood"},{"key":"766_CR44","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.3390\/ijms20236003","volume":"20","author":"JR Sillar","year":"2019","unstructured":"Sillar JR, Germon ZP, DeIuliis GN, Dun MD. The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia. Int J Mol Sci. 2019;20:6003. https:\/\/doi.org\/10.3390\/ijms20236003.","journal-title":"Int J Mol Sci"},{"key":"766_CR45","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1182\/blood.v98.8.2301","volume":"98","author":"ML Guzman","year":"2001","unstructured":"Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98:2301\u20137. https:\/\/doi.org\/10.1182\/blood.v98.8.2301.","journal-title":"Blood"},{"key":"766_CR46","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1089\/ars.2011.4258","volume":"18","author":"ME Irwin","year":"2013","unstructured":"Irwin ME, Rivera-Del Valle N, Chandra J. Redox control of leukemia: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2013;18:1349\u201383. https:\/\/doi.org\/10.1089\/ars.2011.4258.","journal-title":"Antioxid Redox Signal"}],"container-title":["Experimental Hematology & Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40164-026-00766-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40164-026-00766-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40164-026-00766-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:18:08Z","timestamp":1774984688000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40164-026-00766-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["766"],"URL":"https:\/\/doi.org\/10.1186\/s40164-026-00766-4","relation":{},"ISSN":["2162-3619"],"issn-type":[{"value":"2162-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by our institutional review board. Written informed consent was obtained from each patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38"}}