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However, it remains unclear how perturbations of the gut microbiota compromise host infection resistance, especially through changes at species and metabolite levels.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here, we illustrate how <jats:italic>Bacteroides vulgatus<\/jats:italic>, a dominant species of the Bacteroidetes phylum in mouse intestine, suppresses infection by <jats:italic>Vibrio cholerae<\/jats:italic>, an important human pathogen. Clindamycin (CL) is an antibiotic that selectively kills anaerobic bacteria, and accordingly Bacteroidetes are completely eradicated from CL-treated mouse intestines. The Bacteroidetes-depleted adult mice developed severe cholera-like symptoms, when infected with <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic>. Germ-free mice mono-associated with <jats:italic>B<\/jats:italic>. <jats:italic>vulgatus<\/jats:italic> became resistant to <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic> infection. Levels of <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic> growth-inhibitory metabolites including short-chain fatty acids plummeted upon CL treatment, while levels of compounds that enhance <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic> proliferation were elevated. Furthermore, the intestinal colonization process of <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic> was well-simulated in CL-treated adult mice.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Overall, we provide insights into how a symbiotic microbe and a pathogenic intruder interact inside host intestine. We identified <jats:italic>B<\/jats:italic>. <jats:italic>vulgatus<\/jats:italic> as an indigenous microbial species that can suppress intestinal infection. Our results also demonstrate that commensal-derived metabolites are a critical determinant for host resistance against <jats:italic>V<\/jats:italic>. <jats:italic>cholerae<\/jats:italic> infection, and that CL pretreatment of adult mice generates a simple yet useful model of cholera infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40168-019-0746-y","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T05:02:37Z","timestamp":1568437357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine"],"prefix":"10.1186","volume":"7","author":[{"given":"Jin Sun","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungmin","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Taek","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hwan","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-365X","authenticated-orcid":false,"given":"Sang Sun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,14]]},"reference":[{"key":"746_CR1","doi-asserted-by":"publisher","first-page":"11606","DOI":"10.1038\/ncomms11606","volume":"7","author":"MY Yoon","year":"2016","unstructured":"Yoon MY, Min KB, Lee KM, Yoon Y, Kim Y, Oh YT, et al. 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