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In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This analysis was based on a Chinese population with 1475 participants. We estimated the SNP-based heritability, which suggested that\n                      <jats:italic>Desulfovibrionaceae<\/jats:italic>\n                      and\n                      <jats:italic>Odoribacter<\/jats:italic>\n                      had significant heritability estimates (0.456 and 0.476, respectively). We performed a microbiome genome-wide association study to identify host genetic variants associated with the gut microbiome. We then conducted bidirectional Mendelian randomization analyses to examine the potential causal associations between the gut microbiome and complex human diseases. We found that\n                      <jats:italic>Saccharibacteria<\/jats:italic>\n                      could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate. On the other hand, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by host genetics, had potential causal effects on the abundance of some specific gut microbiota. For example, atrial fibrillation increased the abundance of\n                      <jats:italic>Burkholderiales<\/jats:italic>\n                      and\n                      <jats:italic>Alcaligenaceae<\/jats:italic>\n                      and decreased the abundance of\n                      <jats:italic>Lachnobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Bacteroides coprophilus<\/jats:italic>\n                      ,\n                      <jats:italic>Barnesiellaceae<\/jats:italic>\n                      , an undefined genus in the family\n                      <jats:italic>Veillonellaceae<\/jats:italic>\n                      and\n                      <jats:italic>Mitsuokella<\/jats:italic>\n                      . Further disease-microbiome feature analysis suggested that systemic lupus erythematosus and chronic myeloid leukaemia shared common gut microbiome features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that different complex human diseases share common and distinct gut microbiome features, which may help reshape our understanding of disease aetiology in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40168-020-00923-9","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T10:04:02Z","timestamp":1602151442000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases"],"prefix":"10.1186","volume":"8","author":[{"given":"Fengzhe","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglei","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanglong","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-wen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-4890","authenticated-orcid":false,"given":"Ju-Sheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"923_CR1","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3389\/fgene.2018.00637","volume":"9","author":"D Awany","year":"2019","unstructured":"Awany D, Allali I, Dalvie S, Hemmings S, Mwaikono KS, Thomford NE, et al. 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