{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:20:37Z","timestamp":1793974837754,"version":"4.8.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"fellowship of China Postdoctoral Science Foundation","award":["2022T150635"],"award-info":[{"award-number":["2022T150635"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["42407166"],"award-info":[{"award-number":["42407166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["42307165"],"award-info":[{"award-number":["42307165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32361143523"],"award-info":[{"award-number":["32361143523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ningbo S&T project","award":["2021-DST-004"],"award-info":[{"award-number":["2021-DST-004"]}]},{"name":"Ningbo S&T project","award":["2021-DST-004"],"award-info":[{"award-number":["2021-DST-004"]}]},{"name":"Ningbo S&T project","award":["2021-DST-004"],"award-info":[{"award-number":["2021-DST-004"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1304601"],"award-info":[{"award-number":["2023YFF1304601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Partnership Program of Chinese Academy of Sciences","award":["322GJHZ2022028FN"],"award-info":[{"award-number":["322GJHZ2022028FN"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microbiome"],"DOI":"10.1186\/s40168-025-02044-7","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T03:27:16Z","timestamp":1738812436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails"],"prefix":"10.1186","volume":"13","author":[{"given":"Yiyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Breed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Guan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"5601","key":"2044_CR1","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1126\/science.1074153","volume":"298","author":"J Melillo","year":"2002","unstructured":"Melillo J, et al. Soil warming and carbon-cycle feedbacks to the climate system. Science. 2002;298(5601):2173\u20136.","journal-title":"Science"},{"issue":"6035","key":"2044_CR2","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1126\/science.1197479","volume":"332","author":"DA Wardle","year":"2011","unstructured":"Wardle DA, et al. Terrestrial ecosystem responses to species gains and losses. Science. 2011;332(6035):1273\u20137.","journal-title":"Science"},{"issue":"11","key":"2044_CR3","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/ele.12686","volume":"19","author":"BJ Sinclair","year":"2016","unstructured":"Sinclair BJ, et al. Can we predict ectotherm responses to climate change using thermal performance curves and body temperatures? Ecol Lett. 2016;19(11):1372\u201385.","journal-title":"Ecol Lett"},{"issue":"7","key":"2044_CR4","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/s41564-022-01147-3","volume":"7","author":"L Wu","year":"2022","unstructured":"Wu L, et al. Reduction of microbial diversity in grassland soil is driven by long-term climate warming. Nat Microbiol. 2022;7(7):1054\u201362.","journal-title":"Nat Microbiol"},{"issue":"4","key":"2044_CR5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41558-021-00989-9","volume":"11","author":"MM Yuan","year":"2021","unstructured":"Yuan MM, et al. Climate warming enhances microbial network complexity and stability. Nat Clim Chang. 2021;11(4):343\u20138.","journal-title":"Nat Clim Chang"},{"key":"2044_CR6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.soilbio.2017.03.008","volume":"110","author":"DR Coyle","year":"2017","unstructured":"Coyle DR, et al. Soil fauna responses to natural disturbances, invasive species, and global climate change: current state of the science and a call to action. Soil Biol Biochem. 2017;110:116\u201333.","journal-title":"Soil Biol Biochem"},{"issue":"7934","key":"2044_CR7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41586-022-05334-4","volume":"611","author":"LB J\u00f8rgensen","year":"2022","unstructured":"J\u00f8rgensen LB, et al. Extreme escalation of heat failure rates in ectotherms with global warming. Nature. 2022;611(7934):93\u20138.","journal-title":"Nature"},{"issue":"4","key":"2044_CR8","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1111\/brv.12312","volume":"92","author":"PK Abram","year":"2017","unstructured":"Abram PK, et al. Behavioural effects of temperature on ectothermic animals: unifying thermal physiology and behavioural plasticity. Biol Rev. 2017;92(4):1859\u201376.","journal-title":"Biol Rev"},{"issue":"3","key":"2044_CR9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrmicro1614","volume":"5","author":"GD Wright","year":"2007","unstructured":"Wright GD. The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol. 2007;5(3):175\u201386.","journal-title":"Nat Rev Microbiol"},{"issue":"21","key":"2044_CR10","doi-asserted-by":"publisher","first-page":"15034","DOI":"10.1021\/acs.est.2c02471","volume":"56","author":"Q Xiang","year":"2022","unstructured":"Xiang Q, et al. Microbial multitrophic communities drive the variation of antibiotic resistome in the gut of soil woodlice (Crustacea: Isopoda). Environ Sci Technol. 2022;56(21):15034\u201343.","journal-title":"Environ Sci Technol"},{"issue":"18","key":"2044_CR11","doi-asserted-by":"publisher","first-page":"7273","DOI":"10.1021\/acs.est.3c01233","volume":"57","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, et al. Increasing antimicrobial resistance and potential human bacterial pathogens in an invasive land snail driven by urbanization. Environ Sci Technol. 2023;57(18):7273\u201384.","journal-title":"Environ Sci Technol"},{"key":"2044_CR12","doi-asserted-by":"publisher","unstructured":"Bei Q, Thomas R, Beatrix S, Nico E, Martin S, Fran\u00e7ois B, and Anna HB. Extreme summers impact cropland and grassland soil microbiomes. The ISME Journal. 2023;17(10):1589\u20131600. https:\/\/doi.org\/10.1038\/s41396-023-01470-5","DOI":"10.1038\/s41396-023-01470-5"},{"key":"2044_CR13","doi-asserted-by":"publisher","unstructured":"Singh BK, Manuel DB, Eleonora E, and Philip GT. Climate change impacts on plant pathogens, food security and paths forward. Nature Reviews Microbiology. 2023;21(11):640\u2013656. https:\/\/doi.org\/10.1038\/s41579-023-00900-7","DOI":"10.1038\/s41579-023-00900-7"},{"issue":"5","key":"2044_CR14","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1111\/1462-2920.13255","volume":"18","author":"KD Kohl","year":"2016","unstructured":"Kohl KD, Yahn J. Effects of environmental temperature on the gut microbial communities of tadpoles. Environ Microbiol. 2016;18(5):1561\u20135.","journal-title":"Environ Microbiol"},{"issue":"10325","key":"2044_CR15","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJ Murray","year":"2022","unstructured":"Murray CJ, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022;399(10325):629\u201355.","journal-title":"The Lancet"},{"key":"2044_CR16","doi-asserted-by":"publisher","first-page":"132952","DOI":"10.1016\/j.jhazmat.2023.132952","volume":"464","author":"L Wang","year":"2024","unstructured":"Wang L, et al. The pH-specific response of soil resistome to triclocarban and arsenic co-contamination. J Hazard Mater. 2024;464:132952.","journal-title":"J Hazard Mater"},{"issue":"1","key":"2044_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.fsi.2014.02.014","volume":"38","author":"JA Abiona","year":"2014","unstructured":"Abiona JA, et al. Comparative evaluation of haemagglutination potential of haemolymph from two species of giant African land snails (Archachatina marginata and Achatina achatina). Fish Shellfish Immunol. 2014;38(1):96\u2013100.","journal-title":"Fish Shellfish Immunol"},{"key":"2044_CR18","doi-asserted-by":"crossref","unstructured":"Rekha Sarma, R., M. Munsi, and A. Neelavara Ananthram, Effect of climate change on invasion risk of giant African snail (Achatina fulica F\u00e9russac, 1821: Achatinidae) in India. PLoS One. 2015;10(11):e0143724.","DOI":"10.1371\/journal.pone.0143724"},{"issue":"1","key":"2044_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40168-022-01261-8","volume":"10","author":"J Song","year":"2022","unstructured":"Song J, et al. Carbendazim shapes microbiome and enhances resistome in the earthworm gut. Microbiome. 2022;10(1):63.","journal-title":"Microbiome"},{"key":"2044_CR20","doi-asserted-by":"publisher","first-page":"132732","DOI":"10.1016\/j.jhazmat.2023.132732","volume":"461","author":"F Luo","year":"2024","unstructured":"Luo F, et al. Network complexity of bacterial community driving antibiotic resistome in the microbiome of earthworm guts under different land use patterns. J Hazard Mater. 2024;461:132732.","journal-title":"J Hazard Mater"},{"issue":"40","key":"2044_CR21","doi-asserted-by":"publisher","first-page":"e2201473119","DOI":"10.1073\/pnas.2201473119","volume":"119","author":"H-Z Li","year":"2022","unstructured":"Li H-Z, et al. Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics. Proc Natl Acad Sci. 2022;119(40):e2201473119.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"2044_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nmicrobiol.2016.242","volume":"2","author":"P Carini","year":"2016","unstructured":"Carini P, et al. Relic DNA is abundant in soil and obscures estimates of soil microbial diversity. Nat Microbiol. 2016;2(3):1\u20136.","journal-title":"Nat Microbiol"},{"key":"2044_CR23","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.copbio.2020.06.011","volume":"64","author":"D Wang","year":"2020","unstructured":"Wang D, et al. Advances in single cell Raman spectroscopy technologies for biological and environmental applications. Curr Opin Biotechnol. 2020;64:218\u201329.","journal-title":"Curr Opin Biotechnol"},{"issue":"23","key":"2044_CR24","doi-asserted-by":"publisher","first-page":"15472","DOI":"10.1021\/acs.analchem.0c03218","volume":"92","author":"H-Z Li","year":"2020","unstructured":"Li H-Z, et al. Phenotypic tracking of antibiotic resistance spread via transformation from environment to clinic by reverse D2O single-cell Raman probing. Anal Chem. 2020;92(23):15472\u20139.","journal-title":"Anal Chem"},{"issue":"7","key":"2044_CR25","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1111\/1462-2920.14962","volume":"22","author":"Y Wang","year":"2020","unstructured":"Wang Y, et al. Raman-activated sorting of antibiotic-resistant bacteria in human gut microbiota. Environ Microbiol. 2020;22(7):2613\u201324.","journal-title":"Environ Microbiol"},{"key":"2044_CR26","unstructured":"Srivastava PD. Problem of land snail pests in Agriculture: A study of the giant African snail. Dehradun:Concept Publishing Company. 1992. [Book]"},{"key":"2044_CR27","doi-asserted-by":"crossref","unstructured":"Albuquerque, F.S.d., et al., Do climate variables and human density affect Achatina fulica (Bowditch) (Gastropoda: Pulmonata) shell length, total weight and condition factor? Brazilian Journal of Biology, 2009;69: 879\u2013885.","DOI":"10.1590\/S1519-69842009000400016"},{"issue":"15","key":"2044_CR28","doi-asserted-by":"publisher","first-page":"10210","DOI":"10.1021\/acs.est.1c01767","volume":"55","author":"MA Borchardt","year":"2021","unstructured":"Borchardt MA, et al. The environmental microbiology minimum information (EMMI) guidelines: qPCR and dPCR quality and reporting for environmental microbiology. Environ Sci Technol. 2021;55(15):10210\u201323.","journal-title":"Environ Sci Technol"},{"issue":"7","key":"2044_CR29","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13(7):581\u20133.","journal-title":"Nat Methods"},{"issue":"8","key":"2044_CR30","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019;37(8):852\u20137.","journal-title":"Nat Biotechnol"},{"key":"2044_CR31","unstructured":"Andrews, S., FastQC: a quality control tool for high throughput sequence data. 2010, Babraham Bioinformatics, Babraham Institute, Cambridge, United Kingdom."},{"issue":"15","key":"2044_CR32","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114\u201320.","journal-title":"Bioinformatics"},{"issue":"4","key":"2044_CR33","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4):357\u20139.","journal-title":"Nat Methods"},{"key":"2044_CR34","doi-asserted-by":"publisher","unstructured":"Yin X, Ying Yang UM, and Thomas UB. ARGs-OAP v3. 0: Antibiotic-resistance gene database curation and analysis pipeline optimization. Engineering. 2023;19(2):234\u201341. https:\/\/doi.org\/10.1016\/j.eng.2022.10.011","DOI":"10.1016\/j.eng.2022.10.011"},{"issue":"11","key":"2044_CR35","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nmeth.3103","volume":"11","author":"J Alneberg","year":"2014","unstructured":"Alneberg J, et al. Binning metagenomic contigs by coverage and composition. Nat Methods. 2014;11(11):1144\u20136.","journal-title":"Nat Methods"},{"issue":"4","key":"2044_CR36","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/bioinformatics\/btv638","volume":"32","author":"YW Wu","year":"2016","unstructured":"Wu YW, Simmons BA, Singer SW. MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets. Bioinformatics. 2016;32(4):605\u20137.","journal-title":"Bioinformatics"},{"key":"2044_CR37","doi-asserted-by":"publisher","first-page":"e7359","DOI":"10.7717\/peerj.7359","volume":"7","author":"DD Kang","year":"2019","unstructured":"Kang DD, et al. MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies. PeerJ. 2019;7:e7359.","journal-title":"PeerJ"},{"issue":"7","key":"2044_CR38","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1101\/gr.186072.114","volume":"25","author":"DH Parks","year":"2015","unstructured":"Parks DH, et al. CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Genome Res. 2015;25(7):1043\u201355.","journal-title":"Genome Res"},{"key":"2044_CR39","doi-asserted-by":"publisher","unstructured":"Chaumeil PA, Aaron JM, Philip H, and Donovan HP. GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database. Bioinformatics. 2020;36(6):1925\u20137. https:\/\/doi.org\/10.1093\/bioinformatics\/btz848","DOI":"10.1093\/bioinformatics\/btz848"},{"issue":"3","key":"2044_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009490","volume":"5","author":"MN Price","year":"2010","unstructured":"Price MN, Dehal PS, Arkin AP. FastTree 2\u2013approximately maximum-likelihood trees for large alignments. PLoS ONE. 2010;5(3): e9490.","journal-title":"PLoS ONE"},{"issue":"W1","key":"2044_CR41","doi-asserted-by":"publisher","first-page":"W256","DOI":"10.1093\/nar\/gkz239","volume":"47","author":"I Letunic","year":"2019","unstructured":"Letunic I, Bork P. Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Nucleic Acids Res. 2019;47(W1):W256\u20139.","journal-title":"Nucleic Acids Res"},{"key":"2044_CR42","doi-asserted-by":"crossref","unstructured":"Blin, K., et al., antiSMASH 6.0: improving cluster detection and comparison capabilities. Nucleic acids research, 2021. 49(W1): p. W29-W35.","DOI":"10.1093\/nar\/gkab335"},{"key":"2044_CR43","doi-asserted-by":"publisher","first-page":"108431","DOI":"10.1016\/j.envint.2024.108431","volume":"183","author":"D Lin","year":"2024","unstructured":"Lin D, et al. Long-term application of organic fertilizer prompting the dispersal of antibiotic resistance genes and their health risks in the soil plastisphere. Environ Int. 2024;183:108431.","journal-title":"Environ Int"},{"key":"2044_CR44","doi-asserted-by":"publisher","unstructured":"Yin X, Xi Chen Xiao-Tao J, Ying Y, Bing L, Marcus Ho-Hin S, Tommy TY Lam et al. Toward a universal unit for quantification of antibiotic resistance genes in environmental samples. Environmental Science & Technology. 2023;57(26):9713\u201321. https:\/\/doi.org\/10.1021\/acs.est.3c00159","DOI":"10.1021\/acs.est.3c00159"},{"key":"2044_CR45","doi-asserted-by":"crossref","unstructured":"Schoch, C.L., et al., NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database, 2020. 2020: p. baaa062.","DOI":"10.1093\/database\/baaa062"},{"issue":"16","key":"2044_CR46","doi-asserted-by":"publisher","first-page":"11429","DOI":"10.1021\/acs.est.2c03627","volume":"56","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zhang G, Ju F. Using culture-enriched phenotypic metagenomics for targeted high-throughput monitoring of the clinically important fraction of the \u03b2-lactam resistome. Environ Sci Technol. 2022;56(16):11429\u201339.","journal-title":"Environ Sci Technol"},{"issue":"5","key":"2044_CR47","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1021\/acs.estlett.0c00202","volume":"7","author":"EW Rice","year":"2020","unstructured":"Rice EW, et al. Determining hosts of antibiotic resistance genes: a review of methodological advances. Environ Sci Technol Lett. 2020;7(5):282\u201391.","journal-title":"Environ Sci Technol Lett"},{"key":"2044_CR48","unstructured":"Institute, C.a.L.S., Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 11th edition CLSI standard M07. 2018, Wayne, PA: Clinical and Laboratory Standards Institute."},{"key":"2044_CR49","unstructured":"Institute, C.a.L.S., Performance standards for antimicrobial susceptibility testing, 32nd edition CLSI supplement M100. 2022, Wayne, PA: Clinical and Laboratory Standards Institute."},{"key":"2044_CR50","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2021. https:\/\/www.R-project.org\/\u00a0"},{"issue":"2","key":"2044_CR51","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/femsec\/fiaa255","volume":"97","author":"C Liu","year":"2021","unstructured":"Liu C, et al. microeco: an R package for data mining in microbial community ecology. FEMS microbiology ecology. 2021;97(2):255.","journal-title":"FEMS microbiology ecology"},{"issue":"6","key":"2044_CR52","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41558-018-0161-6","volume":"8","author":"DR MacFadden","year":"2018","unstructured":"MacFadden DR, et al. Antibiotic resistance increases with local temperature. Nat Clim Chang. 2018;8(6):510\u20134.","journal-title":"Nat Clim Chang"},{"issue":"11","key":"2044_CR53","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/s41558-020-0899-5","volume":"10","author":"SE Greenspan","year":"2020","unstructured":"Greenspan SE, et al. Warming drives ecological community changes linked to host-associated microbiome dysbiosis. Nat Clim Chang. 2020;10(11):1057\u201361.","journal-title":"Nat Clim Chang"},{"key":"2044_CR54","doi-asserted-by":"publisher","first-page":"128442","DOI":"10.1016\/j.jhazmat.2022.128442","volume":"430","author":"Z Li","year":"2022","unstructured":"Li Z, et al. Climate warming increases the proportions of specific antibiotic resistance genes in natural soil ecosystems. J Hazard Mater. 2022;430:128442.","journal-title":"J Hazard Mater"},{"issue":"9","key":"2044_CR55","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/s41558-022-01426-1","volume":"12","author":"C Mora","year":"2022","unstructured":"Mora C, et al. Over half of known human pathogenic diseases can be aggravated by climate change. Nat Clim Chang. 2022;12(9):869\u201375.","journal-title":"Nat Clim Chang"},{"issue":"12","key":"2044_CR56","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/s41558-018-0347-y","volume":"8","author":"GQ Romero","year":"2018","unstructured":"Romero GQ, et al. Global predation pressure redistribution under future climate change. Nat Clim Chang. 2018;8(12):1087\u201391.","journal-title":"Nat Clim Chang"},{"issue":"4","key":"2044_CR57","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.chom.2023.03.017","volume":"31","author":"JM de Sousa","year":"2023","unstructured":"de Sousa JM, Louren\u00e7o M, Gordo I. Horizontal gene transfer among host-associated microbes. Cell Host Microbe. 2023;31(4):513\u201327.","journal-title":"Cell Host Microbe"},{"key":"2044_CR58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mib.2018.04.004","volume":"45","author":"KL Wyres","year":"2018","unstructured":"Wyres KL, Holt KE. Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria. Curr Opin Microbiol. 2018;45:131\u20139.","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"2044_CR59","doi-asserted-by":"publisher","first-page":"e00181","DOI":"10.1128\/CMR.00181-19","volume":"33","author":"DM De Oliveira","year":"2020","unstructured":"De Oliveira DM, et al. Antimicrobial resistance in ESKAPE pathogens. Clin microbiol rev. 2020;33(3):e00181-19.","journal-title":"Clin microbiol rev."},{"key":"2044_CR60","doi-asserted-by":"publisher","first-page":"133335","DOI":"10.1016\/j.jhazmat.2023.133335","volume":"465","author":"B Ni","year":"2024","unstructured":"Ni B, et al. Effects of heavy metal and disinfectant on antibiotic resistance genes and virulence factor genes in the plastisphere from diverse soil ecosystems. J Hazard Mater. 2024;465:133335.","journal-title":"J Hazard Mater"},{"key":"2044_CR61","first-page":"791","volume-title":"Climate change exacerbates almost two-thirds of pathogenic diseases affecting humans","author":"T McKenzie","year":"2022","unstructured":"McKenzie T, Gaw IM. Climate change exacerbates almost two-thirds of pathogenic diseases affecting humans. Berlin, 14197, Germany: Heidelberger Platz 3; 2022. p. 791\u2013791."},{"issue":"4","key":"2044_CR62","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/1365-2656.12180","volume":"83","author":"BD Elderd","year":"2014","unstructured":"Elderd BD, Reilly JR. Warmer temperatures increase disease transmission and outbreak intensity in a host\u2013pathogen system. J Anim Ecol. 2014;83(4):838\u201349.","journal-title":"J Anim Ecol"},{"issue":"1","key":"2044_CR63","doi-asserted-by":"publisher","first-page":"e04069","DOI":"10.1128\/spectrum.04069-22","volume":"11","author":"SB Busi","year":"2023","unstructured":"Busi SB, et al. Glacier-fed stream biofilms harbor diverse resistomes and biosynthetic gene clusters. Microbiology Spectrum. 2023;11(1):e04069-e4122.","journal-title":"Microbiology Spectrum"},{"issue":"17","key":"2044_CR64","doi-asserted-by":"publisher","first-page":"eadl2281","DOI":"10.1126\/sciadv.adl2281","volume":"10","author":"X Dong","year":"2024","unstructured":"Dong X, et al. A vast repertoire of secondary metabolites potentially influences community dynamics and biogeochemical processes in cold seeps. Science Advances. 2024;10(17):eadl2281.","journal-title":"Science Advances."},{"issue":"7","key":"2044_CR65","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1038\/s41396-022-01232-9","volume":"16","author":"NC Dove","year":"2022","unstructured":"Dove NC, Ta\u015f N, Hart SC. Ecological and genomic responses of soil microbiomes to high-severity wildfire: linking community assembly to functional potential. ISME J. 2022;16(7):1853\u201363.","journal-title":"ISME J"},{"issue":"6","key":"2044_CR66","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.biotechadv.2010.06.005","volume":"28","author":"JM Pastor","year":"2010","unstructured":"Pastor JM, et al. Ectoines in cell stress protection: uses and biotechnological production. Biotechnol Adv. 2010;28(6):782\u2013801.","journal-title":"Biotechnol Adv"},{"issue":"19","key":"2044_CR67","doi-asserted-by":"publisher","first-page":"4454","DOI":"10.1021\/jf500505n","volume":"62","author":"T Bo","year":"2014","unstructured":"Bo T, et al. Metabolomic analysis of antimicrobial mechanisms of \u03b5-poly-l-lysine on Saccharomyces cerevisiae. J Agric Food Chem. 2014;62(19):4454\u201365.","journal-title":"J Agric Food Chem"},{"issue":"6","key":"2044_CR68","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0098-2997(03)00030-X","volume":"24","author":"W Stahl","year":"2003","unstructured":"Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med. 2003;24(6):345\u201351.","journal-title":"Mol Aspects Med"},{"issue":"3","key":"2044_CR69","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41579-019-0284-4","volume":"18","author":"J Kramer","year":"2020","unstructured":"Kramer J, \u00d6zkaya \u00d6, K\u00fcmmerli R. Bacterial siderophores in community and host interactions. Nat Rev Microbiol. 2020;18(3):152\u201363.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"2044_CR70","doi-asserted-by":"publisher","first-page":"7016","DOI":"10.1038\/s41467-021-27297-2","volume":"12","author":"J Behnsen","year":"2021","unstructured":"Behnsen J, et al. Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut. Nat Commun. 2021;12(1):7016.","journal-title":"Nat Commun"},{"issue":"2","key":"2044_CR71","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ismej.2017.137","volume":"12","author":"H Bruns","year":"2018","unstructured":"Bruns H, et al. Function-related replacement of bacterial siderophore pathways. ISME J. 2018;12(2):320\u20139.","journal-title":"ISME J"},{"issue":"11","key":"2044_CR72","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41579-021-00569-w","volume":"19","author":"S Heilbronner","year":"2021","unstructured":"Heilbronner S, et al. The microbiome-shaping roles of bacteriocins. Nat Rev Microbiol. 2021;19(11):726\u201339.","journal-title":"Nat Rev Microbiol"},{"key":"2044_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01155-1","volume":"9","author":"L Liu","year":"2021","unstructured":"Liu L, et al. Charting the complexity of the activated sludge microbiome through a hybrid sequencing strategy. Microbiome. 2021;9:1\u201315.","journal-title":"Microbiome"}],"container-title":["Microbiome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40168-025-02044-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40168-025-02044-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40168-025-02044-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T16:09:27Z","timestamp":1739376567000},"score":1,"resource":{"primary":{"URL":"https:\/\/microbiomejournal.biomedcentral.com\/articles\/10.1186\/s40168-025-02044-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2044"],"URL":"https:\/\/doi.org\/10.1186\/s40168-025-02044-7","relation":{},"ISSN":["2049-2618"],"issn-type":[{"value":"2049-2618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"3 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}