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The longitudinal study was approved by the Ethics committees in Denmark (H-16023435). These studies were additionally approved by the Institutional Review Board at the George Washington University (IRB#041631). Written informed consent was obtained from all participants prior to study inclusion.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"C.M.L. and L.B.P. are stockholders in Trench Therapeutics. The authors declare that this financial interest does not influence the design, analysis, or interpretation of the study findings. The other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38"}}