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While microbial cooperation and competition are known to shape environmental and intestinal microbial communities, their impact on pathogen colonization within the nasal microbiome is largely unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using a newly curated nasal strain collection and systematic pairwise interaction analysis, we investigated competitive and collaborative traits between diverse\n                      <jats:italic>S. aureus<\/jats:italic>\n                      strains and nasal communities. Our experiments revealed that nasal species strongly modulate\n                      <jats:italic>S. aureus<\/jats:italic>\n                      growth in a strain- and community-specific manner both in vitro and in gnotobiotic mice. Nutrient-dependent interactions emerged as key drivers. In one example, we found that tyrosine provided by synthetic communities supported proliferation of an auxotrophic\n                      <jats:italic>S. aureus<\/jats:italic>\n                      strain. Screening of a large collection of\n                      <jats:italic>S. aureus<\/jats:italic>\n                      strains identified tyrosine dependency in 8% of strains, with colonization impaired in the absence of supportive communities, indicating broader relevance of this interaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings reveal distinct metabolic adaptations that enable\n                      <jats:italic>S. aureus<\/jats:italic>\n                      to exploit specific features of resident nasal communities, highlighting complex interspecies networks that influence colonization in the human nose. These insights may inform microbiome-editing strategies to displace\n                      <jats:italic>S. aureus<\/jats:italic>\n                      from the nasal niche.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40168-026-02563-x","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:12:55Z","timestamp":1792732375000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amino acid availability influences Staphylococcus aureus interaction with the nasal microbiota in a strain- and community-specific manner"],"prefix":"10.1186","volume":"14","author":[{"given":"Laura","family":"Camus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey John","family":"Power","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Navarro-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Krismer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser","family":"Bilici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levin Joe","family":"Klages","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Starostin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Kalinowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Largus Theodora","family":"Angenent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Heilbronner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2563_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj3502","volume":"382","author":"F Spragge","year":"2023","unstructured":"Spragge F, et al. 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