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Current pharmacological treatment strategies are ineffective to prevent the OA progression; however, cellular therapies have the potential to regenerate the lost cartilage, combat cartilage degeneration, provide pain relief, and improve patient mobility. One of the most promising sources of cellular regenerative medicine is from mesenchymal stem cells (MSCs). MSCs can be isolated from adipose tissue, bone marrow, synovial tissue, and other sources. The aim of this review is to compile recent advancement in cellular based therapy more specifically in relation to MSCs in the treatment of osteoarthritis.<\/jats:p>","DOI":"10.1186\/s40169-016-0112-7","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T07:42:58Z","timestamp":1470814978000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis"],"prefix":"10.1002","volume":"5","author":[{"given":"John","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Orthopedics Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monte","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kolhe","sequence":"additional","affiliation":[{"name":"Department of Pathology Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Isales","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Georgia Regents University Augusta GA USA"},{"name":"Institute of Regenerative and Reparative Medicine Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hamrick","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy Georgia Regents University Augusta GA USA"},{"name":"Institute of Regenerative and Reparative Medicine Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-6759","authenticated-orcid":false,"given":"Sadanand","family":"Fulzele","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Georgia Regents University Augusta GA USA"},{"name":"Institute of Regenerative and Reparative Medicine Georgia Regents University Augusta GA USA"},{"name":"Department of Orthopedics Surgery Augusta University 30904 Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"issue":"21","key":"e_1_2_10_2_1","first-page":"578","article-title":"Centers for disease control and prevention (cdc). impact of arthritis and multiple chronic conditions on selected life domains\u2014United States, 2013","volume":"64","author":"Qin J","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"44","key":"e_1_2_10_3_1","first-page":"869","article-title":"Prevalence of doctor\u2010diagnosed arthritis and arthritis\u2010attributable activity limitation\u2014United States, 2010\u20132012","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2016.01.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.05.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3457-8"},{"issue":"20","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40001-015-0115-7","article-title":"Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network metaanalysis","volume":"13","author":"Kongtharvonskul J","year":"2015","journal-title":"Eur J Med Res"},{"key":"e_1_2_10_8_1","unstructured":"Vu\u010dkovi\u0107S Vujovi\u0107KS Medi\u0107B SrebroD Mosti\u0107D.Prevention of renal complications induced by non\u2010steroidal anti\u2010inflammatory drugs. 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