{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:06:05Z","timestamp":1767175565175,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be limited in assessing various symptoms of MS that are important. Our study aimed at evaluating the efficacy of a new scoring system, reverse nutech functional score (RNFS) as compared to EDSS in assessing patients with MS treated with human embryonic stem cell (hESC) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The MS patients were treated with hESC therapy for one treatment period. All the patients were evaluated with EDSS and RNFS at baseline and after the hESC therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included a total of 24 MS patients with mean age of 45 year. The patients showed an improvement in parameters (sleeping disorders, paralysis, paraesthesia, myalgia, muscle weakness, memory, language, irritability, eye pain, depression and coordination, communication, breathing pattern, attention and appetite) associated with MS when evaluated with RNFS. This improvement went unnoticed when the patients were assessed with EDSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RNFS can efficiently assess the effectiveness of hESC therapy in treating patients with MS. It could be a suitable scoring system for patients with MS as it can assess the slightest improvements in the patients. Use in other settings would be helpful in assessing its utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40169-016-0124-3","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T07:48:21Z","timestamp":1476949701000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy"],"prefix":"10.1002","volume":"5","author":[{"given":"Geeta","family":"Shroff","sequence":"first","affiliation":[{"name":"Nutech Mediworld H\u20108, Green Park Extension 110016 New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.11.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10251"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073-13.1.4"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"A12","article-title":"The prevalence of multiple sclerosis in 3 US communities","volume":"7","author":"Noonan CW","year":"2010","journal-title":"Prev Chronic Dis"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"1935","article-title":"Diagnosis and management of multiple sclerosis","volume":"70","author":"Calabresi PA","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01352.x"},{"key":"e_1_2_7_8_1","first-page":"CD006264","article-title":"Corticosteroids for the long\u2010term treatment in multiple sclerosis","volume":"1","author":"Ciccone A","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.1.141"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5348\/crint-2015-15-CR-10","article-title":"Human embryonic stem cell for the treatment of multiple sclerosis: a case report","volume":"4","author":"Shroff G","year":"2015","journal-title":"Case Rep Int"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"1066","article-title":"Scoring system approach of reverse Nutech functional score to assess patients with multiple sclerosis","volume":"4","author":"Shroff G","year":"2015","journal-title":"J Neurol Transl Neurosci"},{"issue":"4","key":"e_1_2_7_13_1","first-page":"3730","article-title":"Establishment and characterization of a neuronal cell line derived from a 2\u2010cell stage human embryo: clinically tested cell\u2010based therapy for neurological disorders","volume":"6","author":"Shroff G","year":"2015","journal-title":"Int J Recent Sci Res"},{"issue":"3","key":"e_1_2_7_14_1","first-page":"132","article-title":"Safety of human embryonic stem cells in patients with terminal\/incurable conditions\u2014a retrospective analysis","volume":"22","author":"Shroff G","year":"2015","journal-title":"Ann Neurosci"},{"key":"e_1_2_7_15_1","first-page":"153","article-title":"Measurement of disability in multiple sclerosis","volume":"13","author":"Gray O","year":"2008","journal-title":"Neurol Asia"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.12.1901"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/026921559601000306"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.251"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"HealyBC EnglerD GlanzB MusallamA ChitnisT(2013)Assessment of definitions of sustained disease progression in relapsing\u2010remitting multiple sclerosis. 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