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In this study, we analyzed the association between<jats:italic>CXCL9<\/jats:italic>\u2010<jats:italic>11<\/jats:italic>polymorphisms and liver fibrosis in HCV\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study in 389 patients who were genotyped for<jats:italic>CXCL9<\/jats:italic>\u2010<jats:italic>11<\/jats:italic>polymorphisms (<jats:italic>CXCL9<\/jats:italic>rs10336,<jats:italic>CXCL10<\/jats:italic>rs3921, and<jats:italic>CXCL11<\/jats:italic>rs4619915) using the Sequenom's MassARRAY platform. The primary outcome variable was the liver stiffness measurement (LSM). We established three cut\u2010offs of LSM: LSM \u2265 7.1 kPa (F \u2265 2\u2014significant fibrosis), LSM \u2265 9.5 kPa (F \u2265 3\u2014advanced fibrosis), and LSM \u2265 12.5 kPa (F4\u2014cirrhosis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recessive, overdominant and codominant models of inheritance showed significant values, but the overdominant model was the best fitting our data. In this case,<jats:italic>CXCL9<\/jats:italic>rs10336 AG,<jats:italic>CXCL10<\/jats:italic>rs3921 CG and<jats:italic>CXCL11<\/jats:italic>rs4619915 AG were mainly associated with lower values of LSM [(adjusted GMR (aGMR) = 0.85 (p = 0.005), aGMR = 0.84 (p = 0.003), and aGMR = 0.84 (p = 0.003), respectively]. Patients with<jats:italic>CXCL9<\/jats:italic>rs10336 AG genotype had lower odds of significant fibrosis (LSM \u2265 7.1 kPa) [adjusted OR (aOR) = 0.59 (p = 0.016)], advanced fibrosis (LSM \u2265 9.5 kPa) [aOR = 0.54 (p = 0.010)], and cirrhosis (LSM \u2265 12.5 kPa) [aOR = 0.56 (p = 0.043)]. Patients with<jats:italic>CXCL10<\/jats:italic>rs3921 CG or<jats:italic>CXCL11<\/jats:italic>rs4619915 AG genotypes had lower odds of significant fibrosis (LSM \u2265 7.1 kPa) [adjusted OR (aOR) = 0.56 (p = 0.008)], advanced fibrosis (LSM \u2265 9.5 kPa) [aOR = 0.55 (p = 0.013)], and cirrhosis (LSM \u2265 12.5 kPa) [aOR = 0.57 (p = 0.051)]. Additionally,<jats:italic>CXCL9<\/jats:italic>\u2010<jats:italic>11<\/jats:italic>polymorphisms were related to lower liver stiffness under a codominant model of inheritance, being the heterozygous genotypes also protective against hepatic fibrosis. In the recessive inheritance model, the<jats:italic>CXCL9<\/jats:italic>rs10336 AA,<jats:italic>CXCL10<\/jats:italic>rs3921 CC and<jats:italic>CXCL11<\/jats:italic>rs4619915 AA were associated with higher LSM values [(adjusted GMR (aGMR) = 1.19 (p = 0.030), aGMR = 1.21 (p = 0.023), and aGMR = 1.21 (p = 0.023), respectively]. Moreover, patients with<jats:italic>CXCL9<\/jats:italic>rs10336 AA genotype had higher odds of significant fibrosis (LSM \u2265 7.1 kPa) [adjusted OR (aOR) = 1.83 (p = 0.044)] and advanced fibrosis (LSM \u2265 9.5 kPa) [aOR = 1.85 (p = 0.045)]. Furthermore, patients with<jats:italic>CXCL10<\/jats:italic>rs3921 CC or<jats:italic>CXCL11<\/jats:italic>rs4619915 AA genotypes had higher odds of advanced fibrosis (LSM \u2265 9.5 kPa) [aOR = 1.89 (p = 0.038)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CXCL9\u2010<jats:italic>11<\/jats:italic>polymorphisms were related to likelihood of having liver fibrosis in HCV\u2010infected patients. Our data suggest that<jats:italic>CXCL9<\/jats:italic>\u2010<jats:italic>11<\/jats:italic>polymorphisms may play a significant role against the progression of CHC and could help prioritize antiviral therapy.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40169-017-0156-3","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T12:56:49Z","timestamp":1501246609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>CXCL9<\/i>\u2010<i>11<\/i>polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross\u2010sectional study"],"prefix":"10.1002","volume":"6","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"Jim\u00e9nez\u2010Sousa","sequence":"first","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad Centro Nacional de Microbiolog\u00eda Instituto de Salud Carlos III Carretera Majadahonda\u2010 Pozuelo, Km 2.2 28220 Majadahonda, 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