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We defined biological circadian rhythms as Yin (tumoricidal) and Yang (tumorigenic) arms of acute inflammation (effective immunity) involving immune and non\u2010immune systems. Role of pathogens in altering immunity and inducing diseases and cancer has been documented for over a century. However, in 1955s decision makers in cancer\/medical establishment allowed public (current baby boomers) to consume million doses of virus\u2010contaminated polio vaccines. The risk of cancer incidence and mortality sharply rose from 5% (rate of hereditary\/genetic or innate disease) in 1900s, to its current scary status of 33% or 50% among women and men, respectively. Despite better hygiene, modern detection technologies and discovery of antibiotics, baby boomers and subsequent 2\u20133 generations are sicker than previous generations at same age. American health status ranks last among other developed nations while America invests highest amount of resources for healthcare. In this perspective we present evidence that cancer is an induced disease of twentieth century, facilitated by a great deception of cancer\/medical establishment for huge corporate profits. Unlike popularized opinions that cancer is 100, 200 or 1000 diseases, we demonstrate that cancer is only one disease; the severe disturbances in biorhythms (differential bioenergetics) or loss of balance in Yin and Yang of effective immunity. Cancer projects that are promoted and funded by decision makers are reductionist approaches, wrong and unethical and resulted in loss of millions of precious lives and financial toxicity to society. Public vaccination with pathogen\u2010specific vaccines (e.g., flu, hepatitis, HPV, meningitis, measles) weakens, not promotes, immunity. Results of irresponsible projects on cancer sciences or vaccines are increased population of drug\u2010dependent sick society. Outcome failure rates of claimed \u2018targeted\u2019 drugs, \u2018precision\u2019 or \u2018personalized\u2019 medicine are 90% (\u00b1\u20095) for solid tumors. We demonstrate that aging, frequent exposures to environmental hazards, infections and pathogen\u2010specific vaccines and ingredients are \u2018antigen overload\u2019 for immune system, skewing the Yin and Yang response profiles and leading to induction of \u2018mild\u2019, \u2018moderate\u2019 or \u2018severe\u2019 immune disorders. Induction of decoy or pattern recognition receptors (e.g., PRRs), such as IRAK\u2010M or IL\u20101dRs (\u2018designer\u2019 molecules) and associated genomic instability and over\u2010expression of growth promoting factors (e.g., pyruvate kinases, mTOR and PI3Ks, histamine, PGE2, VEGF) could lead to immune tolerance, facilitating cancer cells to hijack anabolic machinery of immunity (Yang) for their increased growth requirements. Expression of constituent embryonic factors would negatively regulate differentiation of tumor cells through epithelial\u2013mesenchymal\u2010transition and create \u201cdual negative feedback loop\u201d that influence tissue metabolism under hypoxic conditions. It is further hypothesized that induction of tolerance creates \u2018dark energy\u2019 and increased entropy and temperature in cancer microenvironment allowing disorderly cancer proliferation and mitosis along with increased glucose metabolism via Crabtree and Pasteur Effects, under mitophagy and ribophagy, conditions that are toxic to host survival. Effective translational medicine into treatment requires systematic and logical studies of complex interactions of tumor cells with host environment that dictate clinical outcomes. Promoting effective immunity (biological circadian rhythms) are fundamental steps in correcting host differential bioenergetics and controlling cancer growth, preventing or delaying onset of diseases and maintaining public health. The author urges independent professionals and policy makers to take a closer look at cancer dilemma and stop the \u2018scientific\/medical ponzi schemes\u2019 of a powerful group that control a drug\u2010dependent sick society before all hopes for promoting public health evaporate.<\/jats:p>","DOI":"10.1186\/s40169-018-0193-6","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T04:17:01Z","timestamp":1530159421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and \u2018Dark Energy\u2019: loss of biorhythms (Anabolism v. Catabolism)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-2742","authenticated-orcid":false,"given":"Mahin","family":"Khatami","sequence":"first","affiliation":[{"name":"Inflammation Aging and Cancer National Cancer Institute (NCI) National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"273","article-title":"Uber den jetzigen Stand der Karzinomforschung","volume":"5","author":"Ehrlich P","year":"1909","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"5","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1084\/jem.12.5.696","article-title":"A transmissible avian neoplasm (Sarcoma of the common fowl)","volume":"12","author":"Rous P","year":"1910","journal-title":"J Exp Med"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5022.779"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152606"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-66475-0","volume-title":"Inflammation, aging and cancer: biological injustices to molecular village that guard health","author":"Khatami M","year":"2017"},{"key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12013-011-9319-9","article-title":"Unresolved inflammation and cancer: loss of natural immune surveillance as the correct \u2018target\u2019 for therapy! 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