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Phosphonic diamide derivatives enhance the cellular permeability and in turn their biological activities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A series of heteroaryl phosphonicdiamide derivatives were designed as therapeutics to control and manage type2 diabetes. Initially defined Lipinski parameters encouraged them as safer drugs. Molecular docking of these compounds against Protein tyrosine phosphatase (PTP), the potential therapeutic target of type 2 diabetes, revealed their potential binding ability explaining their anti-diabetic activity in terms of PTP inhibition. Human intestinal absorption, Caco-2 cell permeability, MDCK cell permeability, BBB penetration, skin permeability and plasma protein binding abilities of the title compounds were calculated by PreADMET server. A convenient method has been developed for the synthesis of title compounds through the formation of 1-ethoxy-N,N\u2019-bis(4-fluorobenzyl\/pyridin-3-ylmethyl)phosphinediamine by the reaction of 4-fluorobenzylamine\/ 3-picolylamine with ethyldichlorophosphite, subsequently reacted with heteroaryl halides using lanthanum(III) chloride as a catalyst.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All the compounds exhibited significant <jats:italic>in vitro<\/jats:italic> anti-oxidant activity and <jats:italic>in vivo<\/jats:italic> evaluation in streptozotocin induced diabetic rat models revealed that the normal glycemic levels were observed on 12<jats:sup>th<\/jats:sup> day by <jats:bold>9a<\/jats:bold> and 20<jats:sup>th<\/jats:sup> day by <jats:bold>5b<\/jats:bold>, <jats:bold>5c<\/jats:bold>, <jats:bold>9e<\/jats:bold> and <jats:bold>9f.<\/jats:bold> The remaining compounds also exhibited normal glycemic levels by 25<jats:sup>th<\/jats:sup> day.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The results from molecular modeling, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies are suggesting them as safer and effective therapeutic agents against type2 diabetes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40199-014-0076-3","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T16:34:51Z","timestamp":1419611691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents"],"prefix":"10.1186","volume":"22","author":[{"given":"Kuruva Chandra","family":"Sekhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasheed","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhava","family":"Golla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothi Kumar","family":"MV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanda Kumar","family":"Yellapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Appa Rao","family":"Chippada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naga Raju","family":"Chamarthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,27]]},"reference":[{"key":"76_CR1","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S0006-2952(00)00305-1","volume":"60","author":"BP Kennedy","year":"2000","unstructured":"Kennedy BP, Ramachandran C: Protein tyrosine phosphatase-1B in diabetes. 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