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Serum VEGF concentration of participants were determined using enzyme-linked immunosorbent assay (ELISA) technique. Genomic DNAs were isolated from peripheral blood samples and quantified by nanodrop spectrophotometer one. Single nucleotide polymorphisms genotyping was carried out by polymerase chain reaction and restriction fragment length polymorphism (PCR\u2013RFLP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean age of participants was 32.96\u2009\u00b1\u20096.91\u00a0years for control and 32.04\u2009\u00b1\u20097.56\u00a0years for cases. VEGF levels in case and control groups were not statistically different (82.68\u00a0pg\/ml [69.11\u2013121.11\u00a0pg\/ml] vs. 82.81\u00a0pg\/ml [72.90\u2013113.82\u00a0pg\/ml] respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.967). All four genotypes examined were in Hardy\u2013Weinberg equilibrium. Minor allele frequency of\u2009\u2212\u2009460T\u2009&gt;\u2009C,\u2009\u2212\u20091154G\u2009&gt;\u2009A,\u2009+\u2009936C\u2009&gt;\u2009T and\u2009+\u20092578C\u2009&gt;\u2009A were 24%, 8%, 6% and 10% in the control and 19%, 9%, 5% and 14% in endometriosis patients. However, allele and genotype distributions of\u2009\u2212\u2009460T\u2009&gt;\u2009C,\u2009\u2212\u20091154G\u2009&gt;\u2009A,\u2009+\u2009936C\u2009&gt;\u2009T and\u2009+\u20092578C\u2009&gt;\u2009A VEGF polymorphisms in endometriosis patients and control were not significantly different (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our preliminary findings revealed no association between endometriosis and\u2009\u2212\u2009460T\u2009&gt;\u2009C,\u2009\u2212\u20091154G\u2009&gt;\u2009A,\u2009+\u2009936C\u2009&gt;\u2009T and\u2009+\u20092578C\u2009&gt;\u2009A of VEGF genes among Nigerian women.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40246-021-00364-x","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T11:02:43Z","timestamp":1635591763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic polymorphisms of Vascular Endothelial Growth Factor (VEGF) associated with endometriosis in Nigerian women"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-3242","authenticated-orcid":false,"given":"Ochuwa Adiketu","family":"Babah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyesola Oyewole","family":"Ojewunmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinniyi Adediran","family":"Osuntoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosede Bukola","family":"Afolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"issue":"13","key":"364_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA. 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