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Using two-sample Mendelian randomization, we found that genetic proxied plasma campesterol level showed negative correlation with the risk of both cholelithiasis and cholecystitis. Furthermore, the increased risk of cholelithiasis is correlating with the increased level of plasma campesterol. Lastly, genetic colocalization study showed that the leading SNP, rs4299376, which residing at the ABCG5\/ABCG8 gene loci, was shared by plasma campesterol level and cholelithiasis, indicating that the aberrant transportation of plant sterol\/cholesterol from the blood stream to the bile duct\/gut lumen might be the key in preventing cholesterol gallstone formation.<\/jats:p>","DOI":"10.1186\/s40246-024-00583-y","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T14:03:29Z","timestamp":1707746609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasma campesterol and ABCG5\/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses"],"prefix":"10.1186","volume":"18","author":[{"given":"Jiarui","family":"Mi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"5","key":"583_CR1","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1007\/s11605-023-05604-0","volume":"27","author":"S Li","year":"2023","unstructured":"Li S, Guizzetti L, Ma C, Shaheen AA, Dixon E, Ball C, Wani S, Forbes N. Epidemiology and outcomes of symptomatic cholelithiasis and cholecystitis in the USA: trends and urban-rural variations. J Gastrointest Surg. 2023;27(5):932\u201344.","journal-title":"J Gastrointest Surg"},{"key":"583_CR2","doi-asserted-by":"publisher","first-page":"16024","DOI":"10.1038\/nrdp.2016.24","volume":"2","author":"F Lammert","year":"2016","unstructured":"Lammert F, Gurusamy K, Ko CW, Miquel JF, Mendez-Sanchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ. Gallstones. Nat Rev Dis Primers. 2016;2:16024.","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"583_CR3","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1007\/s12072-022-10360-5","volume":"16","author":"J Mi","year":"2022","unstructured":"Mi J, Jiang L, Liu Z, Wu X, Zhao N, Wang Y, Bai X. Identification of blood metabolites linked to the risk of cholelithiasis: a comprehensive Mendelian randomization study. 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