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We confirm that our clinical cohort study adheres fully to the principles outlined in the Declaration of Helsinki. All authors confirmed that all methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"For our Xinhua cohort, consent was obtained from the participants (or from parents or legal guardians for children under 16. Any personally identifiable biomedical, clinical, or biometric data included in the manuscript was informed consent from the subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}