{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:29:56Z","timestamp":1788838196753,"version":"build-2803163510"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Construction Fund of Medical Key Disciplines of Hangzhou","award":["OO20190001"],"award-info":[{"award-number":["OO20190001"]}]},{"DOI":"10.13039\/100022963","name":"Key R&D Program of Zhejiang Province","doi-asserted-by":"crossref","award":["2023C03054"],"award-info":[{"award-number":["2023C03054"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100022963","name":"Key R&D Program of Zhejiang Province","doi-asserted-by":"crossref","award":["2024C03048"],"award-info":[{"award-number":["2024C03048"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum Genomics"],"DOI":"10.1186\/s40246-025-00840-8","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T13:13:41Z","timestamp":1761570821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MX1 is a novel crucial prognostic and therapeutic target inducing chemoresistance in right-sided colon cancer: insights from machine learning-based multi-omics analysis"],"prefix":"10.1186","volume":"19","author":[{"given":"Yingdong","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"840_CR1","first-page":"7","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7\u201334.","journal-title":"CA Cancer J Clin"},{"key":"840_CR2","first-page":"250","volume":"68","author":"AMD Wolf","year":"2018","unstructured":"Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American cancer society. CA Cancer J Clin. 2018;68:250\u201381.","journal-title":"CA Cancer J Clin"},{"key":"840_CR3","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"840_CR4","first-page":"69","volume":"84","author":"S Stintzing","year":"2017","unstructured":"Stintzing S, Tejpar S, Gibbs P, et al. Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes. Eur J Cancer Oxf Engl 1990. 2017;84:69\u201380.","journal-title":"Eur J Cancer Oxf Engl 1990"},{"key":"840_CR5","first-page":"e000599","volume":"4","author":"M Benavides","year":"2019","unstructured":"Benavides M, D\u00edaz-Rubio E, Carrato A, et al. Tumour location and efficacy of first-line EGFR inhibitors in KRAS\/RAS wild-type metastatic colorectal cancer: retrospective analyses of two phase II randomised Spanish TTD trials. ESMO Open. 2019;4:e000599.","journal-title":"ESMO Open"},{"key":"840_CR6","first-page":"106","volume":"184","author":"D Rossini","year":"2023","unstructured":"Rossini D, Boccaccino A, Carullo M, et al. Primary tumour side as a driver for treatment choice in RAS wild-type metastatic colorectal cancer patients: a systematic review and pooled analysis of randomised trials. Eur J Cancer Oxf Engl 1990. 2023;184:106\u201316.","journal-title":"Eur J Cancer Oxf Engl 1990"},{"key":"840_CR7","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1245\/s10434-008-0015-y","volume":"15","author":"RA Meguid","year":"2008","unstructured":"Meguid RA, Slidell MB, Wolfgang CL, et al. Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol. 2008;15:2388\u201394.","journal-title":"Ann Surg Oncol"},{"key":"840_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/jamaoncol.2016.4227","volume":"3","author":"F Petrelli","year":"2017","unstructured":"Petrelli F, Tomasello G, Borgonovo K, et al. Prognostic survival associated with Left-Sided vs Right-Sided colon cancer: A systematic review and Meta-analysis. JAMA Oncol. 2017;3:211\u20139.","journal-title":"JAMA Oncol"},{"key":"840_CR9","first-page":"e671","volume":"17","author":"S Narayanan","year":"2018","unstructured":"Narayanan S, Gabriel E, Attwood K, et al. Association of clinicopathologic and molecular markers on Stage-specific survival of right versus left colon cancer. Clin Colorectal Cancer. 2018;17:e671\u20138.","journal-title":"Clin Colorectal Cancer"},{"key":"840_CR10","doi-asserted-by":"publisher","first-page":"1403171","DOI":"10.3389\/fmed.2024.1403171","volume":"11","author":"D Liu","year":"2024","unstructured":"Liu D, Li C, Deng Z, et al. Multi-omics analysis reveals the landscape of tumor microenvironments in left-sided and right-sided colon cancer. Front Med. 2024;11:1403171.","journal-title":"Front Med"},{"key":"840_CR11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41698-025-00892-y","volume":"9","author":"M Abdel Hamid","year":"2025","unstructured":"Abdel Hamid M, Pammer LM, Oberparleiter S, et al. Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies. NPJ Precis Oncol. 2025;9:116.","journal-title":"NPJ Precis Oncol"},{"key":"840_CR12","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1186\/s12967-025-06481-8","volume":"23","author":"P Gao","year":"2025","unstructured":"Gao P, Zhou C, Yang H, et al. Comparison of Circulating immune signatures across different consensus molecular subtypes (CMS) and between left- and right-sided lesions in stage II colorectal cancer using single-cell mass cytometry. J Transl Med. 2025;23:496.","journal-title":"J Transl Med"},{"key":"840_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12943-024-02133-5","volume":"23","author":"A Jain","year":"2024","unstructured":"Jain A, Morris MT, Berardi D, et al. Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification. Mol Cancer. 2024;23:211.","journal-title":"Mol Cancer"},{"key":"840_CR14","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s40168-024-01987-7","volume":"12","author":"L Liang","year":"2024","unstructured":"Liang L, Kong C, Li J, et al. Distinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer. Microbiome. 2024;12:274.","journal-title":"Microbiome"},{"key":"840_CR15","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1136\/gutjnl-2024-332193","volume":"74","author":"Q Zhou","year":"2025","unstructured":"Zhou Q, Lei L, Cheng J, et al. Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy. Gut. 2025;74:214\u201328.","journal-title":"Gut"},{"key":"840_CR16","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.biochi.2007.04.015","volume":"89","author":"O Haller","year":"2007","unstructured":"Haller O, Staeheli P, Kochs G. Interferon-induced Mx proteins in antiviral host defense. Biochimie. 2007;89:812\u20138.","journal-title":"Biochimie"},{"key":"840_CR17","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/tra.12616","volume":"19","author":"K Ringer","year":"2018","unstructured":"Ringer K, Riehl J, M\u00fcller M, et al. The large GTPase Mx1 binds Kif5B for cargo transport along microtubules. Traffic Cph Den. 2018;19:947\u201364.","journal-title":"Traffic Cph Den"},{"key":"840_CR18","doi-asserted-by":"publisher","first-page":"149084","DOI":"10.1016\/j.gene.2024.149084","volume":"935","author":"Z Shen","year":"2025","unstructured":"Shen Z, Song J, Wang S, et al. Cross-disease drug discovery based on bioinformatics and virtual screening: study of key genes in alzheimer\u2019s disease and ovarian cancer. Gene. 2025;935:149084.","journal-title":"Gene"},{"key":"840_CR19","doi-asserted-by":"publisher","first-page":"e70173","DOI":"10.1002\/cam4.70173","volume":"13","author":"RM Hayes","year":"2024","unstructured":"Hayes RM, O\u2019Donovan TR, McKenna SL. Expression of MxA in esophageal cancer cell lines can influence sensitivity to chemotherapeutic agents but this does not require apoptosis. Cancer Med. 2024;13:e70173.","journal-title":"Cancer Med"},{"key":"840_CR20","doi-asserted-by":"publisher","first-page":"1387860","DOI":"10.3389\/fonc.2024.1387860","volume":"14","author":"R Ma","year":"2024","unstructured":"Ma R, Zheng Y, Wang J, et al. Identification of key genes associated with endometriosis and endometrial cancer by bioinformatics analysis. Front Oncol. 2024;14:1387860.","journal-title":"Front Oncol"},{"key":"840_CR21","doi-asserted-by":"publisher","first-page":"1546047","DOI":"10.3389\/fvets.2025.1546047","volume":"12","author":"B Diehl","year":"2025","unstructured":"Diehl B, Kirchhoff A, Hansmann F. CD86 is linked to apoptosis in canine Histiocytic sarcoma. Front Vet Sci. 2025;12:1546047.","journal-title":"Front Vet Sci"},{"key":"840_CR22","doi-asserted-by":"publisher","first-page":"109346","DOI":"10.1016\/j.abb.2022.109346","volume":"727","author":"J Zhang","year":"2022","unstructured":"Zhang J, Fan M, Jin C, et al. NFIC1 suppresses migration and invasion of breast cancer cells through interferon-mediated Jak-STAT pathway. Arch Biochem Biophys. 2022;727:109346.","journal-title":"Arch Biochem Biophys"},{"key":"840_CR23","doi-asserted-by":"publisher","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","volume":"51","author":"Y Han","year":"2023","unstructured":"Han Y, Wang Y, Dong X, et al. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51:D1425\u201331.","journal-title":"Nucleic Acids Res"},{"key":"840_CR24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.","journal-title":"BMC Bioinformatics"},{"key":"840_CR25","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, et al. ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov Camb Mass. 2021;2:100141.","journal-title":"Innov Camb Mass"},{"key":"840_CR26","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102:15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"840_CR27","doi-asserted-by":"publisher","first-page":"273","DOI":"10.7326\/0003-4819-149-4-200808190-00010","volume":"149","author":"DA Grimes","year":"2008","unstructured":"Grimes DA. The nomogram epidemic: resurgence of a medical relic. Ann Intern Med. 2008;149:273\u20135.","journal-title":"Ann Intern Med"},{"key":"840_CR28","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara K, Shahmoradgoli M, Mart\u00ednez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612.","journal-title":"Nat Commun"},{"key":"840_CR29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220.","journal-title":"Genome Biol"},{"key":"840_CR30","doi-asserted-by":"publisher","first-page":"e107468","DOI":"10.1371\/journal.pone.0107468","volume":"9","author":"P Geeleher","year":"2014","unstructured":"Geeleher P, Cox N, Huang RS. pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS ONE. 2014;9:e107468.","journal-title":"PLoS ONE"},{"key":"840_CR31","doi-asserted-by":"publisher","first-page":"e71880","DOI":"10.7554\/eLife.71880","volume":"11","author":"C Yang","year":"2022","unstructured":"Yang C, Zhang H, Chen M, et al. A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer. eLife. 2022;11:e71880.","journal-title":"eLife"},{"key":"840_CR32","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638\u201346.","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 4","key":"840_CR33","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"C-H Chin","year":"2014","unstructured":"Chin C-H, Chen S-H, Wu H-H, et al. CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.","journal-title":"BMC Syst Biol"},{"key":"840_CR34","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, et al. The genemania prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38:W214\u2013220.","journal-title":"Nucleic Acids Res"},{"key":"840_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s42256-019-0138-9","volume":"2","author":"SM Lundberg","year":"2020","unstructured":"Lundberg SM, Erion G, Chen H, et al. From local explanations to global Understanding with explainable AI for trees. Nat Mach Intell. 2020;2:56\u201367.","journal-title":"Nat Mach Intell"},{"key":"840_CR36","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, et al. Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods. 2019;16:1289\u201396.","journal-title":"Nat Methods"},{"key":"840_CR37","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using cellchat. Nat Commun. 2021;12:1088.","journal-title":"Nat Commun"},{"key":"840_CR38","doi-asserted-by":"publisher","first-page":"e70102","DOI":"10.1111\/jcmm.70102","volume":"28","author":"C Wang","year":"2024","unstructured":"Wang C, Zhao Y, Zhang S, et al. Single-cell RNA sequencing reveals the heterogeneity of MYH11\u2009+\u2009tumour-associated fibroblasts between left-sided and right-sided colorectal cancer. J Cell Mol Med. 2024;28:e70102.","journal-title":"J Cell Mol Med"},{"key":"840_CR39","doi-asserted-by":"publisher","first-page":"101589","DOI":"10.1016\/j.xcrm.2024.101589","volume":"5","author":"B Liu","year":"2024","unstructured":"Liu B, Li S, Cheng Y, et al. Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers. Cell Rep Med. 2024;5:101589.","journal-title":"Cell Rep Med"},{"key":"840_CR40","doi-asserted-by":"publisher","first-page":"7098","DOI":"10.18632\/aging.204894","volume":"15","author":"L Cao","year":"2023","unstructured":"Cao L, Zhang S, Yao D, et al. Comparative analyses of the prognosis, tumor immune microenvironment, and drug treatment response between left-sided and right-sided colon cancer by integrating scRNA-seq and bulk RNA-seq data. Aging. 2023;15:7098\u2013123.","journal-title":"Aging"},{"key":"840_CR41","doi-asserted-by":"publisher","first-page":"216384","DOI":"10.1016\/j.canlet.2023.216384","volume":"574","author":"MT Morris","year":"2023","unstructured":"Morris MT, Jain A, Sun B, et al. Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Cancer Lett. 2023;574:216384.","journal-title":"Cancer Lett"},{"key":"840_CR42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/metabo10060257","volume":"10","author":"Y Cai","year":"2020","unstructured":"Cai Y, Rattray NJW, Zhang Q, et al. Tumor Tissue-Specific biomarkers of colorectal cancer by anatomic location and stage. Metabolites. 2020;10:257.","journal-title":"Metabolites"},{"key":"840_CR43","doi-asserted-by":"publisher","first-page":"e012069","DOI":"10.1136\/jitc-2025-012069","volume":"13","author":"P Zhang","year":"2025","unstructured":"Zhang P, Zhang M, Liu J, et al. Mitochondrial pathway signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma. J Immunother Cancer. 2025;13:e012069.","journal-title":"J Immunother Cancer"},{"key":"840_CR44","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1002\/tox.24155","volume":"39","author":"P Zhang","year":"2024","unstructured":"Zhang P, Wen B, Gong J, et al. Clinical prognostication and immunotherapy response prediction in esophageal squamous cell carcinoma using the DNA damage repair-associated signature. Environ Toxicol. 2024;39:2803\u201316.","journal-title":"Environ Toxicol"},{"key":"840_CR45","first-page":"10","volume":"1","author":"H Zhang","year":"2025","unstructured":"Zhang H, Zhang G, Xu P, et al. Optimized dynamic network biomarker Deciphers a High-Resolution heterogeneity within thyroid cancer molecular subtypes. Med Res. 2025;1:10\u201331.","journal-title":"Med Res"},{"key":"840_CR46","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s00401-025-02895-2","volume":"149","author":"MI Lioudyno","year":"2025","unstructured":"Lioudyno MI, Sevrioukov EA, Olivarria GM, et al. SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a down syndrome in vitro model. Acta Neuropathol (Berl). 2025;149:54.","journal-title":"Acta Neuropathol (Berl)"},{"key":"840_CR47","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11262-025-02136-4","volume":"61","author":"M Lai","year":"2025","unstructured":"Lai M, Lai R, He B, et al. Robust antiviral innate immune response and MiRNA regulatory network were identified in ZIKV-infected cells: implications in the pathogenesis of ZIKV infection. Virus Genes. 2025;61:249\u201364.","journal-title":"Virus Genes"},{"key":"840_CR48","doi-asserted-by":"publisher","first-page":"e0007725","DOI":"10.1128\/jvi.00077-25","volume":"99","author":"H Dong","year":"2025","unstructured":"Dong H, Hao Y, Wang J, et al. Japanese encephalitis virus NS1 inhibits IFN-\u03b2 production by interacting with DDX3X. J Virol. 2025;99:e0007725.","journal-title":"J Virol"},{"key":"840_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3899\/jrheum.2025-0390.O020","volume":"52","author":"S Kahnemuyipour","year":"2025","unstructured":"Kahnemuyipour S, Wither J, Whittall-Garcia L, et al. Characterizing immune cell subsets and interferon in the kidneys of Sle patients. J Rheumatol. 2025;52:19\u201320.","journal-title":"J Rheumatol"},{"key":"840_CR50","first-page":"202","volume":"52","author":"T Panafidina","year":"2025","unstructured":"Panafidina T, Popkova T, Shumilova A, et al. Clinical significance of interferon status in patients with systemic lupus erythematosus: preliminary data. J Rheumatol. 2025;52:202.","journal-title":"J Rheumatol"},{"key":"840_CR51","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1038\/s41388-025-03354-8","volume":"44","author":"X Lv","year":"2025","unstructured":"Lv X, Liu J, Islam K, et al. Hyperactivated YAP1 is essential for sustainable progression of renal clear cell carcinoma. Oncogene. 2025;44:2142\u201357.","journal-title":"Oncogene"},{"key":"840_CR52","doi-asserted-by":"publisher","first-page":"2452025","DOI":"10.1080\/15384047.2025.2452025","volume":"26","author":"J Ma","year":"2025","unstructured":"Ma J, Yang Y, Wang K, et al. RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis. Cancer Biol Ther. 2025;26:2452025.","journal-title":"Cancer Biol Ther"},{"key":"840_CR53","doi-asserted-by":"publisher","first-page":"e70064","DOI":"10.1111\/jpi.70064","volume":"77","author":"S Cardenas-Romero","year":"2025","unstructured":"Cardenas-Romero S, Saderi N, Ramirez-Plascencia OD, et al. Melatonin prevents tumor growth: the role of genes controlling the circadian Clock, the cell Cycle, and angiogenesis. J Pineal Res. 2025;77:e70064.","journal-title":"J Pineal Res"}],"container-title":["Human Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40246-025-00840-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40246-025-00840-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40246-025-00840-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:03:46Z","timestamp":1761573826000},"score":1,"resource":{"primary":{"URL":"https:\/\/humgenomics.biomedcentral.com\/articles\/10.1186\/s40246-025-00840-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["840"],"URL":"https:\/\/doi.org\/10.1186\/s40246-025-00840-8","relation":{},"ISSN":["1479-7364"],"issn-type":[{"value":"1479-7364","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research complies with the guidelines for human studies and was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. Written informed consent was obtained from all participants. Ethical approval was granted by the Institutional Review Board of the Affiliated Hangzhou First People\u2019s Hospital (Approval No. KY-2024466-01). The clinical trial number was not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"123"}}