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The study protocol was approved by the Ethics Committee of Zhejiang University School of Medicine (2020\u2013005 and 2024\u2013007). Approval 2020\u2013005 authorized the collection of human brain tissue samples, and approval 2024\u2013007 permitted the subsequent multi-omics sequencing and analysis of these previously collected samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27"}}