{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:34:40Z","timestamp":1780364080404,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Poverty"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s40249-016-0165-2","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T08:18:41Z","timestamp":1467793121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under"],"prefix":"10.1186","volume":"5","author":[{"given":"Akintunde","family":"Sowunmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazeem","family":"Akano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adejumoke I.","family":"Ayede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin","family":"Ntadom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsie O.","family":"Adewoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayo","family":"Fatunmbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Aderoyeje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"key":"165_CR1","doi-asserted-by":"crossref","DOI":"10.1596\/978-1-4648-0245-4","volume-title":"World malaria report 2014","author":"World Health Organisation","year":"2014","unstructured":"World Health Organisation. World malaria report 2014. Geneva: WHO; 2014. http:\/\/who.int\/malaria\/publications\/world_malaria_report_2014\/en\/ ."},{"key":"165_CR2","unstructured":"Federal Ministry of Health. National Antimalaria Treatment Guideline. Abuja, Nigeria. Federal Ministry of Health; 2005."},{"key":"165_CR3","volume-title":"Status Report on Artemisinin and ACT Resistance","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. Status Report on Artemisinin and ACT Resistance. Geneva: WHO; 2015. http:\/\/www.who.int\/malaria\/publications\/atoz\/update-artemisinin-resistance-sep2015\/en\/ ."},{"key":"165_CR4","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3201\/eid1405.071601","volume":"14","author":"C Wongsrichanalai","year":"2008","unstructured":"Wongsrichanalai C, Meshnick S. Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis. 2008;14:716\u20139.","journal-title":"Emerg Infect Dis"},{"key":"165_CR5","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM. Evidence of artemisinin resistance in western Cambodia. N Engl J Med. 2008;359:2619\u201320.","journal-title":"N Engl J Med"},{"key":"165_CR6","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1086\/657120","volume":"51","author":"H Noedl","year":"2010","unstructured":"Noedl H, Se Y, Sriwichai S, Schaecher K, Teja-Isavadharm P, Smith B, Rutvisuttinunt W, Bethell D, Surasri S, Fukuda MM, Socheat D, Cham TL. Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia. Clin Infect Dis. 2010;51:e82\u20139.","journal-title":"Clin Infect Dis"},{"key":"165_CR7","doi-asserted-by":"crossref","first-page":"e511","DOI":"10.1371\/journal.pone.0004551","volume":"4","author":"VI Carrara","year":"2009","unstructured":"Carrara VI, Zwang J, Ashley EA, Price RN, Stepniewka K, Marion B, Brockman A, Anderson T, McGready R, Phaiphun L, Stephane P, van Vugt M, Hutagalung R, Lwin KM, Phyo AP, Piyanuch P, Imwong M, Pukrittayakamee S, Singhasivanon P, White NJ, Nosten F. Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13\u00a0years of continuous deployment. PLoS One. 2009;4:e511.","journal-title":"PLoS One"},{"key":"165_CR8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-2875-8-11","volume":"8","author":"P Lim","year":"2009","unstructured":"Lim P, Alker A, Khim N, Shah N, Incardona S, Doung S, Yi P, Bouth D, Boucher C, Mercereau P, Meshnick S, Wongsrichanalai C, Fandeur T, Bras J, Ringwald P, Ariey F. Pfmdr1 copy number and artemisinin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar J. 2009;8:11.","journal-title":"Malar J"},{"key":"165_CR9","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","volume":"379","author":"AP Phyo","year":"2012","unstructured":"Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, Moo C, Al-Saai S, Dondorp AM, Lwin KM, Singhasivanon P, Day N, White NJ, Anderson TMJ, Nosten F. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012;379:1960\u20136.","journal-title":"Lancet"},{"key":"165_CR10","doi-asserted-by":"crossref","first-page":"26005","DOI":"10.1371\/journal.pone.0026005","volume":"6","author":"S Borrmann","year":"2011","unstructured":"Borrmann S, Sasi P, Mwai L, Bashraheil M, Abdallah A, Muriithi S, Fr\u00fchauf H, Schaub B, Pfeil J, Peshu J, Hanpithakpong W, Rippert A, Juma E, Tsofa B, Mosobo M, Lowe B, Oseir F, Fegan G, Lindeg\u00e5rdh N, Nzila A, Peshu N, Mackinnon M, Marsh K. Decline responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast. PLoS ONE. 2011;6:26005.","journal-title":"PLoS ONE"},{"key":"165_CR11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1590\/0074-0276130167","volume":"108","author":"SGS Vreden","year":"2013","unstructured":"Vreden SGS, Jitan JK, Bansie RD, Adhin MA. Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether. Mem Inst Oswaldo Cruz Rio de Janeiro. 2013;108:968\u201373.","journal-title":"Mem Inst Oswaldo Cruz Rio de Janeiro"},{"key":"165_CR12","volume-title":"Chemotherapy of Malaria and Resistance to Antimalarials","author":"World Health Organization","year":"1973","unstructured":"World Health Organization. Chemotherapy of Malaria and Resistance to Antimalarials. Geneva: World Health Organization; 1973."},{"key":"165_CR13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/00034983.1990.11812493","volume":"84","author":"LA Salako","year":"1990","unstructured":"Salako LA, Ajayi FO, Sowunmi A, Walker O. Malaria in Nigeria: a revisit. Ann Trop Med Parasitol. 1990;84:435\u201345.","journal-title":"Ann Trop Med Parasitol"},{"key":"165_CR14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4269\/ajtmh.2007.77.235","volume":"77","author":"A Sowunmi","year":"2007","unstructured":"Sowunmi A, Gbotosho GO, Happi CT, Adedeji AA, Fehintola FA. Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulphalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria. Am J Trop Med Hyg. 2007;77:235\u201341.","journal-title":"Am J Trop Med Hyg"},{"key":"165_CR15","first-page":"1190","volume":"118","author":"A Sowunmi","year":"2011","unstructured":"Sowunmi A, Gbotosho GO, Happi CT, Folarin O, Okuboyejo T, Michael O, Fatunmbi B. Use of area under the curve to evaluate the effects of antimalarial drugs on malaria-associated anaemia after treatment. Am J Therap. 2011;118:1190\u20137.","journal-title":"Am J Therap"},{"key":"165_CR16","doi-asserted-by":"publisher","first-page":"235498","DOI":"10.4303\/mcce\/235498","volume":"1","author":"A Sowunmi","year":"2012","unstructured":"Sowunmi A, Okuboyejo TM, Gbotosho GO, Happi CT. Early changes in Plasmodium falciparum asexual and sexual populations in children with acute infections following treatment with artemisinin-based combination drugs. Mal Chemother Ctrl Elim. 2012;1:235498. doi: 10.4303\/mcce\/235498 .","journal-title":"Mal Chemother Ctrl Elim"},{"key":"165_CR17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4269\/ajtmh.2011.10-0722","volume":"84","author":"GO Gbotosho","year":"2011","unstructured":"Gbotosho GO, Sowunmi A, Happi CT, Okuboyejo TM. Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments. Am J Trop Med Hyg. 2011;84:936\u201343.","journal-title":"Am J Trop Med Hyg"},{"key":"165_CR18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4269\/ajtmh.2011.10-0582","volume":"84","author":"GO Gbotosho","year":"2011","unstructured":"Gbotosho GO, Sowunmi A, Okuboyejo TM, Happi CT, Folarin OO, Michael SO, Adewoye EO. Therapeutic efficacy and effect of artemether-lumefantrine and artesunate-amodiaquine cofomulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria. Am J Trop Med Hyg. 2011;84:813\u20139.","journal-title":"Am J Trop Med Hyg"},{"key":"165_CR19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/1475-2875-9-335","volume":"9","author":"OS Michael","year":"2010","unstructured":"Michael OS, Gbotosho GO, Folarin OA, Okuboyejo T, Sowunmi A, Oduola AMJ, Happi CT. Early variations in Plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite clearance. Malar J. 2010;9:335.","journal-title":"Malar J"},{"key":"165_CR20","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4269\/ajtmh.13-0248","volume":"91","author":"S Oguche","year":"2014","unstructured":"Oguche S, Okafor HU, Watila I, Meremikwu M, Agomo P, Ogala W, Agomo C, Ntadom G, Banjo O, Okuboyejo T, Ogunrinde G, Odey F, Aina O, Sofola T, Sowunmi A. Efficacy of artemisinin-based combination treatments of uncomplicated falciparum malaria in under-five year-old Nigerian children. Am J Trop Med Hyg. 2014;91:925\u201335.","journal-title":"Am J Trop Med Hyg"},{"key":"165_CR21","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1128\/AAC.41.7.1413","volume":"41","author":"NJ White","year":"1997","unstructured":"White NJ. Assessment of the pharmacodynamics properties of antimalarial drugs in vivo. Antimicrob Agent Chemother. 1997;41:1413\u201322.","journal-title":"Antimicrob Agent Chemother"},{"key":"165_CR22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2165\/00044011-200121050-00007","volume":"21","author":"A Sowunmi","year":"2001","unstructured":"Sowunmi A, Falade AG, Adedeji AA, Ayede AI, Fateye BA, Sowunmi CO, Oduola AMJ. Comparative Plasmodium falciparum kinetics during treatment with amodiaquine and chloroquine in children. Clin Drug Investig. 2001;21:371\u201381.","journal-title":"Clin Drug Investig"},{"key":"165_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actatropica.2008.09.022","volume":"109","author":"A Sowunmi","year":"2009","unstructured":"Sowunmi A, Balogun ST, Gbotosho GO, Happi CT. Effects of amodiaquine, artesunate, and artesunate-amodiaquine of Plasmodium falciparum malaria-associated anaemia in children. Acta Tropic. 2009;109:55\u201360.","journal-title":"Acta Tropic"},{"key":"165_CR24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12879-015-1219-y","volume":"15","author":"A Sowunmi","year":"2015","unstructured":"Sowunmi A, Akano K, Ayede AI, Ntadom G, Aderoyeje T, Adewoye EO, Fatunmbi, B. Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children. BMC Infect Dis. 2015;15:454.","journal-title":"BMC Infect Dis"},{"key":"165_CR25","volume-title":"Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria","author":"World Health Organization","year":"2003","unstructured":"World Health Organization. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. Geneva: World Health Organization; 2003."},{"key":"165_CR26","volume-title":"Methods for surveillance of antimalarial drug efficacy","author":"World Health Organization","year":"2009","unstructured":"World Health Organization. Methods for surveillance of antimalarial drug efficacy. World Health Organization: Geneva; 2009."},{"key":"165_CR27","volume-title":"Epi Info Version 6. A Word Processing Data Base and Statistics Program for Public Health on IBM-compatible Microcomputers","author":"Anon","year":"1994","unstructured":"Anon. Epi Info Version 6. A Word Processing Data Base and Statistics Program for Public Health on IBM-compatible Microcomputers. Atlanta: Centers for Disease Control and Prevention; 1994."},{"key":"165_CR28","volume-title":"SPSS for Windows Release 20.0 (standard version)","author":"Anon","year":"2011","unstructured":"Anon. SPSS for Windows Release 20.0 (standard version). Chicago: SPSS Inc; 2011."},{"key":"165_CR29","doi-asserted-by":"crossref","unstructured":"Schramm B, Valch P, Baudin C, Mazinda CS, Smith R, Pinoges I, Sundaygar T, Zolia YM, Jones JJ, Comte E, Bruneel A, Branger M, Jullien V, Cam G, Kiechel J-R, Ashley EA, Gu\u00e9rin PJ. Tolerability and safety of artesunate-amodiaquine and artemether-lumefatrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trial in Nimba County, Liberia. Malar J. 2013;12:250.","DOI":"10.1186\/1475-2875-12-250"},{"key":"165_CR30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3201\/eid1705.101229","volume":"17","author":"T Zoller","year":"2011","unstructured":"Zoller T, Junghanss T, Kapaun A, Gj\u00f8rup I, Richter J, Hugo-Persson M, M\u00f8rch K, Foroutan B, Suttorp N, Y\u00fcrek S, Flick H. Intravenous artesunate for severe malaria in travelers, Europe. Emerg Infect Dis. 2011;17:771\u20137.","journal-title":"Emerg Infect Dis"},{"key":"165_CR31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1475-2875-11-102","volume":"11","author":"AR Kreeftmeijer-Vetger","year":"2012","unstructured":"Kreeftmeijer-Vetger AR, Genderen PJ, Visser LG, Bierman WFW, Clerinx J, van Veldehuizen CKW, de Vries PJ. Treatment outcome of intravenous artesunate in patients with severe malaria in Netherlands and Belgium. Malar J. 2012;11:102.","journal-title":"Malar J"},{"key":"165_CR32","volume-title":"WHO information note on delayed haemolytic anaemia following treatment with artesunate","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. WHO information note on delayed haemolytic anaemia following treatment with artesunate. Geneva: WHO; 2013."},{"key":"165_CR33","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/infdis\/jit841","volume":"209","author":"T Rolling","year":"2014","unstructured":"Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, L\u00f6hr SJ, Burchard GD, May J, Mordmuller B, Krishna S, Kremsner PG, Cramer JP. Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria \u2013 a double-center prospective study. J Infect Dis. 2014;209:1921\u20138.","journal-title":"J Infect Dis"},{"key":"165_CR34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2014-02-555953","volume":"124","author":"S Jaur\u00e9guiberry","year":"2014","unstructured":"Jaur\u00e9guiberry S, Ndour PA, Roussel C, Ader F, Safeukui I, Nguyen M, Biligui S, Ciceron L, Mouri O, Kendjo E, Vray M, Angoulvant A, Mayaux J, Haldar K, Mazier D, Danis M, Caumes E, Thellier M, Buffet P. Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins. Blood. 2014;124:167\u201375.","journal-title":"Blood"}],"container-title":["Infectious Diseases of Poverty"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40249-016-0165-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T19:36:10Z","timestamp":1568144170000},"score":1,"resource":{"primary":{"URL":"http:\/\/idpjournal.biomedcentral.com\/articles\/10.1186\/s40249-016-0165-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["165"],"URL":"https:\/\/doi.org\/10.1186\/s40249-016-0165-2","relation":{},"ISSN":["2049-9957"],"issn-type":[{"value":"2049-9957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]},"article-number":"70"}}