{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:25:18Z","timestamp":1792689918283,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Poverty"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The goal of soil-transmitted helminthiases (STH) control programmes is to eliminate STH-associated morbidity in the target population by reducing the prevalence of moderate- and heavy-intensity infections and the overall STH infection prevalence mainly through preventive chemotherapy (PC) with either albendazole or mebendazole. Endemic countries should measure the success of their control programmes through regular epidemiological assessments. We evaluated changes in STH prevalence in countries that conducted effective PC coverage for STH to guide changes in the frequency of PC rounds and the number of tablets needed.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We selected countries from World Health Organization (WHO)\u2018s Preventive Chemotherapy and Transmission control (PCT) databank that conducted \u22655\u2009years of PC with effective coverage for school-age children (SAC) and extracted STH baseline and impact assessment data using the WHO Epidemiological Data Reporting Form, Ministry of Health reports and\/or peer-reviewed publications. We used pooled and weighted means to plot the prevalence of infection with any STH and with each STH species at baseline and after \u22655\u2009years of PC with effective coverage. Finally, using the WHO STH decision tree, we estimated the reduction in the number of tablets needed.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifteen countries in four WHO regions conducted annual or semi-annual rounds of PC for STH for 5\u2009years or more and collected data before and after interventions. At baseline, the pooled prevalence was 48.9% (33.1\u201364.7%) for any STH, 23.2% (13.7\u201332.7%) for <jats:italic>Ascaris lumbricoides,<\/jats:italic> 21.01% (9.7\u201332.3%) for <jats:italic>Trichuris trichiura<\/jats:italic> and 18.2% (10.9\u201325.5%) for hookworm infections, while after \u22655\u2009years of PC for STH, the prevalence was 14.3% (7.3\u201321.3%) for any STH, 6.9% (1.3\u201312.5%) for <jats:italic>A. lumbricoides<\/jats:italic>, 5.3% (1.06\u20139.6%) for <jats:italic>T. trichiura<\/jats:italic> and 8.1% (4.0\u201312.2%) for hookworm infections.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Countries endemic for STH have made tremendous progress in reducing STH-associated morbidity, but very few countries have data to demonstrate that progress. In this study, the data show that nine countries should adapt their PC strategies and the frequency of PC rounds to yield a 36% reduction in drug needs. The study also highlights the importance of impact assessment surveys to adapt control strategies according to STH prevalence.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40249-019-0589-6","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T01:03:03Z","timestamp":1569978183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sustained preventive chemotherapy for soil-transmitted helminthiases leads to reduction in prevalence and anthelminthic tablets required"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-8272","authenticated-orcid":false,"given":"Denise","family":"Mupfasoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bangert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Mikhailov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Montresor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"issue":"10","key":"589_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/trstmh\/trx082","volume":"111","author":"A Montresor","year":"2017","unstructured":"Montresor A, Trouleau W, Mupfasoni D, Bangert M, Joseph SA, Mikhailov A, Fitzpatrick C. Preventive chemotherapy to control soil-transmitted helminthiasis averted more than 500 000 DALYs in 2015. Trans R Soc Trop Med Hyg. 2018. \n                    https:\/\/doi.org\/10.1093\/trstmh\/trx082\n                    \n                  .","journal-title":"Transactions of The Royal Society of Tropical Medicine and Hygiene"},{"key":"589_CR2","unstructured":"Guideline: preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. Geneva: World Health Organization; 2017.\n                    https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/258983\/9789241550116-eng.pdf\n                    \n                  . Accessed 20 Mar 2019."},{"key":"589_CR3","unstructured":"Soil-transmitted helminthiases: eliminating soil-transmitted helminthiases as a public health problem in children: progress report 2001\u20132010 and strategic plan 2011\u20132020. Geneva: World Health Organization; 2012. \n                    https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44804\/9789241503129_eng.pdf\n                    \n                  . Accessed 20 Mar 2019."},{"key":"589_CR4","unstructured":"Helminth control in school-age children: a guide for managers of control programmes, 2nd. Geneva: World Health Organization; 2011. \n                    https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44671\/9789241548267_eng.pdf\n                    \n                  . Accessed 13 Mar 2019."},{"key":"589_CR5","unstructured":"Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2017. Wkly Epidemiol Rec. 2018;93:681\u201392 \n                    https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/276933\/WER9350.pdf\n                    \n                  . Accessed 15 Mar 2019."},{"key":"589_CR6","doi-asserted-by":"publisher","unstructured":"Marocco C, Bangert M, Joseph SA, Fitzpatrick C, Montresor A. Preventive chemotherapy in one year reduces by over 80% the number of individuals with soil-transmitted helminthiases causing morbidity: results from meta-analysis. Trans R Soc Trop Med Hyg. 2017. \n                    https:\/\/doi.org\/10.1093\/trstmh\/trx011\n                    \n                  .","DOI":"10.1093\/trstmh\/trx011"},{"key":"589_CR7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.trstmh.2012.01.003","volume":"106","author":"A Yajima","year":"2012","unstructured":"Yajima A, Mikhailov A, Mbabazi PS, Gabrielli AF, Minchiotti S, Montresor A, et al. Preventive chemotherapy and transmission control (PCT) databank: a tool for planning, implementation and monitoring of integrated preventive chemotherapy for control of neglected tropical diseases. 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