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A complete genome sequence of\n                      <jats:italic>O. hupensis<\/jats:italic>\n                      will enable the fundamental understanding of snail biology as well as its co-evolution with the\n                      <jats:italic>S. japonicum<\/jats:italic>\n                      parasite. Assembling a high-quality reference genome of\n                      <jats:italic>O. hupehensis<\/jats:italic>\n                      will provide data for further research on the snail biology\u00a0and controlling the spread of\n                      <jats:italic>S. japonicum.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding sequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total length of 1.46\u00a0Gb high-quality\n                      <jats:italic>O. hupensis<\/jats:italic>\n                      genome with 17 unique full-length chromosomes (2n\u2009=\u200934) of the individual including a contig N50 of 1.35\u00a0Mb and a scaffold N50 of 75.08\u00a0Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed that\n                      <jats:italic>O. hupensis<\/jats:italic>\n                      was separated from a common ancestor of\n                      <jats:italic>Pomacea canaliculata<\/jats:italic>\n                      and\n                      <jats:italic>Bellamya purificata<\/jats:italic>\n                      approximately 170 million years ago. Comparing the genome of\n                      <jats:italic>O. hupensis<\/jats:italic>\n                      with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Integrated use of multiple sequencing technologies, we have successfully constructed the genome at the chromosomal-level of\n                      <jats:italic>O. hupensis<\/jats:italic>\n                      . These data will not only provide the compressive genomic information, but also benefit future work on population genetics of this snail as well as evolutional studies between\n                      <jats:italic>S. japonicum<\/jats:italic>\n                      and the snail host.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s40249-024-01187-3","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T03:03:08Z","timestamp":1709002988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum"],"prefix":"10.1186","volume":"13","author":[{"given":"Qin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-8427","authenticated-orcid":false,"given":"Xiao-Nong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"11","key":"1187_CR1","doi-asserted-by":"publisher","first-page":"e327","DOI":"10.1016\/S1473-3099(22)00221-3","volume":"22","author":"NC Lo","year":"2022","unstructured":"Lo NC, Bezerra FSM, Colley DG, Fleming FM, Homeida M, Kabatereine N, et al. 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