{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:21:09Z","timestamp":1793863269375,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Poverty"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Aedes aegypti<\/jats:italic>, the primary vector of dengue, chikungunya, and Zika viruses, poses a significant public health threat worldwide. Traditional control methods using insecticides are increasingly challenged by resistance and environmental concerns. The sterile insect technique (SIT) offers an eco-friendly alternative that has been successfully applied to other insect pests. This article aims to briefly review <jats:italic>Ae. aegypti<\/jats:italic> management in Cuba, highlighting the accomplishments, challenges, and future directions of the SIT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Main body<\/jats:title>\n                <jats:p>Here we provide a brief summary of the extensive history of <jats:italic>Ae. aegypti<\/jats:italic> control efforts in Cuba. After a successful eradication campaign in the 1980s, a resurgence of dengue cases has been observed in recent years, suggesting that traditional control methods may have limited effectiveness under current conditions. In response, Cuba initiated a phased approach to develop and evaluate the feasibility of SIT for <jats:italic>Ae. aegypti<\/jats:italic> control, starting in 2008. Initial research focused on <jats:italic>Ae. aegypti<\/jats:italic> mating behavior and sterilization methods, followed by successful laboratory and semi-field trials that demonstrated population suppression. The first open-field trial in 2020 confirmed the efficacy of the SIT in reducing <jats:italic>Ae. aegypti<\/jats:italic> populations under real-world conditions. Currently, the research is in a phase involving a cluster-randomized superiority-controlled trial. This planned trial will compare the standard vector control program with the same program augmented by the SIT, aiming to assess the impact of the SIT on dengue incidence as the primary outcome. Implementing robust epidemiological trials to evaluate the effectiveness of the SIT is complex due to potential spillover effects from mosquito and human movement across study areas. Additionally, conducting the SIT requires significant development and operational investments. Despite these challenges, the ongoing Cuban trial holds promise for establishing the SIT as an effective and sustainable tool for <jats:italic>Ae. aegypti<\/jats:italic> control and for reducing the burden of mosquito-borne diseases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The phased evaluation conducted in Cuba confirms the efficacy of the SIT against <jats:italic>Ae. aegypti<\/jats:italic>, highlighting its potential for sustainable mosquito-borne disease management. The effective implementation of multi-site trials will be crucial in providing evidence of the potential of the sterile insect technique as part of a strategy to reduce the incidence of arboviral diseases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s40249-024-01224-1","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T02:01:57Z","timestamp":1724896917000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Advancing the art of mosquito control: the journey of the sterile insect technique against Aedes aegypti in Cuba"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-2281","authenticated-orcid":false,"given":"Ren\u00e9","family":"Gato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulema","family":"Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misladys","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Guti\u00e9rrez-Bugallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Carmen Marquetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"1224_CR1","volume-title":"Global vector control response 2017\u20132030","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. Global vector control response 2017\u20132030. Geneva: WHO; 2017."},{"issue":"12","key":"1224_CR2","doi-asserted-by":"publisher","first-page":"e0006845","DOI":"10.1371\/journal.pntd.0006845","volume":"12","author":"D Roiz","year":"2018","unstructured":"Roiz D, Wilson AL, Scott TW, Fonseca DM, Jourdain F, M\u00fcller P, et al. Integrated Aedes management for the control of Aedes-borne diseases. PLoS Negl Trop Dis. 2018;12(12):e0006845.","journal-title":"PLoS Negl Trop Dis"},{"key":"1224_CR3","doi-asserted-by":"crossref","unstructured":"Dyck VA, Hendrichs J, Robinson AS, editors. Sterile insect technique: principles and practice in area-wide integrated pest management. 2nd ed. Boca Raton: CRC Press; 2021.","DOI":"10.1201\/9781003035572"},{"key":"1224_CR4","unstructured":"How to design vector control efficacy trials, guidance on phase III vector control field trial design. 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