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Schistosomiasis caused by\n                      <jats:italic>Schistosoma mekongi<\/jats:italic>\n                      is of public health concern on the islands of the Khong district. This study aimed to assess the impact of an Eco-Health\/One-Health approach in combination with mass drug administration (MDA) to reduce these helminth infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a community intervention using a stepped-wedge trial approach on two endemic islands (Donsom and Donkhone) of the Khong district, Champasack province, Lao PDR, between April 2012 and March 2013. In each study village, 30\u201340 households were randomly selected. All members of selected households, who were at home during the study period were invited to participate in the study. A baseline study was conducted to assess helminth infections, knowledge attitudes and practices toward\n                      <jats:italic>Schistosoma mekongi<\/jats:italic>\n                      infection, behavior of open defecation and availability of latrine at home. After the baseline (T0), the Eco-Health\/One-Health approach was implemented on Donsom (intervention) and Donkhone island (control). An assessment was conducted in 2014 (T1), one year after the completion of intervention implementation, to assess the short-term impact of the Eco-Health\/One-Health approach on helminth infections and compare intervention and control islands. Later in 2015, the Eco-Health\/One-Health approach was implemented on control island (Donkhone). After the implementation of intervention, the parasitological assessments were conducted annually in humans in 2015 (T2), in 2016 (T3) and in 2017 (T4), and in dogs in 2017 (T4) to evaluate the long-term impact of the intervention on helminth infections. Frequency was used to describe the prevalence of helminth infections. Logistic regression was applied to associate the KAP (knowledge, attitudes, and practices and open defecation behavior) and the reduction of helminth infections between intervention and control islands. The reduction in prevalence pre- and post-intervention was associated using a McNemar test. A two-independent sample\n                      <jats:italic>t<\/jats:italic>\n                      -test was applied to compare the mean eggs per gram (EPG) of helminth infections between control and intervention islands. A paired t-test test was used to compare the mean EPG of stool samples before (baseline) and after (follow-up) interventions for the two islands separately. A\n                      <jats:italic>P<\/jats:italic>\n                      -value lower than 0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eco-Health\/One-Health approach appears to be associated with reduction in prevalence of\n                      <jats:italic>S. mekongi<\/jats:italic>\n                      by 9.0%\u00a0[odds ratio (\n                      <jats:italic>OR<\/jats:italic>\n                      )\u2009=\u20090.49,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003] compared to the use of mass drug administration alone (control island). Additionally, this intervention package significantly reduced\n                      <jats:italic>O. viverrini<\/jats:italic>\n                      infection by 20.3% (\n                      <jats:italic>OR<\/jats:italic>\n                      \u2009=\u20091.92,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and hookworm by 17.9% (\n                      <jats:italic>OR<\/jats:italic>\n                      \u2009=\u20090.71,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.045), respectively. Annual parasitological assessments between 2012 and 2017 showed that the Eco-Health\/One-Health approach, coupled with MDA, steadily reduced the prevalence of\n                      <jats:italic>S. mekongi<\/jats:italic>\n                      on the intervention island from 29.1% to 1.8% and on the control island from 28.4% to 3.1%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The study findings suggest that the Eco-Health\/One-Health approach appears to be associated with a significant reduction in prevalence of\n                      <jats:italic>S. mekongi<\/jats:italic>\n                      and helminth co-infections, particularly hookworm and\n                      <jats:italic>T. trichiura<\/jats:italic>\n                      . Therefore, implementing the Eco-Health\/One-Health approach in schistosomiasis-endemic areas could accelerate the achievement of national goals for transmission interruption by 2025 and elimination by 2030.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40249-024-01226-z","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:13:07Z","timestamp":1722557587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrated Eco-Health approach significantly reduces helminth infections in endemic Khong islands with emphasis on Schistosoma mekongi"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-9567","authenticated-orcid":false,"given":"Somphou","family":"Sayasone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youthanavanh","family":"Vonghachack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"1226_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s40249-023-01112-0","volume":"12","author":"S Phonekeo","year":"2023","unstructured":"Phonekeo S, Kounnavong S, Vonglokham M, Siengsounthone L, Homsana A, Gummin S, et al. 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Field activities were approved by the Laotian Ministry of Health steering group. An information sheet detailing the study purpose, procedures, potential risks and advantages of participation, and the protection of anonymity was supplied to all eligible participants. A signed informed consent form was received from all adults aged 18\u00a0years and older. For children aged between 12 and 17\u00a0years old, an assent form was received from each participant coupled with an informed consent form from parents or legal guardians, while for children aged below 12\u00a0years, just the informed consent form from parents or legal guardians was obtained prior to their registration. Permission to collect faeces samples from dogs was acquired from their owners. All identified infections were treated free of charge according to Lao national standards [\n                      \n                      ]. Soil-transmitted helminths (STH) were treated with a single oral dose of 400\u00a0mg albendazole and trematode infections with praziquantel (40\u00a0mg\/kg BW), respectively.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}