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This study aimed to fully evaluate disease burden in terms of disability-adjusted life years (DALYs) for clonorchiasis in China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following our previous study which established the fine-scale prevalence distribution of\n                      <jats:italic>C. sinensis<\/jats:italic>\n                      infection in China, we further adopted Bayesian geostatistical models to estimate the infection intensity in terms of eggs per gram of feces (EPG) in infected individuals based on the national surveillance data of clonorchiasis between 2016 and 2021. Disability weight was then captured through its quantitative association with EPG, and used to estimate years of life living with a disability (YLDs). Incidence of cholangiocarcinoma attributed to\n                      <jats:italic>C. sinensis<\/jats:italic>\n                      infection was employed to calculate years of life lost (YLLs). DALYs was then estimated at 5\u2009\u00d7\u20095\u00a0km\n                      <jats:sup>2<\/jats:sup>\n                      resolution, and aggregated by areas and populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2020, 431,009 [95% Bayesian credible interval (BCI): 370,427 to 500,553] DALYs were exerted due to clonorchiasis in China, of which 372,918 (95% BCI: 318,775\u2013435,727) was due to YLDs and 57,998 (95% BCI: 50,816\u201366,069) due to YLLs. The DALYs, YLDs and YLLs per 1000 were 0.31 (95% BCI: 0.26\u20130.35), 0.26 (95% BCI: 0.23\u20130.31), and 0.04 (95% BCI: 0.04\u20130.05), respectively. The DALYs predominantly distributed in southern areas including Guangxi (201,029, 95% BCI: 157,589\u2013248,287) and Guangdong (161,958, 95% BCI: 128,326\u2013211,358). The DALYs was over doubled in male (302,678, 95% BCI: 262,028\u2013348,300) than in female (127,970, 95% BCI: 106,834\u2013151,699), and high in middle aged population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clonorchiasis causes significant disease burden in China especially in southern areas including Guangxi and Guangdong. Urgent control is needed for clonorchiasis in the endemic areas with high burden, and adult males need to be prioritized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s40249-025-01396-4","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T02:44:17Z","timestamp":1766544257000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disability-adjusted life years of clonorchiasis in China: a high-resolution spatial analysis"],"prefix":"10.1186","volume":"14","author":[{"given":"Men-Bao","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Si","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"1396_CR1","volume":"33","author":"HY Xiao","year":"2023","unstructured":"Xiao HY, Chai JY, Fang YY, Lai YS. 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Informed consent was got from each participant or their guardians for those aged below 18\u00a0years.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Xiao-Nong Zhou is an Editor-in-Chief of the journal\n                      Infectious Diseases of Poverty\n                      . He was not involved in the peer-review or handling of the manuscript. The authors have no other competing interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}