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Pattern separation and recognition are hippocampus-dependent forms of learning thought to underlie stimulus discrimination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The present study used the Mnemonic Similarity Task to investigate pattern separation and recognition for the first time in patients with AN (<jats:italic>N<\/jats:italic>\u2009=\u200946) and healthy controls (<jats:italic>N<\/jats:italic>\u2009=\u200956). An Analysis of Covariance examined between-group differences, controlling for age, antidepressant use and method of task delivery (remote vs. in person).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>When controlling for covariates, pattern recognition memory scores were lower in the AN group with a medium effect size (<jats:italic>d<\/jats:italic>\u2009=\u20090.51). In contrast, there was a small effect whereby patients with AN had a greater pattern separation score than controls (<jats:italic>d<\/jats:italic>\u2009=\u20090.34), albeit this difference was not significant at the <jats:italic>p<\/jats:italic>\u2009=\u20090.05 threshold (<jats:italic>p<\/jats:italic>\u2009=\u20090.133). Furthermore, pattern separation and recognition memory abilities were not related to age, body mass index, eating disorder psychopathology or trait anxiety levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This preliminary study provides initial evidence for an imbalance in pattern separation and recognition abilities in AN, a hippocampus-dependent cognitive ability. Further studies should endeavour to investigate pattern separation and recognition performance further in AN, as well as investigate other hippocampus-dependent functions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40337-021-00406-8","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T09:03:03Z","timestamp":1618650183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lower pattern recognition memory scores in anorexia nervosa"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-9857","authenticated-orcid":false,"given":"Johanna","family":"Keeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Olivola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Thuret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Himmerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Treasure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"key":"406_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association A. 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