{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:09:09Z","timestamp":1790752149243,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Eat Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Anorexia nervosa (AN) is a serious psychosomatic disorder with unclear pathomechanisms. Metabolic dysregulation is associated with disruption of redox homeostasis that might play a pivotal role in the development of AN. The aim of our study was to assess oxidative status and carbonyl stress in plasma, urine and saliva of patients with AN and healthy controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Plasma, spot urine, and saliva were collected from 111 girls with AN (aged from 10 to 18\u2009years) and from 29 age-matched controls. Markers of oxidative stress and antioxidant status were measured using spectrophotometric and fluorometric methods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Plasma advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) were significantly higher in patients with AN than in healthy controls (by 96, and 82%, respectively). Accordingly, urinary concentrations of AOPP and fructosamines and salivary concentrations of AGEs were higher in girls with AN compared with controls (by 250, and 41% in urine; by 92% in saliva, respectively). Concentrations of thiobarbituric acid reactive substances (TBARS) in saliva were 3-times higher in the patients with AN than in the controls. Overall antioxidants were lower in plasma of girls with AN compared to the controls, as shown by total antioxidant capacity and ratio of reduced and oxidized glutathione (by 43, and 31%, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is the first study assessing wide range of markers of oxidative status in plasma, urine and saliva of the patients with AN. We showed that both, higher levels of markers of oxidative stress and lower antioxidants play a role in redox disruption. Restoration of redox homeostasis might be of the clinical relevance<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40337-021-00408-6","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:11:12Z","timestamp":1618999872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-7751","authenticated-orcid":false,"given":"Alexandra Ga\u00e1l","family":"Koval\u010d\u00edkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u013dubica","family":"Tich\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katar\u00edna","family":"\u0160ebekov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Celec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u017ebeta","family":"\u010cagalov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Sogutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u013dudmila","family":"Podrack\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"issue":"1","key":"408_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.chc.2014.08.003","volume":"24","author":"B Herpertz-Dahlmann","year":"2015","unstructured":"Herpertz-Dahlmann B. Adolescent eating disorders: update on definitions, symptomatology, epidemiology, and comorbidity. Child Adolesc Psychiatr Clin N Am. 2015;24(1):177\u201396. https:\/\/doi.org\/10.1016\/j.chc.2014.08.003.","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"2","key":"408_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.psc.2019.01.009","volume":"42","author":"D Gibson","year":"2019","unstructured":"Gibson D, Workman C, Mehler PS. Medical complications of anorexia nervosa and bulimia nervosa. Psychiatr Clin North Am. 2019;42(2):263\u201374. https:\/\/doi.org\/10.1016\/j.psc.2019.01.009.","journal-title":"Psychiatr Clin North Am"},{"issue":"4","key":"408_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1054\/mehy.2000.1199","volume":"56","author":"Y Naisberg","year":"2001","unstructured":"Naisberg Y, Modai I, Weizman A. Metabolic bioenergy homeostatic disruption: a cause of anorexia nervosa. Med Hypotheses. 2001;56(4):454\u201361. https:\/\/doi.org\/10.1054\/mehy.2000.1199.","journal-title":"Med Hypotheses"},{"key":"408_CR4","doi-asserted-by":"publisher","unstructured":"Nagata JM, Park KT, Colditz K, Golden NH. Associations of elevated liver enzymes among hospitalized adolescents with anorexia nervosa. J Pediatr. 2015; 166: 439\u2013443.e1. doi: https:\/\/doi.org\/10.1016\/j.jpeds.2014.10.048.","DOI":"10.1016\/j.jpeds.2014.10.048"},{"key":"408_CR5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jpsychires.2018.06.002","volume":"103","author":"B Dalton","year":"2018","unstructured":"Dalton B, Bartholdy S, Robinson L, Solmi M, Ibrahim MAA, Breen G, et al. A meta-analysis of cytokine concentrations in eating disorders. J Psychiatr Res. 2018;103:252\u201364. https:\/\/doi.org\/10.1016\/j.jpsychires.2018.06.002.","journal-title":"J Psychiatr Res"},{"issue":"1","key":"408_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00441-004-0976-5","volume":"318","author":"D Berg","year":"2004","unstructured":"Berg D, Youdim MBH, Riederer P. Redox imbalance. Cell Tissue Res. 2004;318(1):201\u201313. https:\/\/doi.org\/10.1007\/s00441-004-0976-5.","journal-title":"Cell Tissue Res"},{"issue":"1","key":"408_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44\u201384. https:\/\/doi.org\/10.1016\/j.biocel.2006.07.001.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"408_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/cr.2010.178","volume":"21","author":"MJ Morgan","year":"2011","unstructured":"Morgan MJ, Liu Z. Crosstalk of reactive oxygen species and NF-\u03baB signaling. Cell Res. 2011;21(1):103\u201315. https:\/\/doi.org\/10.1038\/cr.2010.178.","journal-title":"Cell Res"},{"issue":"2","key":"408_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3233\/DMA-2009-0606","volume":"26","author":"M Behuliak","year":"2009","unstructured":"Behuliak M, P\u00e1lffy R, Gardl\u00edk R, Hodosy J, Hal\u010d\u00e1k L, Celec P. Variability of thiobarbituric acid reacting substances in saliva. Dis Markers. 2009;26(2):49\u201353. https:\/\/doi.org\/10.3233\/DMA-2009-0606.","journal-title":"Dis Markers"},{"issue":"5","key":"408_CR10","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ki.1996.186","volume":"49","author":"V Witko-Sarsat","year":"1996","unstructured":"Witko-Sarsat V, Friedlander M, Capeill\u00e8re-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996;49(5):1304\u201313. https:\/\/doi.org\/10.1038\/ki.1996.186.","journal-title":"Kidney Int"},{"issue":"9","key":"408_CR11","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1515\/cclm.1997.35.9.669","volume":"35","author":"G M\u00fcnch","year":"1997","unstructured":"M\u00fcnch G, Keis R, We\u00dfels A, Riederer P, Bahner U, Heidland A, et al. Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA. Eur J Clin Chem Clin Biochem. 1997;35(9):669\u201377. https:\/\/doi.org\/10.1515\/cclm.1997.35.9.669.","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"10","key":"408_CR12","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1093\/clinchem\/34.10.2106","volume":"34","author":"H Chung","year":"1988","unstructured":"Chung H, Lees H, Gutman S. Effect of nitroblue tetrazolium concentration on the fructosamine assay for quantifying glycated protein. Clin Chem. 1988;34(10):2106\u201311. https:\/\/doi.org\/10.1093\/clinchem\/34.10.2106.","journal-title":"Clin Chem"},{"issue":"6","key":"408_CR13","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3892\/ol.2012.931","volume":"4","author":"O Zitka","year":"2012","unstructured":"Zitka O, Skalickova S, Gumulec J, Masarik M, Adam V, Hubalek J, et al. Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. Oncol Lett. 2012;4(6):1247\u201353. https:\/\/doi.org\/10.3892\/ol.2012.931.","journal-title":"Oncol Lett"},{"issue":"1","key":"408_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/abio.1996.0292","volume":"239","author":"IF Benzie","year":"1996","unstructured":"Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay. Anal Biochem. 1996;239(1):70\u20136. https:\/\/doi.org\/10.1006\/abio.1996.0292.","journal-title":"Anal Biochem"},{"issue":"4","key":"408_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277\u201385. https:\/\/doi.org\/10.1016\/j.clinbiochem.2003.11.015.","journal-title":"Clin Biochem"},{"issue":"4","key":"408_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/ars.2018.7606","volume":"31","author":"Y Kim","year":"2019","unstructured":"Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, et al. Mitochondria, metabolism, and redox mechanisms in psychiatric disorders. Antioxid Redox Signal. 2019;31(4):275\u201317. https:\/\/doi.org\/10.1089\/ars.2018.7606.","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"408_CR17","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00213-010-2094-2","volume":"214","author":"B Kumar","year":"2011","unstructured":"Kumar B, Kuhad A, Chopra K. Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology. 2011;214(4):819\u201328. https:\/\/doi.org\/10.1007\/s00213-010-2094-2.","journal-title":"Psychopharmacology."},{"key":"408_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jpsychires.2018.02.023","volume":"102","author":"BS Diniz","year":"2018","unstructured":"Diniz BS, Mendes-Silva AP, Silva LB, Bertola L, Vieira MC, Ferreira JD, et al. Oxidative stress markers imbalance in late-life depression. J Psychiatr Res. 2018;102:29\u201333. https:\/\/doi.org\/10.1016\/j.jpsychires.2018.02.023.","journal-title":"J Psychiatr Res"},{"key":"408_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.biopsycho.2015.08.001","volume":"110","author":"FN Kaufmann","year":"2015","unstructured":"Kaufmann FN, Gazal M, Mondin TC, Cardoso TA, Quevedo L\u00c1, Souza LDM, et al. Cognitive psychotherapy treatment decreases peripheral oxidative stress parameters associated with major depression disorder. Biol Psychol. 2015;110:175\u201381. https:\/\/doi.org\/10.1016\/j.biopsycho.2015.08.001.","journal-title":"Biol Psychol"},{"issue":"3","key":"408_CR20","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12640-018-9906-2","volume":"34","author":"M Maes","year":"2018","unstructured":"Maes M, Bonifacio KL, Morelli NR, Vargas HO, Moreira EG, St. Stoyanov D, et al. Generalized anxiety disorder (GAD) and comorbid major depression with GAD are characterized by enhanced nitro-oxidative stress, increased lipid peroxidation, and lowered lipid-associated antioxidant defenses. Neurotox Res. 2018;34(3):489\u2013510. https:\/\/doi.org\/10.1007\/s12640-018-9906-2.","journal-title":"Neurotox Res"},{"issue":"3","key":"408_CR21","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bcmd.2009.12.003","volume":"44","author":"N Rodrigues Pereira","year":"2010","unstructured":"Rodrigues Pereira N, Bandeira Moss M, Assump\u00e7\u00e3o CR, Cardoso CB, Mann GE, Brunini TMC, et al. Oxidative stress, l-arginine\u2013nitric oxide and arginase pathways in platelets from adolescents with anorexia nervosa. Blood Cells Mol Dis. 2010;44(3):164\u20138. https:\/\/doi.org\/10.1016\/j.bcmd.2009.12.003.","journal-title":"Blood Cells Mol Dis"},{"issue":"9","key":"408_CR22","doi-asserted-by":"publisher","first-page":"e106463","DOI":"10.1371\/journal.pone.0106463","volume":"9","author":"VM Victor","year":"2014","unstructured":"Victor VM, Rovira-Llopis S, Saiz-Alarcon V, Sang\u00fcesa MC, Rojo-Bofill L, Ba\u00f1uls C, et al. Altered mitochondrial function and oxidative stress in leukocytes of anorexia nervosa patients. PLoS One. 2014;9(9):e106463. https:\/\/doi.org\/10.1371\/journal.pone.0106463.","journal-title":"PLoS One"},{"issue":"2","key":"408_CR23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/erv.2420","volume":"24","author":"M Solmi","year":"2016","unstructured":"Solmi M, Veronese N, Luchini C, Manzato E, Sergi G, Favaro A, et al. Oxidative stress and antioxidant levels in patients with anorexia nervosa after oral re-alimentation: a systematic review and exploratory meta-analysis. Eur Eat Disord Rev. 2016;24(2):101\u20135. https:\/\/doi.org\/10.1002\/erv.2420.","journal-title":"Eur Eat Disord Rev"},{"issue":"7","key":"408_CR24","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/eat.22443","volume":"48","author":"M Solmi","year":"2015","unstructured":"Solmi M, Veronese N, Manzato E, Sergi G, Favaro A, Santonastaso P, et al. Oxidative stress and antioxidant levels in patients with anorexia nervosa: a systematic review and exploratory meta-analysis. Int J Eat Disord. 2015;48(7):826\u201341. https:\/\/doi.org\/10.1002\/eat.22443.","journal-title":"Int J Eat Disord."},{"key":"408_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.cca.2015.11.028","volume":"453","author":"P Celec","year":"2016","unstructured":"Celec P, T\u00f3thov\u00e1 \u013d, \u0160ebekov\u00e1 K, Podrack\u00e1 \u013d, Boor P. Salivary markers of kidney function \u2014 potentials and limitations. Clin Chim Acta. 2016;453:28\u201337. https:\/\/doi.org\/10.1016\/j.cca.2015.11.028.","journal-title":"Clin Chim Acta"},{"issue":"4","key":"408_CR26","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/eat.22603","volume":"50","author":"M Schorr","year":"2017","unstructured":"Schorr M, Thomas JJ, Eddy KT, Dichtel LE, Lawson EA, Meenaghan E, et al. Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM-IV vs DSM-5. Int J Eat Disord. 2017;50(4):343\u201351. https:\/\/doi.org\/10.1002\/eat.22603.","journal-title":"Int J Eat Disord."},{"issue":"6","key":"408_CR27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3325\/cmj.2018.59.313","volume":"59","author":"V Regecov\u00e1","year":"2018","unstructured":"Regecov\u00e1 V, Hamade J, Janechov\u00e1 H, \u0160ev\u010d\u00edkov\u00e1 \u013d. Comparison of Slovak reference values for anthropometric parameters in children and adolescents with international growth standards: implications for the assessment of overweight and obesity. Croat Med J. 2018;59(6):313\u201326. https:\/\/doi.org\/10.3325\/cmj.2018.59.313.","journal-title":"Croat Med J"},{"key":"408_CR28","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","volume":"114","author":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents","year":"2004","unstructured":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555\u201376 https:\/\/doi.org\/10.1542\/peds.114.2.S2.555.","journal-title":"Pediatrics"},{"issue":"6","key":"408_CR29","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/jcla.10103","volume":"17","author":"S Badiou","year":"2003","unstructured":"Badiou S, Dupuy AM, Descomps B, Cristolead JP. Comparison between the enzymatic vitros assay for creatinine determination and three other methods adapted on the olympus analyzer. J Clin Lab Anal. 2003;17(6):235\u201340. https:\/\/doi.org\/10.1002\/jcla.10103.","journal-title":"J Clin Lab Anal"},{"issue":"8","key":"408_CR30","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/clinchem\/32.8.1551","volume":"32","author":"N Watanabe","year":"1986","unstructured":"Watanabe N, Kamei S, Ohkubo A, Yamanaka M, Ohsawa S, Makino K, et al. Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem. 1986;32(8):1551\u20134. https:\/\/doi.org\/10.1093\/clinchem\/32.8.1551.","journal-title":"Clin Chem"},{"issue":"4","key":"408_CR31","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/ki.2012.169","volume":"82","author":"GJ Schwartz","year":"2012","unstructured":"Schwartz GJ, Schneider MF, Maier PS, Moxey-Mims M, Dharnidharka VR, Warady BA, et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney Int. 2012;82(4):445\u201353. https:\/\/doi.org\/10.1038\/ki.2012.169.","journal-title":"Kidney Int"},{"issue":"1","key":"408_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/(SICI)1098-108X(199901)25:1<99::AID-EAT12>3.0.CO;2-N","volume":"25","author":"D Moyano","year":"1999","unstructured":"Moyano D, Sierra C, Brandi N, Artuch R, Mira A, Garc\u00eda-Tornel S, et al. Antioxidant status in anorexia nervosa. Int J Eat Disord. 1999;25(1):99\u2013103. https:\/\/doi.org\/10.1002\/(sici)1098-108x(199901)25:1<99::aid-eat12>3.0.co;2-n.","journal-title":"Int J Eat Disord"},{"issue":"16","key":"408_CR33","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMra2022774","volume":"383","author":"N Mizushima","year":"2020","unstructured":"Mizushima N, Levine B. Autophagy in human diseases. Longo DL, editor. N Engl J Med. 2020;383(16):1564\u201376. https:\/\/doi.org\/10.1056\/NEJMra2022774.","journal-title":"N Engl J Med"},{"key":"408_CR34","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/eat.23051","volume":"52","author":"AA Hussain","year":"2019","unstructured":"Hussain AA, H\u00fcbel C, Hindborg M, Lindkvist E, Kastrup AM, Yilmaz Z, et al. Increased lipid and lipoprotein concentrations in anorexia nervosa: a systematic review and meta-analysis. Int J Eat Disord. 2019;52:611\u201329. https:\/\/doi.org\/10.1002\/eat.23051.","journal-title":"Int J Eat Disord"},{"issue":"5","key":"408_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s12328-015-0611-x","volume":"8","author":"Y Sato","year":"2015","unstructured":"Sato Y, Fukudo S. Gastrointestinal symptoms and disorders in patients with eating disorders. Clin J Gastroenterol. 2015;8(5):255\u201363. https:\/\/doi.org\/10.1007\/s12328-015-0611-x.","journal-title":"Clin J Gastroenterol"},{"key":"408_CR36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fcimb.2015.00073","volume":"5","author":"L T\u00f3thov\u00e1","year":"2015","unstructured":"T\u00f3thov\u00e1 L, Kamodyov\u00e1 N, \u010cervenka T, Celec P. Salivary markers of oxidative stress in oral diseases. Front Cell Infect Microbiol. 2015;5:73. https:\/\/doi.org\/10.3389\/fcimb.2015.00073.","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"408_CR37","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/jcm9020548","volume":"9","author":"A Zalewska","year":"2020","unstructured":"Zalewska A, Kossakowska A, Taranta-Janusz K, Zi\u0119ba S, Fejfer K, Salamonowicz M, et al. Dysfunction of salivary glands, disturbances in salivary antioxidants and increased oxidative damage in saliva of overweight and obese adolescents. J Clin Med. 2020;9(2):548. https:\/\/doi.org\/10.3390\/jcm9020548.","journal-title":"J Clin Med"},{"issue":"2","key":"408_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bbadis.2004.02.008","volume":"2004","author":"C Capeill\u00e8re-Blandin","year":"1689","unstructured":"Capeill\u00e8re-Blandin C, Gausson V, Descamps-Latscha B, Witko-Sarsat V. Biochemical and spectrophotometric significance of advanced oxidized protein products. Biochim Biophys Acta. 1689;2004(2):91\u201302. https:\/\/doi.org\/10.1016\/j.bbadis.2004.02.008.","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"408_CR39","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/01.ATV.0000214960.85469.68","volume":"26","author":"SX Liu","year":"2006","unstructured":"Liu SX, Hou FF, Guo ZJ, Nagai R, Zhang WR, Liu ZQ, et al. Advanced oxidation protein products accelerate atherosclerosis through promoting oxidative stress and inflammation. Arterioscler Thromb Vasc Biol. 2006;26(5):1156\u201362. https:\/\/doi.org\/10.1161\/01.ATV.0000214960.85469.68.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"408_CR40","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3390\/nu10111573","volume":"10","author":"B Dalton","year":"2018","unstructured":"Dalton B, Campbell I, Chung R, Breen G, Schmidt U, Himmerich H. Inflammatory markers in anorexia nervosa: an exploratory study. Nutrients. 2018;10(11):1573. https:\/\/doi.org\/10.3390\/nu10111573.","journal-title":"Nutrients."},{"issue":"23","key":"408_CR41","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020;383(23):2255\u201373. https:\/\/doi.org\/10.1056\/NEJMra2026131.","journal-title":"N Engl J Med"},{"issue":"6","key":"408_CR42","doi-asserted-by":"publisher","first-page":"921","DOI":"10.33549\/physiolres.933866","volume":"67","author":"M Gyur\u00e1szov\u00e1","year":"2018","unstructured":"Gyur\u00e1szov\u00e1 M, Koval\u010d\u00edkov\u00e1 A, Jan\u0161\u00e1kov\u00e1 K, \u0160ebekov\u00e1 K, Celec P, T\u00f3thov\u00e1 \u013d. Markers of oxidative stress and antioxidant status in the plasma, urine and saliva of healthy mice. Physiol Res. 2018;67(6):921\u201334. https:\/\/doi.org\/10.33549\/physiolres.933866.","journal-title":"Physiol Res"},{"issue":"3","key":"408_CR43","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1017\/S0029665114000603","volume":"73","author":"A Vlassopoulos","year":"2014","unstructured":"Vlassopoulos A, Lean MEJ, Combet E. Oxidative stress, protein glycation and nutrition \u2013 interactions relevant to health and disease throughout the lifecycle. Proc Nutr Soc. 2014;73(3):430\u20138. https:\/\/doi.org\/10.1017\/S0029665114000603.","journal-title":"Proc Nutr Soc"},{"issue":"4","key":"408_CR44","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1053\/ajkd.2001.27414","volume":"38","author":"A Heidland","year":"2001","unstructured":"Heidland A, Sebekova K, Schinzel R. Advanced glycation end products and the progressive course of renal disease. Am J Kidney Dis. 2001;38(4):S100\u20136. https:\/\/doi.org\/10.1053\/ajkd.2001.27414.","journal-title":"Am J Kidney Dis"},{"key":"408_CR45","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.exger.2018.11.012","volume":"117","author":"K \u0160ebekov\u00e1","year":"2019","unstructured":"\u0160ebekov\u00e1 K, Brouder \u0160K. Glycated proteins in nutrition: friend or foe? Exp Gerontol. 2019;117:76\u201390. https:\/\/doi.org\/10.1016\/j.exger.2018.11.012.","journal-title":"Exp Gerontol"},{"issue":"4","key":"408_CR46","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1210\/jc.2007-1817","volume":"93","author":"SY Goh","year":"2008","unstructured":"Goh SY, Cooper ME. The role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008;93(4):1143\u201352. https:\/\/doi.org\/10.1210\/jc.2007-1817.","journal-title":"J Clin Endocrinol Metab"},{"key":"408_CR47","doi-asserted-by":"publisher","unstructured":"Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 1999;344(1):109\u201316. https:\/\/doi.org\/10.1042\/0264-6021:3440109.","DOI":"10.1042\/0264-6021:3440109"},{"key":"408_CR48","doi-asserted-by":"publisher","unstructured":"Tajiri K, Shimizu Y, Tsuneyama K, Sugiyama T. A case report of oxidative stress in a patient with anorexia nervosa. Int J Eat Disord. 2006;39:616\u20138. https:\/\/doi.org\/10.1002\/eat.20326.","DOI":"10.1002\/eat.20326"},{"key":"408_CR49","doi-asserted-by":"publisher","unstructured":"\u0160ebekov\u00e1 K, Somoza V, Jar\u010du\u0161kov\u00e1 M, Heidland A, Podrack\u00e1 L. Plasma advanced glycation end products are decreased in obese children compared with lean controls. Int J Pediatr Obes. 2009;4:112\u20138. https:\/\/doi.org\/10.1080\/17477160802248039.","DOI":"10.1080\/17477160802248039"},{"key":"408_CR50","doi-asserted-by":"publisher","unstructured":"Gaens KH, Da Stehouwer C, Schalkwijk CG. Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity. Curr Opin Lipidol. 2013;24(1):4\u201311. https:\/\/doi.org\/10.1097\/MOL.0b013e32835aea13.","DOI":"10.1097\/MOL.0b013e32835aea13"},{"key":"408_CR51","doi-asserted-by":"crossref","unstructured":"Sitar ME, Aydin S, \u00c7akatay U. Human serum albumin and its relation with oxidative stress. Clin Lab. 2013;59(9-10):945\u201352.","DOI":"10.7754\/Clin.Lab.2012.121115"},{"key":"408_CR52","doi-asserted-by":"publisher","unstructured":"Stheneur C, Bergeron S, Lapeyraque AL. Renal complications in anorexia nervosa. Eat Weight. 2014;19(4):455\u201360. https:\/\/doi.org\/10.1007\/s40519-014-0138-z.","DOI":"10.1007\/s40519-014-0138-z"},{"key":"408_CR53","doi-asserted-by":"publisher","unstructured":"Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med. 2005;34(1):7\u201312. https:\/\/doi.org\/10.1111\/j.1600-0714.2004.00253.x.","DOI":"10.1111\/j.1600-0714.2004.00253.x"},{"key":"408_CR54","doi-asserted-by":"publisher","unstructured":"Celecov\u00e1 V, Kamodyov\u00e1 N, T\u00f3thov\u00e1 \u013d, K\u00fadela M, Celec P. Salivary markers of oxidative stress are related to age and oral health in adult non-smokers. J Oral Pathol Med. 2013;42(3):263\u20136. https:\/\/doi.org\/10.1111\/jop.12008.","DOI":"10.1111\/jop.12008"},{"key":"408_CR55","doi-asserted-by":"publisher","unstructured":"Bigagli E, Lodovici M. Circulating oxidative stress biomarkers in clinical studies on type 2 diabetes and its complications. Oxidative Med Cell Longev. 2019:5953685\u201317. https:\/\/doi.org\/10.1155\/2019\/5953685.","DOI":"10.1155\/2019\/5953685"},{"key":"408_CR56","doi-asserted-by":"publisher","unstructured":"Cost J, Krantz MJ, Mehler PS. Medical complications of anorexia nervosa. Cleve Clin J Med. 2020;87(6):361\u20136. https:\/\/doi.org\/10.3949\/ccjm.87a.19084.","DOI":"10.3949\/ccjm.87a.19084"}],"container-title":["Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40337-021-00408-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40337-021-00408-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40337-021-00408-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:32:46Z","timestamp":1619001166000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeatdisord.biomedcentral.com\/articles\/10.1186\/s40337-021-00408-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["408"],"URL":"https:\/\/doi.org\/10.1186\/s40337-021-00408-6","relation":{},"ISSN":["2050-2974"],"issn-type":[{"value":"2050-2974","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"14 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by The Ethics Committee of The National Institute of Children\u2019s Diseases (NICD), Bratislava, Slovakia. The study was performed in the accordance with the Declaration of Helsinki. Written informed consent was obtained from legal guardians of all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}