{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:44:28Z","timestamp":1772772268782,"version":"3.50.1"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Eat Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Patients who suffer from anorexia nervosa (AN) are characterized by exceedingly lower body weight, micro- and macro-nutrient deficiencies, and hyposalivation as compared to healthy subjects. In addition, AN may predispose to difficulties in oral health maintenance. However, little is known about the relationship between stress-dependent salivary neuro\/immunopeptidergic biomarkers such as opiorphin and immunoglobulins (Ig) and AN.The aim of this case\u2013control study was to evaluate salivary opiorphin and immunoglobulins in female children and adolescents diagnosed with AN compared to healthy controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Adolescent patients with clinically-confirmed severe restrictive subtype AN (Body Mass Index BMI\u2009&lt;\u200915\u00a0kg\/m<jats:sup>2<\/jats:sup>, mean age 15.0\u2009\u00b1\u20091.8, n\u2009=\u200983) were examined in the first week of hospital admission and compared to healthy matched controls (n\u2009=\u200979). Measurements of salivary opiorphin, IgA, IgG, IgM (ELISA technique), and oral hygiene levels (Plaque Control Record index\u2014PCR) were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the AN group, a significantly higher concentration of opiorphin was evidenced (3.1\u2009\u00b1\u20094.1\u00a0ng\/ml) compared to the control group (1.1\u2009\u00b1\u20091.2\u00a0ng\/ml), (p\u2009&lt;\u20090.001), contrary to IgM, which was significantly lower (311.0\u2009\u00b1\u2009185.3\u00a0ng\/ml) than in the control group (421.2\u2009\u00b1\u2009168.1\u00a0ng\/ml), (p\u2009&lt;\u20090.001). There were no significant differences in the levels of IgA and IgG, despite a higher concentration of IgA in the AN group vs. controls (p\u2009=\u20090.14). Spearman analysis revealed a correlation between opiorphin and age (p\u2009&lt;\u20090.05), but also with all immunoglobulins IgA, IgG, IgM (p\u2009=\u20090.006, p\u2009&lt;\u20090.001, p\u2009&lt;\u20090.001). Similarly a correlation was found between PCR index and immunoglobulins IgG, IgM (respectively p\u2009=\u20090.028, p\u2009&lt;\u20090.001), and between body mass, BMI, IBW% and IgA, IgM (all p\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In the acute phase of AN, salivary changes in opiorphin and immunoglobulins related to dental plaque suggest an essential role in oral health balance. Changes related to AN may affect the anti-inflammatory and analgesic components of saliva and suggest their use as neurobiological markers in severe malnutrition.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40337-022-00637-3","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T11:06:39Z","timestamp":1660215999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence"],"prefix":"10.1186","volume":"10","author":[{"given":"Elzbieta","family":"Paszynska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadeusz","family":"Hernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Slopien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tyszkiewicz-Nwafor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Roszak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Bilska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Dmitrzak-Weglarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"issue":"2","key":"637_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.12740\/PP\/64580","volume":"51","author":"G Jagielska","year":"2017","unstructured":"Jagielska G, Kacperska I. 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