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The primary objective of this study was to describe the medical, anthropometric, and psychiatric characteristics of gender diverse adolescents hospitalized for eating disorders and compare these characteristics to cisgender peers hospitalized for eating disorders. The secondary objective was to evaluate percent median body mass index as one marker of malnutrition and treatment goal body mass index as a recovery metric between patients\u2019 birth-assigned sex and affirmed gender using standardized clinical growth charts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective chart review was conducted of 463 patients admitted to an inpatient eating disorders medical unit between 2012 and 2020. To compare medical, anthropometric, and psychiatric data between gender diverse and cisgender patients, chi-square\/Fisher\u2019s exact and <jats:italic>t<\/jats:italic>-tests were used. Clinical growth charts matching the patients\u2019 birth-assigned sex and affirmed gender identity were used to assess percent of median body mass index and treatment goal body mass index.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ten patients (2.2%) identified as gender diverse and were younger than cisgender patients [13.6 (1.5) years vs. 15.6 (2.7) years, <jats:italic>p<\/jats:italic>\u2009=\u20090.017]. Gender diverse patients were hospitalized with a higher percent median body mass index compared to cisgender peers [97.1% (14.8) vs. 87.9% (13.7), <jats:italic>p<\/jats:italic>\u2009=\u20090.037], yet demonstrated equally severe vital sign instability such as bradycardia [44 (8.8) beats per minute vs. 46 (10.6) beats per minute, <jats:italic>p<\/jats:italic>\u2009=\u20090.501], systolic hypotension [84 (7.1) mmHg vs. 84 (9.7) mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.995], and diastolic hypotension [46 (5.8) mmHg vs. 45 (7.3) mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.884]. Gender diverse patients had a higher prevalence of reported anxiety symptoms compared to cisgender patients (60% vs. 28%, <jats:italic>p<\/jats:italic>\u2009=\u20090.037).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Gender diverse patients demonstrated complications of malnutrition including vital sign instability despite presenting with a higher weight. This is consistent with a greater proportion of gender diverse patients diagnosed with atypical anorexia nervosa compared to cisgender peers. Additionally, psychiatric comorbidities were present among both groups, with a larger percentage of gender diverse patients endorsing anxiety compared to cisgender patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40337-022-00722-7","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T16:06:01Z","timestamp":1671811561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transgender and other gender diverse adolescents with eating disorders requiring medical stabilization"],"prefix":"10.1186","volume":"10","author":[{"given":"Anita V.","family":"Chaphekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Stanley R.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Garber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Buckelew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle T.","family":"Ganson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"issue":"1","key":"722_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3109\/09540261.2015.1089217","volume":"28","author":"BA Jones","year":"2016","unstructured":"Jones BA, Haycraft E, Murjan S, Arcelus J. 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The Institutional Review Board (IRB) of the University of California, San Francisco approved this study. This research study was conducted retrospectively from data obtained for clinical purposes. The IRB of the University of California, San Francisco determined that our study did not need informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"199"}}