{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:02:36Z","timestamp":1794445356924,"version":"4.9.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["Melbourne Research Scholarship"],"award-info":[{"award-number":["Melbourne Research Scholarship"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH112748"],"award-info":[{"award-number":["R01MH112748"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1K01MH115247-01A1"],"award-info":[{"award-number":["1K01MH115247-01A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5 U01MH109977"],"award-info":[{"award-number":["5 U01MH109977"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005292","name":"Brigham and Women's Hospital","doi-asserted-by":"publisher","award":["Department of Psychiatry Internal Funding Award"],"award-info":[{"award-number":["Department of Psychiatry Internal Funding Award"]}],"id":[{"id":"10.13039\/100005292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1177370"],"award-info":[{"award-number":["1177370"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194028"],"award-info":[{"award-number":["1194028"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1154651"],"award-info":[{"award-number":["GNT1154651"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1196508"],"award-info":[{"award-number":["1196508"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1159953"],"award-info":[{"award-number":["GNT1159953"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Melbourne Dame Kate Campbell Fellowship"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH125860"],"award-info":[{"award-number":["R01MH125860"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Eat Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Anorexia nervosa (AN) is a potentially fatal psychiatric condition, associated with structural brain changes such as gray matter volume loss. The pathophysiological mechanisms for these changes are not yet fully understood. Iron is a crucial element in the development and function of the brain. Considering the systemic alterations in iron homeostasis in AN, we hypothesized that brain iron would be altered as a possible factor associated with structural brain changes in AN.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, we used quantitative susceptibility mapping (QSM) magnetic resonance imaging to investigate brain iron in current AN (c-AN) and weight-restored AN compared with healthy individuals. Whole-brain voxel wise comparison was used to probe areas with possible group differences. Further, the thalamus, caudate nucleus, putamen, nucleus accumbens, hippocampus, and amygdala were selected as the regions of interest (ROIs) for ROI-based comparison of mean QSM values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Whole-brain voxel-wise and ROI-based comparison of QSM did not reveal any differences between groups. Exploratory analyses revealed a correlation between higher regional QSM (higher iron) and lower body mass index, higher illness severity, longer illness duration, and younger age at onset in the c-AN group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study did not find evidence of altered brain iron in AN compared to healthy individuals. However, the correlations between clinical variables and QSM suggest a link between brain iron and weight status or biological processes in AN, which warrants further investigation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40337-023-00870-4","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:02:12Z","timestamp":1692626532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study"],"prefix":"10.1186","volume":"11","author":[{"given":"Parsa","family":"Ravanfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jarrett","family":"Rushmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Lyall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Cropley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Makris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Desmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Shenton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Rossell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Pantelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warda T.","family":"Syeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Phillipou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"870_CR1","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1002\/jnr.24674","volume":"98","author":"V Alfano","year":"2020","unstructured":"Alfano V, Mele G, Cotugno A, Longarzo M. Multimodal neuroimaging in anorexia nervosa. J Neurosci Res. 2020;98:2178\u2013207. https:\/\/doi.org\/10.1002\/jnr.24674.","journal-title":"J Neurosci Res"},{"key":"870_CR2","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","volume":"68","author":"J Arcelus","year":"2011","unstructured":"Arcelus J, Mitchell AJ, Wales J, Nielsen S. Mortality rates in patients with anorexia nervosa and other eating disorders: a meta-analysis of 36 studies. Arch Gen Psychiatry. 2011;68:724\u201331. https:\/\/doi.org\/10.1001\/archgenpsychiatry.2011.74.","journal-title":"Arch Gen Psychiatry"},{"key":"870_CR3","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","volume":"54","author":"BB Avants","year":"2011","unstructured":"Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage. 2011;54:2033\u201344. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.09.025.","journal-title":"Neuroimage"},{"key":"870_CR4","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1093\/brain\/awx137","volume":"140","author":"S Ayton","year":"2017","unstructured":"Ayton S, Fazlollahi A, Bourgeat P, Raniga P, Ng A, Lim YY, Diouf I, Farquharson S, Fripp J, Ames D, Doecke J, Desmond P, Ordidge R, Masters CL, Rowe CC, Maruff P, Villemagne VL, Salvado O, Bush AI. Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline. Brain J Neurol. 2017;140:2112\u20139. https:\/\/doi.org\/10.1093\/brain\/awx137.","journal-title":"Brain J Neurol"},{"key":"870_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/jha2.321","volume":"3","author":"C Berthou","year":"2022","unstructured":"Berthou C, Iliou JP, Barba D. Iron, neuro-bioavailability and depression. eJHaem. 2022;3:263\u201375. https:\/\/doi.org\/10.1002\/jha2.321.","journal-title":"eJHaem"},{"key":"870_CR6","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/jon.12647","volume":"29","author":"J Boto","year":"2019","unstructured":"Boto J, Askin NC, Regnaud A, Kober T, Gkinis G, Lazeyras F, L\u00f6vblad K-O, Vargas MI. Cerebral gray and white matter involvement in anorexia nervosa evaluated by T1, T2, and T2* mapping. J Neuroimaging. 2019;29:598\u2013604. https:\/\/doi.org\/10.1111\/jon.12647.","journal-title":"J Neuroimaging"},{"key":"870_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7","volume":"17","author":"JR Connor","year":"1996","unstructured":"Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia. 1996;17:83\u201393. https:\/\/doi.org\/10.1002\/(SICI)1098-1136(199606)17:2%3c83::AID-GLIA1%3e3.0.CO;2-7.","journal-title":"Glia"},{"key":"870_CR8","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/ejcn.2016.115","volume":"70","author":"E De Filippo","year":"2016","unstructured":"De Filippo E, Marra M, Alfinito F, Di Guglielmo ML, Majorano P, Cerciello G, De Caprio C, Contaldo F, Pasanisi F. Hematological complications in anorexia nervosa. Eur J Clin Nutr. 2016;70:1305\u20138. https:\/\/doi.org\/10.1038\/ejcn.2016.115.","journal-title":"Eur J Clin Nutr"},{"key":"870_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3546","author":"JH Duyn","year":"2017","unstructured":"Duyn JH, Schenck J. Contributions to magnetic susceptibility of brain tissue, NMR in biomedicine. NIH Public Access. 2017. https:\/\/doi.org\/10.1002\/nbm.3546.","journal-title":"NIH Public Access"},{"key":"870_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/ph12030126","volume":"12","author":"A Ferreira","year":"2019","unstructured":"Ferreira A, Neves P, Gozzelino R. Multilevel impacts of iron in the brain: the cross talk between neurophysiological mechanisms, cognition, and social behavior. Pharmaceuticals (Basel). 2019;12:126. https:\/\/doi.org\/10.3390\/ph12030126.","journal-title":"Pharmaceuticals (Basel)"},{"key":"870_CR11","doi-asserted-by":"publisher","first-page":"1110065","DOI":"10.1016\/j.pscychresns.2020.111065","volume":"300","author":"AD Gianni","year":"2020","unstructured":"Gianni AD, De Donatis D, Valente S, De Ronchi D, Atti AR. Eating disorders: do PET and SPECT have a role? A systematic review of the literature. Psychiatry Res Neuroimaging. 2020;300:1110065. https:\/\/doi.org\/10.1016\/j.pscychresns.2020.111065.","journal-title":"Psychiatry Res Neuroimaging"},{"key":"870_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2018.06.007","volume":"179","author":"S Hametner","year":"2018","unstructured":"Hametner S, Endmayr V, Deistung A, Palmrich P, Prihoda M, Haimburger E, Menard C, Feng X, Haider T, Leisser M, K\u00f6ck U, Kaider A, H\u00f6ftberger R, Robinson S, Reichenbach JR, Lassmann H, Traxler H, Trattnig S, Grabner G. The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation\u2014a biochemical and histological validation study. Neuroimage. 2018;179:117\u201333. https:\/\/doi.org\/10.1016\/j.neuroimage.2018.06.007.","journal-title":"Neuroimage"},{"key":"870_CR13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/eat.23453","volume":"54","author":"MM Hurley","year":"2021","unstructured":"Hurley MM, Murlanova K, Macias LK, Sabir AI, O\u2019Brien SC, Bhasin H, Tamashiro KL, Pletnikov MV, Moran TH. Activity-based anorexia disrupts systemic oxidative state and induces cortical mitochondrial fission in adolescent female rats. Int J Eat Disord. 2021;54:639\u201345. https:\/\/doi.org\/10.1002\/eat.23453.","journal-title":"Int J Eat Disord"},{"key":"870_CR14","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"M Jenkinson","year":"2012","unstructured":"Jenkinson M, Beckmann CF, Behrens TEJ, Woolrich MW, Smith SM. FSL. Neuroimage. 2012;62:782\u201390. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.09.015.","journal-title":"Neuroimage"},{"key":"870_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/children8020137","volume":"8","author":"K Kappou","year":"2021","unstructured":"Kappou K, Ntougia M, Kourtesi A, Panagouli E, Vlachopapadopoulou E, Michalacos S, Gonidakis F, Mastorakos G, Psaltopoulou T, Tsolia M, Bacopoulou F, Sergentanis TN, Tsitsika A. Neuroimaging findings in adolescents and young adults with anorexia nervosa: a systematic review. Children. 2021;8:137. https:\/\/doi.org\/10.3390\/children8020137.","journal-title":"Children"},{"key":"870_CR16","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1440-1754.2004.00432.x","volume":"40","author":"A Kennedy","year":"2004","unstructured":"Kennedy A, Kohn M, Lammi A, Clarke S. Iron status and haematological changes in adolescent female inpatients with anorexia nervosa. J Paediatr Child Health. 2004;40:430\u20132. https:\/\/doi.org\/10.1111\/j.1440-1754.2004.00432.x.","journal-title":"J Paediatr Child Health"},{"key":"870_CR17","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.biopsych.2017.08.011","volume":"83","author":"JA King","year":"2018","unstructured":"King JA, Frank GKW, Thompson PM, Ehrlich S. Structural neuroimaging of anorexia nervosa: future directions in the quest for mechanisms underlying dynamic alterations. Biol Psychiatry. 2018;83:224\u201334. https:\/\/doi.org\/10.1016\/j.biopsych.2017.08.011.","journal-title":"Biol Psychiatry"},{"key":"870_CR18","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","volume":"4","author":"D Lakens","year":"2013","unstructured":"Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863.","journal-title":"Front Psychol"},{"key":"870_CR19","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.neuroimage.2012.05.049","volume":"62","author":"C Langkammer","year":"2012","unstructured":"Langkammer C, Schweser F, Krebs N, Deistung A, Goessler W, Scheurer E, Sommer K, Reishofer G, Yen K, Fazekas F, Ropele S, Reichenbach JR. Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. Neuroimage. 2012;62:1593\u20139. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.05.049.","journal-title":"Neuroimage"},{"key":"870_CR20","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1016\/j.neuroimage.2010.11.088","volume":"55","author":"W Li","year":"2011","unstructured":"Li W, Wu B, Liu C. Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition. Neuroimage. 2011;55:1645\u201356. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.11.088.","journal-title":"Neuroimage"},{"key":"870_CR21","doi-asserted-by":"publisher","first-page":"18108","DOI":"10.1073\/pnas.1114863108","volume":"108","author":"C Lindfors","year":"2011","unstructured":"Lindfors C, Nilsson IAK, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhl\u00e9n M, Ekstr\u00f6m TJ, Davisson MT, H\u00f6kfelt TGM, Schalling M, Johansen JE. Hypothalamic mitochondrial dysfunction associated with anorexia in the anx\/anx mouse. Proc Natl Acad Sci. 2011;108:18108\u201313. https:\/\/doi.org\/10.1073\/pnas.1114863108.","journal-title":"Proc Natl Acad Sci"},{"key":"870_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/ph12030120","volume":"12","author":"V Markova","year":"2019","unstructured":"Markova V, Holm C, Pinborg AB, Thomsen LL, Moos T. Impairment of the developing human brain in iron deficiency: correlations to findings in experimental animals and prospects for early intervention therapy. Pharmaceuticals (Basel). 2019;12:120. https:\/\/doi.org\/10.3390\/ph12030120.","journal-title":"Pharmaceuticals (Basel)"},{"key":"870_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2018.09.033","volume":"133","author":"S Masaldan","year":"2019","unstructured":"Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C. Striking while the iron is hot: iron metabolism and ferroptosis in neurodegeneration. Free Radic Biol Med. 2019;133:221\u201333. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.09.033.","journal-title":"Free Radic Biol Med"},{"key":"870_CR24","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1002\/eat.23160","volume":"52","author":"P Meneguzzo","year":"2019","unstructured":"Meneguzzo P, Collantoni E, Solmi M, Tenconi E, Favaro A. Anorexia nervosa and diffusion weighted imaging: an open methodological question raised by a systematic review and a fractional anisotropy anatomical likelihood estimation meta-analysis. Int J Eat Disord. 2019;52:1237\u201350. https:\/\/doi.org\/10.1002\/eat.23160.","journal-title":"Int J Eat Disord"},{"key":"870_CR25","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/mrm.22825","volume":"66","author":"A Ng","year":"2011","unstructured":"Ng A, Johnston L, Chen Z, Cho Z-H, Zhang J, Egan G. Spatially dependent filtering for removing phase distortions at the cortical surface. Magn Reson Med. 2011;66:784\u201393. https:\/\/doi.org\/10.1002\/mrm.22825.","journal-title":"Magn Reson Med"},{"key":"870_CR26","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3945\/ajcn.111.025817","volume":"95","author":"S Papillard-Marechal","year":"2012","unstructured":"Papillard-Marechal S, Sznajder M, Hurtado-Nedelec M, Alibay Y, Martin-Schmitt C, Dehoux M, Westerman M, Beaumont C, Chevallier B, Puy H, Stheneur C. Iron metabolism in patients with anorexia nervosa: elevated serum hepcidin concentrations in the absence of inflammation. Am J Clin Nutr. 2012;95:548\u201354. https:\/\/doi.org\/10.3945\/ajcn.111.025817.","journal-title":"Am J Clin Nutr"},{"key":"870_CR27","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1038\/s41598-022-06113-x","volume":"12","author":"E Pappaianni","year":"2022","unstructured":"Pappaianni E, Borsarini B, Doucet GE, Hochman A, Frangou S, Micali N. Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study. Sci Rep. 2022;12:2589. https:\/\/doi.org\/10.1038\/s41598-022-06113-x.","journal-title":"Sci Rep"},{"key":"870_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/17474086.2016.1268047","volume":"10","author":"BT Paul","year":"2017","unstructured":"Paul BT, Manz DH, Torti FM, Torti SV. Mitochondria and iron: current questions. Expert Rev Hematol. 2017;10:65\u201379. https:\/\/doi.org\/10.1080\/17474086.2016.1268047.","journal-title":"Expert Rev Hematol"},{"key":"870_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pscychresns.2016.04.008","volume":"251","author":"A Phillipou","year":"2016","unstructured":"Phillipou A, Abel LA, Castle DJ, Hughes ME, Nibbs RG, Gurvich C, Rossell SL. Resting state functional connectivity in anorexia nervosa. Psychiatry Res Neuroimaging. 2016;251:45\u201352. https:\/\/doi.org\/10.1016\/j.pscychresns.2016.04.008.","journal-title":"Psychiatry Res Neuroimaging"},{"key":"870_CR30","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1002\/hbm.24279","volume":"39","author":"A Phillipou","year":"2018","unstructured":"Phillipou A, Carruthers SP, Di Biase MA, Zalesky A, Abel LA, Castle DJ, Gurvich C, Rossell SL. White matter microstructure in anorexia nervosa. Hum Brain Mapp. 2018;39:4385\u201392. https:\/\/doi.org\/10.1002\/hbm.24279.","journal-title":"Hum Brain Mapp"},{"key":"870_CR31","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1111\/ejn.14158","volume":"48","author":"A Phillipou","year":"2018","unstructured":"Phillipou A, Rossell SL, Castle DJ. Anorexia nervosa or starvation? Eur J Neurosci. 2018;48:3317\u20138. https:\/\/doi.org\/10.1111\/ejn.14158.","journal-title":"Eur J Neurosci"},{"key":"870_CR32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/0004867413509693","volume":"48","author":"A Phillipou","year":"2014","unstructured":"Phillipou A, Rossell SL, Castle DJ. The neurobiology of anorexia nervosa: a systematic review. Aust N Z J Psychiatry. 2014;48:128\u201352. https:\/\/doi.org\/10.1177\/0004867413509693.","journal-title":"Aust N Z J Psychiatry"},{"key":"870_CR33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/ejn.13793","volume":"47","author":"A Phillipou","year":"2018","unstructured":"Phillipou A, Rossell SL, Gurvich C, Castle DJ, Abel LA, Nibbs RG, Hughes ME. Differences in regional grey matter volumes in currently ill patients with anorexia nervosa. Eur J Neurosci. 2018;47:177\u201383. https:\/\/doi.org\/10.1111\/ejn.13793.","journal-title":"Eur J Neurosci"},{"key":"870_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.618435","author":"P Ravanfar","year":"2021","unstructured":"Ravanfar P, Loi SM, Syeda W, Van Rheenen TE, Bush AI, Desmond P, Cropley V, Lane DJR, Opazo CM, Moffat B, Velakoulis D, Pantelis C. Systematic review; quantitative susceptibility mapping (QSM) of brain iron profile in neurodegenerative diseases. Front Neurosci. 2021. https:\/\/doi.org\/10.3389\/fnins.2021.618435.","journal-title":"Front Neurosci"},{"key":"870_CR35","doi-asserted-by":"publisher","first-page":"e18138","DOI":"10.7759\/cureus.18138","volume":"13","author":"HE Shah","year":"2021","unstructured":"Shah HE, Bhawnani N, Ethirajulu A, Alkasabera A, Onyali CB, Anim-Koranteng C, Mostafa JA. Iron deficiency-induced changes in the hippocampus, corpus striatum, and monoamines levels that lead to anxiety, depression, sleep disorders, and psychotic disorders. Cureus. 2021;13:e18138. https:\/\/doi.org\/10.7759\/cureus.18138.","journal-title":"Cureus"},{"key":"870_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","volume":"44","author":"SM Smith","year":"2009","unstructured":"Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44:83\u201398. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.03.061.","journal-title":"Neuroimage"},{"key":"870_CR37","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.nicl.2015.10.008","volume":"9","author":"KE Travis","year":"2015","unstructured":"Travis KE, Golden NH, Feldman HM, Solomon M, Nguyen J, Mezer A, Yeatman JD, Dougherty RF. Abnormal white matter properties in adolescent girls with anorexia nervosa. NeuroImage Clin. 2015;9:648\u201359. https:\/\/doi.org\/10.1016\/j.nicl.2015.10.008.","journal-title":"NeuroImage Clin"},{"key":"870_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.04.022","author":"E Walton","year":"2022","unstructured":"Walton E, Bernardoni F, Batury V-L, Bahnsen K, Larivi\u00e8re S, Abbate-Daga G, Andres-Perpi\u00f1a S, Bang L, Bischoff-Grethe A, Brooks SJ, Campbell IC, Cascino G, Castro-Fornieles J, Collantoni E, D\u2019Agata F, Dahmen B, Danner UN, Favaro A, Feusner JD, Frank GK, Friederich H-C, Graner JL, Herpertz-Dahlmann B, Hess A, Horndasch S, Kaplan AS, Kaufmann L-K, Kaye WH, Khalsa SS, LaBar KS, Lavagnino L, Lazaro L, Manara R, Miles AE, Milos GF, Alessio MM, Monteleone P, Mwangi B, O\u2019Daly O, Pariente J, Roesch J, Schmidt UH, Seitz J, Shott ME, Simon JJ, Smeets PAM, Tamnes CK, Tenconi E, Thomopoulos SI, van Elburg AA, Voineskos AN, von Polier GG, Wierenga CE, Zucker NL, Jahanshad N, King JA, Thompson PM, Berner LA, Ehrlich S. Brain structure in acutely underweight and partially weight-restored individuals with anorexia nervosa\u2014a coordinated analysis by the ENIGMA eating disorders working group. Biol Psychiatry. 2022. https:\/\/doi.org\/10.1016\/j.biopsych.2022.04.022.","journal-title":"Biol Psychiatry"},{"key":"870_CR39","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41589-019-0371-x","volume":"15","author":"Z Wang","year":"2019","unstructured":"Wang Z, Zeng Y-N, Yang P, Jin L-Q, Xiong W-C, Zhu M-Z, Zhang J-Z, He X, Zhu X-H. Axonal iron transport in the brain modulates anxiety-related behaviors. Nat Chem Biol. 2019;15:1214\u201322. https:\/\/doi.org\/10.1038\/s41589-019-0371-x.","journal-title":"Nat Chem Biol"},{"key":"870_CR40","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","volume":"92","author":"AM Winkler","year":"2014","unstructured":"Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. Neuroimage. 2014;92:381\u201397. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.01.060.","journal-title":"Neuroimage"},{"key":"870_CR41","doi-asserted-by":"publisher","first-page":"e0173563","DOI":"10.1371\/journal.pone.0173563","volume":"12","author":"A W\u0142odarczyk","year":"2017","unstructured":"W\u0142odarczyk A, Sonakowska L, Kami\u0144ska K, Marchewka A, Wilczek G, Wilczek P, Student S, Rost-Roszkowska M. The effect of starvation and re-feeding on mitochondrial potential in the midgut of Neocaridina davidi (Crustacea, Malacostraca). PLoS ONE. 2017;12:e0173563. https:\/\/doi.org\/10.1371\/journal.pone.0173563.","journal-title":"PLoS ONE"},{"key":"870_CR42","doi-asserted-by":"publisher","first-page":"117701","DOI":"10.1016\/j.neuroimage.2020.117701","volume":"231","author":"N Yaghmaie","year":"2021","unstructured":"Yaghmaie N, Syeda WT, Wu C, Zhang Y, Zhang TD, Burrows EL, Brodtmann A, Moffat BA, Wright DK, Glarin R, Kolbe S, Johnston LA. QSMART: quantitative susceptibility mapping artifact reduction technique. Neuroimage. 2021;231:117701. https:\/\/doi.org\/10.1016\/j.neuroimage.2020.117701.","journal-title":"Neuroimage"},{"key":"870_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnhum.2017.00442","volume":"11","author":"S Yao","year":"2017","unstructured":"Yao S, Zhong Y, Xu Y, Qin J, Zhang N, Zhu X, Li Y. Quantitative susceptibility mapping reveals an association between brain iron load and depression severity. Front Hum Neurosci. 2017;11:1\u20138. https:\/\/doi.org\/10.3389\/fnhum.2017.00442.","journal-title":"Front Hum Neurosci"}],"container-title":["Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40337-023-00870-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40337-023-00870-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40337-023-00870-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T03:54:05Z","timestamp":1700538845000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeatdisord.biomedcentral.com\/articles\/10.1186\/s40337-023-00870-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1186\/s40337-023-00870-4","relation":{},"ISSN":["2050-2974"],"issn-type":[{"value":"2050-2974","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"3 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was granted ethics approval by the Human Research Ethics Committee (HREC) at The Melbourne Clinic (TMC REC 263), and expedited ethics approval from Swinburne\u2019s Human Research Ethics Committee (SUHREC 2016\/152). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A.I.B. is a shareholder in Alterity Ltd, Cogstate Ltd and Mesoblast Ltd. He is a paid consultant for, and has a profit share interest in, Collaborative Medicinal Development Pty Ltd.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"142"}}