{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:56:08Z","timestamp":1789779368665,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Pediatr"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s40348-015-0020-8","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:09:12Z","timestamp":1445213352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lessons learned from metabolomics in cystic fibrosis"],"prefix":"10.1186","volume":"2","author":[{"given":"Marianne S.","family":"Muhlebach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"20_CR1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1183\/09031936.00228013","volume":"44","author":"MA Mall","year":"2014","unstructured":"Mall MA, Hartl D (2014) CFTR: cystic fibrosis and beyond. Eur Respir J 44:1042\u20131054. doi: 10.1183\/09031936.00228013","journal-title":"Eur Respir J"},{"key":"20_CR2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1373\/clinchem.2006.077008","volume":"53","author":"I Batal","year":"2007","unstructured":"Batal I, Ericsoussi MB, Cluette-Brown JE, O\u2019Sullivan BP, Freedman SD, Savaille JE, Laposata M (2007) Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis. Clin Chem 53:78\u201384. doi: 10.1373\/clinchem.2006.077008","journal-title":"Clin Chem"},{"key":"20_CR3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3945\/ajcn.2009.27757","volume":"90","author":"L Iuliano","year":"2009","unstructured":"Iuliano L, Monticolo R, Straface G, Zullo S, Galli F, Boaz M, Quattrucci S (2009) Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis. Am J Clin Nutr 90:477\u2013484. doi: 10.3945\/ajcn.2009.27757","journal-title":"Am J Clin Nutr"},{"key":"20_CR4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clinbiochem.2014.07.019","volume":"47","author":"YY Zhao","year":"2014","unstructured":"Zhao YY, Cheng XL, Vaziri ND, Liu S, Lin RC (2014) UPLC-based metabonomic applications for discovering biomarkers of diseases in clinical chemistry. Clin Biochem 47:16\u201326. doi: 10.1016\/j.clinbiochem.2014.07.019","journal-title":"Clin Biochem"},{"key":"20_CR5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2010.07.015","volume":"406","author":"L Liu","year":"2010","unstructured":"Liu L, Aa J, Wang G, Yan B, Zhang Y, Wang X, Zhao C, Cao B, Shi J, Li M, Zheng T, Zheng Y, Hao G, Zhou F, Sun J, Wu Z (2010) Differences in metabolite profile between blood plasma and serum. Anal Biochem 406:105\u2013112","journal-title":"Anal Biochem"},{"key":"20_CR6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ppul.22859","volume":"49","author":"E Joseloff","year":"2014","unstructured":"Joseloff E, Sha W, Bell SC, Wetmore DR, Lawton KA, Milburn MV, Ryals JA, Guo L, Muhlebach MS (2014) Serum metabolomics indicate altered cellular energy metabolism in children with cystic fibrosis. Pediatr Pulmonol 49:463\u2013472. doi: 10.1002\/ppul.22859","journal-title":"Pediatr Pulmonol"},{"key":"20_CR7","author":"TA Laguna","year":"2015","unstructured":"Laguna TA, Reilly CS, Williams CB, Welchlin C, Wendt CH (2015) Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation. Pediatr Pulmonol. doi: 10.1002\/ppul.23225","journal-title":"Pediatr Pulmonol"},{"key":"20_CR8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJMe038217","volume":"350","author":"B Strandvik","year":"2004","unstructured":"Strandvik B (2004) Fatty acid metabolism in cystic fibrosis. N Engl J Med 350:605\u2013607","journal-title":"N Engl J Med"},{"key":"20_CR9","doi-asserted-by":"crossref","first-page":"L476","DOI":"10.1152\/ajplung.00262.2006","volume":"292","author":"NM White","year":"2007","unstructured":"White NM, Jiang D, Burgess JD, Bederman IR, Previs SF, Kelley TJ (2007) Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 292:L476\u2013L486. doi: 10.1152\/ajplung.00262.2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"20_CR10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007735","volume":"4","author":"IC Guerrera","year":"2009","unstructured":"Guerrera IC, Astarita G, Jais JP, Sands D, Nowakowska A, Colas J, Sermet-Gaudelus I, Schuerenberg M, Piomelli D, Edelman A, Ollero M (2009) A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. PLoS One 4, e7735. doi: 10.1371\/journal.pone.0007735","journal-title":"PLoS One"},{"key":"20_CR11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-1-61779-120-8_16","volume":"742","author":"M Ollero","year":"2011","unstructured":"Ollero M, Guerrera IC, Astarita G, Piomelli D, Edelman A (2011) New lipidomic approaches in cystic fibrosis. Methods Mol Biol 742:265\u2013278","journal-title":"Methods Mol Biol"},{"key":"20_CR12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.freeradbiomed.2012.05.001","volume":"53","author":"J Yang","year":"2012","unstructured":"Yang J, Eiserich JP, Cross CE, Morrissey BM, Hammock BD (2012) Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic Biol Med 53:160\u2013171","journal-title":"Free Radic Biol Med"},{"key":"20_CR13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jcf.2015.02.004","volume":"14","author":"J Zhao","year":"2015","unstructured":"Zhao J, Evans CR, Carmody LA, LiPuma JJ (2015) Impact of storage conditions on metabolite profiles of sputum samples from persons with cystic fibrosis. J Cyst Fibros 14:468\u2013473. doi: 10.1016\/j.jcf.2015.02.004","journal-title":"J Cyst Fibros"},{"key":"20_CR14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/ajrccm.160.1.9808096","volume":"160","author":"MS Muhlebach","year":"1999","unstructured":"Muhlebach MS, Stewart PW, Leigh MW, Noah TL (1999) Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 160:186\u2013191","journal-title":"Am J Respir Crit Care Med"},{"key":"20_CR15","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa1301725","volume":"368","author":"PD Sly","year":"2013","unstructured":"Sly PD, Gangell CL, Chen L, Ware RS, Ranganathan S, Mott LS, Murray CP, Stick SM, Investigators AC (2013) Risk factors for bronchiectasis in children with cystic fibrosis. N Engl J Med 368:1963\u20131970. doi: 10.1056\/NEJMoa1301725","journal-title":"N Engl J Med"},{"key":"20_CR16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/13547500802688194","volume":"14","author":"JE Wolak","year":"2009","unstructured":"Wolak JE, Esther CR Jr, O\u2019Connell TM (2009) Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients. Biomarkers 14:55\u201360. doi: 10.1080\/13547500802688194","journal-title":"Biomarkers"},{"key":"20_CR17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1378\/chest.14-1800","volume":"148","author":"CR Esther Jr","year":"2015","unstructured":"Esther CR Jr, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC (2015) Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis. Chest 148:507\u2013515. doi: 10.1378\/chest.14-1800","journal-title":"Chest"},{"key":"20_CR18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.05.00029705","volume":"26","author":"I Horvath","year":"2005","unstructured":"Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B, Gessner C, Greening A, Ho LP, Hohlfeld J, Jobsis Q, Laskowski D, Loukides S, Marlin D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen EL, Rubinstein I, Silkoff P et al (2005) Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 26:523\u2013548. doi: 10.1183\/09031936.05.00029705","journal-title":"Eur Respir J"},{"key":"20_CR19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/thoraxjnl-2011-200072","volume":"67","author":"P Montuschi","year":"2012","unstructured":"Montuschi P, Paris D, Melck D, Lucidi V, Ciabattoni G, Raia V, Calabrese C, Bush A, Barnes PJ, Motta A (2012) NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis. Thorax 67:222\u2013228. doi: 10.1136\/thoraxjnl-2011-200072","journal-title":"Thorax"},{"key":"20_CR20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1164\/rccm.201402-0249LE","volume":"190","author":"P Montuschi","year":"2014","unstructured":"Montuschi P, Paris D, Montella S, Melck D, Mirra V, Santini G, Mores N, Montemitro E, Majo F, Lucidi V, Bush A, Motta A, Santamaria F (2014) Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis. Am J Respir Crit Care Med 190:229\u2013233. doi: 10.1164\/rccm.201402-0249LE","journal-title":"Am J Respir Crit Care Med"},{"key":"20_CR21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1378\/chest.14-0781","volume":"147","author":"MP Schee van der","year":"2015","unstructured":"van der Schee MP, Paff T, Brinkman P, van Aalderen WM, Haarman EG, Sterk PJ (2015) Breathomics in lung disease. Chest 147:224\u2013231. doi: 10.1378\/chest.14-0781","journal-title":"Chest"},{"key":"20_CR22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1203\/PDR.0b013e3181df4ea0","volume":"68","author":"CM Robroeks","year":"2010","unstructured":"Robroeks CM, van Berkel JJ, Dallinga JW, Jobsis Q, Zimmermann LJ, Hendriks HJ, Wouters MF, van der Grinten CP, van de Kant KD, van Schooten FJ, Dompeling E (2010) Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr Res 68:75\u201380. doi: 10.1203\/00006450-201011001-00143","journal-title":"Pediatr Res"},{"key":"20_CR23","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jcf.2012.12.010","volume":"12","author":"T Paff","year":"2013","unstructured":"Paff T, van der Schee MP, Daniels JM, Pals G, Postmus PE, Sterk PJ, Haarman EG (2013) Exhaled molecular profiles in the assessment of cystic fibrosis and primary ciliary dyskinesia. J Cyst Fibros 12:454\u2013460. doi: 10.1016\/j.jcf.2012.12.010","journal-title":"J Cyst Fibros"},{"key":"20_CR24","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1462-2920.2012.02840.x","volume":"15","author":"V Behrends","year":"2013","unstructured":"Behrends V, Ryall B, Zlosnik JE, Speert DP, Bundy JG, Williams HD (2013) Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections. Environ Microbiol 15:398\u2013408. doi: 10.1111\/j.1462-2920.2012.02840.x","journal-title":"Environ Microbiol"},{"key":"20_CR25","doi-asserted-by":"crossref","unstructured":"Kozlowska J, Rivett DW, Vermeer LS, Carroll MP, Bruce KD, Mason AJ, Rogers GB (2013) A relationship between growth behaviour and cystic fibrosis patient lung function identified in a metabolomic investigation. Metabolomics 9. doi: 10.1007\/s11306-013-0538-5","DOI":"10.1007\/s11306-013-0538-5"},{"key":"20_CR26","doi-asserted-by":"crossref","first-page":"30516","DOI":"10.1074\/jbc.M110.140806","volume":"285","author":"DR Wetmore","year":"2010","unstructured":"Wetmore DR, Joseloff E, Pilewski J, Lee DP, Lawton KA, Mitchell MW, Milburn MV, Ryals JA, Guo L (2010) Metabolomic profiling reveals biochemical pathways and biomarkers associated with pathogenesis in cystic fibrosis cells. J Biol Chem 285:30516\u201330522","journal-title":"J Biol Chem"},{"key":"20_CR27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/ajcn\/85.3.702","volume":"85","author":"SM Innis","year":"2007","unstructured":"Innis SM, Davidson AG, Melynk S, James SJ (2007) Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. Am J Clin Nutr 85:702\u2013708","journal-title":"Am J Clin Nutr"},{"key":"20_CR28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.etap.2008.12.005","volume":"27","author":"BO Keller","year":"2009","unstructured":"Keller BO, Davidson AG, Innis SM (2009) Phthalate metabolites in urine of CF patients are associated with use of enteric-coated pancreatic enzymes. Environ Toxicol Pharmacol 27:424\u2013427. doi: 10.1016\/j.etap.2008.12.005","journal-title":"Environ Toxicol Pharmacol"},{"key":"20_CR29","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100:9440\u20139445. doi: 10.1073\/pnas.1530509100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"20_CR30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Stat Methodol 57:289\u2013300","journal-title":"J Roy Stat Soc B Stat Methodol"},{"key":"20_CR31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.chroma.2014.04.071","volume":"1353","author":"S Naz","year":"2014","unstructured":"Naz S, Vallejo M, Garcia A, Barbas C (2014) Method validation strategies involved in non-targeted metabolomics. J Chromatogr A 1353:99\u2013105. doi: 10.1016\/j.chroma.2014.04.071","journal-title":"J Chromatogr A"}],"container-title":["Molecular and Cellular Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-015-0020-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40348-015-0020-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-015-0020-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:32:32Z","timestamp":1718141552000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.molcellped.com\/content\/2\/1\/9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1186\/s40348-015-0020-8","relation":{},"ISSN":["2194-7791"],"issn-type":[{"value":"2194-7791","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]},"article-number":"9"}}