{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:56:24Z","timestamp":1792598184717,"version":"4.5.0"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Helmholtz Zentrum M\u00fcnchen - Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Pediatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these exposures. Here, we review the relationship between immaturity and prenatal conditions, as well as postnatal exposure to mechanical ventilation and oxygen toxicity, with the imbalance of pro- and anti-inflammatory regulatory networks. In these conditions, cytokine release, protease activity, and sustained presence of innate immune cells in the lung result in pathologic processes contributing to lung injury. We highlight the recruitment and function of myeloid innate immune cells, in particular, neutrophils and monocyte\/macrophages in the BPD lung in human patients and animal models. We also discuss dissimilarities between the infant and adult immune system as a basis for the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.1186\/s40348-022-00148-w","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:05:09Z","timestamp":1659398709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Association of immune cell recruitment and BPD development"],"prefix":"10.1186","volume":"9","author":[{"given":"Motaharehsadat","family":"Heydarian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Stoeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hilgendorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"148_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40348-015-0013-7","volume":"2","author":"S Niedermaier","year":"2015","unstructured":"Niedermaier S, Hilgendorff A (2015) Bronchopulmonary dysplasia - an overview about pathophysiologic concepts. Mol Cell Pediatr 2:2. https:\/\/doi.org\/10.1186\/s40348-015-0013-7","journal-title":"Mol Cell Pediatr"},{"key":"148_CR2","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1213\/ANE.0000000000000705","volume":"120","author":"HC Glass","year":"2015","unstructured":"Glass HC, Costarino AT, Stayer SA et al (2015) Outcomes for extremely premature infants. Anesth Analg 120:1337\u20131351. https:\/\/doi.org\/10.1213\/ANE.0000000000000705","journal-title":"Anesth Analg"},{"key":"148_CR3","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1056\/NEJMoa1513737","volume":"374","author":"MJ McGeachie","year":"2016","unstructured":"McGeachie MJ, Yates KP, Zhou X et al (2016) Patterns of growth and decline in lung function in persistent childhood asthma. N Engl J Med 374:1842\u20131852. https:\/\/doi.org\/10.1056\/NEJMoa1513737","journal-title":"N Engl J Med"},{"key":"148_CR4","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/biomedicines9080944","volume":"9","author":"Y Tong","year":"2021","unstructured":"Tong Y, Zhang S, Riddle S et al (2021) Intrauterine hypoxia and epigenetic programming in lung development and disease. Biomedicines 9:944. https:\/\/doi.org\/10.3390\/biomedicines9080944","journal-title":"Biomedicines"},{"key":"148_CR5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1053\/j.semperi.2006.05.007","volume":"30","author":"MA Biniwale","year":"2006","unstructured":"Biniwale MA, Ehrenkranz RA (2006) The role of nutrition in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol 30:200\u2013208. https:\/\/doi.org\/10.1053\/j.semperi.2006.05.007","journal-title":"Semin Perinatol"},{"key":"148_CR6","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.clp.2012.06.014","volume":"39","author":"A Trembath","year":"2012","unstructured":"Trembath A, Laughon MM (2012) Predictors of bronchopulmonary dysplasia. Clin Perinatol 39:585\u2013601. https:\/\/doi.org\/10.1016\/j.clp.2012.06.014","journal-title":"Clin Perinatol"},{"key":"148_CR7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/BF02723151","volume":"70","author":"PK Riyas","year":"2003","unstructured":"Riyas PK, Vijayakumar KM, Kulkarni ML (2003) Neonatal mechanical ventilation. Indian J Pediatr 70:537\u2013540. https:\/\/doi.org\/10.1007\/BF02723151","journal-title":"Indian J Pediatr"},{"key":"148_CR8","doi-asserted-by":"publisher","first-page":"L23","DOI":"10.1152\/ajplung.00251.2009","volume":"298","author":"LM Mokres","year":"2010","unstructured":"Mokres LM, Parai K, Hilgendorff A et al (2010) Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Am J Physiol Cell Mol Physiol 298:L23\u2013L35. https:\/\/doi.org\/10.1152\/ajplung.00251.2009","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"148_CR9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1189\/jlb.4ru0317-111r","volume":"102","author":"E Jong","year":"2017","unstructured":"Jong E, Strunk T, Burgner D et al (2017) The phenotype and function of preterm infant monocytes: implications for susceptibility to infection. J Leukoc Biol 102:645\u2013656. https:\/\/doi.org\/10.1189\/jlb.4ru0317-111r","journal-title":"J Leukoc Biol"},{"key":"148_CR10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1289\/ehp.97105s51159","volume":"105","author":"KE Driscoll","year":"1997","unstructured":"Driscoll KE, Carter JM, Hassenbein DG, Howard B (1997) Cytokines and particle-induced inflammatory cell recruitment. Environ Health Perspect 105:1159\u20131164. https:\/\/doi.org\/10.1289\/ehp.97105s51159","journal-title":"Environ Health Perspect"},{"key":"148_CR11","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1542\/peds.93.5.712","volume":"93","author":"P Groneck","year":"1994","unstructured":"Groneck P, G\u00f6tze-Speer B, Oppermann M et al (1994) Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics 93:712\u2013718","journal-title":"Pediatrics"},{"key":"148_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2019.00464","volume":"7","author":"Y Sun","year":"2019","unstructured":"Sun Y, Chen C, Zhang X et al (2019) High neutrophil-to-lymphocyte ratio is an early predictor of bronchopulmonary dysplasia. Front Pediatr 7:1\u20139. https:\/\/doi.org\/10.3389\/fped.2019.00464","journal-title":"Front Pediatr"},{"key":"148_CR13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.siny.2008.08.011","volume":"14","author":"BW Kramer","year":"2009","unstructured":"Kramer BW, Kallapur S, Newnham J, Jobe AH (2009) Prenatal inflammation and lung development. Semin Fetal Neonatal Med 14:2\u20137. https:\/\/doi.org\/10.1016\/j.siny.2008.08.011","journal-title":"Semin Fetal Neonatal Med"},{"key":"148_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2015.00090","volume":"2","author":"J Balany","year":"2015","unstructured":"Balany J, Bhandari V (2015) Understanding the impact of infection, inflammation, and their persistence in the pathogenesis of bronchopulmonary dysplasia. Front Med 2:1\u201310. https:\/\/doi.org\/10.3389\/fmed.2015.00090","journal-title":"Front Med"},{"key":"148_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1164\/rccm.200904-0637OC","volume":"182","author":"RJ Wright","year":"2010","unstructured":"Wright RJ, Visness CM, Calatroni A et al (2010) Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. Am J Respir Crit Care Med 182:25\u201333. https:\/\/doi.org\/10.1164\/rccm.200904-0637OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR16","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00281-020-00803-2","volume":"42","author":"A Humberg","year":"2020","unstructured":"Humberg A, Fortmann I, Siller B et al (2020) Preterm birth and sustained inflammation: consequences for the neonate. Semin Immunopathol 42:451\u2013468. https:\/\/doi.org\/10.1007\/s00281-020-00803-2","journal-title":"Semin Immunopathol"},{"key":"148_CR17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.siny.2011.09.001","volume":"17","author":"V Agrawal","year":"2012","unstructured":"Agrawal V, Hirsch E (2012) Intrauterine infection and preterm labor. Semin Fetal Neonatal Med 17:12\u201319. https:\/\/doi.org\/10.1016\/j.siny.2011.09.001","journal-title":"Semin Fetal Neonatal Med"},{"key":"148_CR18","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","volume":"10","author":"S Basha","year":"2014","unstructured":"Basha S, Surendran N, Pichichero M (2014) Immune responses in neonates. Expert Rev Clin Immunol 10:1171\u20131184. https:\/\/doi.org\/10.1586\/1744666X.2014.942288","journal-title":"Expert Rev Clin Immunol"},{"key":"148_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/985646","volume":"2012","author":"P Palmeira","year":"2012","unstructured":"Palmeira P, Quinello C, Silveira-Lessa AL et al (2012) IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol 2012:1\u201313. https:\/\/doi.org\/10.1155\/2012\/985646","journal-title":"Clin Dev Immunol"},{"key":"148_CR20","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1038\/sj.jp.7211476","volume":"26","author":"CP Speer","year":"2006","unstructured":"Speer CP (2006) Pulmonary inflammation and bronchopulmonary dysplasia. J Perinatol 26:S57\u2013S62. https:\/\/doi.org\/10.1038\/sj.jp.7211476","journal-title":"J Perinatol"},{"key":"148_CR21","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.siny.2006.03.004","volume":"11","author":"CP Speer","year":"2006","unstructured":"Speer CP (2006) Inflammation and bronchopulmonary dysplasia: a continuing story. Semin Fetal Neonatal Med 11:354\u2013362","journal-title":"Semin Fetal Neonatal Med"},{"key":"148_CR22","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.3390\/ijms22031138","volume":"22","author":"MJ Goetz","year":"2021","unstructured":"Goetz MJ, Kremer S, Behnke J et al (2021) MSC based therapies to prevent or treat BPD\u2014a narrative review on advances and ongoing challenges. Int J Mol Sci 22:1138. https:\/\/doi.org\/10.3390\/ijms22031138","journal-title":"Int J Mol Sci"},{"key":"148_CR23","doi-asserted-by":"publisher","unstructured":"Heydarian M, Oak P, Zhang X et al (2022) Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant. Thorax thoraxjnl-2021-218083. https:\/\/doi.org\/10.1136\/thoraxjnl-2021-218083","DOI":"10.1136\/thoraxjnl-2021-218083"},{"key":"148_CR24","doi-asserted-by":"publisher","first-page":"L49","DOI":"10.1152\/ajplung.00060.2019","volume":"317","author":"LC Eldredge","year":"2019","unstructured":"Eldredge LC, Creasy RS, Presnell S et al (2019) Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates. Am J Physiol Cell Mol Physiol 317:L49\u2013L56. https:\/\/doi.org\/10.1152\/ajplung.00060.2019","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"148_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nri2075","volume":"7","author":"O Levy","year":"2007","unstructured":"Levy O (2007) Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 7:379\u2013390. https:\/\/doi.org\/10.1038\/nri2075","journal-title":"Nat Rev Immunol"},{"key":"148_CR26","doi-asserted-by":"publisher","unstructured":"Yu JC, Khodadadi H, Malik A et al (2018) Innate immunity of neonates and infants. Front Immunol 9. https:\/\/doi.org\/10.3389\/fimmu.2018.01759","DOI":"10.3389\/fimmu.2018.01759"},{"key":"148_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1203\/01.pdr.0000250274.68571.18","volume":"61","author":"DS Newburg","year":"2007","unstructured":"Newburg DS, Walker WA (2007) Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res 61:2\u20138. https:\/\/doi.org\/10.1203\/01.pdr.0000250274.68571.18","journal-title":"Pediatr Res"},{"key":"148_CR28","doi-asserted-by":"publisher","first-page":"ji2101192","DOI":"10.3389\/fimmu.2014.00434","volume":"5","author":"DM MacGillivray","year":"2014","unstructured":"MacGillivray DM, Kollmann TR (2014) The role of environmental factors in modulating immune responses in early life. Front Immunol 5:ji2101192. https:\/\/doi.org\/10.3389\/fimmu.2014.00434","journal-title":"Front Immunol"},{"key":"148_CR29","doi-asserted-by":"publisher","first-page":"a016303","DOI":"10.1101\/cshperspect.a016303","volume":"7","author":"CL Sokol","year":"2015","unstructured":"Sokol CL, Luster AD (2015) The chemokine system in innate immunity. Cold Spring Harb Perspect Biol 7:a016303. https:\/\/doi.org\/10.1101\/cshperspect.a016303","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"148_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.0022-202X.2005.23856.x","volume":"125","author":"R Clark","year":"2005","unstructured":"Clark R, Kupper T (2005) Old meets new: the interaction between innate and adaptive immunity. J Invest Dermatol 125:629\u2013637. https:\/\/doi.org\/10.1111\/j.0022-202X.2005.23856.x","journal-title":"J Invest Dermatol"},{"key":"148_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2014.00491","volume":"5","author":"G Arango Duque","year":"2014","unstructured":"Arango Duque G, Descoteaux A (2014) Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol 5:1\u201312. https:\/\/doi.org\/10.3389\/fimmu.2014.00491","journal-title":"Front Immunol"},{"key":"148_CR32","doi-asserted-by":"publisher","unstructured":"Ibrahim J, Garantziotis S, Savani RC (2020) The inflammation superhighway. In: Updates on neonatal chronic lung disease. Elsevier, Philadelphia, pp 131\u2013150. https:\/\/doi.org\/10.1016\/B978-0-323-68353-1.00009-9","DOI":"10.1016\/B978-0-323-68353-1.00009-9"},{"key":"148_CR33","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1513\/pats.200508-090JS","volume":"2","author":"TR Martin","year":"2005","unstructured":"Martin TR (2005) Innate immunity in the lungs. Proc Am Thorac Soc 2:403\u2013411. https:\/\/doi.org\/10.1513\/pats.200508-090JS","journal-title":"Proc Am Thorac Soc"},{"key":"148_CR34","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/pathogens8030106","volume":"8","author":"Glaser","year":"2019","unstructured":"Glaser, Coulter, Shields et al (2019) Airway epithelial derived cytokines and chemokines and their role in the immune response to respiratory syncytial virus infection. Pathogens 8:106. https:\/\/doi.org\/10.3390\/pathogens8030106","journal-title":"Pathogens"},{"key":"148_CR35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","volume":"21","author":"RJ Hewitt","year":"2021","unstructured":"Hewitt RJ, Lloyd CM (2021) Regulation of immune responses by the airway epithelial cell landscape. Nat Rev Immunol 21:347\u2013362. https:\/\/doi.org\/10.1038\/s41577-020-00477-9","journal-title":"Nat Rev Immunol"},{"key":"148_CR36","doi-asserted-by":"publisher","unstructured":"Qing C, Ziyun L, Xuefei Y et al (2022) Protective effects of 18\u03b2-glycyrrhetinic acid on neonatal rats with hyperoxia exposure. Inflammation. https:\/\/doi.org\/10.1007\/s10753-021-01616-7","DOI":"10.1007\/s10753-021-01616-7"},{"key":"148_CR37","doi-asserted-by":"publisher","first-page":"204173142098880","DOI":"10.1177\/2041731420988802","volume":"12","author":"M Heydarian","year":"2021","unstructured":"Heydarian M, Schweinlin M, Schwarz T et al (2021) Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: a novel 3D tissue model for bacterial infection and immunity. J Tissue Eng 12:204173142098880. https:\/\/doi.org\/10.1177\/2041731420988802","journal-title":"J Tissue Eng"},{"key":"148_CR38","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1084\/jem.20162152","volume":"214","author":"AV Misharin","year":"2017","unstructured":"Misharin AV, Morales-Nebreda L, Reyfman PA et al (2017) Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med 214:2387\u20132404. https:\/\/doi.org\/10.1084\/jem.20162152","journal-title":"J Exp Med"},{"key":"148_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2014.00514","volume":"5","author":"P Italiani","year":"2014","unstructured":"Italiani P, Boraschi D (2014) From monocytes to M1\/M2 macrophages: phenotypical vs. functional differentiation. Front Immunol 5:1\u201322. https:\/\/doi.org\/10.3389\/fimmu.2014.00514","journal-title":"Front Immunol"},{"key":"148_CR40","doi-asserted-by":"publisher","first-page":"ji2101192","DOI":"10.4049\/jimmunol.2101192","volume":"26","author":"A Honda","year":"2022","unstructured":"Honda A, Hoeksema MA, Sakai M et al (2022) The lung microenvironment instructs gene transcription in neonatal and adult alveolar macrophages. J Immunol 26:ji2101192. https:\/\/doi.org\/10.4049\/jimmunol.2101192","journal-title":"J Immunol"},{"key":"148_CR41","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1542\/peds.2008-0526","volume":"123","author":"N Ambalavanan","year":"2009","unstructured":"Ambalavanan N, Carlo WA, D\u2019Angio CT et al (2009) Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123:1132\u20131141. https:\/\/doi.org\/10.1542\/peds.2008-0526","journal-title":"Pediatrics"},{"key":"148_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ppul.10417","volume":"37","author":"RJ Baier","year":"2004","unstructured":"Baier RJ, Majid A, Parupia H et al (2004) CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia. Pediatr Pulmonol 37:137\u2013148. https:\/\/doi.org\/10.1002\/ppul.10417","journal-title":"Pediatr Pulmonol"},{"key":"148_CR43","doi-asserted-by":"publisher","first-page":"F455","DOI":"10.1136\/adc.2007.121327","volume":"93","author":"CL Bose","year":"2008","unstructured":"Bose CL, Dammann CEL, Laughon MM (2008) Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. Arch Dis Child - Fetal Neonatal Ed 93:F455\u2013F461. https:\/\/doi.org\/10.1136\/adc.2007.121327","journal-title":"Arch Dis Child - Fetal Neonatal Ed"},{"key":"148_CR44","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.freeradbiomed.2003.12.007","volume":"36","author":"GTM Wagenaar","year":"2004","unstructured":"Wagenaar GTM, ter Horst SA, van Gastelen MA et al (2004) Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free Radic Biol Med 36:782\u2013801. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2003.12.007","journal-title":"Free Radic Biol Med"},{"key":"148_CR45","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1684\/ecn.2012.0304","volume":"23","author":"N K\u00f6ksal","year":"2012","unstructured":"K\u00f6ksal N, Kay\u0131k B, \u00c7etinkaya M et al (2012) Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants. Eur Cytokine Netw 23:29\u201335. https:\/\/doi.org\/10.1684\/ecn.2012.0304","journal-title":"Eur Cytokine Netw"},{"key":"148_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2431-3-8","volume":"3","author":"RJ Baier","year":"2003","unstructured":"Baier RJ, Loggins J, Kruger TE (2003) Interleukin-4 and 13 concentrations in infants at risk to develop Bronchopulmonary Dysplasia. BMC Pediatr 3:8. https:\/\/doi.org\/10.1186\/1471-2431-3-8","journal-title":"BMC Pediatr"},{"key":"148_CR47","doi-asserted-by":"publisher","unstructured":"Cai J, Lu H, Su Z et al (2022) Dynamic changes of NCR\u2212 type 3 innate lymphoid cells and their role in mice with bronchopulmonary dysplasia. Inflammation. https:\/\/doi.org\/10.1007\/s10753-021-01543-7","DOI":"10.1007\/s10753-021-01543-7"},{"key":"148_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3908061","volume":"2017","author":"T Kuwabara","year":"2017","unstructured":"Kuwabara T, Ishikawa F, Kondo M, Kakiuchi T (2017) The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators Inflamm 2017:1\u201311. https:\/\/doi.org\/10.1155\/2017\/3908061","journal-title":"Mediators Inflamm"},{"key":"148_CR49","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1182\/blood.V82.8.2478.2478","volume":"82","author":"KR Schibler","year":"1993","unstructured":"Schibler KR, Liechty KW, White WL, Christensen RD (1993) Production of granulocyte colony-stimulating factor in vitro by monocytes from preterm and term neonates. Blood 82:2478\u20132484. https:\/\/doi.org\/10.1182\/blood.V82.8.2478.2478","journal-title":"Blood"},{"key":"148_CR50","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1542\/peds.2010-3875","volume":"128","author":"CJ Wright","year":"2011","unstructured":"Wright CJ, Kirpalani H (2011) Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies? Pediatrics 128:111\u2013126. https:\/\/doi.org\/10.1542\/peds.2010-3875","journal-title":"Pediatrics"},{"key":"148_CR51","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1053\/j.semperi.2018.09.009","volume":"42","author":"RC Savani","year":"2018","unstructured":"Savani RC (2018) Modulators of inflammation in bronchopulmonary dysplasia. Semin Perinatol 42:459\u2013470. https:\/\/doi.org\/10.1053\/j.semperi.2018.09.009","journal-title":"Semin Perinatol"},{"key":"148_CR52","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1465-9921-6-61","volume":"6","author":"B Beck-Schimmer","year":"2005","unstructured":"Beck-Schimmer B, Schwendener R, Pasch T et al (2005) Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury. Respir Res 6:61. https:\/\/doi.org\/10.1186\/1465-9921-6-61","journal-title":"Respir Res"},{"key":"148_CR53","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/nm.2514","volume":"17","author":"M Phillipson","year":"2011","unstructured":"Phillipson M, Kubes P (2011) The neutrophil in vascular inflammation. Nat Med 17:1381\u20131390. https:\/\/doi.org\/10.1038\/nm.2514","journal-title":"Nat Med"},{"key":"148_CR54","doi-asserted-by":"publisher","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","volume":"306","author":"NR Aggarwal","year":"2014","unstructured":"Aggarwal NR, King LS, D\u2019Alessio FR (2014) Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Cell Mol Physiol 306:L709\u2013L725. https:\/\/doi.org\/10.1152\/ajplung.00341.2013","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"148_CR55","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1203\/00006450-198912000-00001","volume":"26","author":"RD Christensen","year":"1989","unstructured":"Christensen RD (1989) Hematopoiesis in the fetus and neonate. Pediatr Res 26:531\u2013532. https:\/\/doi.org\/10.1203\/00006450-198912000-00001","journal-title":"Pediatr Res"},{"key":"148_CR56","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1365-2567.2008.02950.x","volume":"125","author":"RC Furze","year":"2008","unstructured":"Furze RC, Rankin SM (2008) Neutrophil mobilization and clearance in the bone marrow. Immunology 125:281\u2013288. https:\/\/doi.org\/10.1111\/j.1365-2567.2008.02950.x","journal-title":"Immunology"},{"key":"148_CR57","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00441-017-2753-2","volume":"371","author":"K Prame Kumar","year":"2018","unstructured":"Prame Kumar K, Nicholls AJ, Wong CHY (2018) Partners in crime: neutrophils and monocytes\/macrophages in inflammation and disease. Cell Tissue Res 371:551\u2013565. https:\/\/doi.org\/10.1007\/s00441-017-2753-2","journal-title":"Cell Tissue Res"},{"key":"148_CR58","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ni.2921","volume":"15","author":"WM Nauseef","year":"2014","unstructured":"Nauseef WM, Borregaard N (2014) Neutrophils at work. Nat Immunol 15:602\u2013611. https:\/\/doi.org\/10.1038\/ni.2921","journal-title":"Nat Immunol"},{"key":"148_CR59","doi-asserted-by":"publisher","first-page":"S498","DOI":"10.1097\/01.CCM.0000186787.64500.12","volume":"33","author":"H Bayr","year":"2005","unstructured":"Bayr H (2005) Reactive oxygen species. Crit Care Med 33:S498\u2013S501. https:\/\/doi.org\/10.1097\/01.CCM.0000186787.64500.12","journal-title":"Crit Care Med"},{"key":"148_CR60","doi-asserted-by":"publisher","unstructured":"Wen ST, Chen W, Chen HL et al (2013) Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury. PLoS One 8. https:\/\/doi.org\/10.1371\/journal.pone.0075383","DOI":"10.1371\/journal.pone.0075383"},{"key":"148_CR61","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1542\/peds.2005-0123","volume":"117","author":"R Turunen","year":"2006","unstructured":"Turunen R, Nupponen I, Siitonen S et al (2006) Onset of mechanical ventilation is associated with rapid activation of circulating phagocytes in preterm infants. Pediatrics 117:448\u2013454. https:\/\/doi.org\/10.1542\/peds.2005-0123","journal-title":"Pediatrics"},{"key":"148_CR62","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1097\/ALN.0000000000000605","volume":"122","author":"C Yildiz","year":"2015","unstructured":"Yildiz C, Palaniyar N, Otulakowski G et al (2015) Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology 122:864\u2013875. https:\/\/doi.org\/10.1097\/ALN.0000000000000605","journal-title":"Anesthesiology"},{"key":"148_CR63","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3390\/ijms23031254","volume":"23","author":"JM Thomas","year":"2022","unstructured":"Thomas JM, Sudhadevi T, Basa P et al (2022) The role of sphingolipid signaling in oxidative lung injury and pathogenesis of bronchopulmonary dysplasia. Int J Mol Sci 23:1254. https:\/\/doi.org\/10.3390\/ijms23031254","journal-title":"Int J Mol Sci"},{"key":"148_CR64","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.gene.2018.08.031","volume":"678","author":"J Wang","year":"2018","unstructured":"Wang J, Dong W (2018) Oxidative stress and bronchopulmonary dysplasia. Gene 678:177\u2013183. https:\/\/doi.org\/10.1016\/j.gene.2018.08.031","journal-title":"Gene"},{"key":"148_CR65","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1165\/rcmb.2016-0033OC","volume":"55","author":"A Vargas","year":"2016","unstructured":"Vargas A, Roux-Dalvai F, Droit A, Lavoie J-P (2016) Neutrophil-derived exosomes: a new mechanism contributing to airway smooth muscle remodeling. Am J Respir Cell Mol Biol 55:450\u2013461. https:\/\/doi.org\/10.1165\/rcmb.2016-0033OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"148_CR66","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.cell.2018.12.002","volume":"176","author":"KR Genschmer","year":"2019","unstructured":"Genschmer KR, Russell DW, Lal C et al (2019) Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung. Cell 176:113\u2013126.e15. https:\/\/doi.org\/10.1016\/j.cell.2018.12.002","journal-title":"Cell"},{"key":"148_CR67","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1164\/rccm.200402-215OC","volume":"170","author":"M Yi","year":"2004","unstructured":"Yi M, Jankov RP, Belcastro R et al (2004) Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Am J Respir Crit Care Med 170:1188\u20131196. https:\/\/doi.org\/10.1164\/rccm.200402-215OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2015.00091","volume":"2","author":"I Mi\u017e\u00edkov\u00e1","year":"2015","unstructured":"Mi\u017e\u00edkov\u00e1 I, Morty RE (2015) The extracellular matrix in bronchopulmonary dysplasia: target and source. Front Med 2:1\u201320. https:\/\/doi.org\/10.3389\/fmed.2015.00091","journal-title":"Front Med"},{"key":"148_CR69","doi-asserted-by":"publisher","first-page":"14645","DOI":"10.1111\/jcmm.15842","volume":"24","author":"J Xu","year":"2020","unstructured":"Xu J, Mao X, Jin R et al (2020) Neutrophil extracellular traps degrade fibronectin in a rat model of bronchopulmonary dysplasia induced by perinatal exposure to lipopolysaccharide. J Cell Mol Med 24:14645\u201314649. https:\/\/doi.org\/10.1111\/jcmm.15842","journal-title":"J Cell Mol Med"},{"key":"148_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8243378","volume":"2021","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Huang Y, Ji Q et al (2021) Interplay between extracellular matrix and neutrophils in diseases. J Immunol Res 2021:1\u201311. https:\/\/doi.org\/10.1155\/2021\/8243378","journal-title":"J Immunol Res"},{"key":"148_CR71","doi-asserted-by":"publisher","first-page":"L619","DOI":"10.1152\/ajplung.00507.2005","volume":"291","author":"R Yasumatsu","year":"2006","unstructured":"Yasumatsu R, Altiok O, Benarafa C et al (2006) SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia. Am J Physiol Cell Mol Physiol 291:L619\u2013L627. https:\/\/doi.org\/10.1152\/ajplung.00507.2005","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"148_CR72","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1046\/j.1365-2141.2000.01992.x","volume":"110","author":"R Carr","year":"2000","unstructured":"Carr R (2000) Neutrophil production and function in newborn infants. Br J Haematol 110:18\u201328. https:\/\/doi.org\/10.1046\/j.1365-2141.2000.01992.x","journal-title":"Br J Haematol"},{"key":"148_CR73","doi-asserted-by":"publisher","first-page":"e12943","DOI":"10.1111\/eci.12943","volume":"48","author":"P Hellebrekers","year":"2018","unstructured":"Hellebrekers P, Vrisekoop N, Koenderman L (2018) Neutrophil phenotypes in health and disease. Eur J Clin Invest 48:e12943. https:\/\/doi.org\/10.1111\/eci.12943","journal-title":"Eur J Clin Invest"},{"key":"148_CR74","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.1182\/blood-2008-07-171629","volume":"113","author":"CC Yost","year":"2009","unstructured":"Yost CC, Cody MJ, Harris ES et al (2009) Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113:6419\u20136427. https:\/\/doi.org\/10.1182\/blood-2008-07-171629","journal-title":"Blood"},{"key":"148_CR75","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","volume":"30","author":"B Amulic","year":"2012","unstructured":"Amulic B, Cazalet C, Hayes GL et al (2012) Neutrophil function: from mechanisms to disease. Annu Rev Immunol 30:459\u2013489. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-074942","journal-title":"Annu Rev Immunol"},{"key":"148_CR76","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1136\/fn.89.1.F76","volume":"89","author":"P Ballabh","year":"2004","unstructured":"Ballabh P (2004) Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child - Fetal Neonatal Ed 89:76\u201383. https:\/\/doi.org\/10.1136\/fn.89.1.F76","journal-title":"Arch Dis Child - Fetal Neonatal Ed"},{"key":"148_CR77","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.pedneo.2020.08.013","volume":"61","author":"X Li","year":"2020","unstructured":"Li X, Wang Q, Luo T, Li T (2020) Decreased neutrophil levels in bronchopulmonary dysplasia infants. Pediatr Neonatol 61:637\u2013644. https:\/\/doi.org\/10.1016\/j.pedneo.2020.08.013","journal-title":"Pediatr Neonatol"},{"key":"148_CR78","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1203\/PDR.0b013e3181e17caa","volume":"68","author":"AA Kroon","year":"2010","unstructured":"Kroon AA, Wang J, Huang Z et al (2010) Inflammatory response to oxygen and endotoxin in newborn rat lung ventilated with low tidal volume. Pediatr Res 68:63\u201369. https:\/\/doi.org\/10.1203\/PDR.0b013e3181e17caa","journal-title":"Pediatr Res"},{"key":"148_CR79","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/0140-6736(91)91443-X","volume":"338","author":"JM Grigg","year":"1991","unstructured":"Grigg JM, Silverman M, Savill JS et al (1991) Neutrophil apoptosis and clearance from neonatal lungs. Lancet 338:720\u2013722. https:\/\/doi.org\/10.1016\/0140-6736(91)91443-X","journal-title":"Lancet"},{"key":"148_CR80","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/imr.12220","volume":"262","author":"CL Scott","year":"2014","unstructured":"Scott CL, Henri S, Guilliams M (2014) Mononuclear phagocytes of the intestine, the skin, and the lung. Immunol Rev 262:9\u201324. https:\/\/doi.org\/10.1111\/imr.12220","journal-title":"Immunol Rev"},{"key":"148_CR81","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.4049\/jimmunol.179.6.3488","volume":"179","author":"L Landsman","year":"2007","unstructured":"Landsman L, Jung S (2007) Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages. J Immunol 179:3488\u20133494. https:\/\/doi.org\/10.4049\/jimmunol.179.6.3488","journal-title":"J Immunol"},{"key":"148_CR82","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1165\/rcmb.2017-0328ED","volume":"58","author":"AC McQuattie-Pimentel","year":"2018","unstructured":"McQuattie-Pimentel AC, Budinger GRS, Ballinger MN (2018) Monocyte-derived alveolar macrophages: the dark side of lung repair? Am J Respir Cell Mol Biol 58:5\u20136. https:\/\/doi.org\/10.1165\/rcmb.2017-0328ED","journal-title":"Am J Respir Cell Mol Biol"},{"key":"148_CR83","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/path.5076","volume":"245","author":"TV Kalymbetova","year":"2018","unstructured":"Kalymbetova TV, Selvakumar B, Rodr\u00edguez-Castillo JA et al (2018) Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia. J Pathol 245:153\u2013159. https:\/\/doi.org\/10.1002\/path.5076","journal-title":"J Pathol"},{"key":"148_CR84","doi-asserted-by":"publisher","first-page":"17836","DOI":"10.1038\/s41598-020-74639-z","volume":"10","author":"G Sanchez-Schmitz","year":"2020","unstructured":"Sanchez-Schmitz G, Morrocchi E, Cooney M et al (2020) Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. Sci Rep 10:17836. https:\/\/doi.org\/10.1038\/s41598-020-74639-z","journal-title":"Sci Rep"},{"key":"148_CR85","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11:762\u2013774. https:\/\/doi.org\/10.1038\/nri3070","journal-title":"Nat Rev Immunol"},{"key":"148_CR86","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/cvr\/cvv147","volume":"107","author":"T Gerhardt","year":"2015","unstructured":"Gerhardt T, Ley K (2015) Monocyte trafficking across the vessel wall. Cardiovasc Res 107:321\u2013330. https:\/\/doi.org\/10.1093\/cvr\/cvv147","journal-title":"Cardiovasc Res"},{"key":"148_CR87","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2017.03.024","volume":"21","author":"AJ Lechner","year":"2017","unstructured":"Lechner AJ, Driver IH, Lee J et al (2017) Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy. Cell Stem Cell 21:120\u2013134.e7. https:\/\/doi.org\/10.1016\/j.stem.2017.03.024","journal-title":"Cell Stem Cell"},{"key":"148_CR88","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1399-3038.2004.00168.x","volume":"15","author":"U Hallwirth","year":"2004","unstructured":"Hallwirth U, Pomberger G, Pollak A et al (2004) Monocyte switch in neonates: high phagocytic capacity and low HLA-DR expression in VLBWI are inverted during gestational aging. Pediatr Allergy Immunol 15:513\u2013516. https:\/\/doi.org\/10.1111\/j.1399-3038.2004.00168.x","journal-title":"Pediatr Allergy Immunol"},{"key":"148_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.02035","volume":"10","author":"TS Kapellos","year":"2019","unstructured":"Kapellos TS, Bonaguro L, Gem\u00fcnd I et al (2019) Human monocyte subsets and phenotypes in major chronic inflammatory diseases. Front Immunol 10:1\u201313. https:\/\/doi.org\/10.3389\/fimmu.2019.02035","journal-title":"Front Immunol"},{"key":"148_CR90","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.3389\/fimmu.2019.01761","volume":"10","author":"S-M Ong","year":"2019","unstructured":"Ong S-M, Teng K, Newell E et al (2019) A novel, five-marker alternative to CD16\u2013CD14 gating to identify the three human monocyte subsets. Front Immunol 10:1761. https:\/\/doi.org\/10.3389\/fimmu.2019.01761","journal-title":"Front Immunol"},{"key":"148_CR91","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.4049\/jimmunol.1601281","volume":"198","author":"M Chimen","year":"2017","unstructured":"Chimen M, Yates CM, McGettrick HM et al (2017) Monocyte subsets coregulate inflammatory responses by integrated signaling through TNF and IL-6 at the endothelial cell interface. J Immunol 198:2834\u20132843. https:\/\/doi.org\/10.4049\/jimmunol.1601281","journal-title":"J Immunol"},{"key":"148_CR92","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-immunol-042617-053119","volume":"37","author":"PB Narasimhan","year":"2019","unstructured":"Narasimhan PB, Marcovecchio P, Hamers AAJ, Hedrick CC (2019) Nonclassical monocytes in health and disease. Annu Rev Immunol 37:439\u2013456. https:\/\/doi.org\/10.1146\/annurev-immunol-042617-053119","journal-title":"Annu Rev Immunol"},{"key":"148_CR93","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00005-013-0267-5","volume":"62","author":"JH Spahn","year":"2014","unstructured":"Spahn JH, Kreisel D (2014) Monocytes in sterile inflammation: recruitment and functional consequences. Arch Immunol Ther Exp (Warsz) 62:187\u2013194. https:\/\/doi.org\/10.1007\/s00005-013-0267-5","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"148_CR94","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","volume":"19","author":"F Geissmann","year":"2003","unstructured":"Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19:71\u201382. https:\/\/doi.org\/10.1016\/S1074-7613(03)00174-2","journal-title":"Immunity"},{"key":"148_CR95","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1182\/blood-2010-02-258558","volume":"116","author":"L Ziegler-Heitbrock","year":"2010","unstructured":"Ziegler-Heitbrock L, Ancuta P, Crowe S et al (2010) Nomenclature of monocytes and dendritic cells in blood. Blood 116:74\u201380. https:\/\/doi.org\/10.1182\/blood-2010-02-258558","journal-title":"Blood"},{"key":"148_CR96","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.cell.2013.03.010","volume":"153","author":"LM Carlin","year":"2013","unstructured":"Carlin LM, Stamatiades EG, Auffray C et al (2013) Nr4a1-dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal. Cell 153:362\u2013375. https:\/\/doi.org\/10.1016\/j.cell.2013.03.010","journal-title":"Cell"},{"key":"148_CR97","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","volume":"496","author":"TA Wynn","year":"2013","unstructured":"Wynn TA, Chawla A, Pollard JW (2013) Macrophage biology in development, homeostasis and disease. Nature 496:445\u2013455. https:\/\/doi.org\/10.1038\/nature12034","journal-title":"Nature"},{"key":"148_CR98","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1182\/blood-2004-11-4403","volume":"107","author":"J Glod","year":"2006","unstructured":"Glod J, Kobiler D, Noel M et al (2006) Monocytes form a vascular barrier and participate in vessel repair after brain injury. Blood 107:940\u2013946. https:\/\/doi.org\/10.1182\/blood-2004-11-4403","journal-title":"Blood"},{"key":"148_CR99","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/MOH.0000000000000573","volume":"27","author":"GE Hernandez","year":"2020","unstructured":"Hernandez GE, Iruela-Arispe ML (2020) The many flavors of monocyte\/macrophage--endothelial cell interactions. Curr Opin Hematol 27:181\u2013189. https:\/\/doi.org\/10.1097\/MOH.0000000000000573","journal-title":"Curr Opin Hematol"},{"key":"148_CR100","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1189\/jlb.0708400","volume":"85","author":"JM van Gils","year":"2009","unstructured":"van Gils JM, Zwaginga JJ, Hordijk PL (2009) Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 85:195\u2013204. https:\/\/doi.org\/10.1189\/jlb.0708400","journal-title":"J Leukoc Biol"},{"key":"148_CR101","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1182\/blood.V78.10.2721.2721","volume":"78","author":"B Hakkert","year":"1991","unstructured":"Hakkert B, Kuijpers T, Leeuwenberg J et al (1991) Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4. Blood 78:2721\u20132726. https:\/\/doi.org\/10.1182\/blood.V78.10.2721.2721","journal-title":"Blood"},{"key":"148_CR102","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/bies.950171111","volume":"17","author":"S Gordon","year":"1995","unstructured":"Gordon S (1995) The macrophage. BioEssays 17:977\u2013986. https:\/\/doi.org\/10.1002\/bies.950171111","journal-title":"BioEssays"},{"key":"148_CR103","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1128\/CDLI.6.4.525-529.1999","volume":"6","author":"D Kaufman","year":"1999","unstructured":"Kaufman D, Kilpatrick L, Hudson RG et al (1999) Decreased superoxide production, degranulation, tumor necrosis factor alpha secretion, and CD11b\/CD18 receptor expression by adherent monocytes from preterm infants. Clin Diagnostic Lab Immunol 6:525\u2013529. https:\/\/doi.org\/10.1128\/CDLI.6.4.525-529.1999","journal-title":"Clin Diagnostic Lab Immunol"},{"key":"148_CR104","doi-asserted-by":"publisher","unstructured":"Oak P, Hilgendorff A (2017) The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease. Mol Cell Pediatr 4. https:\/\/doi.org\/10.1186\/s40348-017-0076-8","DOI":"10.1186\/s40348-017-0076-8"},{"key":"148_CR105","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1378\/chest.125.2.754","volume":"125","author":"U Bartram","year":"2004","unstructured":"Bartram U, Speer CP (2004) The role of transforming growth factor \u03b2 in lung development and disease. Chest 125:754\u2013765. https:\/\/doi.org\/10.1378\/chest.125.2.754","journal-title":"Chest"},{"key":"148_CR106","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/dvdy.21403","volume":"237","author":"MA Alejandre-Alc\u00e1zar","year":"2008","unstructured":"Alejandre-Alc\u00e1zar MA, Michiels-Corsten M, Vicencio AG et al (2008) TGF-\u03b2 signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn 237:259\u2013269. https:\/\/doi.org\/10.1002\/dvdy.21403","journal-title":"Dev Dyn"},{"key":"148_CR107","doi-asserted-by":"publisher","first-page":"L223","DOI":"10.1152\/ajplung.00159.2006","volume":"292","author":"S Kunzmann","year":"2007","unstructured":"Kunzmann S, Speer CP, Jobe AH, Kramer BW (2007) Antenatal inflammation induced TGF-\u03b21 but suppressed CTGF in preterm lungs. Am J Physiol Cell Mol Physiol 292:L223\u2013L231. https:\/\/doi.org\/10.1152\/ajplung.00159.2006","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"148_CR108","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.immuni.2017.10.007","volume":"47","author":"X Yu","year":"2017","unstructured":"Yu X, Buttgereit A, Lelios I et al (2017) The cytokine TGF-\u03b2 promotes the development and homeostasis of alveolar macrophages. Immunity 47:903\u2013912.e4. https:\/\/doi.org\/10.1016\/j.immuni.2017.10.007","journal-title":"Immunity"},{"key":"148_CR109","doi-asserted-by":"publisher","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","volume":"84","author":"SM Wahl","year":"1987","unstructured":"Wahl SM, Hunt DA, Wakefield LM et al (1987) Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci 84:5788\u20135792. https:\/\/doi.org\/10.1073\/pnas.84.16.5788","journal-title":"Proc Natl Acad Sci"},{"key":"148_CR110","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1084\/jem.20171491","volume":"215","author":"A Kelly","year":"2018","unstructured":"Kelly A, Gunaltay S, McEntee CP et al (2018) Human monocytes and macrophages regulate immune tolerance via integrin \u03b1v\u03b28\u2013mediated TGF\u03b2 activation. J Exp Med 215:2725\u20132736. https:\/\/doi.org\/10.1084\/jem.20171491","journal-title":"J Exp Med"},{"key":"148_CR111","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","volume":"159","author":"Y Lavin","year":"2014","unstructured":"Lavin Y, Winter D, Blecher-Gonen R et al (2014) Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159:1312\u20131326. https:\/\/doi.org\/10.1016\/j.cell.2014.11.018","journal-title":"Cell"},{"key":"148_CR112","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1016\/j.exphem.2015.06.130","volume":"43","author":"EG Perdiguero","year":"2015","unstructured":"Perdiguero EG, Klapproth K, Schulz C et al (2015) Tissue-resident macrophages originate from yolk sac-derived erythro-myeloid progenitors. Exp Hematol 43:S64. https:\/\/doi.org\/10.1016\/j.exphem.2015.06.130","journal-title":"Exp Hematol"},{"key":"148_CR113","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","volume":"42","author":"G Hoeffel","year":"2015","unstructured":"Hoeffel G, Chen J, Lavin Y et al (2015) C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42:665\u2013678. https:\/\/doi.org\/10.1016\/j.immuni.2015.03.011","journal-title":"Immunity"},{"key":"148_CR114","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/ni.3052","volume":"16","author":"M Kopf","year":"2015","unstructured":"Kopf M, Schneider C, Nobs SP (2015) The development and function of lung-resident macrophages and dendritic cells. Nat Immunol 16:36\u201344. https:\/\/doi.org\/10.1038\/ni.3052","journal-title":"Nat Immunol"},{"key":"148_CR115","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1084\/jem.20131199","volume":"210","author":"M Guilliams","year":"2013","unstructured":"Guilliams M, De Kleer I, Henri S et al (2013) Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J Exp Med 210:1977\u20131992. https:\/\/doi.org\/10.1084\/jem.20131199","journal-title":"J Exp Med"},{"key":"148_CR116","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.immuni.2016.02.017","volume":"44","author":"L van de Laar","year":"2016","unstructured":"van de Laar L, Saelens W, De Prijck S et al (2016) Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44:755\u2013768. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.017","journal-title":"Immunity"},{"key":"148_CR117","doi-asserted-by":"publisher","unstructured":"Evren E, Ringqvist E, Doisne J-M et al (2022) CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages. J Exp Med 219. https:\/\/doi.org\/10.1084\/jem.20210987","DOI":"10.1084\/jem.20210987"},{"key":"148_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2050-7771-2-1","volume":"2","author":"J Yang","year":"2014","unstructured":"Yang J, Zhang L, Yu C et al (2014) Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases. Biomark Res 2:1\u20139. https:\/\/doi.org\/10.1186\/2050-7771-2-1","journal-title":"Biomark Res"},{"key":"148_CR119","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1055\/s-0037-1605579","volume":"07","author":"A Milan","year":"2017","unstructured":"Milan A, Priante E, Nardo D et al (2017) Early macrophage activation in preterm newborns and respiratory disease. J Child Sci 07:e110\u2013e119. https:\/\/doi.org\/10.1055\/s-0037-1605579","journal-title":"J Child Sci"},{"key":"148_CR120","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1164\/rccm.201011-1882OC","volume":"184","author":"EN Atochina-Vasserman","year":"2011","unstructured":"Atochina-Vasserman EN, Bates SR, Zhang P et al (2011) Early alveolar epithelial dysfunction promotes lung inflammation in a mouse model of Hermansky-Pudlak Syndrome. Am J Respir Crit Care Med 184:449\u2013458. https:\/\/doi.org\/10.1164\/rccm.201011-1882OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR121","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1164\/rccm.201010-1719OC","volume":"184","author":"MA Gibbons","year":"2011","unstructured":"Gibbons MA, MacKinnon AC, Ramachandran P et al (2011) Ly6C hi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Am J Respir Crit Care Med 184:569\u2013581. https:\/\/doi.org\/10.1164\/rccm.201010-1719OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR122","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1164\/rccm.201011-1891OC","volume":"184","author":"WJ Janssen","year":"2011","unstructured":"Janssen WJ, Barthel L, Muldrow A et al (2011) Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med 184:547\u2013560. https:\/\/doi.org\/10.1164\/rccm.201011-1891OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR123","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/s42003-020-0985-2","volume":"3","author":"D Sahoo","year":"2020","unstructured":"Sahoo D, Zaramela LS, Hernandez GE et al (2020) Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants. Commun Biol 3:259. https:\/\/doi.org\/10.1038\/s42003-020-0985-2","journal-title":"Commun Biol"},{"key":"148_CR124","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1203\/01.PDR.0000066621.11877.33","volume":"54","author":"BW Kramer","year":"2003","unstructured":"Kramer BW, Jobe AH, Ikegami M (2003) Monocyte function in preterm, term, and adult sheep. Pediatr Res 54:52\u201357. https:\/\/doi.org\/10.1203\/01.PDR.0000066621.11877.33","journal-title":"Pediatr Res"},{"key":"148_CR125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-56928-4","volume":"10","author":"S Dreschers","year":"2020","unstructured":"Dreschers S, Ohl K, Schulte N et al (2020) Impaired functional capacity of polarised neonatal macrophages. Sci Rep 10:1\u201312. https:\/\/doi.org\/10.1038\/s41598-019-56928-4","journal-title":"Sci Rep"},{"key":"148_CR126","doi-asserted-by":"publisher","unstructured":"Hegge I, Niepel F, Lange A et al (2019) Functional analysis of granulocyte and monocyte subpopulations in neonates. Mol Cell Pediatr 6. https:\/\/doi.org\/10.1186\/s40348-019-0092-y","DOI":"10.1186\/s40348-019-0092-y"},{"key":"148_CR127","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1128\/iai.60.3.749-753.1992","volume":"60","author":"A Yachie","year":"1992","unstructured":"Yachie A, Takano N, Ohta K et al (1992) Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens. Infect Immun 60:749\u2013753. https:\/\/doi.org\/10.1128\/iai.60.3.749-753.1992","journal-title":"Infect Immun"},{"key":"148_CR128","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1128\/IAI.00535-10","volume":"79","author":"AJ Currie","year":"2011","unstructured":"Currie AJ, Curtis S, Strunk T et al (2011) Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B Streptococcus. Infect Immun 79:1588\u20131596. https:\/\/doi.org\/10.1128\/IAI.00535-10","journal-title":"Infect Immun"},{"key":"148_CR129","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/jcm6010004","volume":"6","author":"L Davidson","year":"2017","unstructured":"Davidson L, Berkelhamer S (2017) Bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes. J Clin Med 6:4. https:\/\/doi.org\/10.3390\/jcm6010004","journal-title":"J Clin Med"},{"key":"148_CR130","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/BF02075762","volume":"155","author":"K Tullus","year":"1996","unstructured":"Tullus K, Noack GW, Burman LG et al (1996) Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia. Eur J Pediatr 155:112\u2013116. https:\/\/doi.org\/10.1007\/BF02075762","journal-title":"Eur J Pediatr"},{"key":"148_CR131","doi-asserted-by":"publisher","first-page":"L1040","DOI":"10.1152\/ajplung.1998.275.6.L1040","volume":"275","author":"J Pugin","year":"1998","unstructured":"Pugin J, Dunn I, Jolliet P et al (1998) Activation of human macrophages by mechanical ventilation in vitro. Am J Physiol 275:L1040\u2013L1050. https:\/\/doi.org\/10.1152\/ajplung.1998.275.6.L1040","journal-title":"Am J Physiol"},{"key":"148_CR132","doi-asserted-by":"publisher","first-page":"F198","DOI":"10.1136\/fn.77.3.F198","volume":"77","author":"B Jonsson","year":"1997","unstructured":"Jonsson B, Tullus K, Brauner A et al (1997) Early increase of TNFalpha and IL-6 in tracheobronchial aspirate fluid indicator of subsequent chronic lung disease in preterm infants. Arch Dis Child - Fetal Neonatal Ed 77:F198\u2013F201. https:\/\/doi.org\/10.1136\/fn.77.3.F198","journal-title":"Arch Dis Child - Fetal Neonatal Ed"},{"key":"148_CR133","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1242\/jcs.186031","volume":"130","author":"L Li","year":"2016","unstructured":"Li L, Chen J, Xiong G et al (2016) Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture. J Cell Sci 130:190\u2013202. https:\/\/doi.org\/10.1242\/jcs.186031","journal-title":"J Cell Sci"},{"key":"148_CR134","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1164\/arrd.1984.130.5.817","volume":"130","author":"BE Ogden","year":"1984","unstructured":"Ogden BE, Murphy SA, Saunders GC et al (1984) Neonatal lung neutrophils and elastase\/proteinase inhibitor imbalance. Am Rev Respir Dis 130:817\u2013821. https:\/\/doi.org\/10.1164\/arrd.1984.130.5.817","journal-title":"Am Rev Respir Dis"},{"key":"148_CR135","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2310\/6650.2001.33902","volume":"49","author":"JR Baier","year":"2001","unstructured":"Baier JR, Loggins J, Kruger TE (2001) Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia. J Investig Med 49:362\u2013369. https:\/\/doi.org\/10.2310\/6650.2001.33902","journal-title":"J Investig Med"},{"key":"148_CR136","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000101432","volume":"92","author":"D Davidson","year":"2007","unstructured":"Davidson D, Miskolci V, Clark DC et al (2007) Interleukin-10 production after pro-inflammatory stimulation of neutrophils and monocytic cells of the newborn. Neonatology 92:127\u2013133. https:\/\/doi.org\/10.1159\/000101432","journal-title":"Neonatology"},{"key":"148_CR137","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/imm.13125","volume":"159","author":"MC Nielsen","year":"2020","unstructured":"Nielsen MC, Andersen MN, M\u00f8ller HJ (2020) Monocyte isolation techniques significantly impact the phenotype of both isolated monocytes and derived macrophages in vitro. Immunology 159:63\u201374. https:\/\/doi.org\/10.1111\/imm.13125","journal-title":"Immunology"},{"key":"148_CR138","doi-asserted-by":"publisher","first-page":"L909","DOI":"10.1152\/ajplung.00367.2015","volume":"310","author":"H Ehrhardt","year":"2016","unstructured":"Ehrhardt H, Pritzke T, Oak P et al (2016) Absence of TNF-\u03b1 enhances inflammatory response in the newborn lung undergoing mechanical ventilation. Am J Physiol - Lung Cell Mol Physiol 310:L909\u2013L918. https:\/\/doi.org\/10.1152\/ajplung.00367.2015","journal-title":"Am J Physiol - Lung Cell Mol Physiol"},{"key":"148_CR139","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.15252\/emmm.201607308","volume":"9","author":"P Oak","year":"2017","unstructured":"Oak P, Pritzke T, Thiel I et al (2017) Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease. EMBO Mol Med 9:1504\u20131520. https:\/\/doi.org\/10.15252\/emmm.201607308","journal-title":"EMBO Mol Med"},{"key":"148_CR140","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1038\/ncomms7915","volume":"6","author":"M Pruenster","year":"2015","unstructured":"Pruenster M, Kurz ARM, Chung K-J et al (2015) Extracellular MRP8\/14 is a regulator of \u03b22 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun 6:6915. https:\/\/doi.org\/10.1038\/ncomms7915","journal-title":"Nat Commun"},{"key":"148_CR141","doi-asserted-by":"publisher","first-page":"1903114","DOI":"10.1002\/adfm.201903114","volume":"29","author":"A Doryab","year":"2019","unstructured":"Doryab A, Tas S, Taskin MB et al (2019) Evolution of bioengineered lung models: recent advances and challenges in tissue mimicry for studying the role of mechanical forces in cell biology. Adv Funct Mater 29:1903114. https:\/\/doi.org\/10.1002\/adfm.201903114","journal-title":"Adv Funct Mater"},{"key":"148_CR142","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/jp.2008.65","volume":"28","author":"M Palta","year":"2008","unstructured":"Palta M, Sadek-Badawi M, Carlton DP (2008) Association of BPD and IVH with early neutrophil and white counts in VLBW neonates with gestational age <32 weeks. J Perinatol 28:604\u2013610. https:\/\/doi.org\/10.1038\/jp.2008.65","journal-title":"J Perinatol"},{"key":"148_CR143","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1164\/rccm.201012-2010OC","volume":"184","author":"A Hilgendorff","year":"2011","unstructured":"Hilgendorff A, Parai K, Ertsey R et al (2011) Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. Am J Respir Crit Care Med 184:537\u2013546. https:\/\/doi.org\/10.1164\/rccm.201012-2010OC","journal-title":"Am J Respir Crit Care Med"},{"key":"148_CR144","doi-asserted-by":"publisher","first-page":"14384","DOI":"10.1073\/pnas.1306859110","volume":"110","author":"MF Nold","year":"2013","unstructured":"Nold MF, Mangan NE, Rudloff I et al (2013) Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia. Proc Natl Acad Sci 110:14384\u201314389. https:\/\/doi.org\/10.1073\/pnas.1306859110","journal-title":"Proc Natl Acad Sci"},{"key":"148_CR145","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12931-014-0162-6","volume":"16","author":"A Sureshbabu","year":"2015","unstructured":"Sureshbabu A, Syed MA, Boddupalli CS et al (2015) Conditional overexpression of TGF\u03b21 promotes pulmonary inflammation, apoptosis and mortality via TGF\u03b2R2 in the developing mouse lung. Respir Res 16:4. https:\/\/doi.org\/10.1186\/s12931-014-0162-6","journal-title":"Respir Res"},{"key":"148_CR146","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41390-019-0524-3","volume":"86","author":"MA Alam","year":"2019","unstructured":"Alam MA, Betal SGN, Aghai ZH, Bhandari V (2019) Hyperoxia causes miR199a-5p-mediated injury in the developing lung. Pediatr Res 86:579\u2013588. https:\/\/doi.org\/10.1038\/s41390-019-0524-3","journal-title":"Pediatr Res"},{"key":"148_CR147","doi-asserted-by":"publisher","unstructured":"Shrestha D, Ye GX, Stabley D et al (2021) Pulmonary immune cell transcriptome changes in double-hit model of BPD induced by chorioamnionitis and postnatal hyperoxia. Pediatr Res. https:\/\/doi.org\/10.1038\/s41390-020-01319-z","DOI":"10.1038\/s41390-020-01319-z"}],"container-title":["Molecular and Cellular Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-022-00148-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40348-022-00148-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-022-00148-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:06:42Z","timestamp":1659398802000},"score":1,"resource":{"primary":{"URL":"https:\/\/molcellped.springeropen.com\/articles\/10.1186\/s40348-022-00148-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":147,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["148"],"URL":"https:\/\/doi.org\/10.1186\/s40348-022-00148-w","relation":{},"ISSN":["2194-7791"],"issn-type":[{"value":"2194-7791","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"12 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}