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This process may be accompanied by increased shedding of soluble MAdCAM-1 (sMAdCAM-1) from endothelial cells. Hence, circulating sMAdCAM-1 may serve as a biomarker of intestinal inflammation in IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This single-center study enrolled pediatric (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) and adult (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973) patients with IBD, as well as healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956). Serum samples were collected from all participants, and sMAdCAM-1 concentrations were quantified using an ELISA assay. In healthy individuals, sMAdCAM-1 levels were highest in early childhood, declined during adolescence, and were lowest in adulthood. Concentrations of sMAdCAM-1 did not correlate with gut inflammation in pediatric or adult patients with Crohn\u2019s disease (CD). In contrast, significantly increased sMAdCAM-1 levels were observed in adults with severe ulcerative colitis (UC). Moreover, sMAdCAM-1 levels distinguished healthy children from pediatric UC patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings provide new insights into sMAdCAM-1 as a marker of gut homeostasis and inflammation. Shedding of sMAdCAM-1 decreases during adolescence, and circulating sMAdCAM-1 levels could serve as a biomarker for ulcerative colitis in both pediatric and adult patients, particularly in severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40348-026-00221-8","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:26:12Z","timestamp":1771907172000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble mucosal addressin cell adhesion molecule 1 is a biomarker for pediatric ulcerative colitis"],"prefix":"10.1186","volume":"13","author":[{"given":"Moritz","family":"Muschaweck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gutbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Sellge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Pappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Wenzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Hamesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schippers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"6589","key":"221_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/382366a0","volume":"382","author":"N Wagner","year":"1996","unstructured":"Wagner N, Lohler J, Kunkel EJ et al (1996) Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. 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