{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:59:55Z","timestamp":1781647195634,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Greifswald"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital cytomegalovirus (cCMV) infection is considered one of the most common infectious pathologies in neonates, showing a wide range of clinical manifestations, ranging from completely asymptomatic to critically ill newborns. Primary infection during the first trimester of pregnancy carries the highest risk of severe fetal involvement. However, the majority of infected fetuses show an asymptomatic or mild course of disease. The most common long-term sequela is sensorineural hearing loss, which is detected in only about 50% of affected children during newborn hearing screenings. Furthermore, epidemiological data on disease burden remain limited and show considerable variability. The aim of this study was to investigate the prevalence of cCMV and its associated disease burden at follow-up, particular sensorineural hearing loss, in a population-based birth cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective analysis for cCMV in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091995 newborns using urine and plasma biosamples from the second baseline cohort of the Survey of Neonates in Pomerania (SNiP-II). Four participants (prevalence rate 0.2%) were tested positive. Two of these cases had already been identified shortly after birth, having been screened for cCMV due to clinical suspicion. The seroprevalence of IgG antibodies among pregnant women was 47.6%. For follow-up, the patient database of our Department of Otolaryngology, Head and Neck Surgery (ENT) was reviewed for hearing pathologies in all children born during the SNiP-II recruitment period (2013\u20132017). Twelve out of\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091138 SNiP-II participants (1.1%) showed confirmed sensorineural hearing loss (SNHL), none of which were associated with cCMV. A complete clinical follow-up of the cCMV-positive cases revealed no sequelae related to the infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By using a population-based retrospective analysis approach, we demonstrated a very low prevalence and disease burden of cCMV in our region. Our data supports the current guideline recommendations of a risk factor-based screening strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40348-026-00231-6","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:07:24Z","timestamp":1775822844000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective screening for congenital cytomegalovirus infection in the Survey of Neonates in Pomerania shows very low disease burden"],"prefix":"10.1186","volume":"13","author":[{"given":"Jan","family":"Baier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Groffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Allenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Asmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Ihler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"231_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1276912","volume":"11","author":"S Salom\u00e8","year":"2023","unstructured":"Salom\u00e8 S, Corrado FR, Mazzarelli LL et al (2023) Congenital cytomegalovirus infection: the state of the art and future perspectives. Front Pediatr 11:1276912. https:\/\/doi.org\/10.3389\/fped.2023.1276912","journal-title":"Front Pediatr"},{"key":"231_CR2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/rmv.544","volume":"17","author":"SC Dollard","year":"2007","unstructured":"Dollard SC, Grosse SD, Ross DS (2007) New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol 17:355\u2013363. https:\/\/doi.org\/10.1002\/rmv.544","journal-title":"Rev Med Virol"},{"key":"231_CR3","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1080\/03007995.2023.2191477","volume":"39","author":"J Diaz-Decaro","year":"2023","unstructured":"Diaz-Decaro J, Myers E, Mucha J et al (2023) A systematic literature review on the humanistic burden of cytomegalovirus. Curr Med Res Opin 39:739\u2013750. https:\/\/doi.org\/10.1080\/03007995.2023.2191477","journal-title":"Curr Med Res Opin"},{"key":"231_CR4","doi-asserted-by":"publisher","first-page":"S182","DOI":"10.1093\/cid\/cit609","volume":"57","author":"KB Fowler","year":"2013","unstructured":"Fowler KB (2013) Congenital cytomegalovirus infection: audiologic outcome. Clin Infect Dis 57:S182\u2013S184. https:\/\/doi.org\/10.1093\/cid\/cit609","journal-title":"Clin Infect Dis"},{"key":"231_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jcv.2005.09.016","volume":"35","author":"KB Fowler","year":"2006","unstructured":"Fowler KB, Boppana SB (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226\u2013231. https:\/\/doi.org\/10.1016\/j.jcv.2005.09.016","journal-title":"J Clin Virol"},{"key":"231_CR6","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.1080\/14992027.2017.1385865","volume":"57","author":"TYC Ching","year":"2018","unstructured":"Ching TYC, Dillon H, Leigh G, Cupples L (2018) Learning from the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study: summary of 5-year findings and implications. Int J Audiol 57:S105\u2013S111. https:\/\/doi.org\/10.1080\/14992027.2017.1385865","journal-title":"Int J Audiol"},{"key":"231_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/rmv.1790","volume":"24","author":"MJ Cannon","year":"2014","unstructured":"Cannon MJ, Griffiths PD, Aston V, Rawlinson WD (2014) Universal newborn screening for congenital CMV infection: what is the evidence of potential benefit? Rev Med Virol 24:291\u2013307. https:\/\/doi.org\/10.1002\/rmv.1790","journal-title":"Rev Med Virol"},{"key":"231_CR8","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1080\/03007995.2023.2222583","volume":"39","author":"J Diaz-Decaro","year":"2023","unstructured":"Diaz-Decaro J, Myers E, Mucha J et al (2023) A systematic literature review of the economic and healthcare resource burden of cytomegalovirus. Curr Med Res Opin 39:973\u2013986. https:\/\/doi.org\/10.1080\/03007995.2023.2222583","journal-title":"Curr Med Res Opin"},{"key":"231_CR9","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1056\/NEJMoa1404599","volume":"372","author":"DW Kimberlin","year":"2015","unstructured":"Kimberlin DW, Jester PM, S\u00e1nchez PJ et al (2015) Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 372:933\u2013943. https:\/\/doi.org\/10.1056\/NEJMoa1404599","journal-title":"N Engl J Med"},{"key":"231_CR10","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/lary.30027","volume":"132","author":"E De Cuyper","year":"2022","unstructured":"De Cuyper E, Acke F, Keymeulen A, Dhooge I (2022) The effect of (Val)ganciclovir on hearing in congenital cytomegalovirus: a systematic review. Laryngoscope 132:2241\u20132250. https:\/\/doi.org\/10.1002\/lary.30027","journal-title":"Laryngoscope"},{"key":"231_CR11","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1016\/S1473-3099(17)30143-3","volume":"17","author":"WD Rawlinson","year":"2017","unstructured":"Rawlinson WD, Boppana SB, Fowler KB et al (2017) Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 17:e177\u2013e188. https:\/\/doi.org\/10.1016\/S1473-3099(17)30143-3","journal-title":"Lancet Infect Dis"},{"key":"231_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jinf.2011.06.012","volume":"63","author":"A Billette De Villemeur","year":"2011","unstructured":"Billette De Villemeur A, Gratacap-Cavallier B, Casey R et al (2011) Occupational risk for cytomegalovirus, but not for parvovirus B19 in child-care personnel in France. J Infect 63:457\u2013467. https:\/\/doi.org\/10.1016\/j.jinf.2011.06.012","journal-title":"J Infect"},{"key":"231_CR13","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ypmed.2012.03.009","volume":"54","author":"MJ Cannon","year":"2012","unstructured":"Cannon MJ, Westbrook K, Levis D et al (2012) Awareness of and behaviors related to child-to-mother transmission of cytomegalovirus. Prev Med 54:351\u2013357. https:\/\/doi.org\/10.1016\/j.ypmed.2012.03.009","journal-title":"Prev Med"},{"key":"231_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-96","volume":"13","author":"SP Walker","year":"2013","unstructured":"Walker SP, Palma-Dias R, Wood EM et al (2013) Cytomegalovirus in pregnancy: to screen or not to screen. BMC Pregnancy Childbirth 13:96. https:\/\/doi.org\/10.1186\/1471-2393-13-96","journal-title":"BMC Pregnancy Childbirth"},{"key":"231_CR15","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1001\/jamapediatrics.2016.2016","volume":"170","author":"S Gantt","year":"2016","unstructured":"Gantt S, Dionne F, Kozak FK et al (2016) Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection. JAMA Pediatr 170:1173\u20131180. https:\/\/doi.org\/10.1001\/jamapediatrics.2016.2016","journal-title":"JAMA Pediatr"},{"key":"231_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05953-1","volume":"184","author":"H Saito","year":"2025","unstructured":"Saito H, Sakai K, Tanaka M et al (2025) Economic evaluation of newborn screening for congenital cytomegalovirus infection: a systematic review. Eur J Pediatr 184:123. https:\/\/doi.org\/10.1007\/s00431-024-05953-1","journal-title":"Eur J Pediatr"},{"key":"231_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/ppe.13160","volume":"39","author":"M Heckmann","year":"2025","unstructured":"Heckmann M, Bruer F, Allenberg H et al (2025) The survey of neonates in Pomerania: design, recruitment and follow\u2010up of the second cohort, 2013\u20132017. Paediatr Perinat Epidemiol 39:207\u2013217. https:\/\/doi.org\/10.1111\/ppe.13160","journal-title":"Paediatr Perinat Epidemiol"},{"key":"231_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70257","volume":"97","author":"M Shimamura","year":"2025","unstructured":"Shimamura M, Kim J, Medoro AK et al (2025) Agreement between dried blood spot and plasma PCR in infants with congenital cytomegalovirus infection. J Med Virol 97:e70257. https:\/\/doi.org\/10.1002\/jmv.70257","journal-title":"J Med Virol"},{"key":"231_CR19","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00313-23","volume":"62","author":"AL Leber","year":"2024","unstructured":"Leber AL (2024) Maternal and congenital human cytomegalovirus infection: laboratory testing for detection and diagnosis. J Clin Microbiol 62:e00313-23. https:\/\/doi.org\/10.1128\/jcm.00313-23","journal-title":"J Clin Microbiol"},{"key":"231_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1128\/CMR.00062-12","volume":"26","author":"S Manicklal","year":"2013","unstructured":"Manicklal S, Emery VC, Lazzarotto T et al (2013) The \u201csilent\u201d global burden of congenital cytomegalovirus. Clin Microbiol Rev 26:86\u2013102. https:\/\/doi.org\/10.1128\/CMR.00062-12","journal-title":"Clin Microbiol Rev"},{"key":"231_CR21","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/dmcn.13556","volume":"59","author":"MJ Korndewal","year":"2017","unstructured":"Korndewal MJ, Oudesluys\u2010Murphy AM, Kroes ACM et al (2017) Long\u2010term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study. Dev Med Child Neurol 59:1261\u20131268. https:\/\/doi.org\/10.1111\/dmcn.13556","journal-title":"Dev Med Child Neurol"},{"key":"231_CR22","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1469-7610.1997.tb01545.x","volume":"38","author":"R Goodman","year":"1997","unstructured":"Goodman R (1997) The strengths and difficulties questionnaire: a research note. Child Psychol Psychiatry 38:581\u2013586. https:\/\/doi.org\/10.1111\/j.1469-7610.1997.tb01545.x","journal-title":"Child Psychol Psychiatry"},{"key":"231_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1177\/0265407595123009","volume":"12","author":"JO Berry","year":"1995","unstructured":"Berry JO, Jones WH (1995) The parental stress scale: initial psychometric evidence. J Soc Pers Relat 12:463\u2013472. https:\/\/doi.org\/10.1177\/0265407595123009","journal-title":"J Soc Pers Relat"},{"key":"231_CR24","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s11136-013-0428-3","volume":"23","author":"U Ravens-Sieberer","year":"2014","unstructured":"Ravens-Sieberer U, Herdman M, Devine J et al (2014) The European KIDSCREEN approach to measure quality of life and well-being in children: development, current application, and future advances. Qual Life Res 23:791\u2013803. https:\/\/doi.org\/10.1007\/s11136-013-0428-3","journal-title":"Qual Life Res"},{"key":"231_CR25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1023\/A:1008853819715","volume":"7","author":"U Ravens-Sieberer","year":"1998","unstructured":"Ravens-Sieberer U, Bullinger M (1998) Assessing health-related quality of life in chronically ill children with the German KINDL: first psychometric and content analytical results. Qual Life Res 7:399\u2013407. https:\/\/doi.org\/10.1023\/A:1008853819715","journal-title":"Qual Life Res"},{"key":"231_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3121\/cmr.2012.1100.ps2-21","volume":"10","author":"F Lynch","year":"2012","unstructured":"Lynch F, Dickerson J (2012) PS2-21: validity and reliability of the family economic impact interview: a new instrument to measure costs related to child mental health conditions. Clin Med Res 10:181\u2013181. https:\/\/doi.org\/10.3121\/cmr.2012.1100.ps2-21","journal-title":"Clin Med Res"},{"key":"231_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/children8090787","volume":"8","author":"D Radanovi\u0107","year":"2021","unstructured":"Radanovi\u0107 D, \u0110or\u0111evi\u0107 D, Stankovi\u0107 M et al (2021) Test of Motor Proficiency Second Edition (BOT-2) Short Form: A Systematic Review of Studies Conducted in Healthy Children. Children 8:787. https:\/\/doi.org\/10.3390\/children8090787","journal-title":"Children"},{"key":"231_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013810","volume":"7","author":"A Yamaguchi","year":"2017","unstructured":"Yamaguchi A, Oh-ishi T, Arai T et al (2017) Screening for seemingly healthy newborns with congenital cytomegalovirus infection by quantitative real-time polymerase chain reaction using newborn urine: an observational study. BMJ Open 7:e013810. https:\/\/doi.org\/10.1136\/bmjopen-2016-013810","journal-title":"BMJ Open"},{"key":"231_CR29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/rmv.535","volume":"17","author":"A Kenneson","year":"2007","unstructured":"Kenneson A, Cannon MJ (2007) Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17:253\u2013276. https:\/\/doi.org\/10.1002\/rmv.535","journal-title":"Rev Med Virol"},{"key":"231_CR30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1001\/jamapediatrics.2024.5562","volume":"179","author":"JKE Dunn","year":"2025","unstructured":"Dunn JKE, Chakraborty P, Reuvers E et al (2025) Outcomes of a population-based congenital cytomegalovirus screening program. JAMA Pediatr 179:332. https:\/\/doi.org\/10.1001\/jamapediatrics.2024.5562","journal-title":"JAMA Pediatr"},{"key":"231_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00430-012-0232-7","volume":"201","author":"G Enders","year":"2012","unstructured":"Enders G, Daiminger A, Lindemann L et al (2012) Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996\u20132010. Med Microbiol Immunol 201:303\u2013309. https:\/\/doi.org\/10.1007\/s00430-012-0232-7","journal-title":"Med Microbiol Immunol"},{"key":"231_CR32","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20736","volume":"4","author":"P Ssentongo","year":"2021","unstructured":"Ssentongo P, Hehnly C, Birungi P et al (2021) Congenital cytomegalovirus infection burden and epidemiologic risk factors in countries with universal screening: a systematic review and meta-analysis. JAMA Netw Open 4:e2120736. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.20736","journal-title":"JAMA Netw Open"},{"key":"231_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-07995-6","volume":"23","author":"Y Torii","year":"2023","unstructured":"Torii Y, Morioka I, Kakei Y et al (2023) Correlation of cytomegalovirus viral load between whole blood and plasma of congenital cytomegalovirus infection under valganciclovir treatment. BMC Infect Dis 23:31. https:\/\/doi.org\/10.1186\/s12879-023-07995-6","journal-title":"BMC Infect Dis"},{"key":"231_CR34","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1093\/jpids\/piad013","volume":"12","author":"N Kabani","year":"2023","unstructured":"Kabani N, Pinninti S, Boppana S et al (2023) Urine and saliva viral load in children with congenital cytomegalovirus infection. J Pediatr Infect Dis Soc 12:230\u2013233. https:\/\/doi.org\/10.1093\/jpids\/piad013","journal-title":"J Pediatr Infect Dis Soc"},{"key":"231_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08392-w","volume":"12","author":"T-H Lo","year":"2022","unstructured":"Lo T-H, Lin P-H, Hsu W-C et al (2022) Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection. Sci Rep 12:5219. https:\/\/doi.org\/10.1038\/s41598-022-08392-w","journal-title":"Sci Rep"},{"key":"231_CR36","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/infdis\/jiu627","volume":"212","author":"G Forner","year":"2015","unstructured":"Forner G, Abate D, Mengoli C et al (2015) High Cytomegalovirus (CMV) DNAemia predicts CMV sequelae in asymptomatic congenitally infected newborns born to women with primary infection during pregnancy. J Infect Dis 212:67\u201371. https:\/\/doi.org\/10.1093\/infdis\/jiu627","journal-title":"J Infect Dis"},{"key":"231_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14030280","volume":"14","author":"I Valen\u010dak","year":"2025","unstructured":"Valen\u010dak I, Stemberger Mari\u0107 L, Vrdoljak Pa\u017eur M et al (2025) Clinical characteristics, neuroimaging findings and long-term sequelae in children with congenital cytomegalovirus infection: a single centre study. Pathogens 14:280. https:\/\/doi.org\/10.3390\/pathogens14030280","journal-title":"Pathogens"},{"key":"231_CR38","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1017\/S0022215108003162","volume":"123","author":"A Lackner","year":"2009","unstructured":"Lackner A, Acham A, Alborno T et al (2009) Effect on hearing of ganciclovir therapy for asymptomatic congenital cytomegalovirus infection: four to 10 year follow up. J Laryngol Otol 123:391\u2013396. https:\/\/doi.org\/10.1017\/S0022215108003162","journal-title":"J Laryngol Otol"},{"key":"231_CR39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0022-3476(03)00192-6","volume":"143","author":"DW Kimberlin","year":"2003","unstructured":"Kimberlin DW, Lin C-Y, S\u00e1nchez PJ et al (2003) Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 143:16\u201325. https:\/\/doi.org\/10.1016\/S0022-3476(03)00192-6","journal-title":"J Pediatr"},{"key":"231_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100892","volume":"40","author":"M Leruez-Ville","year":"2024","unstructured":"Leruez-Ville M, Chatzakis C, Lilleri D et al (2024) Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI). The Lancet Regional Health - Europe 40:100892. https:\/\/doi.org\/10.1016\/j.lanepe.2024.100892","journal-title":"The Lancet Regional Health - Europe"},{"key":"231_CR41","unstructured":"Deutsche Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe, AWMF S2k Leitlinie Pr\u00e4vention, Diagnostik und Therapie der CMV-Infektion bei Schwangeren und der konnatalen CMV-Infektion bei Neugeborenen und Kindern. AWMF-Registrierungsnummer: 093-003. Version 1.0. 2024. available from: https:\/\/register.awmf.org\/de\/leitlinien\/detail\/093-003. Accessed 15 March 2026."}],"container-title":["Molecular and Cellular Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-026-00231-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40348-026-00231-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40348-026-00231-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:46:31Z","timestamp":1781646391000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40348-026-00231-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["231"],"URL":"https:\/\/doi.org\/10.1186\/s40348-026-00231-6","relation":{},"ISSN":["2194-7791"],"issn-type":[{"value":"2194-7791","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The content and design of the SNiP-II baseline and follow-up study were reviewed and approved by the Ethics Committee at the University Medicine Greifswald (BB 133\/12, BB 133\/12a). Written informed consent was obtained from all women who agreed to participate in the study. Additional permission for future contact and data linkage was sought from all study participants at the time of initial consent. In cases of legally minor mothers (i.e., age\u2009<\u200918\u00a0years), additional signatures were required from the newborn's and mother's legal guardians. All above mentioned retrospective analyses for cCMV and its sequelae were reviewed and approved by the Ethics Committee at the University Medicine Greifswald (BB 138\/24). Furthermore, this analysis and data usage was reviewed and approved by the Community Medicine Steering Committee of the University Medicine of Greifswald.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}