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A subclinical variant, loss of control eating (LOC) is prevalent in youth. LOC is associated with similar mental distress as full-blown BED, increases the risk to develop a BED and promotes continuous weight gain. The etiology of LOC is not yet fully understood and specialized treatment for youth is scarce.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The i-BEAT study includes a cross-sectional and longitudinal online questionnaire study (N\u2009=\u2009600), an App based daily-life\u00a0approach and a laboratory virtual reality study in N\u2009=\u200960 youths (14\u201324\u00a0years) with and without LOC as well as a controlled randomized online treatment trial to investigate the feasibility, acceptance and efficacy of a CBT and an interpersonal emotion regulation module for youth (N\u2009=\u2009120). The primary outcomes include self-reported as well as measured (heart rate variability, gaze behavior, reaction times in stop signal task) associations between emotion regulation problems (such as dealing with RS), psychological impairment and binge eating in a healthy control group and youth with LOC. Secondary outcomes encompass general eating disorder pathology, social anxiety, body mass index, hyperscanning behavior and therapists\u2019 rating of patients\u2019 condition pre and post treatment. Epigenetic correlates of RS are assessed in healthy controls and youth with LOC and explored before and after treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The expected findings will specify the role of interpersonal emotion regulation problems such as coping with the experience of social exclusion and rejection sensitivity (RS) in LOC and clarify, whether including a training to cope with RS adds to the efficacy of a cognitive behavioral treatment (CBT).<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: German Clinical Trial Register: DRKS00023706. Registered 27 November 2020, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.drks.de\/drks_web\/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00023706\">https:\/\/www.drks.de\/drks_web\/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00023706<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40359-021-00690-8","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T13:02:38Z","timestamp":1639227758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlates of interpersonal emotion regulation problems in Loss of Control eating (LOC) in youth: study protocol of the combined online and App based questionnaire, laboratory and randomized controlled online intervention i-BEAT trial"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6187-8912","authenticated-orcid":false,"given":"Simone","family":"Munsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-533X","authenticated-orcid":false,"given":"Felicitas","family":"Forrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-7271","authenticated-orcid":false,"given":"Adrian","family":"Naas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-5794","authenticated-orcid":false,"given":"Verena","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-2948","authenticated-orcid":false,"given":"Marius","family":"Rubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4685","authenticated-orcid":false,"given":"Fouad","family":"Hannoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-0862","authenticated-orcid":false,"given":"Elena","family":"Mugellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"690_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association: Diagnostic and Statistical Manual. 5th edition. 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Participants will be remunerated for their expenditure of time in the App based study 1 and study 2. Providing CBT-E and INTER-E interventions for LOC adapted to the needs of youth should produce positive effects (the pilot BEAT trial had strong within subject effects on LOC episodes, ED pathology and mood, and 81% of participants reported at the end of the treatment to have no LOC anymore or that the consumed food amount during a LOC episode decreased). Upcoming problems are monitored and in case of difficulties, support in coping is given by the therapists under supervision of SM and emergency contacts are provided. Collaborators will be trained to handle subject burden of participating youth together with SM. This study has been approved by the ethics committee of the canton of Berne (2018-00230). All participants will be asked for written informed consent before inclusion in the study. The i-BEAT study is registered at the German Clinical Trials Register (DRKS00023706). The participants age ranges between 14 and 24\u00a0years. According to swiss law, youth, even below the age of 14\u00a0years has the right of non-information of their legal guardians with respect to a participation in a psychotherapeutic treatment. All participants under the age of 18\u00a0years are therefore invited but not obliged to inform the legal guardians about their participation in i-BEAT and a respective parents\u2019 information sheet can be provided. Therefore, informed consents are signed either by participating youth alone or together with their legal guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There are no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}