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As of October, 13\n                      th\n                      , 2025, the protocol was approved by the Ethics Committees in all participating countries. For Greece, the protocol was approved by the Hellenic Mediterranean Ethics Committee (approval number 55143; date of approval April 15\n                      th\n                      , 2025). For Spain, the protocol was approved by the Ethics Committee for Research involving medicinal products in the Basque Country (approval number PI2024215; date of approval April, 14\n                      th\n                      , 2025). For Switzerland, the protocol was approved by the Faculty of Arts and Sciences at the University of Zurich (approval number 25.02.22; date of approval February, 28\n                      th\n                      , 2025). For Romania, the protocol was approved by The Oncology Institute \"Prof. Dr. Ion Chiricu\u0163\u0103\" Cluj-Napoca (approval number 305, date of approval August, 30\n                      th\n                      , 2024). For Slovenia, the protocol was approved by the Komisija Republike Slovenije za medicinsko etiko (approval number 0120-282\/2025-2711-9; date of approval September 23th, 2025). For Italy, the protocol was approved by the Italian National Ethics Committee for experiments conducted by public research bodies (EPR) and other national public bodies (CEN) at its meeting on September 22\n                      nd\n                      , 2025 (Ref. AOO-ISS \u2013 09\/29\/2025\u20130039540 Class: PRE BIO CEN 01.00). For Cyprus, the study was approved by the Cyprus National Bioethics Committee with number \u0395\u0395\u0392\u039a \u0395\u03a0 2025.01.278 on 9\/9\/2025. For Belgium, the study protocol was approved by the Ethics Committee of the Faculty of Politics and Social Science at Gent University (approval number Re 2025-28; date of approval 25\n                      th\n                      August, 2025).The trial will be executed in compliance with the Helsinki Declaration. All study participants and their parents\/guardians if necessary due to age and national legislation, will provide online informed consent. Data will be collected pseudonymized on a pre-designed electronic Case Report Form (eCRF) through an authoring tool. The rights of participants will be respected, complying with national and EU data protection laws, and any data exchange will be approved by respective national ethical authorities.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1292"}}