{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:21:48Z","timestamp":1770283308458,"version":"3.49.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capacity Building Grants in Population Health and Health Services Research by National Health and Medical Research Council, Australia","award":["533546"],"award-info":[{"award-number":["533546"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s40360-018-0219-0","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T07:21:15Z","timestamp":1529306475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prescription opioid dispensing in New South Wales, Australia: spatial and temporal variation"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-863X","authenticated-orcid":false,"given":"M Mofizul","family":"Islam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian S.","family":"McRae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Mazumdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Wollersheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaniz","family":"Fatema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"issue":"4","key":"219_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1056\/NEJMra1604339","volume":"375","author":"MA Schuckit","year":"2016","unstructured":"Schuckit MA. Treatment of opioid-use disorders. N Engl J Med. 2016;375(4):357\u201368.","journal-title":"N Engl J Med"},{"issue":"17","key":"219_CR2","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1056\/NEJMp1208498","volume":"367","author":"A Lembke","year":"2012","unstructured":"Lembke A. Why doctors prescribe opioids to known opioid abusers. N Engl J Med. 2012;367(17):1580\u20131.","journal-title":"N Engl J Med"},{"issue":"8","key":"219_CR3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/pds.1452","volume":"16","author":"TJ Cicero","year":"2007","unstructured":"Cicero TJ, Surratt H, Inciardi JA, Munoz A. Relationship between therapeutic use and abuse of opioid analgesics in rural, suburban, and urban locations in the United States. Pharmacoepidemiol Drug Saf. 2007;16(8):827\u201340.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"219_CR4","unstructured":"Cohen H, Webb T. During 2011\u20132015, 3,601 people died from an opioid-related overdose \u2013 a nearly twofold increase from 2001\u20132005: ABC News; 2017. Available at: \n                    http:\/\/www.abc.net.au\/news\/2017-11-24\/deaths-from-prescription-drug-fentanyl-up-by-1800pc\/9184396\n                    \n                  ."},{"key":"219_CR5","volume-title":"Fatal fentanyl overdoses rise as Australians turn to more potent painkillers","author":"The Guardian","year":"2017","unstructured":"The Guardian: Fatal fentanyl overdoses rise as Australians turn to more potent painkillers. 2017, Avialable at: \n                    https:\/\/www.theguardian.com\/australia-news\/2017\/aug\/31\/fatal-fentanyl-overdoses-rise-as-australians-turn-to-more-potent-painkillers\n                    \n                  ."},{"issue":"5","key":"219_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11916-016-0564-x","volume":"20","author":"L Manchikanti","year":"2016","unstructured":"Manchikanti L, Kaye AM, Kaye AD. Current state of opioid therapy and abuse. Curr Pain Headache Rep. 2016;20(5):34.","journal-title":"Curr Pain Headache Rep"},{"issue":"1","key":"219_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1300\/J069v27n01_01","volume":"27","author":"AM Wisniewski","year":"2008","unstructured":"Wisniewski AM, Purdy CH, Blondell RD. The epidemiologic association between opioid prescribing, non-medical use, and emergency department visits. J Addict Dis. 2008;27(1):1\u201311.","journal-title":"J Addict Dis"},{"issue":"2","key":"219_CR8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/ajim.20655","volume":"52","author":"BS Webster","year":"2009","unstructured":"Webster BS, Cifuentes M, Verma S, Pransky G. Geographic variation in opioid prescribing for acute, work-related, low back pain and associated factors: a multilevel analysis. Am J Ind Med. 2009;52(2):162\u201371.","journal-title":"Am J Ind Med"},{"key":"219_CR9","first-page":"22","volume-title":"Geographical variation in opioid prescribing and opioid-related mortality in Ontario","author":"T Gomes","year":"2011","unstructured":"Gomes T, Juurlink D, Moineddin R, Gozdyra P, Dhalla I, Paterson M, Mamdani M: Geographical variation in opioid prescribing and opioid-related mortality in Ontario. Healthcare Quarterly (Toronto) 2011, 14(1):22\u201324."},{"issue":"6","key":"219_CR10","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/pds.1939","volume":"19","author":"JS Brownstein","year":"2010","unstructured":"Brownstein JS, Green TC, Cassidy TA, Butler SF. Geographic information systems and pharmacoepidemiology: using spatial cluster detection to monitor local patterns of prescription opioid abuse. Pharmacoepidemiol Drug Saf. 2010;19(6):627\u201337.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"219_CR11","first-page":"2","volume-title":"The Mercury Tasmania","author":"The Mercury: Morphine addiction woe","year":"2014","unstructured":"The Mercury: Morphine addiction woe. Tasmanian has the nation's highest proportion of drug treatment patients seeking help for morphine Addiction. In: The Mercury Tasmania; 2014. p. 2."},{"issue":"10","key":"219_CR12","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.jpain.2012.07.007","volume":"13","author":"DC McDonald","year":"2012","unstructured":"McDonald DC, Carlson K, Izrael D. Geographic variation in opioid prescribing in the U.S. J Pain. 2012;13(10):988\u201396.","journal-title":"J Pain"},{"issue":"3 Pt 1","key":"219_CR13","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/j.1475-6773.2006.00511.x","volume":"41","author":"LH Curtis","year":"2006","unstructured":"Curtis LH, Stoddard J, Radeva JI, Hutchison S, Dans PE, Wright A, Woosley RL, Schulman KA. Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United States. Health Serv Res. 2006;41(3 Pt 1):837\u201355.","journal-title":"Health Serv Res"},{"issue":"3","key":"219_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.clinthera.2013.02.003","volume":"35","author":"JT Painter","year":"2013","unstructured":"Painter JT, Crofford LJ, Talbert J. Geographic variation of chronic opioid use in fibromyalgia. Clin Ther. 2013;35(3):303\u201311.","journal-title":"Clin Ther"},{"key":"219_CR15","unstructured":"Mapping an Opioid Addiction Community Intervention Plan. Esri Insider. Available at: \n                    https:\/\/blogs.esri.com\/esri\/esri-insider\/2016\/08\/31\/mapping-an-opioid-addiction-community-intervention-plan\/\n                    \n                  ; accessed on 4 Nov 2016."},{"issue":"2","key":"219_CR16","doi-asserted-by":"publisher","first-page":"104","DOI":"10.2174\/187447370802150928185302","volume":"8","author":"S Mazumdar","year":"2015","unstructured":"Mazumdar S, McRae IS, Islam MM. How can geographical information systems and spatial analysis inform a response to prescription opioid misuse? A discussion in the context of existing literature. Curr Drug Abuse Rev. 2015;8(2):104\u201310.","journal-title":"Curr Drug Abuse Rev"},{"issue":"5","key":"219_CR17","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/bcp.12446","volume":"78","author":"B Blanch","year":"2014","unstructured":"Blanch B, Pearson SA, Haber PS. An overview of the patterns of prescription opioid use, costs and related harms in Australia. Br J Clin Pharmacol. 2014;78(5):1159\u201366.","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"219_CR18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1111\/imj.12966","volume":"46","author":"MM Islam","year":"2015","unstructured":"Islam MM, McRae IS, Mazumdar S, Taplin S, McKetin R. Prescription opioid analgesics for pain management in Australia: twenty years of dispensing. Intern Med J. 2015;46(8):955\u201363.","journal-title":"Intern Med J"},{"issue":"5","key":"219_CR19","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/pds.3931","volume":"25","author":"L Degenhardt","year":"2016","unstructured":"Degenhardt L, Gisev N, Cama E, Nielsen S, Larance B, Bruno R. The extent and correlates of community-based pharmaceutical opioid utilisation in Australia. Pharmacoepidemiol Drug Saf. 2016;25(5):521\u201338.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"219_CR20","unstructured":"Australian Government Department of Health: The Pharmaceutical Benefit Scheme. Available at: \n                    http:\/\/www.pbs.gov.au\/info\/about-the-pbs\n                    \n                  ; accessed on 18 August 2016."},{"key":"219_CR21","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2018. Oslo, Norway, 2017. \n                    https:\/\/www.whocc.no\/filearchive\/publications\/guidelines.pdf\n                    \n                  ."},{"key":"219_CR22","unstructured":"World Health Organization: Daily Defined Dose (DDD): Definition and general considerations. Available at: \n                    https:\/\/www.whocc.no\/ddd\/definition_and_general_considera\/\n                    \n                  ; accessed on 1 December 2017."},{"key":"219_CR23","volume-title":"Local government national report, 2013\u201314","author":"Department of Infrastructure and Regional Development (DIRD)","year":"2015","unstructured":"Department of Infrastructure and Regional Development (DIRD). Local government national report, 2013\u201314. Canberra: DIRD; 2015. Available at \n                    http:\/\/regional.gov.au\/local\/publications\/reports\/2013_2014\/INFRA2466_LGNR_2013-14.pdf\n                    \n                  ."},{"key":"219_CR24","volume-title":"Stata Statistical Software: Release 14","author":"StataCorp","year":"2015","unstructured":"StataCorp. Stata Statistical Software: Release 14. College Station: StataCorp LP; 2015."},{"key":"219_CR25","volume-title":"Microsoft Excel [computer software]","author":"Microsoft","year":"2013","unstructured":"Microsoft. Microsoft Excel [computer software]. Redmond, Washington: Microsoft; 2013."},{"key":"219_CR26","unstructured":"R Core Team. R: A language and environment for statistical Computing R Foundation for Statistical Computing. Vienna; 2011. Retrieved from \n                    http:\/\/www.R-project.org\/\n                    \n                  ."},{"issue":"6","key":"219_CR27","doi-asserted-by":"publisher","first-page":"e010364","DOI":"10.1136\/bmjopen-2015-010364","volume":"6","author":"A Fayaz","year":"2016","unstructured":"Fayaz A, Croft P, Langford RM, Donaldson LJ, Jones GT. Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies. BMJ Open. 2016;6(6):e010364.","journal-title":"BMJ Open"},{"issue":"1","key":"219_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1213\/01.ane.0000268145.52345.55","volume":"105","author":"F Brennan","year":"2007","unstructured":"Brennan F, Carr DB, Cousins M. Pain management: a fundamental human right. Anesth Analg. 2007;105(1):205\u201321.","journal-title":"Anesth Analg"},{"key":"219_CR29","unstructured":"Lembke A. Why doctors prescribe opioids to patients they know are abusing them? SCOPE. Stanford Medicine. Available at: \n                    http:\/\/scopeblog.stanford.edu\/2012\/10\/25\/why-doctors-prescribe-opioids-to-patients-they-know-are-abusing-them\/\n                    \n                  ; accessed on 4 November 2016."},{"issue":"2","key":"219_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2105\/AJPH.2007.131714","volume":"99","author":"A Van Zee","year":"2009","unstructured":"Van Zee A. The promotion and marketing of oxycontin: commercial triumph, public health tragedy. Am J Public Health. 2009;99(2):221\u20137.","journal-title":"Am J Public Health"},{"issue":"10","key":"219_CR31","doi-asserted-by":"publisher","first-page":"696","DOI":"10.5694\/mja12.11331","volume":"199","author":"S Nielsen","year":"2013","unstructured":"Nielsen S, Bruno R, Degenhardt L, Stoove MA, Fischer JA, Carruthers SJ, Lintzeris N. The sources of pharmaceuticals for problematic users of benzodiazepines and prescription opioids. Med J Aust. 2013;199(10):696\u20139.","journal-title":"Med J Aust"},{"key":"219_CR32","doi-asserted-by":"publisher","first-page":"280","DOI":"10.5694\/mja10.11450","volume":"195","author":"A Roxburgh","year":"2011","unstructured":"Roxburgh A, Bruno R, Larance B, Burns L. Prescription of opioid analgesics and related harms in Australia. Med J Aust. 2011;195:280\u20134.","journal-title":"Med J Aust"},{"key":"219_CR33","volume-title":"Australian Drug Trend Series No 91","author":"J Stafford","year":"2013","unstructured":"Stafford J, Burns L. Australian Drug Trends 2012: Findings from the Illicit Drug Reporting System (IDRS). In: Australian Drug Trend Series No 91. Sydney: National Drug and Alcohol Research Centre, University of New South Wales; 2013."},{"key":"219_CR34","unstructured":"Black E, Roxburgh A, Degenhardt L, Bruno R, Campbell G, Bd G, Fetherston J, Kinner S, Moon C, Quinn B, et al. Australian Drug Trends 2007: Findings from the Illicit Drug Reporting System (IDRS) Australian Drug Trend Series No. 1. Sydney: National Drug and Alcohol Research Centre, University of New South Wales; 2008."},{"key":"219_CR35","volume-title":"Oxycodone-with-naloxone controlled-release tablets (Targin) for chronic severe pain","author":"NPS Medicinewise","year":"2011","unstructured":"NPS Medicinewise: Oxycodone-with-naloxone controlled-release tablets (Targin) for chronic severe pain. 2011, Available at: \n                    https:\/\/www.nps.org.au\/radar\/articles\/oxycodone-with-naloxone-controlled-release-tablets-targin-for-chronic-severe-pain\n                    \n                  ."},{"issue":"2","key":"219_CR36","first-page":"e322","volume":"16","author":"CA Sadowski","year":"2009","unstructured":"Sadowski CA, Carrie AG, Grymonpre RE, Metge CJ, St John P. Access and intensity of use of prescription analgesics among older Manitobans. Can J Clin Pharmacol. 2009;16(2):e322\u201330.","journal-title":"Can J Clin Pharmacol"},{"issue":"3","key":"219_CR37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1089\/152460900318470","volume":"9","author":"L Simoni-Wastila","year":"2000","unstructured":"Simoni-Wastila L. The use of abusable prescription drugs: the role of gender. J Womens Health Gend Based Med. 2000;9(3):289\u201397.","journal-title":"J Womens Health Gend Based Med"},{"issue":"11","key":"219_CR38","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.addbeh.2010.06.018","volume":"35","author":"SE Back","year":"2010","unstructured":"Back SE, Payne RL, Simpson AN, Brady KT. Gender and prescription opioids: findings from the National Survey on drug use and health. Addict Behav. 2010;35(11):1001\u20137.","journal-title":"Addict Behav"},{"key":"219_CR39","volume-title":"Prescription Painkiller Overdoses: A Growing Epidemic, Especially Among Women","author":"Centers for Disease Control and Prevention","year":"2017","unstructured":"Centers for Disease Control and Prevention: Prescription Painkiller Overdoses: A Growing Epidemic, Especially Among Women. 2017, Available at: \n                    https:\/\/www.cdc.gov\/vitalsigns\/prescriptionpainkilleroverdoses\/index.html\n                    \n                  ; accessed on 18 Nov 2017."},{"issue":"5","key":"219_CR40","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/00952990.2011.596982","volume":"37","author":"SE Back","year":"2011","unstructured":"Back SE, Payne RL, Wahlquist AH, Carter RE, Stroud Z, Haynes L, Hillhouse M, Brady KT, Ling W. Comparative profiles of men and women with opioid dependence: results from a national multisite effectiveness trial. Am J Drug Alcohol Abuse. 2011;37(5):313\u201323.","journal-title":"Am J Drug Alcohol Abuse"},{"issue":"8","key":"219_CR41","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.addbeh.2011.03.013","volume":"36","author":"SE Back","year":"2011","unstructured":"Back SE, Lawson KM, Singleton LM, Brady KT. Characteristics and correlates of men and women with prescription opioid dependence. Addict Behav. 2011;36(8):829\u201334.","journal-title":"Addict Behav"},{"issue":"Suppl 1","key":"219_CR42","first-page":"S135","volume":"117","author":"S Galea","year":"2002","unstructured":"Galea S, Vlahov D. Social determinants and the health of drug users: socioeconomic status, homelessness, and incarceration. Public Health Rep. 2002;117(Suppl 1):S135\u201345.","journal-title":"Public Health Rep"},{"issue":"4","key":"219_CR43","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3138\/cpp.37.4.563","volume":"37","author":"S Allin","year":"2011","unstructured":"Allin S, Laporte A. Socioeconomic status and the use of medicines in the Ontario public drug program. Canadian Public Policy. 2011;37(4):563\u201376.","journal-title":"Canadian Public Policy"},{"key":"219_CR44","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1186\/s12913-014-0563-8","volume":"14","author":"JP Prunuske","year":"2014","unstructured":"Prunuske JP, St Hill CA, Hager KD, Lemieux AM, Swanoski MT, Anderson GW, Lutfiyya MN. Opioid prescribing patterns for non-malignant chronic pain for rural versus non-rural US adults: a population-based study using 2010 NAMCS data. BMC Health Serv Res. 2014;14:563.","journal-title":"BMC Health Serv Res"},{"issue":"5","key":"219_CR45","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/oxfordjournals.aje.a114892","volume":"127","author":"S Piantadosi","year":"1988","unstructured":"Piantadosi S, Byar DP, Green SB. The ecological fallacy. Am J Epidemiol. 1988;127(5):893\u2013904.","journal-title":"Am J Epidemiol"},{"key":"219_CR46","unstructured":"Australian Government Department of Human Servcies. Prescription Shopping Programme. Available at: \n                    https:\/\/www.humanservices.gov.au\/health-professionals\/services\/medicare\/prescription-shopping-programme\n                    \n                  ; accessed on 1 September 2016."},{"issue":"1","key":"219_CR47","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/2050-6511-15-46","volume":"15","author":"MM Islam","year":"2014","unstructured":"Islam MM, McRae IS. An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions. BMC Pharmacol Toxicol. 2014;15(1):46.","journal-title":"BMC Pharmacol Toxicol"},{"issue":"5","key":"219_CR48","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/dar.12195","volume":"33","author":"S Nielsen","year":"2014","unstructured":"Nielsen S, Bruno R. Implementing real-time prescription drug monitoring: are we ready? Drug Alcohol Rev. 2014;33(5):463\u20135.","journal-title":"Drug Alcohol Rev"},{"issue":"4","key":"219_CR49","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5694\/mja15.00929","volume":"204","author":"RP Ogeil","year":"2016","unstructured":"Ogeil RP, Heilbronn C, Lloyd B, Lubman DI. Prescription drug monitoring in Australia: capacity and coverage issues. Med J Aust. 2016;204(4):148.","journal-title":"Med J Aust"},{"issue":"3","key":"219_CR50","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/dar.12242","volume":"34","author":"MM Islam","year":"2015","unstructured":"Islam MM, McRae IS. Real-time prescription drug monitoring program in Australia: we should be ready. Drug Alcohol Rev. 2015;34(3):344\u20135.","journal-title":"Drug Alcohol Rev"},{"key":"219_CR51","volume-title":"Real-time prescription monitoring initiative FAQ","author":"Victoria State Government","year":"2016","unstructured":"Victoria State Government: Real-time prescription monitoring initiative FAQ. Available at: \n                    https:\/\/www2.health.vic.gov.au\/public-health\/drugs-and-poisons\/real-time-prescription-monitoring\n                    \n                  . 2016."},{"issue":"2","key":"219_CR52","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5694\/mja12.10785","volume":"198","author":"FL Shand","year":"2013","unstructured":"Shand FL, Campbell G, Hall W, Lintzeris N, Cohen M, Degenhardt L. Real-time monitoring of schedule 8 medicines in Australia: evaluation is essential. Med J Aust. 2013;198(2):80\u20131.","journal-title":"Med J Aust"},{"key":"219_CR53","unstructured":"Griggs C: 2014\u20132015 APhA policy committee report. Integrated Nationwide Prescription Drug Monitoring Program Available at: \n                    https:\/\/www.pharmacist.com\/sites\/default\/files\/files\/Prescription%20Drug%20Monitoring%20Programs.pdf\n                    \n                  ; Accesson on 26 August 2016."}],"container-title":["BMC Pharmacology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-018-0219-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40360-018-0219-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-018-0219-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T19:33:50Z","timestamp":1560800030000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpharmacoltoxicol.biomedcentral.com\/articles\/10.1186\/s40360-018-0219-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["219"],"URL":"https:\/\/doi.org\/10.1186\/s40360-018-0219-0","relation":{},"ISSN":["2050-6511"],"issn-type":[{"value":"2050-6511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]},"assertion":[{"value":"22 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Human Ethics Committee of La Trobe University (S17\u2013218). All ethical considerations were observed, and personal information were de-identified.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"30"}}