{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:04:38Z","timestamp":1789142678472,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whether there was a correlation between the serum creatine phosphokinase (CPK) level, a specific marker of muscle breakdown, and muscle strength.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, sex, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values \u200b\u200bwere recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The two groups were similar in terms of age, sex, and BMI (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There was no significant difference between the isotretinoin and control groups in terms of muscle strength at the beginning of the treatment (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). No significant change was observed in hamstring and quadriceps PT values in the isotretinoin group after 6 months of treatment compared to baseline (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). No statistically significant correlation was found between the serum CPK level and hamstring and quadriceps muscle strength (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Oral isotretinoin doesn\u2019t alter muscle strength. There is no relationship between the serum CPK levels and muscle strength.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40360-021-00483-0","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T20:02:41Z","timestamp":1616270561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-3885","authenticated-orcid":false,"given":"Cevriye","family":"M\u00fclko\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Karaosmano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"issue":"7","key":"483_CR1","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s10067-014-2733-9","volume":"34","author":"MT Y\u0131ld\u0131zg\u00f6ren","year":"2015","unstructured":"Y\u0131ld\u0131zg\u00f6ren MT, Karatas Togral A, Baki AE, et al. Effects of isotretinoin treatment on cartilage and tendon thicknesses: an ultrasonographic study. Clin Rheumatol. 2015;34(7):1255\u20138. https:\/\/doi.org\/10.1007\/s10067-014-2733-9.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"483_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.7727\/wimj.2014.074","volume":"64","author":"A Karatas Togral","year":"2015","unstructured":"Karatas Togral A, Y\u0131ld\u0131zg\u00f6ren MT, Mustu Kory\u00fcrek \u00d6, et al. Can isotretinoin induce SAPHO syndrome? West Indian Med J. 2015;64(2):167\u20138. https:\/\/doi.org\/10.7727\/wimj.2014.074.","journal-title":"West Indian Med J"},{"issue":"1","key":"483_CR3","first-page":"33","volume":"96","author":"MT Y\u0131ld\u0131zg\u00f6ren","year":"2015","unstructured":"Y\u0131ld\u0131zg\u00f6ren MT, Rifaio\u011flu EN, Demirkap\u0131 M, Ekiz T, Micoo\u011fullar\u0131 A, \u015een T, Turhano\u011flu AD. Isotretinoin treatment in patients with acne vulgaris: does it impact muscle strength, fatigue, and endurance? Cutis. 2015;96(1):33\u20136.","journal-title":"Cutis."},{"issue":"2","key":"483_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/ajcn\/83.2.191","volume":"83","author":"KL Penniston","year":"2006","unstructured":"Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin a. Am J Clin Nutr. 2006;83(2):191\u2013201. https:\/\/doi.org\/10.1093\/ajcn\/83.2.191.","journal-title":"Am J Clin Nutr"},{"key":"483_CR5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1067\/mjd.2001.113721","volume":"45","author":"JJ DiGiovanna","year":"2001","unstructured":"DiGiovanna JJ. Isotretinoin effects on bone. J Am Acad Dermatol. 2001;45:176\u201382.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"483_CR6","first-page":"94","volume":"125","author":"AM Heudes","year":"1998","unstructured":"Heudes AM, Laroche L. Muscular damage during isotretinoin treatment. Ann Dermatol Venereol. 1998;125(2):94\u20137.","journal-title":"Ann Dermatol Venereol"},{"issue":"4pt 1","key":"483_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0190-9622(84)70204-0","volume":"11","author":"CH Dicken","year":"1984","unstructured":"Dicken CH. Retinoids: a review. J Am Acad Dermatol. 1984;11(4pt 1):541\u201352.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"483_CR8","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0190-9622(83)70176-3","volume":"9","author":"AR Shalita","year":"1983","unstructured":"Shalita AR, Cunningham WJ, Leyden JJ, Pochi PE, Strauss JS. Isotretinoin treatment of acne and related disorders: an update. 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Clinical trial number: NCT04626817. Written informed consent was obtained from each participant before recruitment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}